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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie Jian Yu Kun-Ning Zhang Zhou-Bo guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

A dopant-assisted iodide-adduct chemical ionization time-of-flight mass spectrometer based on VUV lamp photoionization for atmospheric low-molecular-weight organic acids analysis

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Journal of Environmental Sciences 2025年第3期149卷 500-511页

作者： Yonglei Zhang ruidong Liu Mei Li yingzhe guo Jichuang Kong Keyong Hou Environment Research Institute Shandong UniversityQingdao 266237China

Formic and acetic acids are the most abundant gaseous organic acids and play the key role in the atmospheric *** iodine-adduct chemical ionizationmass spectrometry(CIMS),the low utilization efficiency of methyl iodide and humidity interference are two major issues of the vacuum ultraviolet(VUV)lamp initiated CIMS for on-line gaseous formic and acetic acids *** this work,we present a new CIMS based on VUV lamp,and the ion-molecular reactor is separated into photoionization and chemical ionization zones by a reducer *** was added to the photoionization zone,and the VUV photoionization acetone provided low-energy electrons for methyl iodide to generate I−,and the addition of acetone reduced the amount of methyl iodide by 2/*** the chemical ionization zone,a headspace vial containing ultrapure water was added for humidity calibration,and the vial changes the sensitivity as a function of humidity from ambiguity to well linear correlation(R2>0.95).With humidity calibration,the CIMS can quantitatively measure formic and acetic acids in the humidity range of 0%-88%*** this mode,limits of detection of 10 and 50 pptv are obtained for formic and acetic acids,*** the relative standard deviation(RSD)of quantitation stability for 6 days were less than 10.5%.This CIMS was successfully used to determine the formic and acetic acids in the underground parking and ambient environment of the Shandong University campus(Qingdao,China).In addition,we developed a simple model based formic acid concentration to assess vehicular emissions.

关键词： Formic acid Acetic acid Vacuum ultraviolet(VUV)lamp photoionization(PI) Chemical ionization(CI) Time-of-flight mass spectrometry (TOFMS) Trace gases measurement

Metrological traceable calibration of organic carbon and elemental carbon based on laboratory-generated reference materials

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Journal of Environmental Sciences 2025年第3期149卷 524-534页

作者： Yue Liu Junjie Liu Ji Xiao Jing Ye Lixu guo Caiqing Yan Center for Environmental Metrology National Institute of Metrology ChinaBeijing 100029China College of Chemistry and Chemical Engineering Taiyuan University of TechnologyTaiyuan 030024China Environment Research Institute Shandong UniversityQingdao 266237China

Carbonaceous aerosol,including organic carbon(OC)and elemental carbon(EC),has significant influence on human health,air quality and climate *** measurement of carbonaceous aerosol is essential to reduce the uncertainty of radiative forcing estimation and source *** accurate separation of OC and EC is controversial due to the charring of ***,the development of reference materials(RM)for the validation of OC/EC separation is an important basis for further *** RMs were mainly based on ambient air sampling,which could not provide traceability of OC and EC *** develop traceable RMs with known OC/EC contents,our study applied an improved aerosol generation and mixing technique,providing uniform deposition of particles on quartz *** generate OC aerosol with similar pyrolytic property of ambient aerosol,both water soluble organic carbon(WSOC)and water insoluble organic carbon(WIOC)were used,and amorphous carbon was selected for EC *** RMs were analyzed using different *** homogeneity within the filter was validated,reaching below 2%.The long-term stability of RMs has been validated with RSD ranged from 1.7%–3.2%.Good correlationwas observed between nominal concentration of RMswithmeasured concentration by two protocols,while the difference of EC concentration was within 20%.The results indicated that the newly developed RMs were acceptable for the calibration of OC and EC,which could improve the accuracy of carbonaceous aerosol ***,the laboratory-generated EC-RMs could be suitable for the calibration of equivalent BC concentration by Aethalometers.

关键词： Carbonaceous aerosol Split point Reference material Laboratory-generated Traceability

Study on the off situ reconstruction of the core neutron field based on dual-task hybrid network architecture

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Nuclear Science and Techniques 2025年第1期36卷 175-191页

作者： Pei Cao Hui Ding Cheng-Long Cao Zi-Hui Yang guo-Min Sun School of Artificial Intelligence and Big Data Hefei UniversityHefei 230001China College of Electronic Engineering National University of Defense TechnologyHefei 230001China Institute of Nuclear Energy Safety Technology HFIPSChinese Academy of SciencesHefei 230027China

The off situ accurate reconstruction of the core neutron field is an important step in realizing real-time reactor *** existing off situ reconstruction method of the neutron field is only applicable to cases wherein a single region changes at a specified location of the ***,when the neutron field changes are complex,the accurate identification of the individual changed regions becomes challenging,which seriously affects the accuracy and stability of the neutron field ***,this study proposed a dual-task hybrid network architecture(DTHNet)for off situ reconstruction of the core neutron field,which trained the outermost assembly reconstruction task and the core reconstruction task jointly such that the former could assist the latter in the reconstruction of the core neutron field under core complex ***,to exploit the characteristics of the ex-core detection signals,this study designed a global-local feature upsampling module that efficiently distributed the ex-core detection signals to each reconstruction unit to improve the accuracy and stability of *** experiments were performed on the simulation datasets of the CLEAR-I reactor to verify the accuracy and stability of the proposed *** results showed that when the location uncertainty of a single region did not exceed nine and the number of multiple changed regions did not exceed ***,the reconstructed ARD was within 2%,RD_(max)was maintained within 17.5%,and the number of RD≥10%was maintained within ***,when the noise interference of the ex-core detection signals was within±2%,although the average number of RD≥10%increased to 16,the average ARD was still within in 2%,and the average RD_(max)was within 22%.Collectively,these results show that,theoretically,the DTHNet can accurately and stably reconstruct most of the neutron field under certain complex core changes.

关键词： Real-time reactor monitoring Core neutron field reconstruction Dual-task hybrid network architecture Global-local feature upsampling module

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住房财富变动与城镇家庭商业保险参与

湘潭大学学报(哲学社会科学版) 2025年第1期49卷 57-63页

作者：任国英李锐山西财经大学经济学院山西太原030006 北京师范大学经济与工商管理学院北京100875

商业保险在提高居民家庭生活保障水平方面的作用日益显著。对2011—2019年五轮中国家庭金融调查(CHFS)数据进行了实证研究,结果表明:城镇家庭住房财富增加显著提升了商业保险参与水平。该结论在一系列稳健性检验后依然成立,设定虚拟断... 详细信息

商业保险在提高居民家庭生活保障水平方面的作用日益显著。对2011—2019年五轮中国家庭金融调查(CHFS)数据进行了实证研究,结果表明:城镇家庭住房财富增加显著提升了商业保险参与水平。该结论在一系列稳健性检验后依然成立,设定虚拟断点进行安慰剂检验之后,住房财富变动对家庭商业保险参与的影响不再显著。异质性分析表明,住房财富增加对家庭商业保险参与率的影响对受访者为女性、教育水平为高中及以上和年龄在65岁以上的家庭更大。机制分析表明,家庭财富增加通过影响家庭风险偏好水平、收入波动和流动性约束来影响家庭商业保险参与率。

关键词：住房财富商业保险参与准自然实验断点回归

Genome-wide association study reveals that enolase gene OsEE1 regulates coleoptile elongation in rice under anaerobic conditions

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Crop Journal 2025年第1期13卷 215-226页

作者： Li, Dandan Liu, Kai Su, Ling Li, Jinrui guo, Yuanyuan guo, Tao Liu, Hong Rao, Dehua College of Agriculture South China Agricultural University Guangdong Guangzhou 510642 China Jiangxi Academy of Eco-Environmental Sciences and Planning/Jiangxi Key Laboratory of Environmental Pollution Control Jiangxi Nanchang 330039 China

Submergence can induce anaerobic stress on germinating seedlings in direct seeded rice paddy fields, limiting the practice of direct seeding. Longer coleoptiles improves the anaerobic tolerance of rice seedlings under submerged conditions. In a search for genes that could be beneficial for developing submergence-tolerant varieties 148 non-repetitive SNP loci were detected in on a genome-wide association study (GWAS) of coleoptile length (CL), coleoptile surface area (CSA), coleoptile volume (CV), and coleoptile diameter (CD) of 591 rice accessions subjected to 4 d of anaerobic conditions. Integration of GWAS results and gene expression data identified OsEE1, an early embryogenesis-specific enolase 1 gene associated with coleoptile length (CL) in rice grown in anaerobic conditions. Disruption of OsEE1 caused reduced CL in plants seeded under anaerobic conditions, whereas CL of OE-OsEE1 overexpression lines was significantly increased compared with the wild type. Functional analysis revealed that OsEE1 affects coleoptile length by modulating the glycolysis and tricarboxylic acid cycle pathways. Transcriptome sequencing of ko-osee1-1 knock out mutants highlighted enrichment in energy and carbohydrate metabolism, glycolysis, amino acid metabolism, and hormone signal transduction. Metabolite analysis indicated decreased levels of key metabolites in the tricarboxylic acid cycle and glycolysis pathways in ko-osee1-1 mutants compared to the wild type under anaerobic conditions. Overall, these findings shed light on the role of OsEE1 in determination coleoptile length of rice seedlings under anaerobic conditions. © 2024 Crop Science Society of China and Institute of Crop Science, CAAS

关键词： Coleoptile length Early embryogenesis-specific enolase 1 GWAS OsEE1 Rice

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习近平文化思想的意识形态意蕴

马克思主义哲学 2025年第1期 38-45页

作者：郭瑞济宁学院

意识形态关乎旗帜、关乎道路、关乎国家政治安全。习近平文化思想坚持意识形态是党的一项极端重要的工作,意识形态决定文化前进方向和发展道路;坚持马克思主义在意识形态领域的指导地位,高度重视文化的意识形态功能;坚持建设具有强大凝... 详细信息

意识形态关乎旗帜、关乎道路、关乎国家政治安全。习近平文化思想坚持意识形态是党的一项极端重要的工作,意识形态决定文化前进方向和发展道路;坚持马克思主义在意识形态领域的指导地位,高度重视文化的意识形态功能;坚持建设具有强大凝聚力和引领力的社会主义意识形态是文化建设的重要内容;坚持中国特色社会主义文化自信,维护意识形态安全。习近平文化思想高屋建瓴、内容博大精深、理论内涵丰富,具有严密的逻辑与丰富的理论内涵。从意识形态视角深刻认识与领悟这一思想的要旨,对正确理解并贯彻习近平文化思想具有重要意义。

关键词：习近平文化思想意识形态马克思主义

Artificial intelligence advances drug delivery system and its clinical transition

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Science Bulletin 2025年第3期70卷 305-308页

作者： Hui Wang Xiao-Yan You guo-Ping Zhao Master Lab for Innovative Application of Nature Products National Center of Technology Innovation for Synthetic BiologyTianjin Institute of Industrial BiotechnologyChinese Academy of Sciences(CAS)Tianjin 300308China Henan Engineering Research Center of Food Microbiology College of Food and BioengineeringHenan University of Science and TechnologyLuoyang 471023China Haihe Laboratory of Synthetic Biology Tianjin 300308China CAS-Key Laboratory of Synthetic Biology CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China CAS Key Laboratory of Quantitative Engineering Biology Shenzhen Institute of Synthetic BiologyShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China

Since November 2022,ChatGPT,an artificial intelligence(AI)chatbot,has rapidly captured global attention for its detailed responses and articulated answers across a broad spectrum of knowledge domains[1],[2].All industries will reorient around it,prompting a reevaluation of how this technology could further promote scientifical research and its clinical applications.

关键词： system transition spectrum

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浸没式喷水推进系统水动力特性分析

船舶力学 2025年第1期29卷 53-62页

作者：张恒汲国瑞邱继涛蔡佑林中国船舶及海洋工程设计研究院上海201100 喷水推进技术重点实验室上海200011

浸没式喷水推进是常规艉板式喷水推进的一种衍变型式,其流道与船体高度耦合,船泵耦合流场更复杂。针对浸没式喷水推进技术发展需求,首次构建浸没式喷水推进控制体与力学模型,并开展其与常规艉板式的差别分析。然后针对同一型船、同一型... 详细信息

浸没式喷水推进是常规艉板式喷水推进的一种衍变型式,其流道与船体高度耦合,船泵耦合流场更复杂。针对浸没式喷水推进技术发展需求,首次构建浸没式喷水推进控制体与力学模型,并开展其与常规艉板式的差别分析。然后针对同一型船、同一型推进泵,在设计航速点开展两种推进形式的船泵一体化多自由度运动数值计算分析。对比结果表明:浸没式喷水推进获流区面积更大,流道效率更高,对船体姿态影响小,浸没式喷水推进推力减额分数较大且为正值。

关键词：浸没式喷水推进推力减额进口流道 CFD