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Gastrointestinal manifestations of critical ill heatstroke patients and their associations with outcomes:A multicentre,retrospective,observational study

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World Journal of Gastroenterology 2024年第4期30卷 346-366页

作者： Yu-Cong Wang Xin-Yang Jin Zheng Lei Xiao-jiao Liu Yu Liu Bang-Guo Zhang Jian Gong Lie-Tao Wang Lv-yuan Shi Ding-yuan Wan Xin Fu Lu-Ping Wang Ai-Jia Ma Yi-Song Cheng Jing Yang Min He Xiao-Dong Jin Yan Kang Bo Wang Zhong-Wei Zhang Qin Wu Department of Critical Care Medicine West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina School of Pharmacy Macao University of Science and TechnologyMacao 999078China Department of Critical Care Medicine The First People's Hospital of Ziyang CityZiyang 641399Sichuan ProvinceChina Department of Critical Care Medicine The First People's Hospital of Guanghan CityChengdu 618399Sichuan ProvinceChina Department of Critical Care Medicine Lezhi County Traditional Chinese Medicine HospitalChengdu 641599Sichuan ProvinceChina Department of Critical Care Medicine Chengdu Qingbaijiang District People's HospitalChengdu 610399Sichuan ProvinceChina Department of Critical Care Medicine Ziyang People's HospitalChengdu 641399Sichuan ProvinceChina

BACKGROUND Extreme heat exposure is a growing health problem,and the effects of heat on the gastrointestinal(GI)tract is *** study aimed to assess the incidence of GI symptoms associated with heatstroke and its impact on *** To assess the incidence of GI symptoms associated with heatstroke and its impact on *** Patients admitted to the intensive care unit(ICU)due to heatstroke were included from 83 *** history,laboratory results,and clinically relevant outcomes were recorded at ICU admission and daily until up to day 15,ICU discharge,or *** symptoms,including nausea/vomiting,diarrhoea,flatulence,and bloody stools,were *** characteristics of patients with heatstroke concomitant with GI symptoms were *** regression analyses were performed to determine significant predictors of GI *** A total of 713 patients were included in the final analysis,of whom 132(18.5%)patients had at least one GI symptom during their ICU stay,while 26(3.6%)suffered from more than one *** with GI symptoms had a significantly higher ICU stay compared with those *** mortality of patients who had two or more GI symptoms simultaneously was significantly higher than that in those with one GI *** logistic regression analysis revealed that older patients with a lower GCS score on admission were more likely to experience GI *** The GI manifestations of heatstroke are common and appear to impact clinically relevant hospitalization outcomes.

关键词： Extreme heat Flatulence Sunstroke Intensive care units Diarrhea

MicroRNA-3162-3p在儿童原发性免疫性血小板减少症不同临床分期中的表达及其意义

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中国实验血液学杂志 2024年第1期32卷 208-213页

作者：胡晓燕贺锐米乐园尹姣姣金斐斐朱生东甘肃省妇幼保健院小儿综合内科甘肃兰州730050 甘肃省妇幼保健院检验科甘肃兰州730050

目的:探讨microRNA-3162-3p在儿童原发性免疫性血小板减少症(ITP)不同临床分期中的表达及其意义。方法:纳入96例ITP患儿,按照病程的不同将其分为新诊断组(病程12个月,26例),同期选择80例健康儿童作为对照组。分离并培养ITP患儿与健康儿... 详细信息

目的:探讨microRNA-3162-3p在儿童原发性免疫性血小板减少症(ITP)不同临床分期中的表达及其意义。方法:纳入96例ITP患儿,按照病程的不同将其分为新诊断组(病程12个月,26例),同期选择80例健康儿童作为对照组。分离并培养ITP患儿与健康儿童的外周血单个核细胞(PBMNC),采用实时荧光定量PCR法检测外周血PBMNC中microRNA-3162-3p的表达情况,ELISA法检测受试者外周血PBMNC中IL-17、IL-23、IL-10、TGF-β的含量。Spearman相关性分析microRNA-3162-3p与血小板计数、IL-17、IL-23、IL-10、TGF-β的相关性。结果:与对照组相比,ITP患儿的外周血PBMNC中microRNA-3162-3p、IL-10的表达及血小板计数显著下降(P<0.05),IL-17、IL-23、TGF-β显著升高(P<0.05);随着病程的延长,microRNA-3162-3p、IL-10在PBMNC中的表达及血小板计数均显著下降(P<0.05),IL-17、IL-23、TGF-β的表达显著升高(P<0.05)。MicroRNA-3162-3p在ITP患儿PBMNC中的表达与血小板数、IL-10呈正相关(r=0.716、0.667),与IL-17、IL-23、TGF-β呈负相关(r=-0.540、-0.641、-0.560)。结论:MicroRNA-3162-3p在ITP患儿PBMNC中的表达明显降低,参与调控Th17/Treg的失衡,可作为ITP潜在的治疗靶点。

关键词： MicroRNA-3162-3p 原发性免疫性血小板减少症外周血单个核细胞 Th17/Treg失衡

Stabilization or degradation?Post-translational modifications of JAZ proteins in plants

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Molecular Plant 2024年第7期17卷 1002-1004页

作者： Xiaoyan Xu Jianping Hu Zheng yuan Joint International Research Laboratory of Metabolic&Developmental Sciences School of Life Sciences and BiotechnologyShanghai Jiao Tong UniversityShanghai200240China Department of Energy Plant Research Laboratory and Plant Biology Department Michigan State UniversityEast LansingMI 48824USA

Jasmonates(JAs)are essential hormones that regulate plant responses to biotic and abiotic stresses and are involved in various developmental processes,including flowering time control,floral organ development,and fertility of male and female gametes(Howe et al.,2018).However,our understanding of the mechanisms by which JAs integrate multiple signals to regulate diverse physiological processes remains *** the canonical JA signaling pathway,activated JAs are perceived by the F-box protein receptor CORONATINE INSENSITIVE 1(COl1),which induces the interaction between COl1 and the Jas domain of the repressor proteins JASMONATE-ZIM DOMAIN PROTEINs(JAZs),leading to the ubiquitination and degradation of JAZ *** proteolytic destruction of the JAZ repressors is a crucial step that releases the inhibition of JAZs on the JA response transcription factor MYC2,allowing MYC2 to activate the expression of downstream genes(Howe et al.,2018).Therefore,the stability and specific spatiotemporal expression pattern of the JAZ proteins are critical for the regulation of JA signaling output,as they determine the activation and repression of JA responses.

关键词： translational fertility release

Population Dynamics in an Advective Environment

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Communications on Applied Mathematics and Computation 2024年第1期6卷 399-430页

作者： King-Yeung Lam Ray Lee yuan Lou Department of Mathematics The Ohio State UniversityColumbusOH43210USA School of Mathematical Sciences CMA-Shanghai and MOE-LSCShanghai Jiao Tong UniversityShanghai200240China

We consider a one-dimensional reaction-diffusion equation describing single-and two-species population dynamics in an advective environment,based on the modeling frameworks proposed by Lutscher et *** *** analyze the effect of rate of loss of individuals at both the upstream and downstream *** the single-species case,we prove the existence of the critical domain size and provide explicit formulas in terms of model *** further derive qualitative properties of the critical domain size and show that,in some cases,the critical domain size is either strictly decreasing over all diffusion rates,or monotonically increasing after first decreasing to a *** also consider competition between species differing only in their diffusion *** two species having large diffusion rates,we give a sufficient condition to determine whether the faster or slower diffuser wins the *** also briefly discuss applications of these results to competition in species whose spatial niche is affected by shifting isotherms caused by climate change.

关键词： Reaction-diffusion-advection Critical domain size Competition Climate change

Xiaoyun,a model accession for functional genomics research in Brassica napus

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Plant Communications 2024年第1期5卷 16-19页

作者： Pengfei Wang Yixian Song Zhaoqi Xie Ming Wan rui Xia Yushun jiao Hui Zhang Guangsheng Yang Zhixiong Fan Qing-Yong Yang Dengfeng Hong National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070China Hubei Hongshan Laboratory Wuhan 430070China Crop Institute Anhui Academy of Agricultural ScienceHefei 230031China Hubei Key Laboratory of Agricultural Bioinformatics College of InformaticsHuazhong Agricultural UniversityWuhan 430070China

Dear Editor,Rapeseed(Brassica napus)provides quality edible plant oil and industrial raw materials,as well as protein-rich animal feed;however,molecular characterization of functional genes in rapeseed remains challenging,largely owing to its complex polyploid genome,relatively long generation time,and environmentally sensitive *** accelerate functional genomics research on rapeseed,especially in an artificially controlled,stable environment like that of comprehensive speed breeding(CSB;Song et al.,2022),we screened out the representative *** accession Xiaoyun(小芸),with a rapid cycling time and scaleddown but normal plant architecture.

关键词： traits functional cycling

Enhanced conductivity and weakened magnetism in Pb-doped Sr2IrO4

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Chinese Physics B 2024年第1期33卷 696-701页

作者：岳智来甄伟立牛瑞焦珂珂朱文卡皮雳张昌锦 High Magnetic Field Laboratory Hefei Institutes of Physical ScienceChinese Academy of Sciences Science Island Branch of Graduate School University of Science and Technology of China Collaborative Innovation Center of Advanced Microstructures Nanjing University

Group IV element Pb has been selected as the dopant to dope at the Sr site of Sr2IrO4. It is exciting to find that the single-phase crystal structure could be maintained with a high Pb doping level of up to x=0.3 in Sr2-xPbxIrO4. The mapping data obtained from energy-dispersive x-ray spectroscopy analyses give solid evidence that the Pb ions are uniformly distributed in the Sr2IrO4matrix. The incorporation of Pb leads to a moderate depression of the canted antiferromagnetic ordering state. The electrical conductivity could be greatly enhanced when the Pb doping content is higher than x=*** present results give a fresh material base to explore new physics in doped Sr2IrO4systems.

关键词： iridates doping conductivity magnetism

Predictors of stricture after endoscopic submucosal dissection of the esophagus and steroids application

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 509-518页

作者： Qing-Xia Wang yuan Ding Qi-Liu Qian Yin-Nan Zhu rui-Hua Shi Department of Gastroenterology Southeast University Affiliated Zhongda HospitalMedical SchoolNanjing 210009Jiangsu ProvinceChina

BACKGROUND Endoscopic submucosal dissection(ESD)is a reliable method to resect early esophageal *** stricture is one of the major complications after ESD of the *** prophylaxis for esophageal strictures,particularly local injection of triamcinolone acetonide(TA),is a relatively effective method to prevent esophageal ***,even with steroid prophylaxis,stenosis still occurs in up to 45%of *** the risk of stenosis formation after local TA injection would enable additional interventions in risky *** To identify the predictors of esophageal strictures after steroids *** Patients who underwent esophageal ESD and steroid prophylaxis and who were comprehensively assessed for lesion-and ESD-related factors at Southeast University Affiliated Zhongda Hospital between February 2018 and March 2023 were included in the *** univariate and multivariate regression analyses were conducted to identify the predictors of stricture among patients undergoing steroid *** A total of 120 patients were included in the *** the oral prednisone and oral prednisone combined with local tretinoin injection groups,the stenosis rates were 44/53(83.0%)and 56/67(83.6%),*** them,univariate analysis showed that the lesion circumference(P=0.01)and submucosal injection solution(P=0.04)showed significant correlation with the risk of stenosis *** regression analyses were then performed using predictors that were significant in the univariate analyses and combined with known predictors from previous reports,such as additional chemoradiotherapy and tumor *** identified a lesion circumference<5/6(OR=0.19;P=0.02)and submucosal injection of sodium hyaluronate(OR=0.15;P=0.03)as independent predictors of on esophageal stricture *** Steroid prophylaxis effectively prevents ***,the lesion circumference and submucosal injection of sodium h

关键词： Endoscopic submucosal dissection Esophageal stricture Oral steroids Triamcinolone acetonide Predictors

Efficiency and safety of Tripterygium Wilfordii Hook F for IgA nephropathy: an update systematic review and meta-analysis

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Pharmacology Discovery 2024年第2期4卷 24-31页

作者： Zi-Yi He Hui-Chuan Tian Yan Zhao rui-Yu Mou Hong-Wei yuan Department of Cardiology The Second Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300150China Department of Oncology The First Affiliated Hospital of Tianjin University of Chinese MedicineTianjin 300110China Department of Oncology National Clinical Research Center of Chinese Acupuncture and MoxibustionTianjin 301617China Department of Chinese Medicine Macao University of Science and TechnologyMacao 999078China

Background:Immunoglobulin A Nephropathy(IgAN)currently stands as the most prevalent primary chronic glomerular disease *** latest guidelines recommend the application of renin-angiotensin system inhibitors(RASi)in conjunction with corticosteroids for the treatment of IgAN patients exhibiting persistent proteinuria of≥1 g/***,numerous randomized controlled trials(RCTs)have revealed a heightened risk of adverse events associated with corticosteroid ***-glycoside of Tripterygium wilfordii Hook.f.(GTW),a traditional Chinese medicine(TCM),has been employed in the treatment of Chronic Kidney Disease(CKD)for an extensive *** years have witnessed an increasing number of RCTs providing evidence supporting the effectiveness of GTW therapy in *** this,there remains a paucity of systematic reviews on the application of GTW therapy for ***,this study undertakes a systematic review to assess the clinical efficacy and safety of GTW therapy,aiming to elucidate the role of GTW therapy in the treatment of ***:To collect relative information of randomized controlled trials(RCTs)of GTW in the treatment of IgAN,we searched for theses and dissertations publicized before April 10,2023,in PubMed,Embase,the Cochrane Library,China National Knowledge Infrastructure(CNKI),Wanfang Data knowledge service platform(Wanfang Data),Chinese Scientific Journal Database(VIP),and Clinical *** language limitation is English and ***,two reviewers performed literature screening,data extraction,and quality evaluation,and the meta-analysis was carried out with RevMan 5.4 and StataSE 15.0 ***:21 RCTs involving 1,405 Chinese patients were *** to ACEI/ARB alone or in combination,GTW with RASi or alone reduced 24 h-Upro,ALB,Scr,GFR,BUN,CD4+,VEGF,ET-1,and improved clinical ***,no associations were found for TC,Ccr,and adverse events due to limited ***:This study hi

关键词： Tripterygium IgA nephropathy systematic review meta-analysis

我国高校青年教师职业身份认同困境的空间解析与破解路径研究

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黑龙江高教研究 2024年第6期42卷 115-120页

作者：霍东娇王睿吉林师范大学吉林四平136000 哈尔滨学院黑龙江哈尔滨150086

青年教师作为高等教育深化改革发展的生力军和中坚力量,对自身职业身份的认同关乎其职业行为的选择与个体发展的向度。通过将列斐伏尔关于空间概念的三维分析,即空间范畴、空间演化历史以及空间生产与教师职业身份的关系解读,发现我国... 详细信息

青年教师作为高等教育深化改革发展的生力军和中坚力量,对自身职业身份的认同关乎其职业行为的选择与个体发展的向度。通过将列斐伏尔关于空间概念的三维分析,即空间范畴、空间演化历史以及空间生产与教师职业身份的关系解读,发现我国高校青年教师存在职业身份认同的空间困境,表现为空间范畴中的身份孤立与精神虚空、矛盾与差异空间中的身份偏差与疑惑、空间生产中的身份隐匿与变形。为摆脱困境,需注重“有机团结”的空间共同体构建,消解身份认同的孤独感;打造纪念碑空间,实现职业身份的诗意回归;推动空间解放,建构多元开放的教师职业形象。

关键词：身份认同空间理论青年教师空间困境破解路径