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Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)

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Oncology Research 2024年第3期32卷 503-515页

作者： XING YE ZHOUTING TUO KAI chen ruicheng WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG Samuel Oschin Comprehensive Cancer Institute Department of MedicineDepartment of Biomedical SciencesCedars-Sinai Medical CenterLos AngelesCA90048USA Department of Urology The Second Afiliated Hospital of Anhui Medical UniversityHefei230601China Department of Urology Institute of UrologyWest China HospitalSichuan UniversityChengdu610041China Department of Pathology Ningbo Diagnostic Pathology Center Ningbo315021China Department of Public Research Platfom Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical UniversityLinhai317000China Department of Rehabilitation West Kyushu UniversityKanzaki shi842-8585Japan Department of Urology Kyung Hee UniversitySeoul446701South Korea Department of Rehabilitation The Afliated Hospital of Southwest Medical UniversityLuwzhou646000China

The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in cancer.We observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these cancers.In conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关键词： Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects

Mechanism of ball milled activated carbon in improving the desalination performance of flow-and fixed-electrode in capacitive deionization desalination

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Frontiers of Environmental Science & Engineering 2023年第5期17卷 145-154页

作者： Ge Shen Junjun Ma Jianrui Niu Ruina Zhang Jing Zhang Xiaoju Wang Jie Liu Jiarong Gu ruicheng chen Xiqing Li Chun Liu College of Environmental Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Pollution Prevention Biotechnology Laboratory of Hebei Province Shijiazhuang 050018China

Capacitive deionization(CDI)is a novel electrochemical water-treatment technology.The electrode material is an important factor in determining the ion separation efficiency.Activated carbon(AC)is extensively used as an electrode material;however,there are still many deficiencies in commercial AC.We adopted a simple processing method,ball milling,to produce ball milled AC(BAC)to improve the physical and electrochemical properties of the original AC and desalination efficiency.The BAC was characterized in detail and used for membrane capacitive deionization(MCDI)and flow-electrode capacitive deionization(FCDI)electrode materials.After ball milling,the BAC obtained excellent pore structures and favorable surfaces for ion adsorption,which reduced electron transfer resistance and ion migration resistance in the electrodes.The optimal ball-milling time was 10 h.However,the improved effects of BAC as fixed electrodes and flow electrodes are different and the related mechanisms are discussed in detail.The average salt adsorption rates(ASAR)of FCDI and MCDI were improved by 134%and 17%,respectively,and the energy-normalized removal salt(ENRS)were enhanced by 21%and 53%,respectively.We believe that simple,low-cost,and environmentally friendly BAC has great potential for practical engineering applications of FCDI and MCDI.

关键词： Ball-milling Capacitive deionization Fixed electrode Flow electrode

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泸定6.8级地震公路抢通保通方案

土木与环境工程学报（中英文） 2024年第3期46卷 216-226页

作者：赵飞朱明李杰徐益飞但晨肖怡邱瑞成成都理工大学地质灾害防治与地质环境保护国家重点实验室成都610059 四川省交通勘察设计研究院有限公司成都610017 交通运输部BIM技术应用行业研发中心成都610017

2022年9月5日,四川泸定发生6.8级地震,公路沿线诱发了大量的地质灾害,造成多处公路损坏或断道,极大地影响了抗震救灾工作。快速摸清震区公路网的受损情况和抢通保通难度,对震后救援至关重要。为此,对震区公路受损情况进行调查,会同地方... 详细信息

2022年9月5日,四川泸定发生6.8级地震,公路沿线诱发了大量的地质灾害,造成多处公路损坏或断道,极大地影响了抗震救灾工作。快速摸清震区公路网的受损情况和抢通保通难度,对震后救援至关重要。为此,对震区公路受损情况进行调查,会同地方交通部门完成公路的抢通保通任务。调查发现了507处受损点,公路灾害以崩塌滑坡为主,占总灾害的90%以上。公路灾害具有数量多、规模小、连片分布的特点,公路震害与地震烈度正相关,与断层距离、河流距离负相关。在不利因子组合下,公路震害程度明显加剧,局部位置的公路受损率可达到92.5%。在抢通保通阶段,利用龙头石及大岗山电站的库区水运资源,快速建立5处码头,建立起通往震中的生命通道,让应急队伍快速进入灾区,让伤员第一时间运送出来;灾后交通网的重建充分利用水运资源,不追求道路等级与路线指标,公路重建以提高公路的抗灾能力及韧性为目标。

关键词：公路工程泸定地震同震灾害抢通保通公路受损率

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多级串联膜电容去离子装置的脱盐性能

环境工程学报 2024年第1期18卷 63-70页

作者：陈瑞程谷佳蓉余铭浩马俊俊牛建瑞李耘科刘春河北科技大学环境科学与工程学院河北省污染防治生物技术实验室

膜电容去离子(membrane capacitive deionization,MCDI)技术具有的装置简单、易操作、易再生、成本低,无污染、节能等优势,使其成为一种新型的脱盐技术。为了提升MCDI的脱盐性能,将多个装置的进水串联,对每个装置单独加电来探究脱盐率,... 详细信息

膜电容去离子(membrane capacitive deionization,MCDI)技术具有的装置简单、易操作、易再生、成本低,无污染、节能等优势,使其成为一种新型的脱盐技术。为了提升MCDI的脱盐性能,将多个装置的进水串联,对每个装置单独加电来探究脱盐率,平均脱盐速率、单位能量脱盐量等指标对多级串联的影响。结果表明,在进水盐质量浓度、水力停留时间、电压等不同操作条件下,二、三级MCDI串联脱盐率都提高了约2、3倍,三级串联较二级串联的脱盐速率提升较小,但具有更高的能耗。综合比较,二级MCDI串联的脱盐性能更优,并获得了最佳的操作条件为1.5 g·L^(-1),0.375 min,1.2 V。在连续脱盐过程中,多级串联能够连续稳定的去除盐离子,并且具有较高的吸附容量,表明了连续脱盐的可行性。研究结果对多级MCDI脱盐工程化应用具有指导意义。

关键词：膜电容去离子多级串联脱盐性能参数优化连续脱盐

Critical review of perovskites-based advanced oxidation processes for wastewater treatment: Operational parameters, reaction mechanisms,and prospects

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Chinese Chemical Letters 2022年第2期33卷 643-652页

作者： ruicheng Ji Jiabin chen Tongcai Liu Xuefei Zhou Yalei Zhang State Key Laboratory of Pollution Control and Resources Reuse College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Key Laboratory of Yangtze Water Environment for Ministry of Education College of Environmental Science and EngineeringTongji UniversityShanghai 200092China Shanghai Institute of Pollution Control and Ecological Security Tongji UniversityShanghai 200092China

In the field of advanced oxidation processes(AOPs) of wastewater, many materials can be used as heterogeneous catalysts. The role of these catalysts is to activate oxidants and generate reactive oxygen species(ROS) to decompose refractory pollutants. Perovskite oxide, an emerging catalyst in the field of AOPs, has been extensively studied in wastewater treatment. Nevertheless, the application of perovskite in AOP systems still faces some problems, such as leaching of metal ions, a small surface area, a low number of active sites, etc. Herein, this critical review comparatively examines the activation mechanisms of peroxymonosulfate, hydrogen peroxide, and peroxydisulfate. Furthermore, the formation pathways of oxidizing species based on recent advances in experimental and theoretical studies were evaluated. In addition, the impacts of water parameters and constituents such as initial p H, oxidant concentration, catalyst dosage,natural organic matter, halide, phosphate, and carbonate were discussed. Finally, a critical discussion and prospects of mechanism exploration and possible materials development are proposed to confront the existing challenges in the application of perovskite oxides in AOPs.

关键词： Perovskite Advanced oxidation processes Wastewater Peroxide Free radical

基于YOLOv5算法的学生课堂行为识别研究

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现代计算机 2024年第8期30卷 62-65,71页

作者：马瑞珵陈继王炳怀龙俊丞刘宇西南民族大学电子信息学院成都610225

随着智慧课堂和教育大数据挖掘的普及,创建一种智慧课堂中学生学习数据的自动检测和分析方法成为可能。基于YOLOv5模型实现两类学习数据:班级同学计数、学习行为识别。该模型对低头写字、低头看书、抬头听课、转头、举手、站立、小组讨... 详细信息

随着智慧课堂和教育大数据挖掘的普及,创建一种智慧课堂中学生学习数据的自动检测和分析方法成为可能。基于YOLOv5模型实现两类学习数据:班级同学计数、学习行为识别。该模型对低头写字、低头看书、抬头听课、转头、举手、站立、小组讨论七种学生课堂行为进行识别,以此辅助教师判断学生学习情况并做出教学决策。研究表明,检测结果精确度达到97.92%。

关键词：学生行为识别 YOLOv5 计算机视觉技术

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高邮鸭蛋特征品质指标分析

食品科学 2024年第2期45卷 240-247页

作者：陈梦颖龚兰何涛朱磊栾枫婷豆维胜邵雪梅方晓敏尤兆荣魏瑞成王冉江苏大学食品与生物工程学院江苏镇江212013 江苏省农业科学院农产品质量安全与营养研究所江苏省食品质量安全重点实验室-省部共建国家重点实验室培育基地江苏南京210014 高邮鸭蛋协会江苏扬州225600

为挖掘高邮鸭蛋品质特征指标,采用代谢组学等技术对高邮鸭蛋的蛋品质指标、基础营养指标及小分子代谢物进行测定分析。结果显示,高邮鸭蛋的蛋质量、蛋形指数、蛋黄色度、哈夫单位、蛋白高度、蛋黄指数、粗蛋白质量分数指标高于其他品种... 详细信息

为挖掘高邮鸭蛋品质特征指标,采用代谢组学等技术对高邮鸭蛋的蛋品质指标、基础营养指标及小分子代谢物进行测定分析。结果显示,高邮鸭蛋的蛋质量、蛋形指数、蛋黄色度、哈夫单位、蛋白高度、蛋黄指数、粗蛋白质量分数指标高于其他品种;总氨基酸、鲜味氨基酸、支链氨基酸、总脂肪酸、不饱和脂肪酸含量较高,饱和脂肪酸含量低,表明高邮鸭蛋的部分感官蛋品品质参数、氨基酸和脂肪酸水平可表征高邮鸭蛋的特征品质。基于代谢组学技术绘制高邮鸭蛋的代谢指纹图谱,通过主成分分析(principal component analysis,PCA)、偏最小二乘法分析(partial least-squares discrimination analysis,PLS-DA)模型、层次聚类分析(hierarchical clustering analysis,HCA)等方法挖掘高邮鸭蛋的特征组分。蛋黄中鉴定出252个化合物,差异化合物22个,蛋清中鉴定出184个化合物,差异化合物40个。其中,尿苷5’-单磷酸、鸟苷5’-单磷酸、N-乙酰基-D-葡萄糖胺为主要差异营养物质,蛋黄中的花生四烯酸为高邮鸭蛋特有营养成分,蛋清中的吲哚在高邮鸭蛋中未检出。

关键词：高邮鸭蛋常规蛋品质指标基础营养指标代谢组学

机器人辅助肾部分切除术出血性并发症预测因素分析

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现代泌尿生殖肿瘤杂志 2024年第2期16卷 70-74页

作者：林博涵邱钱仁顺高睿承许宁薛学义孙雄林郑清水魏勇陈少豪福建医科大学附属第一医院泌尿外科福州350005

目的分析接受机器人辅助肾部分切除术(RAPN)的肾肿瘤患者发生出血性并发症(HCs)的风险预测因素。方法分析2021年3月至2023年1月间接受RAPN的317例患者的临床、手术及术后病理资料,将术后血红蛋白下降>3 g/dl、术后需要输血、治疗性干预... 详细信息

目的分析接受机器人辅助肾部分切除术(RAPN)的肾肿瘤患者发生出血性并发症(HCs)的风险预测因素。方法分析2021年3月至2023年1月间接受RAPN的317例患者的临床、手术及术后病理资料,将术后血红蛋白下降>3 g/dl、术后需要输血、治疗性干预的动静脉瘘或假性动脉瘤的患者纳入出血组,其余纳入无出血组。通过倾向性评分匹配法(PSM)均衡组间混杂因素,通过单因素及多因素Logistic回归分析确定RAPN后HCs的独立预测因子。结果纳入的317例患者中,29例患者术后出现HCs。经过PSM控制纳入研究参数的一致性,将27例RAPN后HCs与27例无HCs的患者进行匹配。单因素Logistic回归分析提示,R.E.N.A.L.评分≥10分(OR=5.92,95%CI=2.36~14.82)、手术时间≥130 min(OR=6.21,95%CI=1.94~19.84)及热缺血时间≥23 min(OR=3.60,95%CI=1.42~9.13)是RAPN后HCs的影响因素,进一步多因素Logistic回归分析显示,R.E.N.A.L.评分≥10分(OR=5.03,95%CI=2.78~9.10)、手术时间≥130 min(OR=1.02,95%CI=1.01~1.03)及热缺血时间≥23 min(OR=1.15,95%CI=1.05~1.26)是RAPN后HCs的危险因素。结论术前R.E.N.A.L.评分≥10分、手术时间≥130 min及热缺血时间≥23 min的患者更有可能在RAPN后发生HCs。

关键词：机器人辅助肾部分切除术 R.E.N.A.L评分出血性并发症

Identification of the lower limit of high-quality source rocks and its relation to hydrocarbon accumulation——Taking the Beier Sag in the Hailaer Basin as an example

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Petroleum Science 2012年第1期9卷 10-17页

作者： Lu Shuangfang chen Fangwen Li Jijun Wang Weiming Li Huiguang Cao ruicheng Ma Yanling College of Geosciences Northeast Petroleum UniversityHeilongjiang 163318China Province Key Laboratory of Petroleum Accumulation Mechanism and Resource Prediction Heilongjiang 163318China The Halaer Exploratory Development Headquarters Daqing Oilfield Company Ltd.Heilongjiang 163000China

The theory of ＂source rock control＂ has evolved from source-rock-control hydrocarbon accumulation, to effective source-rock-control hydrocarbon accumulation, and to high-quality source- rock-control hydrocarbon accumulation. However, there are problems, such as whether high-quality source rocks exist or not？ What high-quality source rocks are, and how to identify them, are yet to be agreed upon. Aimed at this issue of concern to explorationists, and taking the Beier Sag in the Hailaer Basin as an example, this paper defines the high-quality source rocks and the lower limit for evaluation of high-quality source rocks, by using the inflection point on the relationship curve of hydrocarbon （oil） expulsion, which is calculated by the material balance principle, versus total organic carbon （TOC）. The results show that when TOC is low, all source rocks have limited hydrocarbon expulsion and slow growth rate, thus they cannot be high-quality source rocks. However, when TOC rises to some threshold, hydrocarbon expulsion increases significantly with TOC. This inflection point should be the lower limit of high-quality source rocks： those with TOC greater than the inflection-point value are high-quality source rocks. In addition, the lower limit of high-quality source rocks is also related to the type and maturity of organic matters in the source rocks, as well as the mineral components of the source rocks affecting the residual hydrocarbons. Theoretically, the lower limit of high-quality source rocks depends on geological conditions rather than being a constant value. However, for the sake of simplicity and practicability, in this paper TOC=2.0% is regarded as the lower limit of high-quality source rocks. The examination of such standard in the work area indicates that the high-quality source rocks in members K^n2 and K^n~ of the Nantun formation contribute 76% and 82% to oil generation, and 96% and 91% to oil expulsion, respectively. The distribution of high-quality source rocks is also closely related to the distribution

关键词： High-quality source rocks material balance oil generation oil expulsion hydrocarbongeneration potential Beier Sag