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RBM46 is essential for gametogenesis and functions in post-transcriptional roles affecting meiotic cohesin subunits

Protein & Cell 2023年第1期14卷 51-63页

作者： Yue Lv Gang Lu Yuling Cai ruibao su Liang Liang Xin Wang Wenyu Mu Xiuqing He Tao Huang Jinlong Ma Yueran Zhao Zi-Jiang Chen Yuanchao Xue Hongbin Liu Wai-Yee Chan Shandong Key Laboratory of Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250012China Center for Reproductive Medicine Shandong UniversityJinan 250012China CUHK-SDU Joint Laboratory on Reproductive Genetics School of Biomedical SciencesFaculty of MedicineThe Chinese University of Hong KongHong KongChina Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinan 250012China Key Laboratory of RNA Biology Institute of BiophysicsChinese Academy of SciencesBeijing 100101China Fertility Preservation Lab Reproductive Medicine CenterGuangdong Second Provincial General HospitalGuangzhou 510062China Key Laboratory of Systems Health Science of Zhejiang Province School of Life ScienceHangzhou Institute for Advanced StudyUniversity of Chinese Academy of SciencesHangzhou 310024China Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics Shanghai 200135China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200135China

RBM46 is a germ cell-specific RNA-binding protein required for gametogenesis,but the targets and molecular functions of RBM46 remain ***,we demonstrate that RBM46 binds at specific motifs in the 3'UTRs of mRNAs encoding multiple meiotic cohesin subunits and show that RBM46 is required for normal synaptonemal complex formation during meiosis *** a recently reported,high-resolution technique known as LACE-seq and working with low-input cells,we profiled the targets of RBM46 at single-nucleotide resolution in leptotene and zygotene stage *** found that RBM46 preferentially binds target mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs *** Rbm46 knockout mice,the RBM46-target cohesin subunits displayed unaltered mRNA levels but had reduced translation,resulting in the failed assembly of axial elements,synapsis disruption,and meiotic *** study thus provides mechanistic insights into the molecular functions of RBM46 in gametogenesis and illustrates the power of LACE-seq for investigations of RNA-binding protein functions when working with low-abundance input materials.

关键词： RBM46 LACE-seq RNA-binding protein meiosis cohesin

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The role of RAS effectors in BCR/ABL induced chronic myelogenous leukemia

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Frontiers of Medicine 2013年第4期7卷 452-461页

作者： Jessica Fredericks ruibao Ren State Key Laboratory for Medical Genomics Shanghai Institute of HematologyRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Rosenstiel Basic Medical Sciences Research Center and Department of Biology Brandeis UniversityWalthamMA 02454USA EMD Millipore Corporation 17 Cherry Hill DriveDanversMA 01923USA

BCR/ABL is the causative agent of chronic myelogenous leukemia(CML).Through structure/function analysis,several protein motifs have been determined to be important for the development of ***177 of BCR is a Grb2 binding site required for BCR/ABL-induced CML in *** the current study,we use a mouse bone marrow transduction/transplantation system to demonstrate that addition of oncogenic NRAS(NRASG12D)to a vector containing a BCR/ABL^(Y177F)mutant“rescues”the CML phenotype rapidly and *** further narrow down the pathways downstream of RAS that are responsible for this rescue effect,we utilize well-characterized RAS effector loop mutants and determine that the RAL pathway is important for rapid induction of *** of this pathway by a dominant negative RAL is capable of delaying disease *** from the present study support the notion of RAL inhibition as a potential therapy for BCR/ABL-induced CML.

关键词： BCR/ABL chronic myelogenous leukemia(CML) RAS RAL

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Dynamic Critical Behavior of Sierpinski Gasket Type Fractal

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Chinese Physics Letters 1991年第8期8卷 396-399页

作者： WANG Xiaomin TAO ruibao Department of Physics Fudan UniversityShanghai 200433 Center of Theoretical Physics(CCAST World Laboratory) Beijing 100080

We have applied the exact real space renormalisation group method to analyse the critical dynamics of Heisenberg spin system at the percolation threshold embedded in the two dimensional Sierpinski Gasket type *** analysis yields the dynamic critical exponent Z and the scaling behaviors of response function and characteristic *** aha show that the scaling exponent relation is accurately satisfied by the values of the Z and two other exponents.

关键词： exponent Sierpinski scaling

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Elastic Constants and Phonon Dispersion Curves of Tetragonal La_(2)CuO_(4) Single Crystal

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Chinese Physics Letters 1991年第4期8卷 195-198页

作者： MU Yaoming TAO ruibao Department of Physics Fudan UniversityShanghai 200433 Center of Theoretical Physics(CCAST World Laboratory) Beijing 100080

The elastic constants and phonon dispersion curves of tetragonal La_(2)CuO_(4) single crystal are calculated with rigid-ion *** obtain rather good agreement between the computed and measured elastic *** calculated phonon dispersion curves exhibit a rather conventional behavior except the anomaly of aΣ_(4),symmetry TO mode atΓ-X direction.

关键词： phonon dispersion Dispersion

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Phase Transitions of Ultradiffusion Model on Vicsek Snowflakes Fractal

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Chinese Physics Letters 1991年第9期8卷 476-479页

作者： WANG Xiaomin TAO ruibao Department of Physics Fudan UniversityShanghai 200433 Center of Theoretical Physics(CCAST World Laboratory) Beijing

Through an exact real space renormaligation group approach,we analysed the ultradiffusion with a hierarchical pattern of hopping rates defined on Vicsek snowflackes *** transition from anomalous to normal diffusion is shown to occur in the arbitrary n-dimension(n-D)*** the presence of external field,we find another unusual transition which is essentially different from the one for biased ultradiffusion of 1-D multifurcating hierarchical system.

关键词： diffusion Transition transition

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Simultaneous analysis of five taste and odor compounds in surface water using solid-phase extraction and gas chromatography-mass spectrometry

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Frontiers of Environmental Science & Engineering 2012年第1期6卷 66-74页

作者： Wenfeng suN ruibao JIA Baoyu GAO Shandong Key Laboratory of Water Pollution Control and Resource Reuse School of Environmental Science and EngineeringShandong UniversityJinan 250100China Jinan Water and Wastewater Monitoring Center Jinan 250033China

In this paper, a method using solid-phase extraction （SPE） and gas chromatography-mass spectro- metry （GC-MS） was developed to simultaneously analyze five taste and odor compounds in surface water, i.e., 2- methylisoborneol （2-MIB）, 2,4,6-trichloroanisole （TCA）, 2-isopropyl-3-methoxy pyrazine （IPMP）, 2-isobutyl-3- methoxy pyrazine （IBMP）, and trans-l,lO-dimethyl- trans-9-decalol （geosmin, GSM）. The mass spectrometry was operated in selective ion monitoring （SIM） mode. Three kinds of SPE columns and three eluting solvents were compared, the C 18 column was chosen as optimum SPE column, and methanol was chosen as the optimum eluting solvent. It was found that the method showed good linearity in the range of 1-200 ng.L^-1 and gave detection limits of 0.5 1.5 ng.L^-1 for individual compounds. Good recoveries （93.5%-108%） and relative standard deviations （1.58%-7.31%） were also obtained. Additionally, concentrations of these taste and odor compounds in Jinan＇s surface and drinking water were analyzed by applying this method, and the results showed that GSM and 2-MIB were the dominant taste and odor compounds in Jinan＇s raw water.

关键词： solid-phase extraction (SPE) gas chromato- graphy-mass spectrometry (GC-MS) taste and odor compounds surface water micropollutant

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秀丽隐杆线虫RNA结合蛋白复合物AMG-1/SLRP-1通过线粒体稳态维持实现调控生殖腺发育和精子发生

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Science Bulletin 2023年第13期68卷 1399-1412,M0004页

作者：王鹏王秋实陈联万曹铮赵海莲苏瑞宝王宁马肖静单进陈新艳张琦杜宝臣袁志恒赵艳梅张晓荣郭雪江薛愿超苗龙 Key Laboratory of RNA Biology CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100059China National Institute of Biological Sciences Beijing 102206China Department of Automation Tsinghua UniversityBeijing 100084China State Key Laboratory of Reproductive Medicine and Offspring Health Department of Histology and EmbryologyNanjing Medical UniversityNanjing 211166China Center for Biological Imaging Core Facilities for Protein ScienceInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China Key Laboratory of Cell Proliferation and Regulation Biology of Ministry of Education College of Life ScienceBeijing Normal UniversityBeijing 100875China

RNA结合蛋白(mtRBP)介导的mRNA转录后调节对精子发生必不可少但却鲜有报道.在本文中,我们鉴定到一个在生殖腺中特异性表达的线粒体RNA结合蛋白AMG-1,它是秀丽隐杆线虫精子发生过程中必需的蛋白,同时与哺乳动物LRPPRC蛋白同源.amg-1突变... 详细信息

RNA结合蛋白(mtRBP)介导的mRNA转录后调节对精子发生必不可少但却鲜有报道.在本文中,我们鉴定到一个在生殖腺中特异性表达的线粒体RNA结合蛋白AMG-1,它是秀丽隐杆线虫精子发生过程中必需的蛋白,同时与哺乳动物LRPPRC蛋白同源.amg-1突变会阻碍生殖腺的发育,最终导致生殖细胞的线粒体形态和结构异常以及线粒体功能障碍.通过测序鉴定RNA结合蛋白的靶点发现,AMG-1更倾向于与mtDNA编码的参与线粒体核糖体组装的12S和16S核糖体RNA(rRNA)结合,12S rRNA对于维持生殖细胞线粒体蛋白稳态至关重要,而12S rRNA的表达却受AMG-1蛋白调节.此外,哺乳动物SLIRP在秀丽线虫中的同源蛋白SLRP-1蛋白与AMG-1在遗传上存在互作关系,它们可共同调节秀丽线虫的精子发生和育性.综上所述,这些发现揭示了mtRBP蛋白AMG-1在线粒体调控中的新机制,这可能为由线粒体功能障碍引发的男性不育治疗提供新的理论基础.

关键词： Spermatogenesis RNA-binding protein mt-rRNA Mitochondria Caenorhabditis elegans

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Comparison of UV-based advanced oxidation processes for the removal of different fractions of NOM from drinking water

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Journal of Environmental Sciences 2023年第4期126卷 387-395页

作者： Zhenxing Yao Mingquan Wang ruibao Jia Qinghua Zhao Li Liu Shaohua sun Shandong Province City Water supply and Drainage Water Quality Monitoring Center Jinan 250101China

This study examined the effectiveness for degradation of hydrophobic (HPO),transphilic(TPI) and hydrophilic (HPI) fractions of natural organic matter (NOM) during UV/H_(2)O_(2),UV/TiO_(2)and UV/K2S2O8(UV/PS) advanced oxidation processes (AOPs).The changing characteristics of NOM were evaluated by dissolved organic carbon (DOC),the specific UV absorbance (suVA),trihalomethanes formation potential (THMFP),organic halogen adsorbable on activated carbon formation potential (AOXFP) and parallel factor analysis of excitation–emission matrices (PARAFAC-EEMs).In the three UV-based AOPs,HPI fraction with low molecular weight and aromaticity was more likely to degradate than HPO and TPI,and the removal efficiency of suVA for HPO was much higher than TPI and HPI *** terms of the specific THMFP of HPO,TPI and HPI,a reduction was achieved in the UV/H_(2)O_(2)process,and the higest removal rate even reached to 83%.UV/TiO_(2)and UV/PS processes can only decrease the specific THMFP of *** specific AOXFP of HPO,TPI and HPI fractions were all able to be degraded by the three UV-based AOPs,and HPO content is more susceptible to decompose than TPI and HPI ***/H_(2)O_(2)was found to be the most effective treatment for the removal of THMFP and AOXFP under given conditions.C1 (microbial or marine derived humic-like substances),C_(2) (terrestrially derived humic-like substances)and C_(3) (tryptophan-like proteins) fluorescent components of HPO fraction were fairly labile across the UV-based AOPs treatment.C_(3) of each fraction of NOM was the most resistant to degrade upon the UV-based *** from this study may provide the prediction about the consequence of UV-based AOPs for the degradation of different fractions of NOM with varied characteristics.

关键词： Advanced oxidation processes Natural organic matter Trihalomethanes Organic halogen adsorbable on activated carbon Parallel factor analysis

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TRAILS ON A REGULAR DIFFUSION-LIMITED AGGREGATION FRACTAL

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Chinese Physics Letters 1990年第5期7卷 193-196页

作者： WANG Xiaomin ZHENG Dafang LIN Zhifang TAO ruibao Department of Physics Fudan UniversityShanghai 200433 Center of Theoretical Physics CCAST(World Laboratory)And Department of Physics Fudan UniversityShanghai 200433

By an exact renormalization method the trail problem on a regular fractal for the diffusion-limited aggregation is considered,and the mean square end-toend distance critical exponent v is *** is indicated that self-avoiding trails and self-avoiding walks are in different universality classes on this irreversible kinetic growth fractal.

关键词： REG irreversible trail

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Accretion Processes of Oceanic Crust in Slow-spreading Ridges:Plagiogranite Perspective of the Xigaze Ophiolite,South Tibet

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Acta Geologica Sinica(English Edition) 2022年第6期96卷 1945-1959页

作者： LI Yuan LI ruibao YANG Shengbiao ZHANG Jian YANG Jingsui Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China School of Earth Sciences and Resources Chang’an UniversityXi’an 710054China Tianjin Institute of Geology and Mineral Resources Tianjing 300170China School of Earth Sciences and Engineering Nanjing UniversityNanjing 210023China

Structural and petrological data suggest that the Xigaze ophiolite from the Yarlung Zangbo suture Zone(YZSZ)in south Tibet was a typical slow-spreading ridge.A new field,geochemical,mineral,and U-Pb zircon dataset of plagiogranite intrusions were used to constrain the dynamic processes of oceanic accretion in this slow-spreading *** mainly occur as dykes or intrusions intruded into the whole sequence of the ophiolite and have a similar orientation to the dolerite dykes developed in the late stage of detachment faulting.U-Pb zircon ages of 122–123 Ma were obtained for two types of plagiogranites and associated dolerite *** geochemical and mineralogical examinations suggest that the plagiogranites are the product of low-pressure(2–3 kbar)fractional crystallization of midocean ridge basalt-like magma and unlikely to have been derived from the partial melting of hydrous gabbroic *** complex cross-cut relationship between the plagiogranites and ophiolite sequence reflects that they are controlled by small discontinued melt lenses rather than a big magma chamber under the ridge axis and reveals multiple injections during the oceanic crust *** formation of plagiogranites possibly reflects the complex characteristic of oceanic accretion at slow-spreading ridges,time-dependent on structural(external)and magmatic(internal)processes.

关键词： Xigaze ophiolite plagiogranite fractional crystallization multiple magma injection ocean-continent transition zone

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