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Treatment of lacrimal gland adenoid cystic carcinoma:a systematic review and Meta-analysis

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 164-172页

作者： Hai-Han Yan rui Liu Nan Wang Liang-yuan Xu Qi-Han Guo Jing Li Jian-Min Ma Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical UniversityBeijing Ophthalmology&Visual Sciences Key LaboratoryBeijing 100730China

AIM:To evaluate lacrimal gland adenoid cystic carcinoma(LGACC)of prognosis in patients who underwent different treatment ***:We searched PubMed,EMBASE,and the Cochrane Library for studies done on the treatment of LGACC,between January 1987 and April 2022.A Metaanalysis was conducted to pool the 5-year overall survival rate(OR),and the 5-year recurrence rate(RR)and 5-year metastasis rate(MR)were ***:The 30 studies involved 585 patients were included in the *** pooled 5-year OR with surgery alone was 50%,the 5-year RR was 63%,and the 5-year MR was 34%.The pooled 5-year OR with surgery and adjuvant radiotherapy combined was 67%(95%CI 61%,73%),the 5-year RR was 41%,and the 5-year MR was 35%.The pooled 5-year OR with surgery and adjuvant chemoradiotherapy combined was 72%(95%CI 59%,84%),the 5-year RR was 48%,and the 5-year MR was 36%.The pooled 5-year OR with surgery,intra-arterial cytoreductive chemotherapy,and adjuvant chemoradiotherapy combined was 78%(95%CI 68%,89%),the 5-year RR was 15%,and the 5-year MR was 27%.CONCLUSION:Comprehensive treatment is more effective than surgery *** combined with intraarterial chemotherapy and adjuvant chemoradiotherapy seems to add value to the therapeutic effect of comprehensive treatment of LGACC but further high-quality research is required to validate this.

关键词： adenoid cystic carcinoma lacrimal gland Meta-analysis

On the relationship between imprint and reliability in Hf_(0.5)Zr_(0.5)O_(2) based ferroelectric random access memory

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Journal of Semiconductors 2024年第4期45卷 42-47页

作者： Peng yuan Yuting Chen Liguo Chai Zhengying jiao Qingjie Luan Yongqing Shen Ying Zhang Jibin Leng Xueli Ma Jinjuan Xiang Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology Beijing 100176China

The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric HfO_(2).In this work,we present results of a comprehensive reliability evaluation of Hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric random access *** influence of imprint on the retention and endurance is ***,a solution in circuity is pro-posed to effectively solve the misreading problem caused by imprint.

关键词： FeRAM HZO imprint reliability

Towards the insights into the deactivation behavior of acetylene hydrogenation catalyst

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Petroleum Science 2024年第2期21卷 1405-1414页

作者： Hai-Xia Su Yang jiao Jian-Gong Shi Zhi-Wei yuan Di Zhang Xu-Peng Wang Jing Ren Dan Liu Jian-Zhou Gui Hai-Yang Gao Xiao-Li Xu State Key Laboratory of Separation Membranes&Membrane Processes Tianjin Key Laboratory of Green Chemical Technology and Process EngineeringSchool of Material Science and EngineeringTiangong UniversityTianjin300387China Institute of Engineering Technology Sinopec Catalyst Co.LtdBeijing101100China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Green Chemical Technology and Process EngineeringSchool of ChemistryTiangong UniversityTianjin300387China

A series of model catalysts were obtained by treating commercial fresh and spent catalysts unloaded from the factory with different methods, including green oil dipping, extraction and high-temperature regeneration;finally, the deactivation behavior of the commercial catalyst for acetylene hydrogenation were studied. The influence of various possible deactivation factors on the catalytic performance was elucidated via detailed structural characterization, surface composition analysis, and activity *** results showed that green oil, carbon deposit and sintering of active metal were the main reasons for deactivation, among which green oil and carbon deposit led to rapid deactivation, while the activity could be recovered after regeneration by high-temperature calcination. The sintering of active metal components was attributed to the high-temperature regeneration in hydrothermal conditions, which was slow but irreversible and accounted for permanent deactivation. Thus, optimizing the regeneration is expected to extend the service life of the commercial catalyst.

关键词： Acetylene Hydrogenation Green oil Carbon deposit Sintering Catalyst deactivation

Al-enabled properties distribution prediction for high-pressure die casting Al-Si alloy

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Advances in Manufacturing 2024年第3期12卷 591-602页

作者： Yu-Tong Yang Zhong-yuan Qiu Zhen Zheng Liang-Xi Pu Ding-Ding Chen Jiang Zheng rui-Jie Zhang Bo Zhang Shi-Yao Huang Key Laboratory for Light-Weight Materials Nanjing Tech UniversityNanjing211816People’s Republic of China Xi’an jiaotong-Liverpool University Suzhou215000JiangsuPeople’s Republic of China Materials Academy JITRI Suzhou215100JiangsuPeople’s Republic of China Key Laboratory for Light-weight Materials Nanjing University of Science and TechnologyNanjing210009People’s Republic of China College of Materials Science and Engineering Chongqing UniversityChongqing400044People’s Republic of China Collaborate Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083People’s Republic of China Chongqing Millison Technologies Inc. Chongqing401321People’s Republic of China

High-pressure die casting(HPDC)is one of the most popular mass production processes in the automotive industry owing to its capability for part ***,the nonuniform distribution of mechanical properties in large-sized HPDC products adds complexity to part property ***,a methodology for property prediction must be *** characterization,simulation technologies,and artificial intelligence(AI)algorithms were ***,an image recognition technique was employed to construct a temperature-microstructure characteristic model for a typical HPDC Al7Si0.2Mg ***,a porosity/microstructure-mechanical property model was established using a machine learning method based on the finite element method and representative volume element model ***,the computational results of the casting simulation software were mapped with the porosity/microstructure-mechanical property model,allowing accurate prediction of the property distribution of the HPDC Al-Si *** AI-enabled property distribution model developed in this study is expected to serve as a foundation for intelligent HPDC part design platforms in the automotive industry.

关键词： Artificial intelligence(AI) Properties prediction High-pressure die-casting(HPDC) Image recognition Machine learning

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超高性能混凝土与钢筋劈裂黏结强度试验研究

建筑结构学报 2024年第6期45卷 254-261页

作者：梁芮黄远新疆大学建筑工程学院新疆乌鲁木齐830047 湖南大学工程结构损伤诊断湖南省重点实验室湖南长沙410082

超高性能混凝土(UHPC)作为一种新型复合材料,可增强与钢筋界面的黏结性能,减少黏结长度。目前,针对UHPC黏结性能的研究,大多采用拔出试验或搭接拉伸试验,难以模拟结构中梁和柱等弯曲受力构件的实际黏结情况,需要对弯曲应力状态下UHPC与... 详细信息

超高性能混凝土(UHPC)作为一种新型复合材料,可增强与钢筋界面的黏结性能,减少黏结长度。目前,针对UHPC黏结性能的研究,大多采用拔出试验或搭接拉伸试验,难以模拟结构中梁和柱等弯曲受力构件的实际黏结情况,需要对弯曲应力状态下UHPC与中长锚钢筋的黏结行为展开研究。为此,对17根搭接梁式试件进行四点弯曲加载试验,研究UHPC强度、纤维体积率、保护层厚度、搭接长度及搭接段箍筋配置对UHPC与钢筋黏结强度的影响。结果表明:UHPC梁式试件主要发生劈裂黏结破坏;增加UHPC强度和保护层厚度有助于提高黏结强度;黏结强度随搭接长度增加而减小;在搭接段配置箍筋可有效提高试件黏结强度,但箍筋对黏结强度的提高作用存在一个阈值,当达到阈值时,增加箍筋数量对黏结强度的提高将不再明显。此外,对现有黏结强度计算模型进行了评估,发现现有计算模型对UHPC劈裂黏结强度预测结果较为保守,离散程度偏大。在此基础上,提出了改进的UHPC劈裂黏结强度计算表达式,可准确反映各种设计参数对劈裂黏结强度的影响,计算结果与本文及相关文献试验结果之比的平均值为1.076,变异系数为0.149。

关键词：超高性能混凝土中长锚钢筋搭接梁式试验黏结性能劈裂黏结强度

Metal coordination-driven assembly of stimulator of interferon genes-activating nanoparticles for tumor chemo-immunotherapy

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BMEMat(BioMedical Engineering Materials) 2024年第2期2卷 118-133页

作者： Guiqiang Zhang Ning Wang yuan Ma Shumei Zhai To Ngai Shilei Ni Xinyi Jiang Jianwei jiao Jiwei Cui Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical EngineeringShandong UniversityJinanChina Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinanChina Department of Neurosurgery Qilu Hospital and Institute of Brain and Brain-Inspired ScienceCheeloo College of MedicineShandong UniversityJinanChina Department of Chemistry The Chinese University of Hong KongHong KongChina Department of Pharmaceutics School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinanChina

Activating the stimulator of interferon genes(STING)signaling pathway is critical for enhancing antitumor immunity and remodeling the immunosuppressive tumor microenvironment(TME).Herein,we report the preparation of STING-activating nanoparticles via metal coordination-driven assembly of a synthetic STING agonist(i.e.,SR717)and a chemotherapeutic drug(i.e.,curcumin).After intravenous administration,the assembled nanoparticles could efficiently accumulate in tumors to improve the bioavailability of SR717 and trigger potent STING pathway activation for effective immune ***,the released curcumin evokes immunogenic cell death in tumors and regulates amino acid metabolism by inhibiting the activation of indoleamine 2,3-dioxygenase 1,leading to the reversal of the immunosuppressive *** antitumor immunity induced by nanoparticles significantly inhibits the growth of primary,recurrent,and metastatic *** assembled nanoparticles are promising for the co-delivery of STING agonists and drugs in improved tumor chemo-immunotherapy.

关键词： amino acid metabolism immunotherapy nanoparticles self-assembly STING

The role of FMO3 in metabolic diseases

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Traditional Medicine Research 2024年第9期9卷 42-50页

作者： Hui-Wen Ren He-yuan Lu Hai-Bo Zhang rui-Jing Zhang Che Bian Advanced Institute for Medical Sciences Dalian Medical UniversityDalian 116044China College of Basic Medical Sciences Dalian Medical UniversityDalian 116044China Department of Nephrology Xijing HospitalThe Fourth Military Medical UniversityXi’an 710032China Department of Endocrinology and Metabolism The Fourth Affiliated Hospital of China Medical UniversityShenyang 110032China

Flavin containing monooxygenase 3(FMO3)is a member of the flavin monooxygenase family,which can oxidize the precursor Trimethylamine(TMA)provided from food to produce Trimethylamine N-oxide(TMAO).The autosomal recessive inherited disease caused by partial functional loss of Fmo3 gene,which leads to excessive excretion of TMA in body fluids and emits fishy odor,is called Fish Odor Syndrome or *** disease has been documented for 3,000 years ago and was first reported in the case report in ***3 mainly exists in the liver and can participate in the TMA-TMAO metabolic balance in intestinal microorganisms,liver,and kidneys,closely related to insulin resistance,diabetes,cholesterol metabolism,and cardiovascular *** to its wide range of catalytic substrates and low susceptibility to metabolite accumulation,its role in drug metabolism,new drug development,and discovery of new drug targets are increasingly *** review will summarize the research progress on the metabolic process and localization of FMO3,congenital genetic defects,metabolic diseases,and its related possible mechanisms.

关键词： metabolic diseases FMO3 TMA TMAO

Effect of La on the Corrosion Behavior and Mechanism of 3Ni Weathering Steel in a Simulated Marine Atmospheric Environment

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Acta Metallurgica Sinica(English Letters) 2024年第2期37卷 308-324页

作者： Gang Niu rui yuan R.D.K.Misra Na Gong Zhi-Hui Zhang Hao-Xiu Chen Hui-Bin Wu Cheng-Jia Shang Xin-Ping Mao Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing100083China Laboratory for Excellence in Advanced Steel Research Department of MetallurgicalMaterials and Biomedical EngineeringUniversity of Texas at El PasoEl PasoTX79968USA Institute of Materials Research and Engineering Agency for ScienceTechnologyand ResearchSingapore138634Singapore Department of Materials Science and Engineering University of TorontoTorontoONM5S 3E4Canada

The corrosion behavior and mechanism of 3Ni weathering steel in a simulated oceanic atmospheric environment are investigated in order to comprehend the impacts of La,as determined through electrochemical analysis and rust layer *** results of this study demonstrate that the addition of La enhances the corrosion resistance of 3Ni weathering steel in the marine atmospheric environment,thereby reducing the corrosion rate and improving the protection of the rust *** influence of La on corrosion resistance can be attributed to two primary ***,La functions as a grain refiner,minimizing the potential difference of the micro-regions on the substrate surface,thereby significantly reducing the corrosion of bare steel in the marine ***,La inhibits the process of Fe_(3)O_(4) oxidation back toγ-FeOOH during corrosion at the local site,thus decreasing the formation ofγ-FeOOH and enhancing the charge transfer *** research work may serve as a reference for expanding the application of rare earth elements in the field of weathering steel.

关键词： Weathering steel Rare earth Rust layer Corrosion behavior Corrosion resistance

Development and validation of a model integrating clinical and coronary lesion-based functional assessment for longterm risk prediction in PCI patients

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Journal of Geriatric Cardiology 2024年第1期21卷 44-63页

作者： Shao-Yu WU rui ZHANG Sheng yuan Zhong-Xing CAI Chang-Dong GUAN Tong-Qiang ZOU Li-Hua XIE Ke-Fei DOU State Key Laboratory of Cardiovascular Disease BeijingChina Cardiometabolic Medicine Center Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Catheterization Laboratories Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Fu Wai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

OBJECTIVES To establish a scoring system combining the ACEF score and the quantitative blood flow ratio(QFR) to improve the long-term risk prediction of patients undergoing percutaneous coronary intervention(PCI).METHODS In this population-based cohort study, a total of 46 features, including patient clinical and coronary lesion characteristics, were assessed for analysis through machine learning models. The ACEF-QFR scoring system was developed using 1263consecutive cases of CAD patients after PCI in PANDA Ⅲ trial database. The newly developed score was then validated on the other remaining 542 patients in the *** In both the Random Forest Model and the Deep Surv Model, age, renal function(creatinine), cardiac function(LVEF)and post-PCI coronary physiological index(QFR) were identified and confirmed to be significant predictive factors for 2-year adverse cardiac events. The ACEF-QFR score was constructed based on the developmental dataset and computed as age(years)/EF(%) + 1(if creatinine ≥ 2.0 mg/d L) + 1(if post-PCI QFR ≤ 0.92). The performance of the ACEF-QFR scoring system was preliminarily evaluated in the developmental dataset, and then further explored in the validation dataset. The ACEF-QFR score showed superior discrimination(C-statistic = 0.651;95% CI: 0.611-0.691, P < 0.05 versus post-PCI physiological index and other commonly used risk scores) and excellent calibration(Hosmer–Lemeshow χ^(2)= 7.070;P = 0.529) for predicting 2-year patient-oriented composite endpoint(POCE). The good prognostic value of the ACEF-QFR score was further validated by multivariable Cox regression and Kaplan–Meier analysis(adjusted HR = 1.89;95% CI: 1.18–3.04;log-rank P < 0.01) after stratified the patients into high-risk group and low-risk *** An improved scoring system combining clinical and coronary lesion-based functional variables(ACEF-QFR)was developed, and its ability for prognostic prediction in patients with PCI was further validated to be signi

关键词： patients coronary prediction