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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： Jing Yao yuan Li xi Liu Wenping Liang Yu Li Liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： xiao Liang xingping Quan xiaorui Geng Yujing Huang Yonghua Zhao Lei xi Zhen yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

Ru团簇对Ni/Ni_(3)Al合金纳米线形变影响的原子模拟

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原子与分子物理学报 2025年第1期42卷 81-87页

作者：阳喜元岭南师范学院物理科学与技术学院湛江524048

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,... 详细信息

镍基高温合金是制造先进航空发动机热端部件的关键材料之一,其高温力学性能直接关系到发动机运行安全和使用寿命.本文采用改进分析型嵌入原子模型(MAEAM)和分子动力学(MD)研究合金化元素钌(Ru)团簇对Ni/Ni_(3)Al纳米线形变机制的影响,结果表明:在单轴拉伸应变下,纳米线的弹性模量和屈服强度随温度升高而降低.温度较低时,纳米线形变由位错产生与发射而导致晶格滑移所引起.由于晶格热振动非谐效应不明显,Ru团簇阻碍效果显著,使得晶格滑移区域仅限于Ru团簇与Ni/Ni_(3)Al相界面之间且呈非对称分布.温度较高时,纳米线的形变由位错发射而引起晶格滑移所致,但因非谐效应显著,Ru团簇无法阻碍位错运动,滑移区域在Ru团簇周围对称分布于Ni_(3)Al相中.最后从Ru团簇微观结构及其稳定性的角度进一步分析其对纳米线形变影响.

关键词： Ru团簇形变机制 Ni/Ni_(3)Al纳米线原子模拟

Tranylcypromine upregulates Sestrin 2 expression to ameliorate NLRP3-related noise-induced hearing loss

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Neural Regeneration Research 2025年第5期20卷 1483-1494页

作者： xihang Chen Zhifeng Chen Menghua Li Weiwei Guo Shuolong yuan Liangwei Xu Chang Lin xi Shi Wei Chen Shiming Yang Senior Department of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalChinese PLA Medical SchoolBeijingChina State Key Laboratory of Hearing and Balance Science BeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Laboratory of Hearing Science Ministry of EducationBeijingChina Beijing Key Laboratory of Hearing Impairment Prevention and Treatment BeijingChina Department of Otorhinolaryngology Head and Neck Surgery The First Affiliated Hospital of Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Otolaryngology Head and Neck Surgery The 940th Hospital of Joint Logistics Support Force of Chinese PLALanzhouGansu ProvinceChina Key Laboratory of Tropical Biological Resources of Ministry of Education School of Pharmaceutical SciencesHainan UniversityHaikouHainan ProvinceChina Academician Workstation of Hainan University School of Pharmaceutical SciencesYazhou BaySanyaHainan ProvinceChina

Noise-induced hearing loss is the primary non-genetic factor contributing to auditory ***,there are currently no effective pharmacological interventions for patients with noise-induced hearing ***,we present evidence suggesting that the lysine-specific demethylase 1 inhibitor–tranylcypromine is an otoprotective agent that could be used to treat noise-induced hearing loss,and elucidate its underlying regulatory *** established a mouse model of permanent threshold shift hearing loss by exposing the mice to white broadband noise at a sound pressure level of 120 d B for 4 *** found that tranylcypromine treatment led to the upregulation of Sestrin2(SESN2)and activation of the autophagy markers light chain 3B and lysosome-associated membrane glycoprotein 1 in the cochleae of mice treated with *** noise exposure group treated with tranylcypromine showed significantly lower average auditory brainstem response hearing thresholds at click,4,8,and 16 k Hz frequencies compared with the noise exposure group treated with *** findings indicate that tranylcypromine treatment resulted in increased SESN2,light chain 3B,and lysosome-associated membrane glycoprotein 1 expression after noise exposure,leading to a reduction in levels of 4-hydroxynonenal and cleaved caspase-3,thereby reducing noise-induced hair cell ***,immunoblot analysis demonstrated that treatment with tranylcypromine upregulated SESN2 expression via the autophagy *** treatment also reduced the production of NOD-like receptor family pyrin domaincontaining 3(NLRP3)*** conclusion,our results showed that tranylcypromine treatment ameliorated cochlear inflammation by promoting the expression of SESN2,which induced autophagy,thereby restricting NLRP3-related inflammasome signaling,alleviating cochlear hair cell loss,and protecting hearing *** findings suggest that inhibiting lysine-specific demethylase 1 is a

关键词： 4-hydroxynonenal apoptosis autophagy cleaved caspase-3 inflammation NOD-like receptor family pyrin domain-containing 3(NLRP3) noise-induced hearing loss oxidative stress Sestrin2 tranylcypromine

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian Tang yuan-Ming Pan Wei Li rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Research progress on supramolecular structures of asphalt

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第2期10卷 230-242页

作者： Yongjie Ding yuan xi Yanghui Wang rui Zhang Danni Li Department of Road and Urban Railway Engineering Beijing University of TechnologyBeijing 100124China School of Civil Engineering Chongqing Jiaotong UniversityChongqing 400074China The Key Laboratory of Road and Traffic Engineering of Ministry of Education Tongji UniversityShanghai 201804China Department of Civil Environmental Engineering The Hong Kong Polytechnic UniversityHong KongChina

The properties of asphalt binder play an essential role in the design life of asphalt *** of asphalt mechanical behaviors based on the chemical structures provides the theoretical basis for the improvement of asphalt performance in service *** interactions have a significant impact on the macroscopic properties of asphalt,a colloidal material,resulting in the parameters characterizing asphalt molecular structures fail to directly connect with mechanical properties of *** paper introduces the supramolecular theory,presents a brief review of existing supramolecular models and research methods of asphalt,aiming to explore a new methodology for the investigation between asphalt microstructures and macroscopic *** showed the supramolecular theory focuses on the intermolecular interactions,providing more accurate indicators for the investigation on the asphalt *** analysis of asphalt has proposed feasible methods and established favorable connections with asphalt properties,giving a new view of understanding asphalt microstructure and a new approach to capture mechanical behaviors of asphalt.

关键词： Road engineering Asphalt microstructure Supramolecule Intermolecular interaction Performance

THEORETICAL ANALYSES ON DESIGN OF SHEAR EXTRUSION DIE

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中国有色金属学会会刊：英文版 1997年第3期7卷 81-86页

作者： yuan, xi Central South Univ of Technology Changsha China

ＴＨＥＯＲＥＴＩＣＡＬＡＮＡＬＹＳＥＳＯＮＤＥＳＩＧＮＯＦＳＨＥＡＲＥＸＴＲＵＳＩＯＮＤＩＥ①ＹｕａｎＸｉＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵ... 详细信息

ＴＨＥＯＲＥＴＩＣＡＬＡＮＡＬＹＳＥＳＯＮＤＥＳＩＧＮＯＦＳＨＥＡＲＥＸＴＲＵＳＩＯＮＤＩＥ①ＹｕａｎＸｉＤｅｐａｒｔｍｅｎｔｏｆＭａｔｅｒｉａｌｓＳｃｉｅｎｃｅａｎｄＥｎｇｉｎｅｒｉｎｇ，ＣｅｎｔｒａｌＳｏｕｔｈＵｎｉｖｅｒｓｉｔｙｏｆＴｅｃｈｎｏ...

关键词： shape extrusion die design element deformation analysis method

Devitrification of Al-Ce Amorphous Ribbon Investigated Using In situ High Energy X-ray Diffraction

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Acta Metallurgica Sinica(English Letters) 2022年第1期35卷 157-162页

作者： Ying-xi Li Fan-Qiang Meng rui yuan Guo-Qiang Huang Dong-Bai Sun Sino-French Institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai519082China School of Materials Science and Engineering Sun Yat-Sen UniversityGuangzhou510275China

Metastable phases formed during vitrification or devitrification open an avenue to study the intrinsic structural hierarchy in amorphous *** phase transformation sequence of Al89Ce11 amorphous ribbon was investigated using diff erential scanning calorimetry,in situ high energy X-ray diffraction(HEXRD)and ex situ high-resolution scanning transmission electron *** results reveal the devitrification pathway following the reaction:amorphous→ε-Al_(60)Ce_(11)+fcc-Al→η-Al_(41)Ce_(5)+fcc-Al→Al_(11)Ce_(3)+*** has been found that bothε-Al_(60)Ce_(11)andη-Al_(41)Ce_(5)metastable phases have same Ce-centered 1-6-6-6-1 motif,suggesting that the structural motif can be *** of metastable phase with large unit cell is related to the short-range orders developed during *** heredity provides a new method to tailor the microstructure and properties of Al-based alloys based on genetic mechanism.

关键词： Synchrotron radiation Amorphous alloys Crystallization Phase transformation

Architecture of stem and branch affects yield formation in short season cotton

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Journal of Integrative Agriculture 2020年第3期19卷 680-689页

作者： ZHANG xiang rui Qiu-zhi LI yuan CHEN yuan CHEN yuan ZHANG xi-ling CHEN De-hua SONG Mei-zhen Institute of Cotton Research Chinese Academy of Agricultural Sciences/State Key Laboratory of Cotton BiologyAnyang 455000P.R.China Jiangsu Key Laboratory of Crop Genetics and Physiology/Co-Innovation Center for Modern Production Technology of Grain Crops Yangzhou UniversityYangzhou 225009P.R.China

The cotton direct seeding after wheat(rape) harvested is under trial and would be the future direction at the Yangtze River Valley region of *** objective of this study was to quantify the effects of branch and stem architecture on cotton yield and identify the optimal cotton architecture to compensate the yield loss due to the reduction of individual production capacity under high planting density in the direst seeding after wheat harvested cropping *** characteristics of the stem and branch architecture and the relationships between architecture of the stem and branch with yield formation were studied on eight short season cotton cultivars during 2015 and 2016 cotton growth *** on the two years results,three cultivars with different architectures of stem and branch were selected to investigate the effect of mepiquat chloride(MC) application on the architecture of the stem and branch,boll retention,and the yield in *** differences were observed on plant height,all fruiting nodes to branches ratio(NBR) in the cotton plant,and the curvature of the fruiting branch(CFB) among the studied *** were three types of stem and fruiting branch structures: Zhong425 with stable and suitable plant height and NBR(about 90 cm and 2.5,respectively),high CFB(more than 10.0),and high boll retention speed and seed cotton yield;Siyang 822 with excessive plant height and NBR,low CFB,and low boll retention speed and seed cotton yield;and other studied cultivars with unstable structure of stem and branch,boll retention speed,and seed cotton yield across *** MC application could promote the appropriate plant height and NBR and high CFB and thus resulted in high boll retention speed and the *** results suggested that the suitable plant height and NBR(about 90 cm and 2.5 respectively),and high CFB(more than 10.0),which was related to both genotype and cultural practice,could promote the higher boll retention speed and seed cotton yie

关键词： short season cotton architecture of the stem and branch boll retention speed seed cotton yield mepiquat chloride