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钛/铝异种金属旋转摩擦焊接接头界面组织与性能

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焊管 2023年第11期46卷 26-33页

作者：胡茂辉陈继兵李瑞迪支盛兴刘博文武汉轻工大学机械工程学院武汉430023 中南大学粉末冶金国家重点实验室长沙410083

为了研究钛/铝异种金属旋转摩擦焊接接头界面金属间化合物形成的过程,对激光增材制造技术制备的Ti6Al4V和AlSi10Mg进行了旋转摩擦焊接,并通过显微组织分析、拉伸试验、硬度测试等手段研究了接头界面的组织和力学性能。从X射线衍射结果和... 详细信息

为了研究钛/铝异种金属旋转摩擦焊接接头界面金属间化合物形成的过程,对激光增材制造技术制备的Ti6Al4V和AlSi10Mg进行了旋转摩擦焊接,并通过显微组织分析、拉伸试验、硬度测试等手段研究了接头界面的组织和力学性能。从X射线衍射结果和EDS元素变化发现接头界面处形成了TiAl3相,SEM图也观察到焊接界面有脆性金属层的存在。通过显微组织表征和力学性能测试,系统地验证了界面生成较少的脆性金属化合物。

关键词：旋转摩擦焊异种接头 Ti6Al4V/AlSi10Mg 金属间化合物

林才志主任医师运用双术汤治疗脾胃病验案3则

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广西中医药 2021年第6期44卷 57-59页

作者：陈浩彬江晓珊刘文健李瑞迪林才志(指导) 广西中医药大学研究生院广西南宁530020 不详

林才志,主任医师,硕士研究生导师,是首批全国名老中医秦家泰教授学术传人,并师从梁申教授、李桂贤教授等诸多名医。其集诸名医学术经验于一身,临床经验丰富,尤其擅用中医中药治疗各种脾胃病及疑难杂症,对中医脾胃病的证治有自己独到的... 详细信息

林才志,主任医师,硕士研究生导师,是首批全国名老中医秦家泰教授学术传人,并师从梁申教授、李桂贤教授等诸多名医。其集诸名医学术经验于一身,临床经验丰富,尤其擅用中医中药治疗各种脾胃病及疑难杂症,对中医脾胃病的证治有自己独到的见解。双术汤源自秦老之经验方,其由苍术、白术、姜半夏、茯苓、厚朴、陈皮、延胡索、川楝子、鸡内金、麦芽、神曲、山楂、石斛、甘草等药组成,诸药合用,具有健运脾胃、燥化痰湿、化积消食、调畅气机之功效,为秦老治疗脾胃病之第一验方。

关键词：脾胃病林才志双术汤验案

Ni含量对激光粉末床熔融成形NiTi形状记忆合金显微组织和力学性能的影响

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铸造技术 2023年第7期44卷 649-656页

作者：康景涛刘子豪郑聃李瑞迪赖端刘鑫炎黄文静梁恩泉中南大学粉末冶金国家重点实验室湖南长沙410083 湖南华曙高科技有限责任公司湖南长沙410221 上海飞机设计研究院上海201210

激光粉末床熔融(laser powder bed fusion,LPBF)成形NiTi合金由于Ni元素的蒸发导致成分偏离粉末设计成分,而NiTi合金的形状记忆效应、超弹性等性能受Ni含量影响极大。因此有必要对不同Ni含量NiTi合金的LPBF成形性、显微组织以及力学性... 详细信息

激光粉末床熔融(laser powder bed fusion,LPBF)成形NiTi合金由于Ni元素的蒸发导致成分偏离粉末设计成分,而NiTi合金的形状记忆效应、超弹性等性能受Ni含量影响极大。因此有必要对不同Ni含量NiTi合金的LPBF成形性、显微组织以及力学性能开展研究。采用真空电极感应熔炼气雾化技术制备了Ni_(50.8)Ti、Ni_(51.0)Ti以及Ni_(51.5)Ti(原子分数,%)3种预合金粉末,研究其在不同工艺参数下的冶金缺陷、显微组织及力学性能的演化规律。结果表明,高Ni含量NiTi合金在LPBF成形过程中容易产生垂直于建造方向的裂纹,成形性较低Ni含量NiTi合金差。Ni_(51.5)Ti合金室温下的临界应力可达476 MPa,但断裂伸长率仅为2%;Ni_(50.8)Ti合金临界应力仅为122 MPa,断裂伸长率可达8%。

关键词：粉末床激光熔融 NiTi合金显微组织力学性能成分调控

Involvement of GluA1-AMPAR-mediated LTP in time-dependent decline of cognitive function in rats with temporal lobe epilepsy

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Acta Epileptologica 2021年第1期3卷 7-14页

作者： Xiaoqing Luo Xiaoli Yu Jufang liang ruidi Sun Cheng li Jun Jiang Department of Electrophysiology Wuhan Children’s Hospital(Wuhan Maternal and Child Healthcare Hospital)Tongji Medical CollegeHuazhong University of Science and TechnologyNo.100 of Hong Kong RoadJiang’an District430016 WuhanChina

Background:Cognitive impairment is one of the common comorbidities in patients with temporal lobe epilepsy(TLE),but the underlying mechanisms remain largely *** studies have found significant decay of hippocampal long-term potentiation(LTP)in TLE rats with cognitive *** the activation ofα-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors(AMPARs)is responsible for LTP formation and learning and memory,we investigated whether AMPARs are involved in the LTP inhibition and the TLE-associated cognitive ***:TLE rat model was established by intraperitoneal injection of lithium chloride-pilocarpine on postnatal day 21(P21).Learning and memory performance,hippocampal expression of membrane GluA1-AMPARs,and hippocampal LTP were tested by behavioral tests,western blotting,and field potential recording,respectively,at 1,5 and 13 weeks after induction of status epilepticu(SE).Finally,the effects of(S)-AMPA,an agonist of AMPARs,on LTP and cognitive function were ***:Results of behavioral tests revealed an time-dependent decline in the learning and memory of TLE rats when compared to the age-matched controls at week 5 and 13,rather than at week 1 after the induction of *** blotting showed that the hippocampal expression of membrane GluA1 was significantly decreased in a time-dependent manner in the TLE rats when compared to the age-matched controls at weeks 5 and 13,rather than at week 1 after the induction of ***,the hippocampal LTP was inhibited in a time-dependent manner in TLE rats at weeks 5 and 13,rather than at week 1 after the induction of ***,intra-hippocampal injection of(S)-AMPA ameliorated the deficits in learning as well as spatial and emotional memory in a dosedependent manner,and partially reversed the inhibition of CA1 LTP in the TLE rats at week 13 after the induction of ***:The reduced expression of hippocampal membrane GluA1 may be involved in LTP decay in CA1 and co

关键词： Cognitive impairment Temporal lobe epilepsy Long-term potentiation Hippocampus AMPA receptor

激光熔化沉积成形Cu-Al-Mn-Ti形状记忆合金组织与性能研究

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有色金属材料与工程 2023年第5期44卷 60-67页

作者：刘旭涂燕玲胡碧艳游新月汪龙霞宋王翼邵君麒邓声华李瑞迪江西理工大学材料冶金化学学部江西赣州341000 中南大学粉末冶金国家重点实验室长沙410000

采用激光熔化沉积(laser melting deposition,LMD)成形Cu-Al-Mn-Ti形状记忆合金,研究其组织、冶金缺陷与性能特点。研究表明,LMD成形Cu-Al-Mn-Ti合金的显微组织具有各向异性特征:建造面为柱状晶组织,扫描面为等轴晶组织。这是由于LMD成... 详细信息

采用激光熔化沉积(laser melting deposition,LMD)成形Cu-Al-Mn-Ti形状记忆合金,研究其组织、冶金缺陷与性能特点。研究表明,LMD成形Cu-Al-Mn-Ti合金的显微组织具有各向异性特征:建造面为柱状晶组织,扫描面为等轴晶组织。这是由于LMD成形过程沉积方向存在较大的温度梯度导致的。LMD成形Cu-Al-Mn-Ti合金的基体组织为β相板条马氏体,并存在大量Cu2AlMn颗粒状析出相。孔隙缺陷是LMD成形Cu-Al-Mn-Ti合金中主要的冶金缺陷,严重影响了合金的力学性能。热处理可提高LMD成形Cu-Al-Mn-Ti合金的力学性能及形状记忆性能。固溶、时效处理后,LMD成形Cu-Al-Mn-Ti合金的抗拉强度可由453.6 MPa提高至519.5 MPa,形状回复率可由68%提高至97%;当时效温度为500℃时,在晶界上开始析出网状α相导致Cu基体中的Al含量增加,使合金的力学性能和形状回复率下降。

关键词：激光熔化沉积 Cu-Al-Mn-Ti合金形状记忆显微组织力学性能

HPV-CCDC106 integration alters local chromosome architecture and hijacks an enhancer by three-dimensional genome structure remodeling in cervical cancer

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Journal of Genetics and Genomics 2020年第8期47卷 435-448页

作者： Canhui Cao Ping Hong Xingyu Huang Da lin Gang Cao liming Wang Bei Feng Ping Wu Hui Shen Qian Xu Ci Ren Yifan Meng Wenhua Zhi ruidi Yu Juncheng Wei Wencheng Ding Xun Tian Qinghua Zhang Wei li Qinglei Gao Gang Chen Kezhen li Wing-Kin Sung Zheng Hu Hui Wang Guoliang li Peng Wu Department of Gynecologic Oncology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China Cancer Biology Research Center(Key Laboratory of the Ministry of Education) Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan430070China Agricultural Bioinformatics Key Laboratory of Hubei Province Hubei Engineering Technology Research Center of Agricultural Big DataCollege of InformaticsHuazhong Agricultural UniversityWuhan430070China State Key Laboratory of Agricultural Microbiology Huazhong Agricultural UniversityWuhan430070China Bio-Medical Center Huazhong Agricultural UniversityWuhan430070China College of Veterinary Medicine Huazhong Agricultural UniversityWuhan430070China Department of Obstetrics and Gynecology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430022China Department of Obstetrics and Gynecology Key Laboratory for Molecular Diagnosis of Hubei ProvinceThe Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430010China Department of Computational and Systems Biology Genome Institute of SingaporeSingapore Department of Gynecological Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou510080China

Integration of human papillomavirus(HPV)DNA into the human genome is a reputed key driver of cervical ***,the effects of HPV integration on chromatin structural organization and gene expression are largely *** studied a cohort of 61 samples and identified an integration hot spot in the CCDC106 gene on chromosome *** then selected fresh cancer tissue that contained the unique integration loci at CCDC106 with no HPV episomal DNA and performed whole-genome,RNA,chromatin immunoprecipitation and high-throughput chromosome conformation capture(Hi-C)sequencing to identify the mechanisms of HPV integration in cervical *** analyses indicated that chromosome 19 exhibited significant genomic variation and differential expression densities,with correlation found between three-dimensional(3D)structural change and gene ***,HPV integration divided one topologically associated domain(TAD)into two smaller TADs and hijacked an enhancer from PEG3 to CCDC106,with a decrease in PEG3 expression and an increase in CCDC106 *** expression dysregulation was further confirmed using 10 samples from our cohort,which exhibited the same HPV-CCDC106 *** summary,we found that HPV-CCDC106 integration altered local chromosome architecture and hijacked an enhancer via 3D genome structure ***,this study provides insight into the 3D structural mechanism underlying HPV integration in cervical carcinogenesis.

关键词： Cervical cancer HPV integration Fusion gene Hi-C Enhancer TAD

基于用电偏好的可平移负荷参与需求响应最优激励合同与激励策略

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中国电机工程学报 2021年第S01期41卷 185-193页

作者：李伟韩瑞迪孙晨家傅鹏张杰王冲东北电力大学经济管理学院吉林省吉林市132012

充分调动负荷侧可平移负荷(shiftableloads,SL)参与需求响应成为解决高比例新能源接入电网带来的波动性的有效途径之一。分析该类用户参与需求响应的积极性不高的原因,主要是由于缺乏一套有效激发该类用户参与需求响应积极性的激励合同... 详细信息

充分调动负荷侧可平移负荷(shiftableloads,SL)参与需求响应成为解决高比例新能源接入电网带来的波动性的有效途径之一。分析该类用户参与需求响应的积极性不高的原因,主要是由于缺乏一套有效激发该类用户参与需求响应积极性的激励合同和调度策略。而SL用户参与需求响应的积极性与其舒适型和经济型偏好结构密切相关,想要提高其积极性就需要从用户用电偏好结构切入,以负荷聚集商与SL用户之间的实际利益平衡为出发点,基于委托–代理理论构建信息不对称情形下的最优激励模型。通过对模型的求解和模拟分析,给出最优激励合同和调度策略建议。与基准方案相比,该文给出的最优策略可以将用户参与积极性提高23%,合作双方经济性提高61%。算例结果验证了最优激励合同、最优激励策略的有效性。

关键词：用电偏好可平移负荷需求响应激励机制

Study for High Efficiency Water Reducing Agents with High Temperature Retardation Setting and Its Application to RCC

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Study for High Efficiency Water Reducing Agents with High Te...

麦角酰二乙胺类物质1-环丙酰基-麦角酰二乙胺(1cP-LSD)的定性检验

The Fifth International Symposium on Roller Compacted Concrete(RCC) Dams

作者： Wen Jinbao Xu Xiarong Wang Yi li Keliang Huang Guohong ruidi High-Tech Company Nanjing Hydraulic Research Institute Nanjing 210024 China

＜正＞In consideration of the technical requirement of the admixture for RCC of the Guangzhao Hydropower Station and the characteristic of the extreme high temperature in summer at construction site,several groups of admixtures and prescriptions are designed in this *** last,the optimum sample is selected and *** result shows that high efficiency water reducing agents with retardation are characterized by low dosage,high water-reducing rate and extra-long *** products can greatly reduce the dosage of the cement in concrete per *** the same time,the characteristic of the retarding can reduce and retard the peak of the temperature of interior hydration heat,as well as benefit for combination of ***,the result shows that properties of the products are able to meet the technical requirements for the admixtures that match with corresponding needs for RCC of the Guangzhao Hydropower Station and it will be applied in the dams of the Guangzhao Hydropower Station.

关键词： High efficiency water reducing agents with high temperature set-retarding roller compacted concrete setting time compressive strength

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刑事技术 2023年第5期48卷 498-504页

作者：沈瑞迪李彭钱振华公安部禁毒情报技术中心北京100193

针对在中国未见报道的麦角酰二乙胺类物质1-环丙酰基-麦角酰二乙胺,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆/静电场轨道阱高分辨质谱联用(UPLC-Q-Exactive Orbitrap-MS)定性检验方法。本文对未知样品用甲醇和水提取,取上清... 详细信息

针对在中国未见报道的麦角酰二乙胺类物质1-环丙酰基-麦角酰二乙胺,建立其气相色谱-质谱(GC-MS)、超高效液相色谱-四极杆/静电场轨道阱高分辨质谱联用(UPLC-Q-Exactive Orbitrap-MS)定性检验方法。本文对未知样品用甲醇和水提取,取上清液,分别采用GC-MS和UPLC-Q-Exactive Orbitrap-MS进行分析,麦角酰二乙胺(lysergic acid diethylamide,LSD)进行同步对照分析。经GC-MS检测,保留时间为23.85 min的未知组分的质谱碎片主要特征离子峰有m/z 221,289,391,69,181,207,249,348。经UPLCQ-Exactive Orbitrap-MS检测,保留时间为3.99 min的未知组分的准分子离子峰为m/z 392.2328,二级质谱主要离子有m/z 291.1487,349.1904,281.1643,265.1333,223.1226,208.0753,251.1176。基于缺少对照品的现状,经SWGDRUG和Cayman谱库检索、已报道文献中信息比对及对其高分辨质谱数据的解析,实现了目标物确认,鉴定为1-环丙酰基-麦角酰二乙胺(1-cylopropanoyl-lysergic acid diethylamide,1cP-LSD)。该方法具有分析简便、快速的特点,有很好的应用前景,可以用于实际案件的检测。

关键词：麦角酰二乙胺类 1-环丙酰基-麦角酰二乙胺气相色谱–质谱联用(GC-MS) 超高效液相色谱–四极杆/静电场轨道阱高分辨质谱联用(UPLC-Q-Exactive Orbitrap-MS)