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Targeting colorectal cancer with Herba Patriniae and Coix seed:Network pharmacology,molecular docking,and in vitro validation

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3539-3558页

作者： Cheng-Lei Wang Bing-Wei Yang Xin-Yan Wang Xue Chen Wei-Dong Li Hao-Yu Zhai Ying Wu Mu-YaoCui Jia-He Wu Qing-Hui Meng nan Zhang Department of Oncology Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China The First Clinical Medical College Shaanxi University of Chinese MedicineXianyang 712046Shaanxi ProvinceChina Department of Scientific Research Management Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China School of Clinical Medicine Qinghai University Xining 810000Qinghai ProvinceChina School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

BACKGROUND Herba Patriniae and Coix seed(HC)constitute a widely utilized drug combination in the clinical management of colorectal cancer(CRC)that is known for its diuretic,anti-inflammatory,and swelling-reducing *** its efficacy has been demonstrated in a clinical setting,the active compounds and their mechanisms of action in CRC treatment remain to be fully *** To identify the active,CRC-targeting components of HC and to elucidate the mechanisms of action *** Active HC components were identified and screened using *** for each component were ***-related targets were obtained from human gene *** targets between HC and CRC were identified.A“drug-ingredient-target”network was created to identify the core components and targets *** Ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were conducted to elucidate the key pathways *** docking between core targets and key components was *** vitro experiments validated core *** Nineteen active components of HC were identified,with acacetin as the primary active *** predictive analysis identified 454 targets of the active compounds in *** mapping with 2685 CRC-related targets yielded 171 intervention targets,including 30 core *** and KEGG analyses indicated that HC may influence the phosphoinositide 3-kinase(PI3K)/Akt signaling *** docking showed that acacetin exhibited an optimal interaction with AKT1,identifying PI3K,AKT,and P53 as key genes likely targeted by HC during CRC *** inhibited HT-29 cell proliferation and migration,as well as promoted apoptosis,in *** blotting analysis revealed increased p53 and cleaved caspase-3 expression and decreased levels of p-PI3K,p-Akt,and survivin,which likely contributed to CRC *** Acacetin,the principal active compound in the HC pair,inhibited the proliferati

关键词： Colorectal cancer Baijiangcao(Herba Patriniae) Yiyiren(Coix seed) Acacetin Proliferation Migration Apoptosis Network pharmacology

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Healthy life expectancy with cardiovascular disease among Chinese rural population based on the prospective cohort study

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Journal of Geriatric Cardiology 2024年第8期21卷 799-806页

作者： Feng JIANG Xiao-Tian LIU Ze HU Wei LIAO Shuo-Yi LI rui-Fang ZHU Zhen-Xing MAO Jian HOU Sohail Akhtar Fayaz Ahmad Tahir Mehmood Chong-Jian WANG Department of Epidemiology and Biostatistics College of Public HealthZhengzhou UniversityZhengzhouChina Department of Mathematics and Statistics The University of HaripurHaripurPakistan School of Natural Sciences National University of Sciences and TechnologyIslamabadPakistan

BACKGROUND Limited research has explored the impact of cardiovascular disease(CVD)on healthy life expectancy(HLE)especially in resource-limited *** study aimed to investigate the association between CVD and HLE in Chinese rural *** This study included 11,994 participants aged 45 years and older from the baseline and follow-up surveys of the Henan rural cohort *** status was measured via a Visual Analogue *** multistate Markov model was applied to estimate the association between CVD and transitions in health,unhealthiness and ***-specific total life expectancy,HLE and unhealthy life expectancy were calculated by the multistate life table *** During a mean follow-up time of 3.85(3.84–3.86)years,there were 588 deaths *** individuals with CVD,the risk of switching from health to unhealthiness status was increased by 71%[hazard ratio(HR)=1.71,95%ci:1.42–2.07],the chance of recovery was reduced by 30%(HR=0.70,95%ci:0.60–0.82).Men aged 45 years without CVD could gain an extra 7.08(4.15–10.01)years of HLE and lose 4.00(1.60–6.40)years of unhealthy life expectancy compared to their peers with CVD,*** corresponding estimates among women were 8.62(5.55–11.68)years and 5.82(2.59–9.04)years,*** This study indicated that CVD was significantly associated with poorer health status and lower HLE among Chinese rural *** is an important public health policy to adopt targeted measures to reduce the CVD burden and enhance the quality of life and HLE in resource-limited areas.

关键词： Healthy cardiovascular life

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Long-term prognosis and its associated predictive factors in patients with eosinophilic gastroenteritis

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World Journal of Gastroenterology 2024年第2期30卷 146-157页

作者： Kai-Wen Li Ge-Chong Ruan Shuang Liu Tian-Ming Xu Ye Ma Wei-Xun Zhou Wei Liu Peng-Yu Zhao Zhi-Rong Du Ji Li Jing-nan Li Department of Gastroenterology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Allergy Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Pathology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Department of Radiology Chinese Academy of Medical Sciences and Peking Union Medical College HospitalBeijing 100730China Affairs Office Chinese Academy of Medical Sciences and Peking Union Medical College Hospital(West campus)Beijing 100032China

BACKGROUND Eosinophilic gastroenteritis(EGE)is a chronic recurrent disease with abnormal eosinophilic infiltration in the gastrointestinal *** remain the most common treatment ***,disease relapse and glucocorticoid dependence remain notable *** date,few studies have illuminated the prognosis of EGE and risk factors for disease *** To describe the clinical characteristics of EGE and possible predictive factors for disease relapse based on long-term *** This was a retrospective cohort study of 55 patients diagnosed with EGE admitted to one medical center between 2013 and *** records were collected and ***-Meier curves and log-rank tests were conducted to reveal the risk factors for long-term relapse-free survival(RFS).RESULTS EGE showed a median onset age of 38 years and a slight female predominance(56.4%).The main clinical symptoms were abdominal pain(89.1%),diarrhea(61.8%),nausea(52.7%),distension(49.1%)and vomiting(47.3%).Forty-three(78.2%)patients received glucocorticoid treatment,and compared with patients without glucocorticoid treatments,they were more likely to have elevated serum immunoglobin E(IgE)(86.8%vs 50.0%,P=0.022)and descending duodenal involvement(62.8%vs 27.3%,P=0.046)at *** a median follow-up of 67 mo,all patients survived,and 56.4%had at least one *** variables at baseline might have been associated with the overall RFS rate,including age at diagnosisci):1.0082–4.1312,P=0.044],body mass index(BMI)>24 kg/m^(2)(HR 0.3922,95%ci:0.1916-0.8027,P=0.014),disease duration from symptom onset to diagnosis>3.5 mo(HR 2.4725,95%ci:1.220-5.0110,P=0.011),vomiting(HR 3.1259,95%ci:1.5246-6.4093,P=0.001),total serum IgE>300 KU/L at diagnosis(HR 0.2773,95%ci:0.1204-0.6384,P=0.022)and glucocorticoid treatment(HR 6.1434,95%ci:2.8446-13.2676,P=0.003).CONCLUSION In patients with EGE,younger onset age,longer disease c

关键词： Eosinophilic gastroenteritis Prognosis Relapse Glucocorticoid Glucocorticoid dependence

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Is recovery enhancement after gastric cancer surgery really a safe approach for elderly patients?

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1334-1343页

作者： Zi-Wei Li Xiao-Juan Luo Fei Liu Xu-rui Liu Xin-Peng Shu Yue Tong Quan Lv Xiao-Yu Liu Wei Zhang Dong Peng Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Endoscopy Center The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400012China

BACKGROUND This study aimed to evaluate the safety of enhanced recovery after surgery(ERAS)in elderly patients with gastric cancer(GC).AIM To evaluate the safety of ERAS in elderly patients with *** The PubMed,EMBASE,and Cochrane Library databases were used to search for eligible studies from inception to April 1,*** mean difference(MD),odds ratio(OR)and 95%confidence interval(95%ci)were pooled for *** quality of the included studies was evaluated using the Newcastle-Ottawa Scale *** used Stata(V.16.0)software for data *** This study consists of six studies involving 878 elderly *** analyzing the clinical outcomes,we found that the ERAS group had shorter postoperative hospital stays(MD=-0.51,I2=0.00%,95%ci=-0.72 to-0.30,P=0.00);earlier times to first flatus(defecation;MD=-0.30,I²=0.00%,95%ci=-0.55 to-0.06,P=0.02);less intestinal obstruction(OR=3.24,I2=0.00%,95%ci=1.07 to 9.78,P=0.04);less nausea and vomiting(OR=4.07,I2=0.00%,95%ci=1.29 to 12.84,P=0.02);and less gastric retention(OR=5.69,I2=2.46%,95%ci=2.00 to 16.20,P=0.00).Our results showed that the conventional group had a greater mortality rate than the ERAS group(OR=0.24,I2=0.00%,95%ci=0.07 to 0.84,P=0.03).However,there was no statistically significant difference in major complications between the ERAS group and the conventional group(OR=0.67,I2=0.00%,95%ci=0.38 to 1.18,P=0.16).CONCLUSION Compared to those with conventional recovery,elderly GC patients who received the ERAS protocol after surgery had a lower risk of mortality.

关键词： Enhanced recovery after surgery Gastric cancer Elderly Mortality

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毛泽东运用“五年计划”探索中国式现代化道路的历史经验

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海派经济学 2024年第1期22卷 66-77页

作者：韩慈上海对外经贸大学马克思主义学院

运用“五年计划”探索中国式现代化道路的实践,源起于以毛泽东同志为核心的中国共产党第一代中央领导集体。毛泽东运用“五年计划”探索中国式现代化道路的历史经验主要包括:以“五年计划”为标尺制定发展战略;以“五年计划”为抓手解... 详细信息

运用“五年计划”探索中国式现代化道路的实践,源起于以毛泽东同志为核心的中国共产党第一代中央领导集体。毛泽东运用“五年计划”探索中国式现代化道路的历史经验主要包括:以“五年计划”为标尺制定发展战略;以“五年计划”为抓手解决社会矛盾;以“五年计划”为机制保障共同富裕。系统总结毛泽东运用“五年计划”探索中国式现代化道路的历史经验,对新时代推进中国式现代化具有重要意义。

关键词：毛泽东 “五年计划” 中国式现代化

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建筑物、室内空气中挥发性羰基化合物检测的研究进展

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化学试剂 2024年第5期46卷 71-77页

作者：宋词中国刑事警察学院基建处辽宁沈阳110854

建筑物、室内空气中甲醛和乙醛等物质被归类为致癌物,并受到严格的监管,测定室内空气中羰基化合物的质量和数量在“碳中和”背景下显得尤为重要和必要的。重点阐述与建筑物、室内环境有关的挥发性羰基化合物的经典和现代的分析方法,并... 详细信息

建筑物、室内空气中甲醛和乙醛等物质被归类为致癌物,并受到严格的监管,测定室内空气中羰基化合物的质量和数量在“碳中和”背景下显得尤为重要和必要的。重点阐述与建筑物、室内环境有关的挥发性羰基化合物的经典和现代的分析方法,并详细介绍了各种分析方法的适用目标。比色法操作简单,是目前使用最多的检测方法;许多小分子首先需要进行衍生化,然后利用气相色谱-质谱联用法或高效液相色谱-质谱联用法进行分析;光声光谱法和在线质谱法尽管有一些限制,但鉴定多组分混合物中的羰基化合物是目前最有效的方法。

关键词：挥发性羰基化合物检测方法室内空气建筑物实时监测碳中和

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基于深度卷积测量网络的滚动轴承压缩域故障特征提取方法

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振动工程学报 2024年第3期37卷 485-496页

作者：林慧斌王洪畅习慈羊华南理工大学机械与汽车工程学院广东广州510641

压缩感知可有效降低机械状态监测信号的数据存储和传输压力,而现有压缩感知方法在故障诊断的应用中存在压缩效率低下、信号重构过程缓慢等问题。本文利用自编码网络与压缩感知的对应关系,提出了一种基于深度卷积测量网络的滚动轴承压缩... 详细信息

压缩感知可有效降低机械状态监测信号的数据存储和传输压力,而现有压缩感知方法在故障诊断的应用中存在压缩效率低下、信号重构过程缓慢等问题。本文利用自编码网络与压缩感知的对应关系,提出了一种基于深度卷积测量网络的滚动轴承压缩域故障特征提取方法。针对无噪声的故障信号样本难以获取的问题,提出一种利用故障机理构建数据集的方法,利用该仿真数据集训练得到的模型适用于不同工况下的实测轴承信号。构造网络层数由所需要的信号压缩率确定、隐含层与原信号的频率呈对应关系的深度卷积去噪自编码网络。截取训练完备的编码子网络(即深度卷积测量网络)代替传统的观测矩阵对滚动轴承振动信号进行压缩测量,实现压缩域的故障特征提取。仿真分析验证了所提数据集构造方法及压缩域特征提取方法的有效性。滚动轴承实验信号分析进一步验证了采用所提方法训练得到的深度卷积测量网络具有很好的泛化性,且能够在压缩率远低于传统压缩感知方法的情况下有效地提取轴承故障特征成分并进行故障诊断。

关键词：故障诊断滚动轴承故障特征提取压缩感知深度卷积测量网络

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全球变暖与季风

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气候变化研究进展 2024年第1期20卷 118-120页

作者：赵宗慈罗勇黄建斌清华大学地球系统科学系北京100084 中国气象局国家气候中心北京100081 中国科学院大学资源环境学院北京100049

全球很多地区是季风气候,季风带来风和雨对人类生产和生活以及社会与经济发展有明显影响,因此,长期以来,季风是热门研究课题。根据有关研究,本文简述观测到的全球和区域季风变化,人类活动的影响,以及预估未来全球变暖背景下,全球和区域... 详细信息

全球很多地区是季风气候,季风带来风和雨对人类生产和生活以及社会与经济发展有明显影响,因此,长期以来,季风是热门研究课题。根据有关研究,本文简述观测到的全球和区域季风变化,人类活动的影响,以及预估未来全球变暖背景下,全球和区域的季风变化。

关键词：全球变暖热门研究课题社会与经济发展季风

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Predicting depression in patients with heart failure based on a stacking model

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World Journal of Clinical Cases 2024年第21期12卷 4661-4672页

作者： Hui Jiang rui Hu Yu-Jie Wang Xiang Xie Department of Ultrasound The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina Department of Obstetrics and Gynecology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Ultrasound Diagnosis The Second Affiliated Hospital of Anhui Medical UniversityHefei 230601Anhui ProvinceChina

BACKGROUND There is a lack of literature discussing the utilization of the stacking ensemble algorithm for predicting depression in patients with heart failure(HF).AIM To create a stacking model for predicting depression in patients with *** This study analyzed data on 1084 HF patients from the National Health and Nutrition Examination Survey database spanning from 2005 to *** univariate analysis and the use of an artificial neural network algorithm,predictors significantly linked to depression were *** predictors were utilized to create a stacking model employing tree-based *** performances of both the individual models and the stacking model were assessed by using the test ***,the SHapley additive exPlanations(SHAP)model was applied to interpret the stacking *** The models included five *** these models,the stacking model demonstrated the highest performance,achieving an area under the curve of 0.77(95%ci:0.71-0.84),a sensitivity of 0.71,and a specificity of *** calibration curve supported the reliability of the models,and decision curve analysis confirmed their clinical *** SHAP plot demonstrated that age had the most significant impact on the stacking model's *** The stacking model demonstrated strong predictive *** can utilize this model to identify highrisk depression patients with HF,thus enabling early provision of psychological interventions.

关键词： National health and nutrition examination survey Depression Heart failure Stacking ensemble model Machine learning

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Associations between residence and cognitive function among Chinese older adults: the mediating role of leisure activity

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Medical Data Mining 2024年第3期7卷 46-52页

作者： Xiao-Dong Leng Wen-Ping Zeng Mao-rui Qian School of Public Health Chongqing Medical UniversityChongqing 401331China

Background:Cognitive function is a current research hotspot,residence may be related to differences in cognitive function,and the mediating role of leisure activities are limited in Chinese *** study used leisure activities as a mediating variable to investigate the mediating role of leisure activity between place of residence(city-town-rural)and cognitive function among Chinese older,this is where the innovation of the article comes ***:Using cross-sectional data from the 2018 Chinese Longitudinal Healthy Longevity Survey,Pearson correlation analyses were employed to examine the relationships among various *** analyses were conducted using the SPSS PROCESS macro program,version 3.5,written by Hayes,to explore the mediating effects of leisure activity between place of residence and cognitive function in older ***:A total of 10955 older adults were included in this study,with a mean age of(84.23±11.57)*** them,2739(24.8%)lived in the city,3627(33.1%)in town,and 4615(42.1%)in rural areas;their leisure activity score was(5.34±3.77),and their cognitive function score was(24.69±6.65).Place of residence,leisure activities,and cognitive function were significantly correlated(Pcity as a reference,place of residence is negatively associated with cognitive function,and place of residence not only had a direct effect on cognitive function in older adults:town-cognitive function(effect=–0.399;95%confidence interval(ci)=(–0.685,–0.113));rural-cognitive function(effect=–0.42;95%ci=(–0.698,–0.141)).There were also indirect effects on cognitive function through the pathway of leisure activity:town-leisure activity-cognitive function(effect=–0.17;95%ci=(–0.246,–0.1)),rural-leisure activity-cognitive function(effect=–0.199;95%ci=(–0.272,–0.13)).Conclusion:Leisure activities play a partially mediating role between the impact of place of residence and cognitive function in Chinese older adults,and it is vital to pay atte

关键词： residence leisure activity cognitive function intermediary role older adults

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