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Therapeutic effect of naloxone on radiation optic neurapathy Based on rabbit models

Neural Regeneration Research 2007年第8期2卷 475-478页

作者： ruibin liu Chuanfu Wang Ophthalmology Center Union Hospital Changzhi Medical College Changzhi 046000 Shanxi Province China

BACKGROUND： Radiation therapy is widely used to treat tumor of brain; however, irradiation of radiation into eye tissues may easily cause ischemia and hypoxia in retina and optic nerve tissue so as to induce radiation optic neurapathy. Noloxone is a specific antagonist of opiate receptor, and it can change injured effect of f3 -endorphin. OBJECTIVE： To observe the axoplasmic transport of optic nerve at various phases after radiation injury so as to investigate the mechanism and regularity of optic nerve injury; meanwhile, to verify the therapeutic effects of naloxone on radiation optic neurapathy. DESIGN： Randomized controlled animal study. SETTINGS： Medical College of Qingdao University, Changzhi Medical College. MATERIALS： A total of 40 healthy adult New Zealand rabbits, weighing 2 - 2.5 kg, of either gender, were checked by using slit lamp and ophthalmoscop before radiation in order to exclude eye diseases. FCC-7000 vertical kilocurie ^60Co therapeutic machine was made in Yantai, China; in addition, naloxone was provided by Beijing Sihuan Pharmaceutical Factory. METHODS： The experiment was carried out in the Animal Experimental Laboratory, Medical College of Qingdao University from January 2005 to December 2006. The experimental rabbits were randomly divided into radiation group （n =16）, treatment group （n =16）, blank control group （n=4） and injured control group （n=4）. Except blank control group, rabbits in other three groups were irradiated in as the center of optic chiasma including the area of optic nerve by using ^60Co therapeutic machine. Radioactive source was 85 cm away from head, and the size of operative field was 5 cm × 5 cm. The radiation was performed once a day with the dosage of 3 Gy for 8 days in total. The total dosage was 24 Gy. When radioactive dosage reached 24 Gy, 2 mg/kg naloxone was dropped into ear vein of rabbits in the treatment group once a day for 10 days in total. Rabbits in the injured control group were only irradiated but not given

关键词： naloxone optic nerve injuries radioactivity

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Three-primary-color molecular cocrystals showing white-light luminescence,tunable optical waveguide and ultrahigh polarized emission

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Science China Chemistry 2022年第2期65卷 408-417页

作者： Shuzhen Li Yan Hao Shuai Guo Chunjie Ding Yujuan Ma ruibin liu Dongpeng Yan Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Beijing Key Lab of Nanophotonics and Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China College of Chemistry and Molecular Engineering Zhengzhou UniversityZhengzhou 450001China

Three-primary-color luminescent materials are highly desirable to construct white-light emitting resource,multi-color optical displays,and tunable photonic ***,the efficient strategy to establish the three-primary-color systems with unique photofunctionalities is still rather limited,particularly for molecular ***,we developed a molecular cocrystal route to obtain three-primary-color emissive materials by tuning different donor-acceptor units based on the same chromophore(4,4′-bis(2,5-dimethylstyryl)biphenyl,Bdb).The warm and cold white-light together with multi-color emission in most of visible region can be highly adjusted by rationally tuning different mixture components of three-primary-color cocrystals through an energy transfer ***,the blue/green/red emitters endow Bdb molecular cocrystals novel colortunable photonic properties(such as one-dimensional(1D)/2D optical waveguide,polarized fluorescence,up-conversion luminescence,and amplified spontaneous emission),benefitting from their well-defined micro/nanostructures and high ***,the high luminescence quantum yield(82.49%)and polarized anisotropy(0.723)outperform most of state-ofthe-art molecular crystalline ***,this work supplies an effective way to fabricate new types of three-primarycolor phosphors through luminescent cocrystals,which have promising applications in the fields of full-color displays,whitelight irradiation,low-dimensional optical polarization,and micro/nanophotonics.

关键词： three-primary-color emission molecular crystal white light optical waveguide polarized luminescence

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Effect of matrix thermal properties on laser-induced plasma

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Chinese Physics B 2024年第10期33卷 331-336页

作者： Yuheng Shan An Li Xinyu Zhang Wen Yi Ying Zhang Xiaodong liu ruibin liu Key Laboratory of Precision Spectroscopy and Optoelectronic Technology School of PhysicsBeijing Institute of TechnologyBeijing 100081China

The matrix thermal properties have an important impact on laser-induced plasma,as the thermal effect dominates the interaction between ns-pulsed laser and matter,especially in *** used a series of pure metals and aluminum alloys to measure plasma temperature and electron density through laser-induced breakdown spectroscopy,in order to investigate the effect of matrix thermal properties on laser-induced *** pure metals,a significant negative linear correlation was observed between the matrix thermal storage coefficient and plasma temperature,while a weak correlation was observed with electron *** results indicate that metals with low thermal conductivity or specific heat capacity require less laser energy for thermal diffusion or melting and evaporation,resulting in higher ablation rates and higher plasma ***,considering ionization energy,thermal effects may be a secondary factor affecting electron *** experiment of aluminum alloy further confirms the influence of thermal conductivity on plasma temperature and its mechanism explanation.

关键词： laser-induced plasma thermal properties matrix effect thermal storage coefficient plasma temperature

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Two‑Dimensional Cr_(5)Te_(8)@Graphite Heterostructure for Efficient Electromagnetic Microwave Absorption

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Nano-Micro Letters 2024年第3期16卷 407-422页

作者： Liyuan Qin Ziyang Guo Shuai Zhao Denan Kong Wei Jiang ruibin liu Xijuan Lv Jiadong Zhou Qinghai Shu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing 100081People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(MOE)School of PhysicsBeijing Institute of TechnologyBeijing 100081People’s Republic of China Advanced Research Institute of Multidisciplinary Science Beijing Institute of TechnologyBeijing 100081People’s Republic of China Tangshan Research Institute Beijing Institute of TechnologyTangshan 063099People’s Republic of China

Two-dimensional(2D)transition metal chalcogenides(TMCs)hold great promise as novel microwave absorption materials owing to their interlayer interactions and unique magnetoelectric ***,overcoming the impedance mismatch at the low loading is still a challenge for TMCs due to the restricted loss pathways caused by their high-density ***,an interface engineering based on the heterostructure of 2D Cr_(5)Te_(8) and graphite is in situ constructed via a one-step chemical vapor deposit to modulate impedance matching and introduce multiple attenuation ***,the Cr_(5)Te_(8)@EG(ECT)heterostructure exhibits a minimum reflection loss of up to−57.6 dB at 15.4 GHz with a thin thickness of only 1.4 mm under a low filling rate of 10%.The density functional theory calculations confirm that the splendid performance of ECT heterostructure primarily derives from charge redistribution at the abundant intimate interfaces,thereby reinforcing interfacial polarization ***,the ECT coating displays a remarkable radar cross section reduction of 31.9 dB m^(2),demonstrating a great radar microwave scattering *** work sheds light on the interfacial coupled stimulus response mechanism of TMC-based heterogeneous structures and provides a feasible strategy to manipulate high-quality TMCs for excellent microwave absorbers.

关键词： Chemical vapor deposition Interface polarization engineering Cr_(5)Te_(8)-graphite heterojunctions Microwave absorption

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Enhancing the photo-luminescence stability of CH_(3)NH_(3)PbI_(3) film with ionic liquids

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Chinese Physics B 2022年第3期31卷 550-554页

作者： Weifeng Ma Chunjie Ding Nasrullah Wazir Xianshuang Wang Denan Kong An Li Bingsuo Zou ruibin liu Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBejing 100081China

The methylammonium lead triiodide(CH_(3)NH_(3)PbI_(3))-based perovskite shows a great alluring prospect in areas of solar cells, lasers, photodetectors, and light emitting diodes owing to their excellent optical and electrical advantages. However,it is very sensitive to the surrounding oxygen and moisture, which limits its development seriously. It is urgent to spare no effort to enhance its optical and electrical stability for further application. In this paper, we synthesize the MAPbI_(3) perovskite film on the glass substrate with/without the ionic liquid(IL) of 1-Butyl-3-methylimidazolium tetrafluoroborate(BMIMBF_(4)) by a simple two-step sequential solution method. The additive of BMIMBF_(4)can improve the quality of crystal structure. Moreover, the photo-luminescence(PL) intensity of MAPbI_(3) film with BMIMBF_(4) is much stronger than the pure MAPbI_(3) film after a week in the air, which is almost ten-fold of the pure one. Meanwhile, under the illumination of 405-nm continuous wave(CW) laser, the fluorescent duration of the MAPbI_(3) film with BMIMBF_(4) is approximately 2.75 min, while the pure MAPbI;film is only about 6 s. In fact, ionic liquid of BMIMBF_(4) in the perovskite film plays a role of passivation, which prevents the dissolution of MAPbI_(3) into CH_(3)NH_(3)and PbI_(2) and thus enhances the stability of environment. In addition, the ionic liquid of BMIMBF;possesses high ionic conductivity, which accelerates the electron transport, so it is beneficial for the perovskite film in the areas of solar cells, photodetectors, and lasers. This interesting experiment provides a promising way to develop the perovskite’s further application.

关键词： CH_(3)NH_(3)PbI_(3)perovskite film photo-luminescence BMIMBF_(4)ionic liquid

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Formation and Optical Properties of ZnO:ZnFe_(2)O_(4) Superlattice Microwires

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Nano Research 2010年第5期3卷 326-338页

作者： Yun Li Guozhang Dai Chunjiao Zhou Qinglin Zhang Qiang Wan Limin Fu Jianping Zhang ruibin liu Chuanbao Cao Anlian Pan Yunhong Zhang Bingsuo Zou State Key Laboratory of Chemo/biosensing and Chemometrics(CBSC) Hunan UniversityChangsha 410082China School of Materials Science and Engineering(MSE) Beijing Institute of TechnologyBeijing 100081China Chemistry Department Renmin University of ChinaBeijing 100872China

Pure ZnO hexagonal microwires and Fe(Ⅲ)-doped ZnO microwires(MWs)with a novel rectangular cross section were synthesized in a confined chamber by a convenient one-step thermal evaporation *** oriented attachment mechanism is consistent with a vapor-solid growth ***(PL)and Raman spectroscopy of the Fe(Ⅲ)-doped ZnO MWs and in situ spectral mappings indicate a quasi-periodic distribution of Fe(Ⅲ)along a one-dimensional(1-D)superlattice ZnO:ZnFe_(2)O_(4) wire,while PL mapping shows the presence of optical multicavities and related *** PL spectra at room temperature show weak near-edge doublets(376 nm and 383 nm)and a broad band(450-650 nm)composed of strong discrete lines,due to a 1-D photonic crystal *** a 1-D coupled optical cavity material may find many applications in future photonic and spintronic devices.

关键词： ZnO superlattice microwire micro-photoluminescence micro-Raman spectroscopy

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Why is the Omicron main protease of SARS-CoV-2 less stable than its wild-type counterpart?A crystallographic,biophysical,and theoretical study

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hLife 2024年第8期2卷 419-433页

作者： Mohamed Ibrahim Xinyuanyuan Sun Vinicius Martins de Oliveira ruibin liu Joseph Clayton Haifa El Kilani Jana Shen Rolf Hilgenfeld Institute of Molecular Medicine University of Lübeck23562 LübeckGermany Department of Pharmaceutical Sciences University of Maryland School of PharmacyBaltimoreMD 21201USA Division of Applied Regulatory Science Office of Clinical PharmacologyOffice of Translational SciencesCenter for Drug Evaluation and ResearchUnited States Food and Drug AdministrationSilver SpringMD 20993USA German Center for Infection Research(DZIF) Hamburg-Lübeck-Borstel-Riems SiteUniversity of Lübeck23562 LübeckGermany

During the continuing evolution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the Omicron variant of concern emerged in the second half of 2021 and has been dominant since November of that *** with its sublineages,it has maintained a prominent role ever *** Nsp5 main protease(Mpro)of the Omicron virus is characterized by a single dominant mutation,*** we determined the X-ray crystal structures of the P132H mutant(or O-Mpro)as a free enzyme and in complex with the Mpro inhibitor,the alpha-ketoamide 13b-K,and we conducted enzymological,biophysical,as well as theoretical studies to characterize the *** found that O-Mpro has a similar overall structure and binding with 13b-K;however,it displays lower enzymatic activity and lower thermal stability compared to the WT-Mpro(with“WT”referring to the prototype strain).Intriguingly,the imidazole ring of His132 and the carboxylate plane of Glu240 are in a stacked configuration in the X-ray structures determined *** folding free energy calculations suggest that the O-Mpro dimer is destabilized relative to the WT-Mpro due to less favorable van der Waals interactions and backbone conformations in the individual ***-atom continuous constant-pH molecular dynamics(MD)simulations reveal that His132 and Glu240 display coupled *** pH 7,His132 is predominantly neutral and in a stacked configuration with respect to Glu240 which is *** order to examine whether the Omicron mutation eases the emergence of further Mpro mutations,we also analyzed the P132H+T169S double mutant,which is characteristic of the BA.1.1.2 ***,we found little evidence of a correlation between the two mutation sites.

关键词： severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) main protease Omicron molecular dynamics Pro>His mutant double mutant

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Highly luminescent and stable lead-free cesium copper halide perovskite powders for UV-pumped phosphor-converted light-emitting diodes

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Photonics Research 2020年第6期8卷 768-775页

作者： LINGLING XIE BINGKUN CHEN FA ZHANG ZHENG ZHAO XINXIN WANG LIJIE SHI YUE liu LINGLING HUANG ruibin liu BINGSUO ZOU YONGTIAN WANG Beijing Key Laboratory of Nanophotonics and Ultrafine Optoelectronic Systems School of PhysicsBejing Institute of TechnologyBeijing 100081China Bejjing Engineering Research Center of Mixed Reality and Advanced Display School of Optics and PhotonicsBejjing Institute of Technology Bejjing 100081China AICFVE of Bejing Film AcademyBejing 100088China

Lead halide perovskites have drawn extensive attention over recent decades owing to their outstanding photo-electric ***,their toxicity and instability are big issues that need to be solved for further ***,we adopt a facile dry ball milling method to synthesize lead-free Cs3Cu2X5(X=I,CI)perovskites with photoluminescence(PL)quantum yield up to 60%.The optical features including broad emission spectrum,large Stokes shift,and long PL lifetime can be attributed to self-trapped exciton *** as-synthesized blue emissive Cs3Cu2I5 and green emissive Cs3Cu2Cl5 lead-free perovskite powders have good thermal stability and ***,UV-pumped phosphor-converted light-emitting diodes were obtained by using Cs3Cu2I5 and Cs3Cu2Cl5 as phosphors.

关键词： stability. perovskite converted

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Low-threshold and narrow-emission random lasing in a self-assembly TiN nanoparticle-doped carbon quantum dot/DCM nanowire composite

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Photonics Research 2022年第9期10卷 2239-2246页

作者： JING LYU XINYU ZHANG LEI CAI LI TAO WEIFENG MA AN LI YE TIAN YUNSONG YIN DENAN KONG WEN YI XIANSHUANG WANG ruibin liu Beijing Key Laboratory of Nano-photonics and Ultrafine Optoelectronic Systems School of PhysicsBeijing Institute of TechnologyBeijing 100081China Yangtze Delta Region Academy of Beijing Institute of Technology Jiaxing 314000China Jiangsu Key Laboratory for Carbon-Based Functional Materials&Devices Institute of Functional Nano&Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China

The random lasing in quantum dot systems is in anticipation for widespread applications in biomedical therapy and image recognition,especially in random laser devices with high brightness and high ***,low-threshold,narrowband emission,and stable random lasing is realized in carbon quantum dot(CQD)/DCM nanowire composite-doped TiN nanoparticles,which are fabricated by the mixture of carbon quantum dots and self-assembly DCM dye *** F?rster resonance energy transfer process results in a high luminescence efficiency for the composite of carbon dots and DCM nanowires,allowing significant random lasing actions to emerge in CQD/DCM composite as TiN particles are doped that greatly enhance the emission efficiency through the plasmon resonance and random ***,sharp and low-threshold random lasing is finally realized and even strong single-mode lasing occurs under higher pumping energy in the TiN-doped CQD/DCM *** work provides a promising way in high monochromaticity random laser applications.

关键词： pumping lasing random

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基于多维贫困测度的湖北省精准扶贫成效评价

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统计与决策 2020年第4期36卷 44-48页

作者：石丹刘睿彬武汉理工大学经济学院武汉430070

扶贫成效的精准评价是开展扶贫后续工作的重要保障。在精准扶贫的背景下,文章以湖北省及各大连片特困地区的建档立卡贫困户为研究对象,设计了多维贫困指标体系,利用A-F模型,对多维贫困状况进行测度和分解,进而分析和评价精准扶贫的工作... 详细信息

扶贫成效的精准评价是开展扶贫后续工作的重要保障。在精准扶贫的背景下,文章以湖北省及各大连片特困地区的建档立卡贫困户为研究对象,设计了多维贫困指标体系,利用A-F模型,对多维贫困状况进行测度和分解,进而分析和评价精准扶贫的工作成效。研究表明,湖北省精准扶贫工作总体上取得一定成果,特别是在提高住房环境方面成效显著,但在增加收入、加强教育、保障养老、促进产业升级、培养健康生活方式等方面有待进一步改善。各大连片特困地区的扶贫成效则普遍低于全省平均水平。

关键词：精准扶贫成效评价多维贫困测度

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