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Association between Fundus Atherosclerosis and Carotid Arterial Atherosclerosis

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International Journal of Clinical Medicine 2023年第5期14卷 282-289页

作者： Ting Wang Xiaoqian Xu ruifang xiang Juan Wang Xiaoqin Liu Health Management Center Deyang People’s Hospital Deyang China

Objective: To investigate the correlation between fundus atherosclerosis and carotid arterial atherosclerosis. Methods: A total of 516 people undergoing physical examination in Deyang People’s Hospital between June 2020 and December 2022 were randomly selected. Fundus atherosclerosis and carotid arterial atherosclerosis were evaluated by fundus photography and carotid artery ultrasonography, respectively. Results: Among the 516 physical examination patients, 198 (38.4%) had normal fundus examination, and 318 (61.6%) had fundus arteriosclerosis. Among them, 166 cases were of grade I (32.2%), 86 cases were of grade II (16.7%), and 66 cases were of grade III (12.8%). There were 286 cases (55.4%) without carotid atherosclerosis, 201 cases (38.9%) with carotid atherosclerotic plaque, and 33 cases (6.4%) with carotid stenosis. Fundus arteriosclerosis is independently associated with carotid artery intima-media thickness, vulnerable plaques, plaque scores, and carotid artery stenosis (P Conclusion: In summary, there is a close relationship between carotid artery disease and the degree of arteriosclerosis in the eyeground. Fundus photography is a simple, non-invasive, and easily acceptable method of inspection. The results obtained from it are useful in determining the severity of carotid atherosclerosis and guiding early detection and intervention in clinical cases. This can help reduce the incidence of cardiovascular and cerebrovascular diseases.

关键词： Carotid Arterial Atherosclerosis Fundus Carotid Plaque Carotid Stenosis Ultrasonography

Unraveling the regulatory network of flower coloration in soybean:Insights into roles of GmMYBA3 and GmMYBR1

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The Crop Journal 2024年第2期12卷 443-455页

作者： ruifang Gao Yueqing Li Yanan Wang Xiaotong Shan Siqi Yang Ye Zhang Saiyu Ma Chunbao Zhang Jianchun Qin Li Wang xiang Gao College of Plant Science Jilin UniversityChangchun 130062JilinChina Key Laboratory of Molecular Epigenetics of MOE and Institute of Genetics&Cytology Northeast Normal UniversityChangchun 130024JilinChina Soybean Research Institute National Engineering Research Center for SoybeanJilin Academy of Agricultural SciencesChangchun 130033JilinChina

Anthocyanins play crucial roles in pollen protection and pollinator attraction in flowering ***,the mechanisms underlying flower color determination and whether floral anthocyanin regulators participate in other processes remain largely unresolved in soybeans(Glycine max).In this study,we investigated the genetic components and mechanisms governing anthocyanin biosynthesis in soybean *** and genetic studies have characterized two antagonistic regulators,the positive activator GmMYBA3 and the negative repressor GmMYBR1,that modulate the gene expression of anthocyanin biosynthesis in soybean *** findings revealed a regulatory interplay between GmMYBA3 and GmMYBR1 bridged by GmTT8a,highlighting the complexity of anthocyanin regulation in different soybean *** of additional soybean cultivars demonstrated the universality of GmMYBA3 and GmMYBR1 in regulating floral anthocyanin biosynthesis-related genes,with GmF3’5’H identified as a crucial determinant of white flower *** study provides a molecular mechanism underlying soybean flower color determination,paving the way for the molecular modification of soybean flowers to probably enhance their resistance to abiotic stresses and attractiveness to pollinators.

关键词： Anthocyanin Flower color determination MBW complex MYB repressor Pleiotropic regulator

Robust Transfer of Optical Frequency over 500km Fiber Link with Instability of 10^(−21)

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Chinese Physics Letters 2024年第8期41卷 22-27页

作者： Qian Zhou xiang Zhang Qi Zang Mengfan Wu Dan Wang Jie Liu ruifang Dong Tao Liu Shougang Zhang National Time Service Center Chinese Academy of SciencesXi’an 710600China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Time and Frequency Standards Chinese Academy of SciencesXi’an 710600China Hefei National Laboratory Hefei 230088China

Our primary objective is to mitigate the adverse effects of temperature fluctuations on the optical frequency transmission system by reducing the length of the *** optimization,the phase-temperature coefficient of the optical system is reduced to approximately 1.35 fs/*** applying a sophisticated temperature control to the remained“out-of-loop”optics fiber,the noise floor of the system has been effectively lowered to 10−21 *** on this performance-enhanced transfer system,we demonstrate coherent transmission of optical frequency through 500-km spooled fiber *** being actively compensated,the transfer instability of 4.5×10^(−16) at the averaging time of 1 s and 5.6×10^(−21) at 10000 s is *** frequency uncertainty of received light at remote site relative to that of the origin light at local site is achieved to be 1.15×10^(−19).This enhanced system configuration is particularly well suited for future long-distance frequency transmission and comparison of the most advanced optical clock signals.

关键词： fiber interferometer system

The influence of silica on reaction rates and molecular hydrogen(H_(2))generation during olivine hydrothermal alteration

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Science China Earth Sciences 2024年第1期67卷 222-233页

作者： ruifang HUANG Weidong SUN Xing DING Yusheng ZHAO Yibing LI Xiuqi SHANG CAS Key Laboratory of Ocean and Marginal Sea Geology South China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou 510301China SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and TechnologyShenzhen 518055China Center of Deep Sea Research Institute of OceanologyChinese Academy of SciencesQingdao 266071China State Key Laboratory of Isotope Geochemistry Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China Institue of Geology Chinese Academy of Geological SciencesBeijing 100037China

Hydrothermal alteration of olivine greatly influences geodynamics and the recycling of volatiles(such as water and carbon)in subduction *** is an important component of geological fluids,and its influence on the hydrothermal alteration of olivine remains poorly *** this study,we performed experiments at 300–515℃ and 3.0 kbar(1 bar=10^(5)Pa)by reacting well homogenized mixtures of olivine and silica powders with saline solutions(0.5 mol L^(−1)NaCl).Silica greatly influences the reaction pathways,reaction rates,and molecular hydrogen(H_(2))formation during olivine hydrothermal *** experiments at 300℃ and 3.0 kbar with mixtures of olivine and 10 wt%silica,olivine was replaced by serpentine and *** proportions of serpentine and talc were determined according to standard curves based on infrared spectroscopy *** 6.5%serpentine and 12%talc were produced after an experimental duration of 7 days,which had no change after a longer period(14 days).Compared to the kinetics in silica-free systems,the rates of olivine hydrothermal alteration in experiments with 10 wt%silica are much *** overall reaction is:4.5Forsterite+5.5SiO_(2),aq+4H_(2)O=Serpentine+*** the addition of more silica(20 wt%and 40 wt%),olivine was transformed into *** rates of reaction were much faster,e.g.,for experiments with olivine and 20 wt%silica,43%of talc was produced after 14 days,which increased to 77%for experiments with 40 wt%silica over the same *** overall reaction is:3Forsterite+5SiO_(2),aq+2H_(2)O=*** experiments at 400–505℃ and 3.0 kbar,the promoting effect of silica on olivine hydrothermal alteration was also observed,which is closely associated with a decrease in Gibbs free energies of olivine hydrothermal *** 300℃ and 3.0 kbar,silica decreased H_(2)formed during olivine hydrothermal alteration by around an order of magnitude,resulting in an increase in oxygen *** on measured H_(2),we calibrated ox

关键词： Olivine hydrothermal alteration Silica Serpentinization Hydrogen Serpentine

Efficacy of substances containing 3 types of active ingredients-saponins, flavones, and alkaloids in regulation of cytokines in autoimmune diseases a systematic review and Meta-analysis based on animal studies

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Journal of Traditional Chinese Medicine 2024年第3期44卷 417-426页

作者： ZHU ruifang ZHANG Jun LYU Yaru CHEN Yulu HAN Shifan WANG Hongwei Key Laboratory for Molecular Diagnosis and Treatment of Hematologic Diseases Second Hospital of Shanxi Medical UniversityShanxi 030001China School of Nursing Shanxi Medical UniversityShanxi 030001China Editorial Office First Hospital of Shanxi Medical UniversityShanxi 030001China

OBJECTIVE: To investigate the efficacy of substances containing 3 types of active ingredients-saponins,flavones, and alkaloids on experimental animals with autoimmune diseases(AIDs).METHODS: The protocol for this systematic review and Meta-analysis was prospectively registered with PROSPERO(CRD42023395741). Searches were conducted in the China National Knowledge Infrastructure, Wanfang, Chinese Science and Technology Journals, China Biomedical, Pub Med,Cochrane Library, and Embase databases to screen for animal studies investigating the therapeutic effects of saponins, flavones, or alkaloids on autoimmune diseases;consequently, corresponding data extraction tables were prepared. Systematic Review Centre for Laboratory Animal Experimentation was used to assess the risk of methodological bias in the included literature. RevMan 5.4 was used for the Meta-analysis on the 8 serum ***: A total of 31 studies were included, all of which were randomized controlled studies. Meta-analysis indicated that substances rich in saponins, flavones, and alkaloids reduced serum levels of interleukin(IL)-1β[standardized mean difference(SMD) =-1.94, 95%confidence interval(CI)(-2.99,-0.90), P = 0.0003], IL-6 [SMD =-1.65, 95% CI(-2.33,-0.97,) P < 0.000 01],IL-17 [SMD =-2.41, 95% CI(-3.61,-1.20), P <0.0001], tumor necrosis factor(TNF)-α [SMD =-1.84, 95%CI(-2.61,-1.06), P < 0.0001], and interferon(IFN)-γ[SMD =-1.54, 95% CI(-2.43,-0.65), P = 0.0007], but increased serum levels of IL-4 [SMD = 1.30, 95% CI(0.15,2.44), P = 0.03) and IL-10 [SMD = 2.05, 95% CI(1.39,2.70), P < 0.000 01) in animal models. However, no significant regulatory effect of these three active components was observed on serum levels of IL-2 [SMD =-0.63, 95% CI(-1.82, 0.57), P = 0.30].CONCLUTIONS: Substances containing saponins,flavones, and alkaloids regulated the changes of immunerelated cytokines, it may be a novel dietary substance to relieve and control autoimmune diseases in the future.

关键词： autoimmune diseases saponins flavones alkaloids system evaluation Meta-analysis

Fibroblast activation protein (FAP) as a prognostic biomarker in multiple tumors and its therapeutic potential in head and neck squamous cell carcinoma

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Oncology Research 2024年第8期32卷 1323-1334页

作者： ruifang LI XINRONG NAN MING LI OMAR RAHHAL School of Stomatology Shanxi Medical UniversityTaiyuan030001China Department of Stomatology The First Hospital of Shanxi Medical UniversityTaiyuan030001China Department of Oral and Maxillofacial Surgery Xiangya Stomatology HospitalCentral South UniversityChangsha410005China

Background:Fibroblast activation protein(FAP),a cell surface serine protease,plays roles in tumor invasion and immune ***,there is currently no pan-cancer analysis of ***:We aimed to assess the pan-cancer expression proﬁle of FAP,its molecular function,and its potential role in head and neck squamous cell carcinoma(HNSC).Methods:We analyzed gene expression,survival status,immune inﬁltration,and molecular functional pathways of FAP in The Cancer Genome Atlas(TCGA)and Genotype Tissue Expression(GTEx)***,to elucidate the role of FAP in HNSC,we performed proliferation,migration,and invasion assays post-FAP overexpression or ***:FAP expression was elevated in nine tumor types and was associated with poor survival in eight of *** the context of immune inﬁltration,FAP expression negatively correlated with CD8+T-cell inﬁltration inﬁve tumor types and positively with regulatory T-cell inﬁltration in four tumor *** enrichment analysis highlighted FAP’s involvement in the PI3K-Akt signaling *** HNSC cells,FAP overexpression activated the PI3K-Akt pathway,promoting tumor proliferation,migration,and ***,FAP knockdown showed inhibitory ***:Our study unveils the association of FAP with poor tumor prognosis across multiple cancers and highlights its potential as a therapeutic target in HNSC.

关键词： FAP Head and neck squamous cell carcinoma Cancer Prognosis Tumor microenvironment Molecular function

资赋优异学生甄别研究——以上海市文来初中课程实验班为例

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教育发展研究 2016年第2期36卷 49-53页

作者：项瑞芳柏彬刘少雪上海交通大学高等教育研究院上海200240 上海市文来初中上海201101

如何从培养的角度甄别资赋优异学生,一直是资优教育的核心问题。本研究以"千鸟格经纬论"为基础,采用教育测量法,对上海市文来初中课程实验班的262名学生进行了资赋优异的甄别研究。依据学生资赋优异的甄别结果,将他们分成四种类型;依据... 详细信息

如何从培养的角度甄别资赋优异学生,一直是资优教育的核心问题。本研究以"千鸟格经纬论"为基础,采用教育测量法,对上海市文来初中课程实验班的262名学生进行了资赋优异的甄别研究。依据学生资赋优异的甄别结果,将他们分成四种类型;依据学生资优行为的表现程度,将他们分为三层;最后统合学生的资赋类型及资优行为的分层结果,得出基于培养角度的"三层次四类型"甄别模型。

关键词：资赋优异资优行为分类分层个案研究

Porous Graphene-Based Electrodes for Fiber-Shaped Supercapacitors with Good Electrical Conductivity

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Journal of Donghua University(English Edition) 2023年第2期40卷 134-141页

作者：向睿芳陈馨逸刘岩张坤陆春红 Shanghai Frontiers Science Center of Advanced Textiles Donghua UniversityShanghai 201620China College of Textiles Donghua UniversityShanghai 201620China

Graphene fibers(GFs)are ideal electrodes for f ibrous supercapacitors because of their excellent mechanical and electrical ***,the actual specific s urface area(SSA)of GFs is low due to the restacking of g raphene sheets,which limits the capacitance enhancement o f *** of the effective ways to increase the SSA of GFs is to construct a porous fiber structure,but it disrupts t he conductive pathway and adversely affects the electrochemical(EC)performance of ***,a wet-spun porous GF electrode coated with polypyrrole(PPy)was reported in this *** resulting electrode exhibits an areal specific capacitance of 31.25 mF·cm^(-2)and a good c ycling stability with a capacitance retention rate of 95%after 5000 charge/discharge *** indicate that porous structures and PPy coating can synergistically improve the EC performance of GFs.

关键词： graphene fiber(GF) wet-spinning polypyrrole(PPy) capacitance supercapacitor

Electrochemical Performance of Core-Sheath Dip-Coated Lignin Derived Carbon/Wet-Spun Graphene Electrodes for Fiber-Shaped Supercapacitors

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Journal of Donghua University(English Edition) 2021年第2期38卷 91-98页

作者： HU Wenxin LIU Yan xiang ruifang JING Yuanyuan XU Qingli ZHANG Juan HU Xuefeng JIN Yanhong YANG Xiaona CHENG Yu LIN Jiaxian ZHANG Kun LU Chunhong Key Laboratory of Textile Science&Technology Ministry of EducationDonghua UniversityShanghai 201620China College of Textiles Donghua UniversityShanghai 201620China

One-dimensional graphene fibers(GFs)possess excellent properties,including high electrical conductivity,good physical and chemical stability,high thermal conductivity,flexibility,*** are ideal electrode materials for fiber-shaped ***,due to the lack of an effective method to manufacture GFs with high specific capacitance,their low energy density hinders their practical ***,we decorated wet-spun graphene oxide fibers(GOFs)by dip-coating them with graphene oxide(GO)solutions containing different contents of lignin to obtain a core-sheath lignin/GO composite *** carbonization and activation,we successfully prepared lignin derived carbon/GF *** assembled fiber-shaped supercapacitors(FSSCs)exhibit a specific capacitance of 9.98 mF/cm^(2)and an energy density of 0.89μW·h/cm^(2),about 6 times of those of pure GFs(1.57 mF/cm^(2)and 0.14μW·h/cm^(2),respectively),long cycling life and cycling *** suggests that the introduction of lignin derived carbon into GFs can effectively increase the specific capacitance and the energy density of FSSCs.

关键词： wet-spinning lignin derived carbon graphene specific capacitance energy density