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Impact of HIV Pretreatment Drug Resistance on Virological Failure After One-Year Antiretroviral Therapy--China,2018-2019

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China CDC weekly 2022年第25期4卷 535-540页

作者： Miaomiao Li Chang Song Aobo Dong Jing Hu ruihua kang Hui Xing Yuhua Ruan Yiming Shao Kunxue Hong Lingjie Liao State Key Laboratory of Infectious Disease Prevention and Control National Center for AIDS/STD Control and PreventionChinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?While antiretroviral therapy(ART)has been rapidly scaled-up among the population living with human immunodeficiency virus or acquired immune deficiency syndrome(HIV/AIDS)... 详细信息

关键词： Therapy Impact patients

打造癌症防治体系赋能癌症全程管理——河南省癌症防控60年发展历程与展望

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中国肿瘤 2024年第5期33卷 342-348页

作者：徐慧芳刘茵王潇杨郭肖利王红刘曙正陈琼郭兰伟康瑞华刘红伟郑黎阳张韶凯郑州大学附属肿瘤医院/河南省肿瘤医院河南省肿瘤防治研究办公室河南省肿瘤防控工程研究中心河南省肿瘤预防国际联合实验室

河南省是我国肿瘤高发地区之一，也是我国肿瘤防治研究的发源地。自20世纪60年代起，河南省在癌症防治体系建设、肿瘤登记、早诊早治等方面采取了有效措施，在癌症防治方面取得重要成就。全文就河南省癌症综合防治工作的历程与成就进行... 详细信息

河南省是我国肿瘤高发地区之一，也是我国肿瘤防治研究的发源地。自20世纪60年代起，河南省在癌症防治体系建设、肿瘤登记、早诊早治等方面采取了有效措施，在癌症防治方面取得重要成就。全文就河南省癌症综合防治工作的历程与成就进行了总结，并对河南省未来癌症防治工作重点进行探讨。

关键词：癌症防治肿瘤登记筛查河南

2019年河南省肺癌流行特征及2010—2019年变化趋势分析

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中国肿瘤 2024年第5期33卷 358-365页

作者：郭肖利陈琼徐慧芳刘茵王潇杨康瑞华王红郑黎阳吴思雅刘红伟郭兰伟刘曙正张韶凯郑州大学附属肿瘤医院/河南省肿瘤医院河南省肿瘤防治研究办公室河南省肿瘤防控研究中心河南省肿瘤预防国际联合实验室

[目的]分析2019年河南省肺癌发病与死亡情况及2010—2019年河南省肿瘤登记地区肺癌发病与死亡变化趋势。[方法]利用各肿瘤登记处上报且质控合格的肺癌发病与死亡资料，结合全省户籍人口数据，估算2019年河南省肺癌分城乡、性别、年龄组... 详细信息

[目的]分析2019年河南省肺癌发病与死亡情况及2010—2019年河南省肿瘤登记地区肺癌发病与死亡变化趋势。[方法]利用各肿瘤登记处上报且质控合格的肺癌发病与死亡资料，结合全省户籍人口数据，估算2019年河南省肺癌分城乡、性别、年龄组别肺癌发病/死亡例数、粗率、中标率、世标率、构成比、0～74岁累积率。采用Joinpoint Regression Program 4.8软件，计算2010—2019年河南省肿瘤登记地区肺癌中标发病率和死亡率的年度变化百分比（APC）和平均年度变化百分比（AAPC）。[结果] 2019年河南省肺癌估计新发病例56 892例，粗发病率为51.95/10万，中标率和世标率分别为37.85/10万和38.06/10万，占全省所有恶性肿瘤新发病例的19.73%。河南省估计肺癌死亡病例43 625例，粗死亡率为39.83/10万，中标率和世标率分别为27.93/10万、28.11/10万，占全省全部恶性肿瘤死亡的26.35%。河南省2019年男性的发病率与死亡率均高于女性（男性：中标发病率为52.95/10万，中标死亡率为41.73/10万；女性：中标发病率为23.50/10万，中标死亡率为15.09/10万）。肺癌年龄别发病率与死亡率均在85岁及以上组达到高峰。2010—2019年间，河南省肿瘤登记地区的肺癌中标发病率和死亡率波动均呈平稳趋势，但城市地区男性在2014—2019年间肺癌中标发病率和死亡率每年分别下降4.6%和4.7%，农村地区男性中标死亡率每年下降4.7%。2010—2019年间，40～49岁年龄组男性、女性肺癌发病率与死亡率均呈现明显下降趋势。[结论]河南省肺癌发病与死亡水平依旧较高，疾病负担较重，后续应继续加强肺癌防控和筛查与早诊早治工作。

关键词：肺癌发病死亡趋势分析河南

Changing Proportions of HIV-1 Subtypes and Transmitted Drug Resistance Among Newly Diagnosed HIV/AIDS Individuals—China,2015 and 2018

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China CDC weekly 2021年第53期3卷 1133-1138页

作者： Jingjing Hao Shan Zheng Mengze Gan Aobo Dong ruihua kang Miaomiao Li Shuai Zhao Jing Hu Chang Song Lingjie Liao Yi Feng Yiming Shao Yuhua Ruan Hui Xing State Key Laboratory of Infectious Disease Prevention and Control(SKLID) National Center for AIDS/STD Control and Prevention(NCAIDS)Chinese Center for Disease Control and Prevention(China CDC)Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesBeijingChina.

Introduction:With the expansion of human immunodeficiency virus(HIV)antiretroviral therapy(ART),HIV drug resistance is becoming more and more *** study describes the changing prevalence of HIV-1 subtypes and transmitted drug resistance(TDR)among newly diagnosed individuals in China,2015 and ***:A total of 8,980 individuals in 2015 and 2018 from 31 provincial-level administrative divisions(PLADs)were enrolled in this *** RNAs were amplified and sequenced using an in-house polymerase chain reaction(PCR)*** Stanford HIV Drug Resistance Database(HIVdb)was used to predict susceptibility to 12 antiretroviral ***:The prevalence of TDR was not significantly increased over *** prevalence of TDR was 3.8%and 4.4%in 2015 and 2018,respectively(P=0.13).The prevalence of CRF55_01B increased from 2.3%in 2015 to 3.9%in 2018(P<0.001).The drug resistance prevalence of nonnucleoside reverse transcriptase inhibitors(NNRTI)increased from 2.4%in 2015 to 3.3%in 2018(P<0.01).The prevalence of E138(P<0.001),H221(P=0.03),and V179(P<0.001)mutations increased from 0.30%,0.09%,and 0.70%in 2015 to 1.10%,0.30%,and 1.70%in 2018,***:HIV drug resistance affects the effect of antiretroviral treatment,so the monitoring of HIV TDR should be strengthened to control the transmission of HIV drug resistance.

关键词： drugs Stanford HIV/AIDS

河南省2015—2019年恶性肿瘤5年相对生存率分析

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中华肿瘤杂志 2024年第10期46卷 954-960页

作者：陈琼张明霞郭兰伟郑黎阳刘纯亚王一先刘茵王红徐慧芳康瑞华王潇杨刘曙正张韶凯郑州大学附属肿瘤医院河南省肿瘤医院疾病预防控制科河南省肿瘤防控工程研究中心河南省肿瘤预防国际联合实验室郑州兰州大学公共卫生学院兰州

目的利用人群肿瘤登记数据分析2015—2019年河南省恶性肿瘤5年相对生存率。方法提取河南省肿瘤登记数据库中诊断日期在2010年1月1日至2019年12月31日之间的恶性肿瘤病例, 采用现时生存分析方法估计恶性肿瘤5年相对生存率, Ederer Ⅱ方... 详细信息

目的利用人群肿瘤登记数据分析2015—2019年河南省恶性肿瘤5年相对生存率。方法提取河南省肿瘤登记数据库中诊断日期在2010年1月1日至2019年12月31日之间的恶性肿瘤病例, 采用现时生存分析方法估计恶性肿瘤5年相对生存率, Ederer Ⅱ方法计算期望生存率, 感兴趣时期设定为2015—2019年, 随访截至2019年12月31日。使用国际癌症生存标准年龄结构进行标化, 标化生存率的组间比较采用Z检验。结果河南省2015—2019年恶性肿瘤总体5年相对生存率为43.3%。总体标化5年相对生存率为40.2%, 其中女性高于男性(分别为45.9%和34.7%;Z=39.60, P70%的恶性肿瘤有2种(甲状腺癌82.2%, 乳腺癌71.6%), <30%的有4种(胰腺癌18.2%, 肝癌19.6%, 肺癌24.0%, 胆囊癌26.6%)。结论河南省恶性肿瘤5年相对生存率相对滞后于全国平均水平, 应继续加强肿瘤综合防控力度。

关键词：恶性肿瘤现时生存分析 5年相对生存率肿瘤防控河南省

2013—2021年河南省淮河流域地区上消化道癌筛查效果分析

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中国肿瘤 2024年第5期33卷 366-372页

作者：康瑞华刘曙正王一先徐慧芳刘茵王潇杨郭肖利王红郑黎阳陈琼郭兰伟刘红伟张韶凯郑州大学附属肿瘤医院/河南省肿瘤医院河南省肿瘤防治研究办公室河南省肿瘤防控工程研究中心河南省肿瘤预防国际联合实验室

目的]分析2013—2021年河南省淮河流域地区上消化道癌筛查效果。[方法]采用整群抽样的方式，选取发病率和死亡率较高的乡镇或村庄作为筛查现场，对当地40至69岁常住居民进行筛查。对评估为高危人群的个体采用“内镜+碘染色”方法进一步... 详细信息

目的]分析2013—2021年河南省淮河流域地区上消化道癌筛查效果。[方法]采用整群抽样的方式，选取发病率和死亡率较高的乡镇或村庄作为筛查现场，对当地40至69岁常住居民进行筛查。对评估为高危人群的个体采用“内镜+碘染色”方法进一步检查，分别计算上消化道癌（包括食管癌与胃癌）各级别病变、早期病例和阳性病例检出率以及早诊率等评价指标。采用χ2检验和趋势χ2检验对不同性别、年龄及时间的检出率进行比较。[结果]2013至2021年间，河南省淮河流域地区上消化道各级别病变的检出率为4.96%（1 980/39 895），其中，食管各级别病变检出率为3.05%（1 215/39 895），胃各级别病变检出率为1.93%（768/39 895）。上消化道阳性病例的检出率为0.83%（330/39 895），早期病例的检出率为0.62%（248/39 895），早诊率为75.15%（248/330）。男性各级别病变的检出率均高于女性（P0.05)。[结论]上消化道癌筛查有助于及时发现各级别病变患者。男性和老年人群在上消化道癌筛查中属于重点关注群体，需要提升该人群的筛查参与度，以进一步提高上消化道癌的筛查效果。

关键词：上消化道癌筛查检出率淮河流域河南

Dynamic transcriptome profiles and novel markers in bovine spermatogenesis revealed by single-cell sequencing

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Journal of Integrative Agriculture 2024年第7期23卷 2362-2378页

作者： Yuan Gao Fuxia Bai Qi Zhang Xiaoya An Zhaofei Wang Chuzhao Lei ruihua Dang Key Laboratory of Animal Genetics Breeding and Reproduction of Shaanxi ProvinceCollege of Animal Science and TechnologyNorthwest A&F UniversityYangling 712100China College of Life Sciences Northwestern Polytechnical UniversityXi’an 710072China

Testicular development is an important biological process in male and requires interaction between the male germ cells and somatic ***,the mechanisms of testicular development in livestock,particularly in cattle,are poorly ***,cellular heterogeneity hinders the profiling of different cell types at different developmental *** this study,we first performed a single-cell transcriptomic study of the bovine testis development during puberty by using 10×genomics single-cell RNA sequencing(scRNA-seq).By collecting the scRNA-seq data from 11,083 cells from prepubertal and pubertal bovine testes,a high-resolution scRNA-seq atlas was described,identifying 9 somatic and 13 spermatogenic *** also distinguished several stage-specific marker genes for bovine germ cells and somatic cells,such as GRAF2 and MORC1 for SSC(spermatogonial stem cells),HJURP and TCF19 for differentiating spermatogonia,ARSE for immature Sertoli,CLEC12B for mature Sertoli,LOC112441470 for *** conclusion,we have examined the transcription levels and constructed the single-cell developmental maps of germ cells and somatic cells during testicular development in Angus *** datasets provided new insights into spermatogenesis and testicular somatic cell development in cattle.

关键词： scRNA-seq cattle spermatogenesis testis development

Atherosis-associated lnc_000048 activates PKR to enhance STAT1-mediated polarization of THP-1 macrophages to M1 phenotype

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Neural Regeneration Research 2024年第11期19卷 2488-2498页

作者： Yuanyuan Ding Yu Sun Hongyan Wang Hongqin Zhao ruihua Yin Meng Zhang Xudong Pan Xiaoyan Zhu Department of Neurology The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Qingdao Cadre Health Care Service Center The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of Critical Care Medicine The Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

Our previous study has demonstrated that lnc_000048 is upregulated in large-artery atherosclerotic stroke and promotes atherosclerosis in ApoE^(-/-)***,little is known about the role of lnc_000048 in classically activated macrophage(M1)*** this study,we established THP-1-derived testing state macrophages(M0),M1 macrophages,and alternately activated macrophages(M2).Real-time fluorescence quantitative PCR was used to verify the expression of marker genes and the expression of lnc_000048 in *** cytometry was used to detect phenotypic proteins(CD11b,CD38,CD80).We generated cell lines with lentivirus-mediated upregulation or downregulation of lnc_*** cytometry,western blot,and real-time fluorescence quantitative PCR results showed that down-regulation of lnc_000048 reduced M1 macrophage polarization and the inflammation response,while over-expression of lnc_000048 led to the opposite *** blot results indicated that lnc_000048 enhanced the activation of the STAT1 pathway and mediated the M1 macrophage ***,catRAPID prediction,RNA-pull down,and mass spectrometry were used to identify and screen the protein kinase RNA-activated(PKR),then catRAPID and RPIseq were used to predict the binding ability of lnc_000048 to ***(IF)-RNA fluorescence in situ hybridization(FISH)double labeling was performed to verify the subcellular colocalization of lnc_000048 and PKR in the cytoplasm of M1 *** speculate that lnc_000048 may form stem-loop structure-specific binding and activate PKR by inducing its phosphorylation,leading to activation of STAT1 phosphorylation and thereby enhancing STAT1 pathway-mediated polarization of THP-1 macrophages to M1 and inflammatory factor *** together,these results reveal that the lnc_000048/PKR/STAT1 axis plays a crucial role in the polarization of M1 macrophages and may be a novel therapeutic target for atherosclerosis alleviation in stroke.

关键词： atherosclerosis inflammation lnc_000048 lncRNA macrophage polarization protein kinase RNA-activated(PKR) STAT1

Computational fluid dynamics simulation and experimental study on mixing performance of a three-dimensional circular cyclone-type microreactor

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Chinese Chemical Letters 2024年第4期35卷 382-388页

作者： Shiyu Hou Maolin Sun Liming Cao Chaoming Liang Jiaxin Yang Xinggui Zhou Jinxing Ye ruihua Cheng School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Microchannels enable the fast and efficient mixing of multiphase *** this study, a millimeter-scale three-dimensional(3D) circular cyclone-type microreactor was designed for the *** flow characteristics and mixing intensity were simulated by computational fluid dynamics simulations at a flow rate range of 12–96 m L/min using a water/ethyl acetate *** the 3D variable-diameter structure,the microreactor induced paired opposite vortices and abruptly changed the local pressure to achieve a stable turbulent effect within the theoretical range of laminar *** injection simulations indicated that sufficient mixing units successfully promote fluid ***-coupling experiments showed a segregation index of X_S= 0.00,039 within a residence time of 9 *** experiments on the nbutanol/succinic acid/water system showed that the 3D circular cyclone-type microreactor achieved 100%extraction efficiency(E) in 4.25 s, and the overall volume mass transfer coefficient(K_La) reached 0.05–1.5s^(-1) in 12–96 m L/*** isolated yield of the phase transfer alkylation and oxidation reactions in the 3D circular cyclone-type microreactor achieved 99% within 36 s, which was superior to the coil microreactor and batch reactor.

关键词： Microfluidics Passive microreactor CFD simulation Extraction Liquid-liquid biphase reaction