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Chinese Chemical Letters 2024年第4期35卷 382-388页

作者： Shiyu Hou Maolin Sun Liming Cao Chaoming Liang Jiaxin Yang Xinggui Zhou Jinxing Ye ruihua cheng School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China

Microchannels enable the fast and efficient mixing of multiphase *** this study, a millimeter-scale three-dimensional(3D) circular cyclone-type microreactor was designed for the *** flow characteristics and mixing intensity were simulated by computational fluid dynamics simulations at a flow rate range of 12–96 m L/min using a water/ethyl acetate *** the 3D variable-diameter structure,the microreactor induced paired opposite vortices and abruptly changed the local pressure to achieve a stable turbulent effect within the theoretical range of laminar *** injection simulations indicated that sufficient mixing units successfully promote fluid ***-coupling experiments showed a segregation index of X_S= 0.00,039 within a residence time of 9 *** experiments on the nbutanol/succinic acid/water system showed that the 3D circular cyclone-type microreactor achieved 100%extraction efficiency(E) in 4.25 s, and the overall volume mass transfer coefficient(K_La) reached 0.05–1.5s^(-1) in 12–96 m L/*** isolated yield of the phase transfer alkylation and oxidation reactions in the 3D circular cyclone-type microreactor achieved 99% within 36 s, which was superior to the coil microreactor and batch reactor.

关键词： Microfluidics Passive microreactor CFD simulation Extraction Liquid-liquid biphase reaction

A sequential continuous flow synthesis and purification process of calcium dibutyryladenosine cyclophosphate

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Chinese Chemical Letters 2024年第2期35卷 402-406页

作者： Liming Cao Maolin Sun Chaoming Liang Lei Yang Yueyue Ma ruihua cheng Yanxiong Ke Wei Yu Jinxing Ye Engineering Research Center of Pharmaceutical Process Chemistry Ministry of EducationSchool of PharmacyEast China University of Science and TechnologyShanghai 200237China School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China Shanghai No.1 Biochemical& Pharmaceutical Co. Ltd.Shanghai 200080China

Calcium dibutyryladenosine cyclophosphate is a widely used cardiovascular *** traditional batch synthesis process suffers from long reaction times,tedious operations,and unstable ***,a sequential continuous flow synthesis combined with a multistage in-line purification process of calcium dibutyryladenosine cyclophosphate was *** acylation reaction was completed in a continuous coil reactor at 160℃ in 20 *** the high toxic solvent pyridine was replaced by ***,the multistage in-line purification process was integrated into the homemade 3D circular cyclone-type micromixer *** with the membrane phase separators,the residence time of the purification step was 30 *** isolated yield of this sequential continuous process was 92%with 99%purity.

关键词： Flow chemistry Calcium dibutyryladenosine cyclophosphate Continuous flow synthesis In-line purification 3D circular cyclone-type micromixer chip

Two-step continuous flow process of sodium tanshinone ⅡA sulfonate using a 3D circular cyclone-type microreactor

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Chinese Chemical Letters 2024年第1期35卷 290-294页

作者： Maolin Sun Chaoming Liang Liming Cao Yaguo Wang Jiasheng Yang Shiyu Hou Wei Yu Yueyue Ma ruihua cheng Jinxing Ye School of Biomedical and Pharmaceutical Sciences Guangdong University of TechnologyGuangzhou 510006China School of Pharmacy East China University of Science and TechnologyShanghai 200237China School of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Shanghai No.1 Biochemical&Pharmaceutical Co. Ltd.Shanghai 200080China

A sustainable and practical process is presented for the direct synthesis of sodium tanshinone IIA sulfonate(STS).Our approach was inspired by the well-established and industrially applied batch synthetic route for STS *** constructed a telescoped two-step continuous flow *** involved a continuous tanshinone IIA sulfonation and in-line salt *** the setup,we constructed a 3D circular cyclone-type microreactor using femtosecond laser *** to the 68%yield for 2 h in batch,the two-step continuous flow had an STS yield of 90%,achieved for a total residence time of<3.0 min under optimal *** proposed continuous flow method vastly simplified the operation and improved procedural safety,while significantly reducing the required acid content and wastewater production.

关键词： Continuous flow Sodium tanshinone IIA sulfonate Cardiovascular Microreactor Green chemistry

高静压和热预处理对真空冷冻干燥重组果蔬块品质的影响

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食品科学 2024年第5期45卷 201-209页

作者：袁林梁旭娟程瑞华陈国刚石训劳菲李雪峰吴继红中国农业大学食品科学与营养工程学院国家果蔬加工工程技术研究中心农业农村部果蔬加工重点实验室食品非热加工北京市重点实验室北京100083 石河子大学食品学院新疆石河子832000 好想你健康食品股份有限公司河南新郑451100 新疆乐优食品有限公司新疆阿克苏843000

以芒果、甜瓜、菠萝和胡萝卜为原料,采用传统热处理及不同高静压条件对复合果蔬浆进行预处理后,通过冷冻干燥(freeze?drying,FD)技术生产重组果蔬块,研究不同高静压压力对FD果蔬块理化品质、生物活性物质、抗氧化活性和感官品质的影响... 详细信息

以芒果、甜瓜、菠萝和胡萝卜为原料,采用传统热处理及不同高静压条件对复合果蔬浆进行预处理后,通过冷冻干燥(freeze?drying,FD)技术生产重组果蔬块,研究不同高静压压力对FD果蔬块理化品质、生物活性物质、抗氧化活性和感官品质的影响。结果表明:与热预处理相比,高静压预处理能显著提高FD果蔬块产品的a*值、b*值、可滴定酸含量、抗氧化活性(1,1-二苯基-2-三硝基苯肼自由基清除率、羟自由基清除率、铁离子还原能力),总酚、总黄酮、VC含量分别较热预处理提高21.11%~30.27%、59.96%~68.58%、13.35%~15.34%;醇类和酮类挥发性风味物质含量分别为189.65~207.82?μg/kg和59.60~81.16μg/kg,相较于热预处理显著提高。此外,高静压预处理FD果蔬块在5种香气属性上的感官强度和色泽、气味、滋味的喜好度也显著高于热预处理FD果蔬块。在300?MPa和500?MPa的高静压预处理条件下,FD果蔬块的感官品质最接近未处理组。高静压预处理通过提高细胞膜通透性,促进了生物活性物质和风味物质的释放,提高了抗氧化活性,与传统热预处理相比,高静压预处理有效改善了FD果蔬块的品质特性。

关键词：重组果蔬块休闲食品高静压预处理真空冷冻干燥挥发性化合物抗氧化活性

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Gas phase ethylene polymerization over SiO_(2)-supported organosilyl chromate UCC S-2 catalyst using a high-speed stirred-autoclave reactor

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Frontiers of Chemical Science and Engineering 2011年第1期5卷 89-95页

作者： Liuzhong LI Aiyou HAO ruihua cheng Boping LIU School of Chemistry and Chemical Engineering Shandong UniversityJinan 250100China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237China Research Institute of Qilu Branch Co. SINOPECZibo 255400China

Although an important industrial catalyst for producing high density polyethylene,the SiO_(2)-supported organosilyl chromate UCC S-2 catalyst has not been fully investigated compared with the SiO_(2)-supported oxo chromium Phillips *** this work,gas phase ethylene polymerization by S-2 catalysts(Cat-1,Cat-2,and Cat-3)was carried out in a high-speed stirredautoclave *** effects of temperature,time,and pressure on kinetics,activity,and product properties were *** kinetics were typical built-up types with slow *** to the simple physical mixtures of Cat-1 and Cat-2,Cat-3 showed higher activity and its product had a broader molecular weight distribution,indicating new active species induced during blending of Cat-1 and Cat-2 in *** innovation by a simple catalyst technology created a new application to meet market demands.

关键词： UCC S-2 catalyst Al-alkyl co-catalyst gasphase ethylene polymerization high density polyethylene

ZmCYP90D1 regulates maize internode development by modulating brassinosteroid-mediated cell division and growth

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The Crop Journal 2024年第1期12卷 58-67页

作者： Canran Sun Yang Liu Guofang Li Yanle Chen Mengyuan Li ruihua Yang Yongtian Qin Yongqiang Chen Jinpeng cheng Jihua Tang Zhiyuan Fu Key Laboratory of Wheat and Maize Crops Science/Collaborative Innovation Center of Henan Grain Crops/College of Agronomy Henan Agricultural UniversityZhengzhou 450046HenanChina The Shennong Laboratory Zhengzhou 450002HenanChina Hebi Academy of Agricultural Sciences Hebi 458030HenanChina Yunnan Tang Jihua Expert Workstation/Zhaotong Academy of Agricultural Sciences Zhaotong 657000YunnanChina

Plant height(PH)is associated with lodging resistance and planting density,which is regulated by a complicated gene *** this study,we identified a spontaneous dwarfing mutation in maize,m30,with decreased internode number and length but increased internode diameter.A candidate gene,ZmCYP90D1,which encodes a member of the cytochrome P450 family,was isolated by map-based ***90D1 was constitutively expressed and showed highest expression in basal internodes,and its protein was targeted to the nucleus.A G-to-A substitution was identified to be the causal mutation,which resulted in a truncated protein in *** of function of ZmCYP90D1 changed expression of hormoneresponsive genes,in particular brassinosteroid(BR)-responsive genes which is mainly involved in cell cycle regulation and cell wall extension and modification in *** concentration of typhasterol(TY),a downstream intermediate of ZmCYP90D1 in the BR pathway,was reduced.A haplotype conferring dwarfing without reducing yield was ***90D1 was inferred to influence plant height and stalk diameter via hormone-mediated cell division and cell growth via the BR pathway.

关键词： Maize ZmCYP90D1 BR biosynthesis Dwarf plant

A machine learning model for predicting acute kidney injury secondary to severe acute pancreatitis

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Chinese Medical Journal 2024年第5期137卷 619-621页

作者： Wanyue Zhang Yongjian Chang Cuie cheng Xiaodan Zhao Xiajiao Tang Fenying Lu Yanli Hu Chunying Yang Yuan Ding ruihua Shi School of Medicine Southeast UniversityNanjingJiangsu 210009China School of Cyber Science and Engineering Southeast UniversityNanjingJiangsu 210009China Department of Gastroenterology Changshu No.2 People’s HospitalChangshuJiangsu 215500China Department of Gastroenterology Zhongda HospitalSoutheast UniversityNanjingJiangsu 210009China Department of Gastroenterology Pizhou People’s HospitalXuzhouJiangsu 221300China Department of Gastroenterology Pizhou Hospital of Traditional Chinese MedicineXuzhouJiangsu 221300China

To the Editor:Severe acute pancreatitis(SAP)is a common critical disease in gastroenterology,and 69.3%of patients have acute kidney injury(AKI).^([1])Early diagnosis and treatment are very important in improving the prognosis of these *** recent years,machine learning models have been widely used in the medical field due to their excellent prediction *** scholars have developed machine learning models that can solve the AKI prediction problem in specific populations and achieved good results.^([2])However,considering that the occurrence of AKI in patients with pancreatitis is also closely related to factors such as amylase and inflammatory markers,it is necessary to construct an AKI prediction model for the pancreatitis population.

关键词： pancreatitis acute kidney

Mechanism of ethylene tetramerization over Cr-2, 2-dipyridylamine Catalysts

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Mechanism of ethylene tetramerization over Cr-2, 2-dipyridyl...

稀土三元催化体系ZnO/SiO_2负载化及季铵盐催化CO_2与环氧丙烷合成高分子量聚碳酸酯（英文）

第十七届全国金属有机化学学术讨论会

作者： Siyang Tang Zhen Liu ruihua cheng Boping Liu East China University of Science and Technology

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来源： cnki会议评论

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Chinese Journal of Catalysis 2018年第8期39卷 1303-1310页

作者：程瑞华周宇杰侯侨丽刘柏平华东理工大学化学工程国家重点实验室上海200237

由环氧丙烷(PO)和CO_2交替共聚合成脂肪族聚碳酸亚丙酯,CO_2利用率高,所得产物具有一定的力学性能和生物降解性能,具有广泛应用前景.目前,用于CO_2和环氧化合物共聚的催化体系主要包含锌、钴、镉、铬、铝和稀土等金属活性中心,结构、活... 详细信息

由环氧丙烷(PO)和CO_2交替共聚合成脂肪族聚碳酸亚丙酯,CO_2利用率高,所得产物具有一定的力学性能和生物降解性能,具有广泛应用前景.目前,用于CO_2和环氧化合物共聚的催化体系主要包含锌、钴、镉、铬、铝和稀土等金属活性中心,结构、活性各异的催化剂体系,其催化性能和产物性能也各具特色.其中,稀土三元催化剂(ZnEt_2-甘油-三氯乙酸钇)因合成聚碳酸酯产物的分子量高、碳酸酯单元含量高、聚醚及环碳酸酯副产物少的特点而受到关注.但是由于催化剂催化效率低,聚合时间长,产品成本高,使得工业化规模生产受到限制.本文基于稀土三元催化体系,将催化剂负载于硅胶及锌改性硅胶,优化了其制备条件,同时考察了添加季铵盐对催化CO_2/环氧丙烷共聚合成聚碳酸酯性能的影响.结果表明,在1 L聚合釜中,于3.5 MPa和70 ℃反应条件下,ZnO担载量及ZnO/SiO_2添加量对反应性能均有影响.当3 wt%ZnO/SiO_2的添加量为5 g时,稀土三元催化体系的活性为4845.2 g/mol_(Zn).所得聚合物经过多次纯化处理后,能够有效提高材料的热学性能,即有效除去产物中的ZnO对聚合物的热稳定性有重要作用.添加含有不同阴离子(F^-,Cl^-和Br^-)的季铵盐可显著影响稀土三元催化剂的活性.其中,仅四甲基氟化铵可以明显提高反应活性乃至聚合物分子量.在3 wt%ZnO/SiO_2载体和四甲基氟化铵的协同作用下,稀土三元催化体系的共聚性能明显提升,活性最高可达5223.0 g/mol_(Zn).聚合物结构分析表明,在载体和四甲基氟化铵存在下,聚合物分子量明显提高,可达到20万以上,分子量分布明显变窄,且聚合物结构如碳酸酯的单元含量、副产物含量以及聚合物产品玻璃化温度基本不变,后者均保持在40.41℃.基于此,我们提出了在ZnO改性硅胶载体及四甲基氟化铵存在下稀土三元催化体系催化CO_2/环氧丙烷共聚的反应机理:ZnO/SiO_2载体有利于稀土三元催化体系的分散。

关键词： CO2/环氧烷烃共聚稀土金属催化剂 ZnO改性硅胶季铵盐分子量

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转子偏心对永磁同步电动机电磁力特性的影响

河南理工大学学报（自然科学版） 2024年第5期43卷 133-141页

作者：唐旭成豪杰马兆兴王瑞华青岛理工大学信息与控制工程学院山东青岛266520

目的永磁同步电动机在变频供电下运行时,转子偏心将加剧电动机的电磁振动,并加大电动机电磁力特性的分析难度。为了研究永磁同步电动机转子偏心时的电磁力特性,方法提出一种快速电磁力特性解析分析方法,在建立电动机永磁体磁动势、定子... 详细信息

目的永磁同步电动机在变频供电下运行时,转子偏心将加剧电动机的电磁振动,并加大电动机电磁力特性的分析难度。为了研究永磁同步电动机转子偏心时的电磁力特性,方法提出一种快速电磁力特性解析分析方法,在建立电动机永磁体磁动势、定子绕组基波及谐波磁动势、气隙磁导函数的解析模型的基础上,构建电动机无偏心、静态偏心、动态偏心时径向电磁力的解析分析模型,并研究电动机电磁力的阶数成分、频率成分特征。结果经分析发现,与电动机不偏心时电磁力的阶数r和频率成分fk相比,电动机静态偏心、动态偏心时均会增加阶数为r±1和r±2的电磁力;电动机静态偏心时,新出现的电磁力的频率成分为fk;电动机动态偏心时,新出现的电磁力的频率成分为fk±f1/p,fk±2f1/p。搭建电动机本体和矢量控制电路结合的联合仿真模型,该模型能够反映电动机不同运行状态下绕组电感、永磁体磁链等参数的变化,利用该模型分别仿真分析电动机无偏心、静态偏心和动态偏心带载运行时径向电磁力的阶数成分、频率成分。仿真分析结果与解析分析结果相符,验证了本文解析分析方法的正确性。结论研究结果可为电磁振动的削弱、电动机故障的预测与诊断提供理论依据。

关键词：永磁同步电动机径向电磁力解析分析静态偏心动态偏心变频供电