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A Global Optimality Principle for Fully Coupled Mean-field Control Systems

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Acta Mathematicae Applicatae Sinica 2024年第2期40卷 379-413页

作者： tao HAO School of Statistics and Mathematics Shandong University of Finance and EconomicsJinan 250014China

This paper concerns a global optimality principle for fully coupled mean-field control *** the first-order and the second-order variational equations are fully coupled mean-field linear FBSDEs. A new linear relation is introduced, with which we successfully decouple the fully coupled first-order variational equations. We give a new second-order expansion of Y^(ε) that can work well in mean-field framework. Based on this result, the stochastic maximum principle is proved. The comparison with the stochastic maximum principle for controlled mean-field stochastic differential equations is supplied.

关键词： optimal control global maximum principle fully coupled general mean-field FBSDE adjoint equation recursive utility

Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li Dong-Yuan Liu Jing Leng xue-Mei tao Hui-Qin Wu Yan-Peng Zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

Mitochondria-targeted Janus mesoporous nanoplatform for tumor photodynamic therapy

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Chinese Chemical Letters 2024年第2期35卷 544-547页

作者： Min Dong rui Tang Jing Li Jiajia Zhao Yu Wang Lin Ouyang Wei Lu Jun tao Meng Dang Yuxia Tang Zhaogang Teng Key Laboratory for Organic Electronics & Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced MaterialsJiangsu National Synergetic Innovation Centre for Advanced MaterialsNanjing University of Post and TelecommunicationsNanjing 210023China Laboratory of Molecular Imaging Department of RadiologyThe First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029China Department of Radiology The 909th HospitalSoutheast HospitalSchool of MedicineXiamen UniversityZhangzhou 363000China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China

Photodynamic therapy(PDT)is an effective treatment method for *** the specifically accumulated of photosensitizer was very difficult in the tumor site,which greatly limited the efficacy of ***,mitochondria-targeted Janus mesoporous nanoplatform(JPMO-Pt-CTPP-ZnPc)for PDT was prepared,the nanoplatform has uniform size(275 nm)and good dispersion and *** confocal laser scanning microscopy(CLSM)revealed the signal of ZnPc of JPMO-Pt-CTPP-ZnPc were higher than JPMO-Pt-ZnPc in tumor cells,and flow cytometry results showed the cell uptake efficiency of JPMO-Pt-CTPP-ZnPc was 2.5-fold higher than that of *** revealed the modification of CTPP significantly improves the targeting ability of the *** vitro anti-tumor experiment showed the JPMO-Pt-CTPP-ZnPc significantly inhibited the growth of tumor cells upon the irradiation of low-power laser,and the survival rate of cells incubated with 60μg/mL JPMO-Pt-CTPP-ZnPc was only 3%.Simultaneously,compared with JPMO-Pt-ZnPc(not modified with mitochondria targeting molecules CTPP),the PDT efficacy of JPMO-Pt-CTPP-ZnPc was significantly better,as it has targeted mitochondria in cells.

关键词： Mesoporous materials Janus particle Photodynamic therapy Mitochondria targeting Tumor treatment

基于UPLC-Q-orbitrap-MS技术探究西黄丸抗乳腺增生的作用机制

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药学学报 2024年第1期59卷 214-224页

作者：王婧瑞陶蕊马学莉王俊亮韩涛甘肃中医药大学药学院甘肃兰州730000 甘肃省中药药理与毒理学重点实验室甘肃兰州730000

基于UPLC-Q-orbitrap-MS与生物网络分析工具系统分析西黄丸改善乳腺组织增生的作用机制。肌注苯甲酸雌二醇和黄体酮建立乳腺增生大鼠模型,采用LC-MS的组织代谢组学探索西黄丸改善乳腺组织增生的关键代谢物和代谢途径。整合生物网络分析... 详细信息

基于UPLC-Q-orbitrap-MS与生物网络分析工具系统分析西黄丸改善乳腺组织增生的作用机制。肌注苯甲酸雌二醇和黄体酮建立乳腺增生大鼠模型,采用LC-MS的组织代谢组学探索西黄丸改善乳腺组织增生的关键代谢物和代谢途径。整合生物网络分析工具对西黄丸调节的关键代谢物进行网络分析,聚焦关键代谢通路,挖掘西黄丸改善乳腺组织增生的潜在靶点。与空白组比,模型组大鼠组织中有49种差异代谢物含量有显著差异(P<0.05),西黄丸能显著回调L-丙氨酸、苏氨酸、吲哚-3-羧酸醛、赖氨酸、精氨酸、丙氨酰亮氨酸、甘氨酰络氨酸、γ-谷氨酰亮氨酸、维生素B3、丝氨酰亮氨酸、苏氨酰亮氨酸、异亮氨酰谷氨酸、γ-谷氨酰酪氨酸、癸酰-L-肉碱、2,6,8-三羟基嘌呤、亮氨酰亮氨酸、S-腺苷-蛋氨酸等17种代谢物。对西黄丸调控的关键代谢物进一步网络分析及文献研究表明,晚期糖基化终末产物(AGE)-晚期糖基化终产物受体(RAGE)信号通路可能是西黄丸改善乳腺组织增生的重要通路之一,AGE-RAGE信号通路上的STAT3、MAPK1、EGFR、CASP3、CASP8、PRKCA、JUN等7个蛋白可能为西黄丸改善乳腺组织增生的潜在作用靶点。本文涉及的动物实验操作均遵循甘肃中医药大学动物伦理委员会的规定并通过动物实验伦理审查(批号:2022-705)。

关键词：乳腺增生 UPLC-Q-orbitrap-MS AGE-RAGE信号通路西黄丸

Modulation of starch synthesis in Arabidopsis via phytochrome B-mediated light signal transduction

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Journal of Integrative Plant Biology 2024年第5期66卷 973-985页

作者： Qingbiao Shi Ying Xia Na xue Qibin Wang Qing tao Mingjing Li Di Xu Xiaofei Wang Fanying Kong Haisen Zhang Gang Li National Key Laboratory of Wheat Improvement College of Life SciencesShandong Agricultural UniversityTai'an 271018China National Key Laboratory of Wheat Improvement College of AgronomyShandong Agricultural UniversityTai'an 271018China

Starch is a major storage carbohydrate in plants and is critical in crop yield and *** synthesis is intricately regulated by internal metabolic processes and external environmental cues;however,the precise molecular mechanisms governing this process remain largely *** this study,we revealed that high red to far-red(high R:FR)light significantly induces the synthesis of leaf starch and the expression of synthesis-related genes,whereas low R:FR light suppress these *** phytochrome B(phyB),the primary R and FR photoreceptor,was identified as a critical positive regulator in this *** of phyB,basic leucine zipper transcription factor ELONGATED HYPOCOTYL5(HY5)was found to enhance starch synthesis,whereas the basic helix-loop-helix transcription factors PHYTOCHROME INTERACTING FACTORs(PIF3,PIF4,and PIF5)inhibit starch synthesis in Arabidopsis ***,HY5 and PIFs directly compete for binding to a shared G-box cis-element in the promoter region of genes encoding starch synthases GBSS,SS3,and SS4,which leads to antagonistic regulation of their expression and,consequently,starch *** findings highlight the vital role of phyB in enhancing starch synthesis by stabilizing HY5 and facilitating PIFs degradation under high R:FR light ***,under low R:FR light,PIFs predominantly inhibit starch *** study provides insight into the physiological and molecular functions of phyB and its downstream transcription factors HY5 and PIFs in starch synthesis regulation,shedding light on the regulatory mechanism by which plants synchronize dynamic light signals with metabolic cues to module starch synthesis.

关键词： Arabidopsis thaliana HY5 light signal phyB PIFs starch synthesis

Track-before-detect for bistatic radar based on pseudo-spectrum

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Chinese Journal of Aeronautics 2024年第1期37卷 236-246页

作者： tao HAN Gongjian ZHOU School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Marine Environmental Monitoring and Information Processing Ministry of Industry and Information TechnologyHarbin 150001China

Track-Before-Detect(TBD) is an efficient method to detect dim targets for radars. Conventional TBD usually follows an approximate motion model of the target, which may cause an inaccurate integration of the target energy. A TBD technique on basis of pseudo-spectrum in mixed coordinates adopting an accurate motion model for bistatic radar system is developed in this *** predicted position in bistatic polar plane is derived according to a nonlinear function that exactly describes the constant Cartesian velocity motion. Then around the predicted position, a pseudo-spectrum is formulated and its samples are accumulated to the integration frame for energy integration. The evolution of the state and the procedure of accumulation of the target energy are derived elaborately. The superior performance of the proposed method is demonstrated by some simulations.

关键词： Weak target detection Bistatic radar Track-before-detect Pseudo-spectrum Multiframe integration

Heat Transfer and Friction Characteristics of Printed Circuit Heat Exchangers with Different Channel Structures for S-CO_(2) Power System

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Journal of Thermal Science 2024年第3期33卷 1132-1147页

作者： JIANG tao LI Mingjia Key Laboratory of Thermo-Fluid Science and Engineering of Ministry of Education School of Energy and Power EngineeringXi’an Jiaotong UniversityXi’an710049China School of Mechanical Engineering Beijing Institute of TechnologyBeijing100081China

Printed circuit heat exchanger(PCHE)has been widely used in supercritical carbon dioxide(S-CO_(2))power systems because of its high heat transfer efficiency and good ***,due to the large variety of PCHE configurations,channel selection in practical applications lacks a ***,this paper discussed the heat transfer and friction characteristics and the synergy of three fields in the channel under the guidance of the field synergy principle for four typical PCHE ***,the comprehensive performance of four channels was ***,the heat transfer and friction factor correlations for S-CO_(2)in four channels were *** findings demonstrate that the synergy of velocity and pressure fields of the straight channel PCHE is better(β≈180°),so its resistance loss is relatively *** zigzag and sinusoidal wavy channels and the airfoil fins can reduce the angle a between the temperature gradient and velocity,thus enhancing the heat *** sinusoidal wavy channel can reduce flow resistance compared to the zigzag channel due to the rounded *** streamlined airfoil structure can guide the flow and reduce backflow,thus reducing resistance *** the range of Re studied in this paper,the maximum error of the proposed heat transfer and friction factor correlations of PCHE is 7.0%,which shows good fitting *** research in this paper can provide a reference for the selection and design of PCHE with different channel configurations.

关键词： printed circuit heat exchanger supercritical carbon dioxide typical channel structure field synergy analysis

Gas-surface interaction features under effects of gas-gas molecules interaction in high-speed flows

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Chinese Journal of Aeronautics 2024年第5期37卷 228-242页

作者： ruiling tao Zhihui WANG School of Engineering Science University of Chinese Academy of SciencesBeijing 100049China

Understanding interactions between gas molecules and solid surface is key to the aerodynamic design of high-speed,high-altitude aerospace vehicles,but there is a large dispersion of gas-surface interaction parameters or namely accommodation *** uncertainty results partly from different considerations of the interaction between gas molecules in various experimental and numerical *** this study,effects of gas-gas molecules interaction are systematically discussed by comparing two different approaches of molecular dynamics simulation of high-speed argon molecules scattering on a graphite *** popularly-used“single scattering”approach repeats the scattering process of a single gas molecule without considering the gas-gas molecules *** newly-developed“continual scattering”approach continually shoots gas molecules at the surface,considering collisions between gas molecules in addition to gas molecules’collisions with ***-surface interaction features in the two approaches are compared and discussed under various affecting factors including rarefaction degree,gas-surface interaction strength,surface temperature and incident *** is shown that these two approaches usually produce different accommodation coefficients,and the corresponding mechanisms are *** study could help clarify some doubts about the selection of accommodation coefficients in engineering practice,and also provide an instruction on design of an appropriate molecular dynamics simulation approach.

关键词： Gas-surface interaction Molecular dynamics Accommodation coefficient Aerospace vehicles High-speed flow

A survey of composite robot for aviation intelligent manufacturing application

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High Technology Letters 2024年第1期30卷 85-98页

作者：陶永 xue Jiao WEI Hongxing LIU Haitao GAO He WANG Tianmiao School of Mechanical Engineering&Automation Beihang UniversityBeijing 100191P.R.China Research Institute of Aero Engine Beihang UniversityBeijing 100191P.R.China

With the rapid development of the aviation industry,the development of intelligent manufacturing equipment represented by composite robots has been paid close attention by the aviation *** on the analysis of the background and main structure function of composite robots,this paper focuses on the analysis of key technologies such as composite robot hardware design,visual sensing and planning system,integrated control of‘hands,feet,and eyes',multi-robot collaborative operation,and *** typical applications of composite robots in aviation intelligent manufacturing such as automatic drilling and connection of aircraft,aircraft surface spraying and finishing,parts handling,aircraft measurement,and inspection are *** development trends such as standardization of composite robots,integration of‘5G+cloud computing+AI',and fusion of intelligent sensors are proposed.

关键词： aviation manufacturing composite robot key technology development trend safety