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Cutaneous metastasis from esophageal squamous cell carcinoma:A case report

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World Journal of Clinical Cases 2022年第14期10卷 4676-4683页

作者： rui-yan zhang Shi-Jie Zhu Peng Xue Sheng-Qi He Department of Oncology Wangjing HospitalChina Academy of Chinese Medicine SciencesBeijing 100102China

BACKGROUND Esophageal cancer is a common cause of cancer-related death *** metastasis of esophageal squamous cell carcinoma is rare,particularly in diffuse skin *** SUMMARY In this case report,we describe an 82-year-old male who was diagnosed with esophageal squamous cell *** tumor was staged as T4N3M1(Stage IVB).The pathological findings revealed poorly differentiated squamous cell carcinoma of the *** months after diagnosis,the patient began chemotherapy,and symptoms were relieved after four cycles of *** that,the patient returned home without a systematic physical *** year after diagnosis,the patient realized that the skin of the abdominal wall was hard and rough without pain,and the color became darker than normal *** months after diagnosis,a biopsy of the patient’s abdominal lesion revealed that the skin metastasis was derived from the *** the patient received two cycles of apatinib combined with docetaxel,but the abdominal lesion *** cycles of nivolumab were administered,but the patient eventually died of multiple organ *** This report highlights cutaneous metastasis as a late and untreatable metastasis of esophageal cancer.

关键词： Esophageal carcinoma Squamous cell carcinoma Cutaneous metastasis Immunological checkpoint inhibitor Chemotherapy Case report

Hierarchical Crystalline Structures Induced by Temperature Profile in HDPE Bars during Melt Penetration Process

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Chinese Journal of Polymer Science 2017年第1期35卷 108-122页

作者： chun-xia zhu rui-yan zhang yan-hao huang wei yang zheng-ying liu jian-ming feng 杨鸣波 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials Engineering Sichuan University Chengdu 610065 China

The hierarchical crystalline morphologies and orientation structures across the thickness direction in high-density polyethylene （HDPE） molded bars were investigated via a novel melt-penetrating processing method named multi-melt multi-injection molding （M3IM）. The samples with various mold temperatures （20, 40 and 60 ℃） were prepared, and the effects of the external temperature profile on the evolution of crystalline microstructures were studied. With scanning electron microscopy （SEM）, the transition of crystalline morphology from ring-banded structure to oriented lamellae was observed with decreasing mold temperature, and the oriented lamellae were formed at the sub-skin layer of the samples at the lowest mold temperature, which was further testified by differential scanning calorimetry （DSC）. With the decline of mold temperature, the degree of orientation, obtained from two-dimensional small angle X-ray scattering （2D-SAXS）, was increased and long periods rose a little. Thus, decreasing mold temperature was beneficial to the formation of orientation structures because the relaxation of chains was weakened.

关键词： Hierarchical structures Orientation Multi-melt multi-injection molding Mold temperature

Predictive value of SYNTAX score II for clinical outcomes in octogenarian undergoing percutaneous coronary intervention

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Journal of Geriatric Cardiology 2016年第9期13卷 733-739页

作者： Evan Kurniawan Feng-Hua DING Qi zhang Zhen-Kun yanG Jian HU Wei-Feng SHEN rui-yan zhang Department of Cardiology Rui Jin Hospital School of Medicine Shanghai Jiao Tong University Shanghai China

Objective To evaluate the predictive value of SYNTAX Score II （SS-II） for percutaneous coronary intervention （PCI） in octogenarian （≥ 80 years old） undergoing PCI. Methods ＆ Results Data from three consecutive years of octogenarian undergoing PCI from ruijin Hospital （Shanghai, China） was retrospectively collected （n = 308）. Follow up clinical data at one year including all cause mortality, cardiac mortality and main adverse cardiovascular and cerebrovascular events （MACCE） were collected. Patients were stratified according to tertiles of SS-II for PCI： SS-II 〈 26 （n = 104）, SS-II： 27-31 （n = 102）, SS-II 〉 31 （n = 102）. After adjustment for confounding factors, SS-II for PCI was an independent risk factors for all cause mortality （odds ratio： 2.77, 95% CI： 1.13-8.06; P = 0.04）. Kaplan-Meier curves showed higher event rates for all cause mortality and cardiac mortality in higher tertile of SS-II for PCI （Log-Rank test P = 0.002 and P = 0.001, respectively）. SSdl for PCI predicted one year mortality in octogenarian population undergoing PCI. Conclusions In octogenarian, SS-II which incorporated clinical variables with angiographic anatomy variable was suitable in risk stratifying and predicting clinical outcomes at one year.

关键词： Clinical research Elderly Risk stratification

Screening for significant atherosclerotic renal artery stenosis with a regression model in patients undergoing transradial coronary angiography/intervention

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第8期13卷 631-637页

作者： Li-jin PU Ying SHEN rui-yan zhang Qi zhang Lin LU Feng-hua DING Jian HU Zheng-kun yanG Wei-feng SHEN Department of Cardiology Ruijin Hospital Shanghai Jiao Tong Uniwzrsity School of MedicineShanghai 200025China Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Early detection of atherosclerotic renal artery stenosis (ARAS) is clinically important with respect to blood pressure control, prevention of renal insufficiency, and even improving survival. We investigated whether the presence of significant ARAS (luminal diameter narrowing ≥70%) could be predicted using a logistic regression model before coronary angiography/intervention. Methods:Initially, we developed a logistic regression model for detecting significant ARAS based upon clinical and angiographic features and biochemical measurements in a cohort of 1 813 patients undergoing transfemoral coronary and renal angiography. This model was then prospectively applied to an additional 495 patients who received transradial renal angiography to ascertain its predictive accuracy for the presence of significant ARAS. Results:Multivariate regression analysis revealed that older age (≥65 years), resistant hypertension, type 2 diabetes, creatinine clearance (Ccr) ≤60 ml/min, and multivessel coronary disease were independent predictors for significant ARAS. A logistic regression model for detecting ARAS by incorporating conventional risk factors and multivessel coronary disease was generated as:P/(1 P)=exp( 2.618+1.112[age≥65 years]+1.891[resistant hypertension]+0.453[type 2 diabetes]+0.587[Ccr≤60 ml/min]+2.254[multivessel coronary disease]). When this regression model was prospectively applied to the additional 495 patients undergoing transradial coronary and renal angiography, significant ARAS could be detected with a sensitivity of 81.2%, specificity of 88.9%, and positive and negative predictive accuracies of 53.8% and 96.7%, respectively. Conclusions:The logistic regression model generated in this study may be useful for screening for significant ARAS in patients undergoing transradial coronary angiography/intervention.

关键词： Renal artery stenosis Transradial coronary angiography Resistant hypertension

Clinical and angiographic features associated with coronary collateralization in stable angina patients with chronic total occlusion

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2013年第8期14卷 705-712页

作者： Zhen SUN Ying SHEN Lin LU rui-yan zhang Li-jin PU Qi zhang Zheng-kun yanG Jian HU Qiu-jing CHEN Wei-feng SHEN Department of Cardiology Shanghai Ruijin Hospital Institute of Cardiovascular Diseases Shanghai Jiao Tong University School of Medicine

Objective： Coronary collateral circulation is an alternative source of blood supply to myocardium in the presence of advanced coronary artery disease. We sought to determine which clinical and angiographic variables are associated with collateral development in patients with stable angina and chronic total coronary occlusion. Methods： Demographic variables, biochemical measurements, and angiographic findings were collected from 478 patients with stable angina and chronic total coronary occlusion. The presence and extent of collaterals supplying the distal aspect of a total coronary occlusion from the contra-lateral vessel were graded from 0 to 3 according to the Rentrop scoring system. Results： Low （Rentrop score of 0 or 1） and high （Rentrop score of 2 or 3） coronary collateralizations were detected in 186 and 292 patients, respectively. Despite similar age, cigarette smoking, and medical treatment, patients with low collateralization were female in a higher proportion and less hypertensive, and had higher rates of type 2 diabetes and dyslipidemia than those with high coUateralization （for all comparisons, P〈0.05）. In addition, patients with low collateralization exhibited more single-vessel disease, less right coronary artery occlusion, more impaired renal function, and higher serum levels of high-sensitivity C-reactive protein （hsCRP） compared with those with high col- lateralization. Multivariate analysis revealed that age of 〉65 years, female gender, diabetes, no history of hypertension dyslipidemia, moderate to severe renal dysfunction, single-vessel disease, and elevated hsCRP levels were inde- pendently associated with low coronary collateralization. Conclusions： Coronary collateralization was reduced in almost 40% of stable angina patients with chronic total occlusion, which was related to clinical and angiographic factors. The impact of coronary collateralization on outcomes after revascularization needs further investigation.

关键词： Stable angina Coronary collateral circulation Risk factors Angiography Chronic total coronary occlusion

Investment Insight Opportunities Ahead

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Beijing Review 2006年第35期49卷 46-47页

作者： TAO rui & zhang yan

Over the next five years, China will be shitting its focus to more balanced development and what it sees as quality growth. Its two main strategies are promoting innovation-with the government-backed industrial upgrading-and strengthening the rural economy. This shift will lead to massive investment and fresh, wealth-making opportunities. In the

关键词： will

Outcomes of autologous bone marrow mononuclear cell transplantation in decompensated liver cirrhosis

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World Journal of Gastroenterology 2014年第26期20卷 8660-8666页

作者： yang-Qiu Bai Yu-Xiu yang Ya-Ge yang Song-Ze Ding Fang-Li Jin Ming-Bo Cao yan-rui zhang Bing-Yong zhang Department of Gastroenterology and Hepatology Zhengzhou University People’s Hospital Department of Gastroenterology and Hepatology The First Affiliated Hospital of Zhengzhou University The Seventh People’s Hospital of Zhengzhou City

AIM: To determine the long-term efficacy of autologous bone marrow mononuclear cells (BM-MNCs) transplantation in terms of improving liver function and reducing complications in patients with decompensated cirrhosis.

关键词： Autologous Bone marrow mononuclear cells Transplantation Liver cirrhosis Hepatitis B virus

Type Ⅰ and type Ⅱ Helicobacter pylori infection status and their impact on gastrin and pepsinogen level in a gastric cancer prevalent area

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World Journal of Gastroenterology 2020年第25期26卷 3673-3685页

作者： Lin Yuan Jun-Bo Zhao Ying-Lei Zhou Ya-Bin Qi Qiong-Ya Guo Hai-Hui zhang Muhammad Noman Khan Ling Lan Chang-He Jia yan-rui zhang Song-Ze Ding Department of Gastroenterology and Hepatology People's Hospital of Zhengzhou UniversityHenan ProvinceChina Henan Provincial People’s Hospital Henan ProvinceChina Henan University School of Medicine Zhengzhou 450003Henan ProvinceChina

BACKGROUND Type I Helicobacter pylori(***)infection causes severe gastric inflammation and is a predisposing factor for gastric ***,its infection status in stepwise gastric disease progression in this gastric cancer prevalent area has not been evaluated;it is also not known its impact on commonly used epidemiological gastric cancer risk markers such as gastrin-17(G-17)and pepsinogens(PGs)during clinical *** To explore the prevalence of type I and type II *** infection status and their impact on G-17 and PG levels in clinical *** Thirty-five hundred and seventy-two hospital admitted patients with upper gastrointestinal symptoms were examined,and 523 patients were enrolled in this *** infection was confirmed by both 13C-urea breath test and serological *** were divided into non-atrophic gastritis(NAG),nonatrophic gastritis with erosion(NAGE),chronic atrophic gastritis(CAG),peptic ulcers(PU)and gastric cancer(GC)*** serological G-17,PG I and PG II values and PG I/PG II ratio were also *** A total *** infection rate of 3572 examined patients was 75.9%,the infection rate of 523 enrolled patients was 76.9%,among which type I *** infection accounted for 72.4%(291/402)and type II was 27.6%;88.4%of GC patients were *** positive,and 84.2%of them were type I infection,only 11.6%of GC patients were *** *** rates of type I *** in NAG,NAGE,CAG,PU and GC groups were 67.9%,62.7%,79.7%,77.6%and 84.2%,*** infection resulted in significantly higher G-17 and PG II values and decreased PG I/PG II *** types of *** induced higher G-17 level,but type I strain infection resulted in an increased PG II level and decreased PG I/PG II ratio in NAG,NAGE and CAG groups over uninfected *** PG I levels showed no difference among all disease groups and in the presence or absence of ***;in stratified analysis,its level w

关键词： Helicobacter pylori Chronic gastric diseases Gastrin-17 Pepsinogen Gastric cancer

Outcomes of primary percutaneous coronary intervention for acute ST-elevation myocardial infarction in patients aged over 75 years

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Chinese Medical Journal 2006年第14期119卷 1151-1156页

作者： zhang Qi zhang rui-yan zhang Jian-sheng HU Jian yanG Zhen-kun ZHENG Ai-fang zhang Xian SHEN Wei-feng Department of Cardiology Shanghai Ruijin Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200025 China

Background The optimal reperfusion strategy in elderly patients with ST-elevation myocardial infarction （STEMI） remains unclear. The purpose of this study was to evaluate the safety, in-hospital and one-year clinical outcomes for patients 〉75 years of age with STEMI receiving primary percutaneous coronary intervention （PCI）, compared with those treated by conservative approach. Methods One hundred and two patients 〉75 years of age with STEMI presented 〈12 hours were randomly allocated to primary PCI （n=50） or conservative therapy only （n=52）. The baseline characteristics, in-hospital outcome and major adverse cardiac events （MACE）, including death, non-fatal myocardial infarction and target vessel revascularization at one-year clinical follow-up were compared between the two groups. Results Age, gender distribution, risk factors for coronary artery disease, infarct site and clinical functional status were similar between the two groups, but the patients in primary PCI group received less low-molecular- weight heparin during hospitalization. Compared with conservative group, the patients in primary PCI group had significantly lower occurrence rate of re-infarction and death and shortened hospital stay. The composite endpoint for in-hospital survivals at 30-day follow-up was similar between the two groups, but one-year MACE rate was significantly lower in the primary PCI group （21.3% and 45.2%, P=0.029）. Left ventricular ejection fraction was not significantly changed in both groups during follow-up. Multivariate analysis revealed that primary PCI （OR=0.34, 95% CI： 0.21-0.69, P =0.03） improved MACE-free survival rate for STEMI patients aged 〉 75 years. Conclusion Our results indicated that primary PCI was safe and effective in reducing in-hospital mortality and one-year MACE rate for elderly patients with STEMI.

关键词： myocardial infarction elderly angioplasty outcome