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交通运输专业国际本科生在线教学质量保障机制研究

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物流科技 2024年第5期47卷 179-181页

作者：张英贵张云丽胡睿华中南大学交通运输工程学院湖南长沙410075

结合中南大学交通运输专业国际本科生教学现状、学院国际交流和国际本科生培养管理实践及经验,解析以轨道交通为特色的交通运输专业国际本科生在线教学特征,从课堂教学和实践教学两个层面构建交通运输专业国际本科生在线教学质量保障机... 详细信息

结合中南大学交通运输专业国际本科生教学现状、学院国际交流和国际本科生培养管理实践及经验,解析以轨道交通为特色的交通运输专业国际本科生在线教学特征,从课堂教学和实践教学两个层面构建交通运输专业国际本科生在线教学质量保障机制。提出具体的实施保障策略,尽可能降低因国际本科生与授课教师之间的时空限制和文化差异带来的负面影响,以期提高交通运输专业国际本科生在线教育教学质量,推动交通运输专业国际本科生教育内涵式发展,为新时代面向来华留学生开展在线课堂和实践模式的探索与改革创造有利条件,助力国家“一带一路”倡议和铁路“走出去”战略的高质量发展。

关键词：国际本科生在线教学质量保障机制交通运输

MicroRNA与子宫内膜异位症相关研究进展

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中国计划生育和妇产科 2024年第3期16卷 40-42,48页

作者：胡瑞花李佳佳张淑萍常珩新疆医科大学研究生院新疆乌鲁木齐830054 中国人民解放军新疆军区总医院新疆特殊环境医学重点实验室新疆乌鲁木齐830054 中国人民解放军新疆军区总医院妇科新疆乌鲁木齐830054

子宫内膜异位症(endometriosis,EMs)是指子宫内膜组织(腺体和间质)生长在子宫腔与子宫肌层以外的部位,为多发于育龄期女性的一种慢性妇科疾病,近年来在青春期及更年期女性中发病率呈上升趋势。主要临床表现为进行性痛经、性交痛、不孕等... 详细信息

子宫内膜异位症(endometriosis,EMs)是指子宫内膜组织(腺体和间质)生长在子宫腔与子宫肌层以外的部位,为多发于育龄期女性的一种慢性妇科疾病,近年来在青春期及更年期女性中发病率呈上升趋势。主要临床表现为进行性痛经、性交痛、不孕等,部分患者还因此存在不同程度的情绪障碍^([1])。MicroRNA(miRNA)是非编码RNA的一种,在许多人类疾病中通过促进mRNA降解或抑制蛋白质翻译来调节基因表达,具有在转录后水平调控目标基因的功能。

关键词：子宫内膜异位症 microRNA 发病机制诊断标志物

RISK ANALYSIS OF JACKET PLATFORMS DURING INSTALLATION ON SEA

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China Ocean Engineering 1990年第2期5卷 199-207页

作者： Li, Jianchao hu, ruihua China Jilin Int Engineering Designing Inst Changchun China

In this paper, the uncertainty of environmental loads and soil resistance is analyzed, and the wave and current loads acting on a jacket during the unpiled installation phase are converted to its foundation loads. With a probability model of soil resistance, risk applied to the design of temporary seafloor support of a platform and the risk of failure, or probability of horizontal sliding, tilting and ovrturning can be pridicted. Thereby, optimum design and installation procedure may be chosen according to safety and economical factors. A Fortran program based on the model is developed. The application of the program to a jacket in South China Sea is described.

关键词： Economics Foundations Soil Structure Interaction Probability

Disulfide bridge-targeted metabolome mining unravels an antiparkinsonian peptide

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Acta Pharmaceutica Sinica B 2024年第2期14卷 881-892页

作者： Zhiwu Tong Xiahong Xie huiming Ge ruihua Jiao Tingting Wang Xincun Wang Wenying Zhuang Gang hu Renxiang Tan State Key Laboratory of Pharmaceutical Biotechnology Institute of Functional BiomoleculesSchool of Life SciencesNanjing UniversityNanjing 210023China State Key Laboratory Cultivation Base for TCM Quality and Efficacy Nanjing University of Chinese MedicineNanjing 210023China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China

Peptides are a particular molecule class with inherent attributes of some small-molecule drugs and macromolecular biologics,thereby inspiring continuous searches for peptides with therapeutic and/or agrochemical ***,the success rate is decreasing,presumably because many interesting but less-abundant peptides are so scarce or labile that they are likely‘overlooked’during the characterization ***,we present the biochemical characterization and druggability improvement of an unprecedented minor fungal RiPP(ribosomally synthesized and post-translationally modified peptide),named acalitide,by taking the relevant advantages of metabolomics approach and disulfide-bridged substructure which is more frequently imprinted in the marketed peptide drug *** is biosynthetically unique in the macrotricyclization via two disulfide bridges and a protease(AcaB)-catalyzed lactamization of AcaA,an unprecedented precursor *** a biosynthetic logic was successfully re-edited for its sample supply renewal to facilitate the identification of the in vitro and in vivo antiparkinsonian efficacy of acalitide which was further confirmed safe and rendered brain-targetable by the liposome encapsulation *** together,the work updates the mining strategy and biosynthetic complexity of RiPPs to unravel an antiparkinsonian drug candidate valuable for combating Parkinson’s disease that is globally prevailing in an alarming manner.

关键词： Fungal RiPPs Biosynthesis Macrocyclic peptide Acalitide Antiparkinsonian

Effect of Si_3N_4 Addition on the Mechanical Properties, Microstructures, and Wear Resistance of Ti-6Al-4V Alloy

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Journal of Materials Science & Technology 2007年第2期23卷 257-261页

作者： ruihua hu Montasser M. Dewidar Hyo-Jin KIM Jae-Kyoo LIM Henan University of Science and Technology Luoyang 471003 China Department of Mechanical Design Chonbuk National University Dokjin 1-664-14 Jeonju South Korea Department of Mechanical Design and Materials High Institute of Energy South Valley University Aswan Egypt Automobile High-Technology Research Institute Faculty of Mechanical and Aerospace System Engineering Chonbuk National University Dokjin 1-664-14 Jeonju South Korea

In order to improve the wear resistance of Ti-6Al-4V, different amounts of Si3N4 powder were added into the alloy powder and sintered at 1250℃. Porous titanium alloy with higher wear resistance was successfully fabricated. At sintering temperature, reaction took place and a new hard phase of Ti5Si3 formed. The mechanical properties of the fabricated alloys with different amounts of Si3N4 addition were investigated. The hardness of Ti-6Al-4V, which is the index of wear resistance, was increased by the addition of Si3N4. Amounts of Si3N4 addition have very significant influences on hardness and compressive strength. In present study,titanium alloy with 5 wt pct Si3N4 addition has 62% microhardness and 45% overall bulk hardness increase,respectively. In contrast, it has a 16.4% strength reduction. Wear resistance was evaluated by the weight loss during wear test. A new phase of Ti5Si3 was detected by electron probe microanalyzer （EPMA） and X-ray diffraction （XRD） method. The original Si3N4 decomposed during sintering and transformed into titanium silicide. Porous structure was achieved due to the sintering reaction.

关键词： Ti-6Al-4V Silicon nitride Sintering reaction Mechanical properties

A machine learning model for predicting acute kidney injury secondary to severe acute pancreatitis

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Chinese Medical Journal 2024年第5期137卷 619-621页

作者： Wanyue Zhang Yongjian Chang Cuie Cheng Xiaodan Zhao Xiajiao Tang Fenying Lu Yanli hu Chunying Yang Yuan Ding ruihua Shi School of Medicine Southeast UniversityNanjingJiangsu 210009China School of Cyber Science and Engineering Southeast UniversityNanjingJiangsu 210009China Department of Gastroenterology Changshu No.2 People’s HospitalChangshuJiangsu 215500China Department of Gastroenterology Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China Department of Gastroenterology Pizhou People’s HospitalXuzhouJiangsu 221300China Department of Gastroenterology Pizhou Hospital of Traditional Chinese MedicineXuzhouJiangsu 221300China

To the Editor:Severe acute pancreatitis(SAP)is a common critical disease in gastroenterology,and 69.3%of patients have acute kidney injury(AKI).^([1])Early diagnosis and treatment are very important in improving the prognosis of these *** recent years,machine learning models have been widely used in the medical field due to their excellent prediction *** scholars have developed machine learning models that can solve the AKI prediction problem in specific populations and achieved good results.^([2])However,considering that the occurrence of AKI in patients with pancreatitis is also closely related to factors such as amylase and inflammatory markers,it is necessary to construct an AKI prediction model for the pancreatitis population.

关键词： pancreatitis acute kidney

核苷类似物、干扰素及心理治疗对慢性乙肝患者的疗效及对心理状态的影响

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国际精神病学杂志 2022年第1期49卷 141-144页

作者：胡瑞华河南省濮阳市人民医院感染性疾病科濮阳457000

目的探讨分析核苷类似物(NAs)、干扰素(IFN)及心理治疗对慢性乙肝(CHB)患者的疗效及对心理状态的影响。方法选取本院2019年1月~2019年12月期间收治的80例CHB患者作为本次研究的对象,按随机数字表法将研究对象随机分为观察组和对照组... 详细信息

目的探讨分析核苷类似物(NAs)、干扰素(IFN)及心理治疗对慢性乙肝(CHB)患者的疗效及对心理状态的影响。方法选取本院2019年1月~2019年12月期间收治的80例CHB患者作为本次研究的对象,按随机数字表法将研究对象随机分为观察组和对照组。对照组40例CHB患者给予NAs+IFN治疗,观察组40例CHB患者加用心理治疗。观察比较两组患者治疗前后的抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分、肝纤维化指标、健康调查简表(SF-36),以及治疗后谷丙转氨酶(ALT)复常率。结果治疗后观察组患者SAS和SDS评分低于对照组(P<0.05);治疗后观察组患者HA、LN、IV-C水平低于对照组(P<0.05);治疗后观察组SF-36评分高于对照组(P<0.05);观察组患者治疗1、3、6、12个月时的ALT复常率高于对照组(P<0.05)。结论 NAs+IFN+心理治疗对CHB患者有较好疗效,可促进ALT复常,改善患者肝功能及心理状态,提高生活质量。

关键词：核苷类似物干扰素慢性乙肝临床疗效心理状态心理治疗

考虑冗余时间的区域铁路车站股道运用计划协同编制优化方法

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铁道科学与工程学报 2023年第2期20卷 506-515页

作者：高全张英贵陈治亚陈曾儒胡睿华中南大学交通运输工程学院湖南长沙410075

股道运用是区域铁路车站作业组织的核心,局部站点的非常态事件会经由列车运行不同程度地影响相邻车站股道运用计划,协同编制具有强抗干扰能力的多站股道运用计划尤为重要,亦是区域铁路列车运行计划编制的重要内容。统筹考虑区域铁路车... 详细信息

股道运用是区域铁路车站作业组织的核心,局部站点的非常态事件会经由列车运行不同程度地影响相邻车站股道运用计划,协同编制具有强抗干扰能力的多站股道运用计划尤为重要,亦是区域铁路列车运行计划编制的重要内容。统筹考虑区域铁路车站股道运用计划协同编制影响因素,基于整体和计划编制视角,引入冗余时间的概念,建立区域铁路多站股道运用冗余时间分配优化模型,并以最大化车站股道运用全局抗干扰能力与均衡性为优化目标函数,构建区域铁路车站股道运用计划融合编制优化模型。以列车运行和车站到发时刻为纽带,建立考虑冗余时间的区域铁路车站股道运用计划协同编制双层规划模型。通过构造非常态事件随机干扰概率函数,设计多站股道运用冗余时间分配优化算法,结合模拟退火算法思想,给出区域铁路车站股道运用计划协同编制启发式求解算法,提出一种考虑冗余时间的区域铁路车站股道运用计划协同编制优化方法。算例表明:所提方法能合理编制出具有强抗干扰能力的区域铁路相邻若干车站的股道运用计划,逐步降低非常态突发事件对后续车站股道运用的影响程度;对比传统的平均、比例分配方法,所提冗余时间分配方法更能有效缓解不同车站股道运用计划的站间影响;所提方法能够为区域铁路调度人员协同编制车站股道运用和列车运行计划提供强有力的决策支撑。

关键词：区域铁路车站股道运用协同编制优化冗余时间抗干扰能力

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植物叶器官树脂标本保色研究

现代农业研究 2022年第9期28卷 115-119页

作者：胡瑞华宋军阳西北农林科技大学风景园林艺术学院陕西杨凌712100

本文以未干燥处理的叶片树脂标本为对照,分别选取10种不同质地、颜色的叶片作为试验材料,从不同干燥处理方法、不同干燥时间进行研究,将不同干燥处理的植物叶片材料,用环氧树脂A B胶包埋,进一步制作成叶片树脂标本。在此过程中,用色差... 详细信息

本文以未干燥处理的叶片树脂标本为对照,分别选取10种不同质地、颜色的叶片作为试验材料,从不同干燥处理方法、不同干燥时间进行研究,将不同干燥处理的植物叶片材料,用环氧树脂A B胶包埋,进一步制作成叶片树脂标本。在此过程中,用色差仪测量叶片实验材料在采摘时、干燥后、叶片树脂标本包埋15d、120d颜色数据并进行比较。数据显示:叶片植物材料运用草纸干燥法制作的树脂标本色差变化最小,没有进行干燥处理的色差变化最大;在草纸干燥法中,进行了不同干燥时间的处理,随着干燥时间的增加,叶片树脂标本色差逐渐变小,并逐渐趋于稳定。

关键词：树脂植物标本干燥色差