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Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong tang Li Jiang Xiong-Ying Ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin tang Jun Zhan Yiyuan Xue Feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

Sulfur-driven methylmercury production in paddies continues following soil oxidation

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Journal of Environmental Sciences 2022年第9期34卷 166-174页

作者： Wenli tang Chao tang Pei Lei School of the Environment State Key Laboratory of Pollution Control and Resource ReuseNanjing UniversityNanjing 210023China School of Environment Nanjing Normal UniversityNanjing 210023China

Methylmercury(MeHg) production in paddy soils and its accumulation in rice raise global concerns since rice consumption has been identified as an important pathway of human exposure to MeHg. Sulfur(S) amendment via fertilization has been reported to facilitate Hg methylation in paddy soils under anaerobic conditions, while the dynamic of S-amendment induced MeHg production in soils with increasing redox potential remains unclear. This critical gap hinders a comprehensive understanding of Hg biogeochemistry in rice paddy system which is characterized by the fluctuation of redox potential. Here, we conducted soil incubation experiments to explore MeHg production in slow-oxidizing paddy soils amended with different species of S and doses of sulfate. Results show that the elevated redox potential(1) increased MeHg concentrations by 10.9%-35.2%, which were mainly attributed to the re-oxidation of other S species to sulfate and thus the elevated abundance of sulfatereducing bacteria, and(2) increased MeHg phytoavailability by up to 75% due to the reductions in acid volatile sulfide(AVS) that strongly binds MeHg in soils. Results obtained from this study call for attention to the increased MeHg production and phytoavailability in paddy soils under elevated redox potentials due to water management, which might aggravate the MeHg production induced by S fertilization and thus enhance MeHg accumulation in rice.

关键词： Mercury Sulfur Availability Mercury methylation Rice

Boundary-effect and scale-heating rate equivalence effect of cracking behavior in the rock models subjected to heating from the central borehole

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Science China(Technological Sciences) 2020年第5期63卷 809-818页

作者： HUANG Xin tang ShiBin tang ChunAn State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

Thermal cracking is broadly observed in rock engineering.A finite element numerical model which considers the heterogeneity of rock materials and the damage evolution process was used to simulate the thermal cracking behavior of square rock samples heated from the central *** thermal and mechanical behaviors of two cases,i.e.,the case with large size but low heating rate and the case with small size but high heating rate were compared to study the crack initiation location in the models with different model sizes and heating *** simulated stress and temperature fields,as well as the failure pattern,were in good agreement with the experimental *** temperature and thermal stress distribution during the heating process in both cases indicated that high tensile stress was concentrated around the thermal gradient front,which resulted in the cracks initiating at the location with a certain distance away from the *** results show that under the same heating rate,crack initiation location moves outwards with the increment of the model size then remains approximately at one location,which reflects the ***,the results indicate that the relative crack initiation locations in two cases are nearly the same if the ratio between the heating rate in two cases(Tx/Ty)nearly equal to the square of the inverse ratio of corresponding model side lengths((ay/ax)2).This concept is named the scale-heating rate equivalence effect in this *** is beneficial for studying thermal cracking of rock both numerically and experimentally since the model size can be significantly decreased.

关键词： thermal cracking nuclear waste disposal numerical simulation boundary-effect scale-heating rate equivalence effect

千里光通过抑制肥大细胞P2X7受体缓解炎性疼痛

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中国药理学通报 2025年第1期41卷 131-137页

作者：叶凡廖利辉唐婧玥陈佳慧成江陈功锡唐宗湘吉首大学药学院湖南吉首416000 武陵山区药用资源化学与药理湖南省高校重点实验室湖南吉首416000 南京中医药大学医学院·整合医学学院江苏南京210000

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是... 详细信息

目的探讨千里光对肥大细胞P2X7受体介导的炎症性疼痛的影响。方法采用高浓度ATP诱导脚掌炎症性疼痛模型,利用免疫荧光染色技术,甲苯胺蓝染色技术,探究千里光对肥大细胞上P2X7受体是否有抑制作用。利用钙离子成像实验技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活引起的细胞内钙离子富集。利用全细胞膜片钳技术,探究千里光是否可以抑制小鼠腹膜肥大细胞上P2X7受体激活后引起的内向电流。结果体内实验结果显示,千里光(3.9 g·kg^(-1))明显缓解ATP诱导的炎性疼痛(P<0.05);千里光(3.9 g·kg^(-1))明显抑制P2X7受体阳性肥大细胞的浸润(P<0.01);敲除肥大细胞可以消减千里光(3.9 g·kg^(-1))的镇痛效果(P=0.645)。体外实验结果显示,千里光明显抑制肥大细胞P2X7受体介导的钙离子内流(300 mg·L^(-1),P<0.05;1 g·L^(-1),P<0.01;3 g·L^(-1):P<0.01);千里光(1 g·L^(-1))明显抑制肥大细胞P2X7受体介导的内向电流(P<0.01)。结论千里光通过抑制肥大细胞P2X7受体功能缓解ATP诱导的炎性疼痛。

关键词：千里光疼痛肥大细胞 P2X7受体炎症 ATP

基于稀疏注意力卷积ViT模型的锌浮选工况识别

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工程科学学报 2025年第2期47卷 328-338页

作者：苏越唐朝晖谢永芳高小亮张虎马炜烨汤海玚中南大学自动化学院长沙410083 中南大学数学与统计学院长沙410083

准确识别锌浮选工况并用于指导锌浮选操作,可以提高浮选效率、优化选矿过程.目前浮选现场主要通过人工肉眼观察泡沫并依据经验判断工况,这种方法主观性强,难以客观准确地评价锌浮选工况.针对该问题,本文通过研究锌浮选泡沫视觉特征和浮... 详细信息

准确识别锌浮选工况并用于指导锌浮选操作,可以提高浮选效率、优化选矿过程.目前浮选现场主要通过人工肉眼观察泡沫并依据经验判断工况,这种方法主观性强,难以客观准确地评价锌浮选工况.针对该问题,本文通过研究锌浮选泡沫视觉特征和浮选工况的密切联系,提出基于稀疏注意力卷积ViT模型的锌浮选工况识别方法.首先,所提模型融合了卷积神经网络(Convolutional neural networks,CNN)和视觉Transformer(Vision transformer,ViT)的结构和优点,同时感知泡沫局部空间信息和全局信息,完备表征泡沫图像.其次,模型引入稀疏的多头注意力机制,每个注意力头以不同的稀疏程度处理特征,从不同尺度下感知全局信息,同时引入注意力门控单元优化特征传递,最终实现锌浮选工况识别.实验结果表明,本文所提工况识别方法在锌浮选泡沫图像数据集上的准确率达到88.62%,解决了传统CNN和ViT模型不能充分利用泡沫图像全局信息,且无法自适应捕捉泡沫图像重要特征的问题,为浮选流程优化提供有力支持.

关键词：工况识别卷积神经网络视觉Transformer 稀疏注意力泡沫浮选

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Harboring CAR-T cells using an injectable scaffold to treat solid tumors

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National Science Review 2024年第5期11卷 91-92页

作者： Li tang Institute of Bioengineering (IBI) école polytechnique fédérale de Lausanne (EPFL)

Genetic expression of chimeric antigen receptors (CAR) enables T cells to target and kill cancer cells in an MHCindependent manner, resulting in a potent antitumor response [1]. To date, more than 10 CAR-T cell products have been approved globally for the treatment of hematologic disorders such as relapsed/refractory B-cell acute lymphoblastic leukemia, non-Hodgkin lymphoma, and multiple myeloma [2,3].

关键词： scaffold cells solid treat harboring injectable tumors using

Non-noble metal anode based dual-ion batteries： promising high-energy and low-cost energy storage devices

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Science China Materials 2017年第4期60卷 368-370页

作者： Zhiyong tang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Lithium-ion batteries(LIBs),as one of the most commonly used electrochemical energy storage devices,have dominated todays markets for portable electronics and electric vehicles[1].Llowever,their energy density cannot yet satisfy the increasing requirement,so it is imperative for developing next-generation batteries with high energy density together with long cycling life and good *** recent years,a novel type of battery called as

关键词：科学研究材料学工程材料中国

Global change hydrology:Terrestrial water cycle and global change

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Science China Earth Sciences 2020年第3期63卷 459-462页

作者： Qiuhong tang Key Laboratory of Water Cycle and Related Land Surface Processes Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences University of Chinese Academy of Sciences

*** Global Change Hydrology(GCH)is an emerging interdisciplinary field that links global change research and *** integrates hydrology,climatology,and geography to study the interactions between the terrestrial water cycle and global change across various time and space *** main objective of GCH is to understand the natural and anthropogenic causes of the changing terrestrial water cycle and the associated influences and feedbacks in the Earth system.

关键词： hydrology terrestrial Global