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Mixture prepared with Chinese medicines in terms of releasing exterior cold and clearing interior heat: its efficacy and safety in patients with seasonal influenza-a randomized controlled trial

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Journal of Traditional Chinese Medicine 2018年第5期38卷 746-753页

作者： Wu Zhisong Li Guodong Wei Wan Liu Zhaoheng Wang Wei ma ruihong Liu Wenhong ma Jiaju Wang Yuguang Jiao Yang Department of Intensive care unit Dongfang Hospital Affiliated to Beijing University of Chinese Medicine Graduate School Beijing University of Chinese Medicine Department of Chinese Medicine Concord Hospital Affiliated to Fujian Medical University Department of Respiratory medicine Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University Department of Internal Medicine Dongfang Hospital Affiliated to Beijing University of Chinese Medicine

OBJECTIVE: To assess the efficacy and safety in 105 patients with seasonal Influenza in Beijing, the mixture prepared with Chinese medicines follows the treatment regimen of releasing exterior cold andclearing interior ***: Total 330 patients with seasonal influenza were enrolled and randomly and averagely divided into the Chinese herbal medicine, the western medicine and the Chinese patent medicine group. They were treated with Chinese medicine Oseltamivir Phosphate Capsules and the Scattering Wind and Resolving Toxins Capsules. The main efficacy indicators were the antifebrile onset time and recovery time of body temperature. The efficacy and safety of the mixture was scientifically evaluated. Comparisons of several variables were ***: Median antifebrile onset time of the Chinese herbal medicine group was significantly shorter than the western medicine group(P main symptoms and some minor symptom patterns of the Chinese herbal medicine group were higher than the other 2 ***: The mixture of releasing exterior cold and clearing interior heat could significantly shorten the fever time with safety.

关键词： Releasing exterior cold and clearing interior heat Influenza efficacy Mixture prepared with Chinese medicines

Complete genome sequence of a plant growth-promoting endophytic bacterium V4 isolated from tea(Camellia sinensis)leaf

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Beverage Plant Research 2023年第1期3卷 219-230页

作者： Huiyan Jia Yaxing Yan Jinqing ma Enhua Xia ruihong ma Yifan Li Miao Wang Wei-Wei Deng State Key Laboratory of Tea Plant Biology and Utilization Anhui Agricultural University130 Changjiang West RoadHefeiAnhui 230036China

V4 is a Gram-negative,plant growth promoting endophytic bacterium that promotes the growth of tea *** appearance of V4 is rod shaped,with average dimensions of 1.34−1.5×0.32−0.39μm and flagellum at both *** complete genome contains one circular chromosome and two *** is 4,697,109 bp in size,and contains 4,189 protein-coding genes,four gene islands and two *** classification suggested that V4 was a strain of Erwinia *** was possible to find genes involved in plant growth promotion traits present in the genome of ***,V4 was consistent with plant growth-promoting endophytic bacteria containing key synthetic genes associated with IAA synthesis,and P-solubilization,siderophores.V4 has siderophore biosynthesis genes compared with plant pathogenic bacteria showing stronger survival ability and the ability to interaction with the host *** addition,V4 endophytic bacteria possess a higher copy number of genes for flagellar assembly,bacterial chemotaxis and P-pilus assembly indicating stronger colonization and communication ability with host plants compared with five other bacteria in comparative genomic *** of the V4 endophytic bacterium complete genome sequence provides novel insights into the endophytic bacteria-host plant relationship,and suggests many candidate genes for post-genomic experiments.

关键词： sinensis traits sequence

Heyan Kuntai capsule versus dehydroepiandrosterone in treating Chinese patients with infertility caused by diminished ovarian reserve： a multicenter, randomized controlled trial

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Journal of Traditional Chinese Medicine 2017年第4期37卷 530-537页

作者： Gao Hui Xia Tian ma ruihong Zhao Zhimei Song Xueru Wang Baojuan Liu Lijing Han Kaimei Wang Guoqing Fu Yu Hao Guimin Department of Traditional Chinese Medicine Affiliated Hospital of Chengde Medical College Chengde 067000 China Department of Reproductive Center First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Reproductive center Tianjin Medical University General Hospital Tianjin 300052 China Graduate School Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Department of Acupuncture First TeachingHospital of Tianjin University of TCM Tianjin 300193 China Department of Reproductive Center The Second Hospital of Hebei Medical University Shijiazhuang 050000 China

OBJECTIVE: To evaluate the clinical efficacy and safety of Heyan Kuntai capsule(HYKT) in treating women with infertility caused by diminished ovarian reserve(DOR).METHODS: One hundred eight eligible patientsfrom three Chinese hospitals were randomly divided into an HYKT treatment group(n = 55) or a dehydroepiandrosterone(DHEA) treatment group(n =53). Patients in the HYKT group were treated orally with four 0.5 g HYKT three times a day; patients in the DHEA group were treated with one 25.0 mg DHEA capsule three times a day. All patients were treated for 3 months and followed up over a3-month ***: Of 108 patients, 12 dropped out: six from the HYKT group, and six from the DHEA group. Eleven patients got pregnant during the treatment. Serum anti-Müllerian hormone levels and antral follicle counts increased significantly in both groups after treatment(P < 0.05) especially in the HYKT group(P < 0.05). Serum follicle stimulating hormone(FSH) levels and FSH/luteinizing hormone ratios decreased(P < 0.05) with no significant difference between the two groups. Estradiol levels in the HYKT group and DHEA-sulfate levels in the DHEA group both increased(P < 0.05). The spontaneous pregnancy rates were 12% and 11% in the HYKT and DHEA groups, respectively(not significant). During the follow-up period, 16 patients in the HYKT group underwent in vitro fertilization-embryo transfer(IVF-ET) and the number of retrieved oocytes was(5.1 ± 1.8). In DHEA group, 20 patients underwent IVF-ET and the number of retrieved oocyte was(4.2 ± 1.9)(not significant); clinical pregnancy rates were 38% in the HYKT group and 20%in DHEA group(not significant). No significant adverse reactions were ***: HYKT can improve the ovarian re-serve and hormone levels in patients with infertility caused by DOR. Pregnancy rates after HYKT treatment were similar to those of DHEA *** might be an alternative to the treatment of infertility caused by DOR.

关键词： Infertility, female Ovarian reserve Hormones Dehydroepiandrosterone Heyan Kuntai capsule Randomized controlled trial

Epidemiological and Subtype Characterization of Influenza Viruses Infection in Children in Shenzhen, China during Three Consecutive Seasons (January 2016-December 2018)

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Open Journal of Pediatrics 2024年第5期14卷 851-864页

作者： Yaxian Kuang ruihong ma Lei Jia Qiang Yao Chenhui Zhang Xiaoying Fu Department of Laboratory Medicine Shenzhen Childrens Hospital Affiliated to Shantou University Medical College Shenzhen China The Department of Clinical Laboratory The Sixth Peoples Hospital of Nansha Guangzhou China Guangxi Key Laboratory of Intelligent Precision Medicine Nanning China International Health Medicine Innovation Center Shenzhen University Shenzhen China

Background: Children with seasonal influenza infection cause a significant burden of disease each year in the pediatric clinic. Influenza A and B viruses are the major types responsible for illness. A better understanding of the periodicity facilitates the prevention and control of influenza in children. Objective: This study aims to analyze the epidemiological patterns and subtype characterization of influenza viruses among children in Shenzhen, China. Methods: Influenza samples were collected by nasopharyngeal swabs from influenza like illness patients in Shenzhen Children’s Hospital from January 2016 to December 2018. The positive cases and influenza subtypes were determined by gold labeled antigen detection and reverse transcriptase polymerase chain reaction. The influenza periodicity and age, subtype distribution as well as the association between climate parameters and different influenza subtypes were analyzed by SPSS 22.0. Results: The influenza positive rate during 2016-2018 was 21.0%, with a highest positive rate in the year 2018. The positive rate varied by month, season, and year describing a sequence of peaks presenting primarily in all year including spring, summer and winter. The characteristics of influenza peak were different in each year, with a spring peak in 2016 and a summer plus a winter-spring peaks in 2017 and 2018. In addition, influenza B exhibited a winter-spring seasonal pattern while influenza A displayed a more variable seasonality, highlighting influenza B rather than influenza A which had a negative association with climate parameters. Influenza-positive cases were older than influenza-negative cases (P P Conclusion: Influenza activity in children from Shenzhen typically displays both winter-spring and summer peaks. Influenza A epidemic occurred separately or co-circulated with influenza B, with a winter-spring pattern for influenza B and a much more variable seasonality for influenza A. Influenza B had a negative association with cli

关键词： Influenza Influenza Like Illness Gold Labeled Antigen Detection Reverse Transcriptase Polymerase Chain Reaction Influenza A Influenza B

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浅谈我国医疗保障制度的改革

生产力研究 2009年第7期 89-91页

作者：马睿宏山西财经大学山西太原030006

随着经济体制改革的深入,支撑计划经济体制下形成的医疗保障制度的经济基础被瓦解,人们在社会中的经济地位发生了深刻变化。由于医疗制度改革的错位,医药价格飞涨,"看病难、看病贵"成为困扰人们心身健康的社会问题。为此,建立、健全与... 详细信息

随着经济体制改革的深入,支撑计划经济体制下形成的医疗保障制度的经济基础被瓦解,人们在社会中的经济地位发生了深刻变化。由于医疗制度改革的错位,医药价格飞涨,"看病难、看病贵"成为困扰人们心身健康的社会问题。为此,建立、健全与社会经济发展相适应的医疗保障制度具有深远的历史意义和极为重要的现实意义。

关键词：医疗保障制度建设合作医疗

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线粒体功能与多囊卵巢综合征关系的研究进展

中华生殖与避孕杂志 2022年第12期42卷 1305-1309页

作者：张元月马瑞红夏天天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300193

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是常见的生殖内分泌代谢紊乱性疾病。有研究显示PCOS患者常伴线粒体功能障碍。线粒体功能异常时氧化应激水平升高,引发或加重高雄激素血症、胰岛素抵抗以及肥胖,干扰卵泡发育,进而影响P... 详细信息

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是常见的生殖内分泌代谢紊乱性疾病。有研究显示PCOS患者常伴线粒体功能障碍。线粒体功能异常时氧化应激水平升高,引发或加重高雄激素血症、胰岛素抵抗以及肥胖,干扰卵泡发育,进而影响PCOS女性的月经和生殖功能。线粒体功能是近年来关注的热点,本文就线粒体功能障碍在PCOS发生发展中潜在机制的研究进展进行总结。

关键词：线粒体多囊卵巢综合征氧化应激高雄激素血症胰岛素抵抗卵泡

Keap1-Nrf2/ARE系统抵抗蜕膜化缺陷的研究进展

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中华生殖与避孕杂志 2023年第11期43卷 1198-1202页

作者：张静马瑞红刘静夏天天津中医药大学第一附属医院生殖医学科、国家中医针灸临床医学研究中心天津300300

蜕膜化缺陷可导致不孕症以及其他不良妊娠结局的发生,氧化应激、炎症、毒物暴露等多种不良应激源均是蜕膜化缺陷的诱因。近年来,Keap1-Nrf2/ARE系统作为细胞防御机制的关键调节因子,成为多种慢性疾病的研究热点。越来越多的证据支持Keap... 详细信息

蜕膜化缺陷可导致不孕症以及其他不良妊娠结局的发生,氧化应激、炎症、毒物暴露等多种不良应激源均是蜕膜化缺陷的诱因。近年来,Keap1-Nrf2/ARE系统作为细胞防御机制的关键调节因子,成为多种慢性疾病的研究热点。越来越多的证据支持Keap1-Nrf2/ARE系统在抵抗蜕膜化缺陷过程中发挥重要作用,除了经典的细胞防御作用外,Nrf2被证实可以被雌孕激素激活,并可能通过FoxO1通路调控蜕膜化过程,因此该系统有望成为临床改善不良妊娠结局的重要靶点。本文综述了Keap1-Nrf2/ARE系统通过抵抗应激损伤、与雌孕激素相互作用、调控FoxO1因子等方面参与调控蜕膜化过程的依据。

关键词：妊娠结局 Nrf2 蜕膜化细胞防御

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麒麟丸治疗女性不孕症的临床研究进展

药物评价研究 2022年第6期45卷 1173-1180页

作者：马瑞红李萌夏天天津中医药大学第一附属医院国家中医针灸临床医学研究中心天津300381 天津市河西医院天津300202

麒麟丸是在“肾主生殖”理论上创立的治疗不孕不育的经验方,近年来的临床研究表明其在治疗女性不孕症方面效果突出,可有效治疗多囊卵巢综合征、卵巢储备功能减退、薄型子宫内膜等。笔者总结梳理相关文献,综述麒麟丸治疗女性不孕症的临... 详细信息

麒麟丸是在“肾主生殖”理论上创立的治疗不孕不育的经验方,近年来的临床研究表明其在治疗女性不孕症方面效果突出,可有效治疗多囊卵巢综合征、卵巢储备功能减退、薄型子宫内膜等。笔者总结梳理相关文献,综述麒麟丸治疗女性不孕症的临床研究进展,以期为其在女性不孕症治疗中的应用提供依据,同时为深入研究其作用机制和临床合理用药提供参考。

关键词：麒麟丸女性不孕症临床应用多囊卵巢综合征卵巢储备功能下降薄型子宫内膜

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3D打印技术在生物医学领域的应用之我见

当代化工研究 2019年第1期 198-199页

作者：马瑞宏吕梁市离石区江阴高级中学山西033000

随着经济的高速发展,医疗投入的不断加大促使医疗水平的不断提高,在很大程度上减轻了人们的病患痛苦;随着科技的发展,各种新产品、新技术也逐步应用到医疗行业中。3D打印技术作为一项新技术,具有技术含量高,印刷速度快,印刷产品保真度... 详细信息

随着经济的高速发展,医疗投入的不断加大促使医疗水平的不断提高,在很大程度上减轻了人们的病患痛苦;随着科技的发展,各种新产品、新技术也逐步应用到医疗行业中。3D打印技术作为一项新技术,具有技术含量高,印刷速度快,印刷产品保真度高等优点,深受各行业欢迎,在生物医学领域也不例外。将3D打印技术应用到生物医学领域,一直是医学领域科研工作者研究的重点,虽然目前取得稍许进展,但仍需很大努力,提升应用空间。本文结合相关资料描述,主要讲述了3D打印技术及其在生物医疗领域的主要应用。

关键词： 3D打印生物医学领域综合应用