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附红细胞体的生物学及形态学特征

吉林畜牧兽医 2016年第3期37卷 13-15,18页

作者：李静萍盖晋宏蔡亚南高瑞峰胡士林山东畜牧兽医职业学院山东潍坊261061 吉林农业大学动物科技学院吉林长春130018 长春科技学院动物科技学院吉林长春130600

附红细胞体是一种以特异性侵染红细胞为特征的原核生物。能引起各年龄段的多种家畜感染。由于其难于体外培养,目前对它的生物学特性和引起发病的机制了解不多。附红细胞体可以通过光学显微镜在新采集的血液样本中观察到。目前已获得了... 详细信息

附红细胞体是一种以特异性侵染红细胞为特征的原核生物。能引起各年龄段的多种家畜感染。由于其难于体外培养,目前对它的生物学特性和引起发病的机制了解不多。附红细胞体可以通过光学显微镜在新采集的血液样本中观察到。目前已获得了悬液标本、染色标本、免疫组化染色标本及电镜观察的认识。对于其生物学规律、发病机制等方面的认识仍有待于进一步的研究。

关键词：附红细胞体形态学光镜扫描电镜透射电镜

Coupled GIMP and CPDI material point method in modelling blast-induced three-dimensional rock fracture

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International Journal of Mining Science and Technology 2022年第5期32卷 1097-1114页

作者： Duanying Wan Meng Wang Zheming Zhu Fei Wang Lei Zhou ruifeng Liu Weiting gao Yun Shu Hu Xiao MOE Key Laboratory of Deep Earth Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan ProvinceSichuan UniversityChengdu 610065China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resources and HydropowerSichuan UniversityChengdu 610065China College of Civil and Architecture Engineering Panzhihua UniversityPanzhihua 617099China

Three-dimensional rock fracture induced by blasting is a highly complex problem and has received considerable attention in geotechnical *** material point method is firstly applied to treat this challenging *** inherent weaknesses can be overcome by coupling the generalized interpolation material point(GIMP)and the convected particle domain interpolation technique(CPDI).For the media in the borehole,unchanged GIMP-type particles are used to guarantee a homogenous blast *** type particles are employed to avoid the fake numerical fracture near the borehole for the rock material.A blasting experiment using three-dimensional single-borehole rock was simulated to examine the applicability of the coupled model under realistic loading and boundary conditions.A good agreement was achieved between the simulation and experimental ***,the mechanism of three-dimensional rock fracture was *** was concluded that rock particle size and material parameters play an important role in rock *** reflected tensile waves cause severe damage in the lower part of the *** waves occur on the top face of the rock model to induce a hoop failure band.

关键词： Material point method(MPM) Convected particle domain interpolation (CPDI) Generalized interpolation material point (GIMP) Rock fracture Blast

心室射血分数自动测量法评价心肌梗死患者左室整体收缩功能的可行性研究

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临床超声医学杂志 2015年第3期17卷 159-162页

作者：蔚俊丽高瑞锋张园园何慧崔艳华张全斌山西医科大学附属太钢总医院超声科太原市030003 山西省人民医院超声科

目的探讨心室射血分数自动测量(Auto EF)法评价心肌梗死患者左室整体收缩功能的可行性和重复性。方法选取我院心肌梗死患者(心肌梗死组)和健康体检者(健康对照组)各35例,应用Auto EF法测量左室舒张末期容积(LVEDV)、收缩末期容积(LVESV... 详细信息

目的探讨心室射血分数自动测量(Auto EF)法评价心肌梗死患者左室整体收缩功能的可行性和重复性。方法选取我院心肌梗死患者(心肌梗死组)和健康体检者(健康对照组)各35例,应用Auto EF法测量左室舒张末期容积(LVEDV)、收缩末期容积(LVESV)及射血分数(LVEF);并与传统双平面Simpson’s法比较,分析其相关性;随机选取20例心肌梗死患者行Auto EF重复性研究。结果 70例研究对象中,68例(97%)完成Auto EF测量,其中43例(63%)为完全自动,25例(37%)需手动校正;Auto EF测量时间为(59.28±13.13)s,少于Simpson’s法[(96.67±8.26)s],差异有统计学意义(P<0.01);68例总体Auto EF与双平面Simpson’s法测量LVEDV、LVESV、LVEF均有高度相关性(r分别为0.947、0.971、0.974,P<0.01);心肌梗死组和健康对照组中,两法所测LVEDV、LVESV和LVEF差异均无统计学意义,且有良好相关性,但心肌梗死组相关系数均较健康对照组偏低;在观察者自身和观察者间,Auto EF法测定心肌梗死患者LVEF均有良好的一致性。结论 Auto EF法能够简便、及时和快速测量左室容积和LVEF,且经验依赖性较小。

关键词：超声心动描记术心肌梗死心室功能左斑点追踪成像

诃子鞣酸对LPS诱导的小鼠子宫内膜炎的保护作用

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中国兽医学报 2024年第5期44卷 1041-1048页

作者：张兰欣郭文瑞巩志国李姣姣王建宁刘鑫煜杨英李政忆李娟高瑞峰内蒙古农业大学兽医学院内蒙古呼和浩特010018 农业农村部动物疾病临床诊疗技术重点实验室内蒙古呼和浩特010018

为探究诃子鞣酸(chebulagic acid, CA)对脂多糖(lipopolysaccharide, LPS)诱导的小鼠子宫内膜炎的保护作用。本研究体外试验部分,使用MTT法检测CA对小鼠腹腔巨噬细胞活性的影响,通过ELISA和Westen blot分别检测CA对LPS刺激的巨噬细胞促... 详细信息

为探究诃子鞣酸(chebulagic acid, CA)对脂多糖(lipopolysaccharide, LPS)诱导的小鼠子宫内膜炎的保护作用。本研究体外试验部分,使用MTT法检测CA对小鼠腹腔巨噬细胞活性的影响,通过ELISA和Westen blot分别检测CA对LPS刺激的巨噬细胞促炎性细胞因子(TNF-α、IL-1β和IL-6)分泌水平和ERK、p38和p65磷酸化水平的影响;体内试验部分,通过ELISA分析CA对LPS刺激后小鼠子宫组织TNF-α、IL-1β和IL-6分泌水平的影响,使用组织免疫荧光法检测小鼠子宫损伤相关因子(HMGB1)的表达水平,通过HE染色法观察小鼠子宫组织的病理变化,使用血常规法分析小鼠全血中白细胞数、中性粒细胞数和单核细胞数的变化。结果显示,CA质量浓度为12.5、25.0、50.0 mg/L对巨噬细胞活性均无显著影响,因此后续试验结果与CA的细胞毒性无关。CA可显著下调受到LPS刺激的巨噬细胞中的TNF-α,IL-1β和IL-6分泌水平,且具有浓度依赖性。此外,CA可显著下调受LPS诱导的巨噬细胞中ERK、p38和p65的磷酸化水平。CA可显著下调LPS刺激小鼠后子宫组织中TNF-α、IL-1β和IL-6的分泌水平;LPS刺激可增加小鼠全血中的白细胞数、中性粒细胞数和单核细胞数,而使用CA治疗可使其显著降低;相比于LPS刺激组,CA治疗组子宫组织中HMGB1的表达水平显著降低;LPS刺激小鼠子宫后导致子宫角出血和水肿,使用CA治疗后子宫角出血程度和水肿程度均有所降低。同时,HE病理切片显示LPS刺激组小鼠子宫组织中出现大量的嗜中性粒细胞浸润,子宫内膜上皮发生增生、水肿、坏死及脱落,CA(100 mg/kg)治疗后,子宫组织基本恢复正常,具有浓度依赖性。以上结果表明,CA可通过抑制小鼠腹腔巨噬细胞中MAPK和NF-κB通路的激活,下调巨噬细胞和子宫组织中炎症介质的表达水平从而减轻LPS诱导的小鼠子宫内膜炎。

关键词：子宫内膜炎诃子鞣酸脂多糖炎症介质炎症信号通路高迁移率蛋白1 小鼠

Efficacy of vinorelbine combined with low-dose methotrexate for treatment of inoperable desmoid tumor and prognostic factor analysis

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Chinese Journal of Cancer Research 2017年第5期29卷 455-462页

作者： Shu Li Zhengfu Fan Zhiwei Fang Jiayong Liu Chujie Bai ruifeng Xue Lu Zhang Tian gao Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Bone and Soft Tissue TumorsPeking University Cancer Hospital & Institute

Objective： To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor（DT） and analyze the prognostic ***：From November 2008 to April 2016,71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors,Peking University Cancer Hospital＆Institute,and enrolled in this retrospective *** chemotherapy duration is one *** efficacy of chemotherapy and the prognosis were ***：Of the 71 patients,55% were *** of onset varied from 1 to 47 years,and the median age was *** 11（15.5%）cases suffered primary *** distribution of the site of tumors was：31（43.7%）in the trunk,36（50.7%）in the limbs,and 4（5.6%）in the peritoneal and pelvic *** size of tumor（the maximum diameter）differed from 2 to 37 cm with a mean of 9.3 *** median follow-up duration was 28（range,6–87）*** side effects included：nausea and vomiting,liver injury,bone marrow suppression and oral *** the chemotherapy finished,1（1.4%）case achieved complete response,24（33.8%）achieved partial response,37（52.1%）achieved stable disease and 9（12.7%）had progressive *** overall response rate was 87.3%.The progression-free survival（PFS）of the participants were from 6 to 87 months,and the 2-,3-and 5-year PFS was 79.9%,68.4% and 36.3%,*** significant difference was identified in PFS in subgroups of gender,age of onset,age of chemotherapy,tumor site and tumor ***：For recurrent,inoperable and progressive DT,enough course of chemotherapy with vinorelbine combined with low-dose methotrexate was an optional choice for local control.

关键词： Desmoid tumor aggressive fibromatosis chemotherapy

The prediction of exit choice using cumulative prospect value

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Journal of Safety Science and Resilience 2023年第1期4卷 20-25页

作者： Dongli gao Wei Xie ruifeng Cao Eric Wai Ming Lee Richard Kwok Kit Yuen Jingwen Weng Department of Architecture and Civil Engineering City University of Hong KongHong KongChina State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei230026China

Exit choice is essential for pedestrian safety and evacuation efficiency during the context of an emergency. Cumulative prospect theory is a widespread realistic decision-making theory that can transform choice outcomes and probabilities into subjective terms and integrate them as a parameter of cumulative prospect value (CPV), which determines the decision. The main contribution of this paper is the use of the CPV to predict exit choice. Furthermore, the different decision-making rules including Max, exponential(Expo), and Ratio (i.e., the three variable choice functions) were summarized and examined. This study used a confusion matrix to compare the predicted results with experimental data. Consequently, the parameters of Accuracy and F1-score showed that the predictions from Max and Expo were significantly more realistic while the results from Ratio were much more robust.

关键词： Decision-making behavior Exit choice Evacuation model Cumulative prospect value

Study on single-group dynamics in evacuation considering pre-defined and undeclared leadership

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Journal of Safety Science and Resilience 2023年第1期4卷 52-60页

作者： Wei Xie Dongli gao ruifeng Cao Eric Wai Ming Lee Richard Kwok Kit Yuen Jingwen Weng Department of Architecture and Civil Engineering City University of Hong KongKowloon TongHong KongChina State Key Laboratory of Fire Science University of Science and Technology of ChinaHefei 230026China

Grouping is a common phenomenon that occurs *** leader-follower relationship inside groups has often been qualitatively characterized in previous models using simple ***,a general method is lacking to quantitatively explain leadership in an evacuating *** understand the evolution of single-group dynamics throughout an evacuation,we developed an extended social force model integrated with a group force.A series of single-group evacuations from a room were *** information-theoretic method,transfer entropy(TE),was applied to detect predefined and undeclared leadership among *** results showed that the predefined leader was correctly detected by TE,suggesting its capability in measuring leadership based on time series of evacuees’movement information(e.g.,velocity and acceleration).When evacuees were grouped together,TE was higher than when they were *** presented a monotonically increasing cumulative influence curve over the investigated period,whereas followers showed a diminishing *** found that leadership emergence correlated with evacuees’spatial *** individual located in the foremost part of the group was most likely to become a leader of those in the rear,which concurred with the experimental *** observed how a large group split into smaller ones with undeclared leadership during *** observations were quantitatively verified by TE *** study provides novel insights into quantifying leadership and understanding single-group dynamics during evacuations.

关键词： Evacuation Social force model Group behavior Leadership Transfer entropy

彩色多普勒超声在大动脉炎患者锁骨下动脉受累中的诊断价值

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中国实用医刊 2018年第15期45卷 56-58页

作者：崔艳华严继萍张全斌蔚俊丽高瑞峰张园园山西省人民医院超声科太原030012 太钢总医院超声科太原030008

目的探讨彩色多普勒超声在大动脉炎锁骨下动脉受累中的诊断价值.方法选取山西省人民医院2016年3月至2018年3月收治的82例大动脉炎锁骨下动脉受累患者设为研究组,另选取同期85例健康体检者纳入对照组.应用二维及彩色多普勒超声、脉冲... 详细信息

目的探讨彩色多普勒超声在大动脉炎锁骨下动脉受累中的诊断价值.方法选取山西省人民医院2016年3月至2018年3月收治的82例大动脉炎锁骨下动脉受累患者设为研究组,另选取同期85例健康体检者纳入对照组.应用二维及彩色多普勒超声、脉冲多普勒超声观察研究组病变段血管的形态学及血流动力学改变,并与对照组进行比较.结果研究组病变段血管声像图典型表现为对称的内-中膜弥漫性增厚,管腔不同程度狭窄甚至闭塞,且病变段血管内-中膜厚度与对照组比较差异有统计学意义[（2.75±0.87）mm比（0.67±0.34）mm,t=20.212,P〈0.001].脉冲多普勒显示病变段血管相应血流动力学改变,频谱示狭窄处血流多数显示出加速,少数血流速度减慢.研究组病变段血管血流速度与对照组比较差异有统计学意义[（187.92±86.28）cm/s比（110.58±57.45）cm/s,t=6.793,P〈0.001].结论彩色多普勒超声能准确反映大动脉炎锁骨下动脉受累的病变段血管的变化,可为临床大动脉炎锁骨下动脉受累提供可靠的诊断依据.

关键词：大动脉炎锁骨下动脉彩色多普勒超声

Orientation dependent behavior of tensile-creep deformation of hot rolled Ti65 titanium alloy sheet

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Journal of Materials Science & Technology 2021年第16期75卷 265-275页

作者： Zhixin Zhang Jiangkun Fan ruifeng Li Hongchao Kou Zhiyong Chen Qingjiang Wang Hailong Zhang Jian Wang Qi gao Jinshan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China National Local Joint Engineering Research Center for Precision Thermoforming Technology of Advanced Metal Materials Xi'an 710072China Baoji Titanium Industry Co. Ltd.Baoji 721014China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China Baoti Group Co. Ltd.Baoji 721014China

The mill products like sheet always have one or more severe textures inevitably,and its effect on mechanical properties is not a negligible *** orientation dependent tensile-creep behavior induced by rolling texture of Ti65 titanium alloy sheet has been systematically investigated at 650℃.There are some anisotropic characteristics between TD and RD of Ti65 *** UTS and TYS of TD are higher than RD at 650℃.Besides,the creep endurance time of TD(172.6–174.5 h)is about three times longer than RD(55.6–65.1 h)at 650℃and 240 ***,the grains are inclined to form Texture III■after creep along with TD,but to form Texture I■after creep along with ***,the crack initiation site is different during creep in TD and *** reason for anisotropic properties of tensile and creep has been summarized in two aspects:(i)the change of the SFs(Schmid factors)value between TD and RD;(ii)the difference of creep mechanism between TD(grain boundary sliding)and RD(dislocation slip).Anisotropy of Ti65 sheet should be fully considered to increase structural efficiency in the engineering design and application.

关键词： Titanium alloy Texture Anisotropy Tensile Creep