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Spatiotemporal deformation analysis of glaciers and surrounding landscapes in the Shishapangma region using InSAR techniques

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Journal of Mountain Science 2025年第1期22卷 210-229页

作者： LIANG Wenli LIU rui JI qin KOU Pinglang Chongqing Key Laboratory of GIS Application School of Geography and TourismChongqing Normal UniversityChongqing 401331China National Earth System Science Data Center Beijing 100000China Chongqing Engineering Research Center of Spatial Big Data Intelligent Technology Chongqing University of Posts and TelecommunicationsChongqing 400065China Key Laboratory of Tourism Multisource Data Perception and Decision Ministry of Culture and Tourism(TMDPDMCT)Chongqing University of Posts and TelecommunicationsChongqing 400065China

Glacier dynamics in the Himalayan midlatitudes,particularly in regions like the Shishapangma,are not yet fully understood,especially the localized topographic and climatic impacts on glacier *** study analyzes the spatiotemporal characteristics of glacier surface deformation in the Shishapangma region using the Small Baseline Subset(SBAS)Interferometric Synthetic Aperture Radar(In SAR)*** analysis reveals an average deformation rate of-4.02±17.65 mm/yr across the entire study area,with glacier regions exhibiting significantly higher rates of uplift(16.87±13.20 mm/yr)and subsidence(20.11±14.55 mm/yr)compared to non-glacier *** identifies significant surface lowering on the mountain flanks and localized uplift in certain catchments,emphasizing the higher deformation rates in glacial areas compared to non-glacial *** found a strong positive correlation between temperature and cumulative deformation(correlation coefficient of 0.63),particularly in glacier areas(0.82).The research highlights the role of temperature as the primary driver of glacier wastage,particularly at lower elevations,with strong correlations found between temperature and cumulative *** also indicates the complex interactions between topographic features,notably,slope gradient,which shows a positive correlation with subsidence rates,especially for slopes below 35°.South-,southwest-,and west-facing slopes exhibit significant uplift,while north-,northeast-,and east-facing slopes predominantly ***,we identified transition zones between debris-covered glaciers and clean ice as areas of most intense deformation,with average rates exceeding 30 mm/yr,highlighting these as potential high-risk zones for *** study comprehensively analyzes the deformation characteristics in both glacier and non-glacier areas in the Shishapangma region,revealing the complex interplay of topographic,climatic,and hydrological factors influencing glacier dynamic

关键词： Glacier melting SBAS-InSAR Topographic factors Temperature change Middle Himalayas

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Sulfur doping and oxygen vacancy in In2O3 nanotube co-regulate intermediates of CO2 electroreduction for efficient HCOOH production and rechargeable Zn-CO2 battery

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Journal of Energy Chemistry 2025年第2期101卷 474-484页

作者： Yu Li Zhengrong Xu Quanxin Guo qin Li rui Liu Key Laboratory of Advanced Civil Engineering Materials of Ministry of Education School of Materials Science and Engineering Tongji University

By manipulating the distribution of surface electrons,defect engineering enables effective control over the adsorption energy between adsorbates and active sites in the CO2reduction reaction（CO2RR）.Herein,we report a hollow indium oxide nanotube containing both oxygen vacancy and sulfur doping（V_o-Sx-In2O3） for improved CO2-to-HCOOH electroreduction and *** componential synergy significantly reduces the*OCHO formation barrier to expedite protonation process and creates a favorable electronic micro-environment for*HCOOH *** a result,the CO2RR performance of Vo-Sx-In2O3outperforms Pure-In2O3and V_o-In2O3,where V_o-S53-In2O3exhibits a maximal HCOOH Faradaic efficiency of 92.4% at-1,2 V *** hydrogen electrode（RHE） in H-cell and above 92%over a wide window potential with high current density(119.1 mA cm-2at-1.1 V ***) in flow ***,the rechargeable Zn-CO2battery utilizing V_o-S53-In2O3as cathode shows a high power density of 2.29 mW cm-2and a long-term stability during charge-discharge *** work provides a valuable perspective to elucidate co-defective catalysts in regulating the intermediates for efficient CO2RR.

关键词： CO2 electroreduction In2O3 Intermediate Oxygen vacancy Sulfur doping Zn-CO2 battery

Tanreqing Injection Inhibits Activation of NLRP3 Inflammasome in Macrophages Infected with Influenza A Virus by Promoting Mitophagy

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Chinese Journal of Integrative Medicine 2025年第1期31卷 19-27页

作者： LIU Tian-yi HAO Yu MAO qin ZHOU Na LIU Meng-hua WU Jun WANG Yi YANG Ming-rui School of Life Sciences Beijing University of Chinese MedicineBeijing102488China Experimental Research Center China Academy of Chinese Medical SciencesBeijing100700China

Objective: To investigate the inhibitory effect of Tanreqing Injection(TRQ) on the activation of nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3(NLRP3) inflammasome in macrophages infected with influenza A virus and the underlying mechanism based on mitophagy pathway. Methods:The inflammatory model of murine macrophage J774A.1 induced by influenza A virus [strain A/Puerto Rico/8/1934(H1N1), PR8] was constructed and treated by TRQ, while the mitochondria-targeted antioxidant Mito-TEMPO and autophagy specific inhibitor 3-methyladenine(3-MA) were used as controls to intensively study the anti-inflammatory mechanism of TRQ based on mitophagy-mitochondrial reactive oxygen species(mt ROS)-NLRP3 inflammasome pathway. The levels of NLRP3, Caspase-1 p20, microtubule-associated protein 1 light chain 3 Ⅱ(LC3Ⅱ) and P62 proteins were measured by Western blot. The release of interleukin-1β(IL-1β) was tested by enzyme linked immunosorbent assay, the mt ROS level was detected by flow cytometry, and the immunofluorescence and co-localization of LC3 and mitochondria were observed under confocal laser scanning microscopy. Results: Similar to the effect of Mito-TEMPO and contrary to the results of 3-MA treatment, TRQ could significantly reduce the expressions of NLRP3, Caspase-1 p20, and autophagy adaptor P62, promote the expression of autophagy marker LC3Ⅱ, enhance the mitochondrial fluorescence intensity, and inhibit the release of mt ROS and IL-1β(all P<0.01).Moreover, LC3 was co-localized with mitochondria, confirming the type of mitophagy. Conclusion: TRQ could reduce the level of mt ROS by promoting mitophagy in macrophages infected with influenza A virus, thus inhibiting the activation of NLRP3 inflammasome and the release of IL-1β, and attenuating the inflammatory response.

关键词： Tanreqing Injection influenza virus anti-inflammation mitophagy nucleotide-binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome Chinese medicine

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Electronic band structures of topological kagome materials

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Chinese Physics B 2025年第1期34卷 29-44页

作者： Man Li huan Ma rui Lou Shancai Wang School of Information Network Security People’s Public Security University of ChinaBeijing 100038China Department of Physics Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education)and Beijing Key Laboratory of Opto-electronic Functional Materials&Micronano DevicesRenmin University of ChinaBeijing 100872China Leibniz Institute for Solid State and Materials Research IFW Dresden01069 DresdenGermany Helmholtz-Zentrum Berlin fur Materialien und Energie Albert-Einstein-Strabe 1512489 BerlinGermany Joint Laboratory“Functional Quantum Materials”at BESSY II 12489 BerlinGermany

The kagome lattice has garnered significant attention due to its ability to host quantum spin Fermi liquid ***,the combination of unique lattice geometry,electron–electron correlations,and adjustable magnetism in solid kagome materials has led to the discovery of numerous fascinating quantum *** include unconventional superconductivity,charge and spin density waves(CDW/SDW),pair density waves(PDW),and Chern insulator *** emergent states are closely associated with the distinctive characteristics of the kagome lattice's electronic structure,such as van Hove singularities,Dirac fermions,and flat bands,which can exhibit exotic quasi-particle excitations under different symmetries and magnetic ***,various quantum kagome materials have been developed,typically consisting of kagome layers stacked along the z-axis with atoms either filling the geometric centers of the kagome lattice or embedded between the *** this topical review,we begin by introducing the fundamental properties of several kagome *** gain an in-depth understanding of the relationship between topology and correlation,we then discuss the complex phenomena observed in these *** include the simplest kagome metal T_(3)X,kagome intercalation metal T X,and the ternary compounds AT_(6)X_(6)and RT_(3)X_(5)(A=Li,Mg,Ca,or rare earth;T=V,Cr,Mn,Fe,Co,Ni;X=Sn,Ge;R=K,Rb,Cs).Finally,we provide a perspective on future experimental work in this field.

关键词： kagome lattice quasi-particle excitation electronic correlation magnetism

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Network pharmacology and in vivo study:Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis

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World Journal of Gastroenterology 2025年第9期31卷 83-99页

作者： Yan qin rui-Ya Zhang Yu Zhang Yi-qing Zhao Hai-Feng Hao Jun-Ping Wang Department of Gastroenterology Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current *** Chinese medicine(TCM),known for its multi-stage and multi-targeted approach,has a long history in treating gastrointestinal diseases and offering a promising alternative UC *** ginseng(***),a commonly used remedy for UC in TCM,exemplifies this potential,although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated,highlighting the need for further research to unlock its full potential as a treatment *** To investigate the key constituents and biological pathways through which *** exerts therapeutic effects on *** Network pharmacology investigated the UC-alleviating mechanism of ***,including“active ingredient-target-disease”network analysis,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment ***(PD;active ingredient of ***)was tested in a mouse model of 3%dextran sulfate sodium-induced UC,with assessments of body weight,Disease Activity Index scores,and colon *** and intestinal barrier integrity were analyzed via hematoxylin-eosin and Alcian blue and periodic acid-Schiff staining,immunohistochemistry,real time-quantitative PCR,and western *** By integrating and analyzing the targets of *** and UC,15 critical hub genes were *** Encyclopedia of Genes and Genomes pathway analysis revealed the mechanisms involved to be linked to MAPK and PI3K-Akt *** the 10 main active ingredients identified as potentially effective,PD was most abundant and was validated in vivo to mitigate weight loss,reduce Disease Activity Index scores,and prevent colon *** also reduced inflammation and suppressed expression of pro-inflammatory cytokines and me

关键词： Ulcerative colitis Panax ginseng Network pharmacology Panaxadiol MAPK NF-κB AMPK NRF2

The long noncoding RNA ALEX1 confers a functional phase state of ARF3 to enhance rice resistance to bacterial pathogens

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Molecular Plant 2025年第1期18卷 114-129页

作者： Meng-Qi Lei rui-rui He Yan-Fei Zhou Lu Yang Zhen-Fei Zhang Chao Yuan Wen-Long Zhao Yu Cheng Jian-Ping Lian Yu-Chan Zhang Wen-Tao Wang Yang Yu Yue-qin Chen Guangdong Provincial Key Laboratory of Plant Stress Biology State Key Laboratory for BiocontrolSchool of Life SciencesSun Yat-Sen UniversityGuangzhou 510275P.R.China Guangdong Key Laboratory of Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China Plant Protection Research Institute Guangdong Academy of Agricultural SciencesGuangzhou 510640P.R.China

Rice bacterial blight is a devastating disease worldwide,causing significant yield *** how plants defend against microbial infection is critical for sustainable crop *** this study,we show that ALEX1,a previously identified pathogen-induced long noncoding RNA,localizes to the nucleus and directly binds AUXIN RESPONSE FACTOR 3(ARF3).We showed that ARF3 forms the condensates in the nucleus via its intrinsically disordered middle region(MR),and that these ARF3 condensates display solid-like *** further revealed that ALEX1 directly binds the MR of ARF3 to regulate ARF3 condensate dynamics and promote ARF3 *** dispersed,dimeric form of ARF3,referred to as its functional phase state,enhances its ability to transcriptionally repress the expression of downstream target genes such as JAZ13,thereby modulating the jasmonic acid signaling pathway and enhancing pathogen resistance in ***,this study reveals the role of a long noncoding RNA in regulating protein condensation and complex assembly,thus contributing to plant pathogen resistance.

关键词： lncRNA Xoo ARF3 protein condensates

Precise spectroscopy of metastable Li plus using the optical Ramsey technique in support of time dilation tests

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PHOTONICS RESEARCH 2025年第1期13卷 201-209页

作者： Zhou, Peng-peng Chen, Shao-long qin, Cheng-gang Chang, Xu-rui Zhou, Zhi-qiang Sun, Wei huang, Yao Gao, Ke-lin Guan, Hua Chinese Acad Sci Innovat Acad Precis Measurement Sci & Technol State Key Lab Magnet Resonance & Atom & Mol Phys Wuhan 430071 Peoples R China Informat Engn Univ Zhengzhou 450001 Peoples R China Chinese Acad Sci Key Lab Time Reference & Applicat Wuhan 430206 Peoples R China Huazhong Univ Sci & Technol MOE Key Lab Fundamental Phys Quant Measurement Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Hubei Key Lab Gravitat & Quantum Phys PGMF Wuhan 430074 Peoples R China Huazhong Univ Sci & Technol Sch Phys Wuhan 430074 Peoples R China Univ Chinese Acad Sci Beijing 100049 Peoples R China Chinese Acad Sci Qinghai Inst Salt Lakes Key Lab Green & High end Utilizat Salt Lake Resour Xining 810008 Peoples R China Wuhan Inst Quantum Technol Wuhan 430206 Peoples R China

Time dilation constitutes a crucial aspect of Lorentz invariance within special relativity and undergoes constant scrutiny through numerous Ives-Stilwell-type experiments employing the Doppler effect. In our study, we employed optical Ramsey spectroscopy on a Li+ ion beam to enhance the precision of measuring the intrinsic transition frequency 23S1 - 23P2 to the level of four parts in 1010 with speed of 0.00035c. Our findings reconciled an existing 2 MHz disparity between collinear and perpendicular laser spectroscopy. Furthermore, in conjunction with previous studies on Li+ ion beams traveling at speeds of 0.064c and 0.338c [Nat. Phys. 3, 861 (2007);Phys. Rev. Lett. 113, 120405 (2014)], we updated the Robertson-Mansouri-Sexl parameter alpha to be (-10.0 f 9.9) x 10-8 and (-2.9 f 2.0) x 10-8, respectively. (c) 2024 Chinese Laser Press

关键词： Doppler effect Frequency combs Laser beams Nodal aberration theory Optical clocks Optical fields

Enhanced mechanical squeezing in an optomechanical system via backward stimulated Brillouin scattering

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Chinese Physics B 2025年第1期34卷 315-322页

作者： Shan-Shan Chen Yi-Long Xie Jing-Jing Zhang Na-Na Zhang Yong-rui Guo huan Yang Yong Ma School of Optoelectronic Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065China China Electronics Technology Group Corporation 44th Research Institute Chongqing 400065China

We investigate theoretically the enhancement of mechanical squeezing in a multimode optomechanical system by introducing a coherent phonon–photon interaction via the backward stimulated Brillouin scattering(BSBS)*** coherent photon–phonon interaction where two optical modes couple to a Brillouin acoustic mode with a large decay rate provides an extra channel for the cooling of a Duffing mechanical *** squeezing degree and the robustness to the thermal noises of the Duffing mechanical mode can be enhanced *** the Duffing nonlinearity is weak,the squeezing degree of the mechanical mode in the presence of BSBS can be improved by more than one order of magnitude compared with that in the absence of *** scheme may be extended to other quantum systems to study novel quantum effects.

关键词： mechanical squeezing optomechanical system backward stimulated Brillouin scattering Duffing nonlinearity

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细胞工厂设计数字化赋能绿色生物制造

中国科学院院刊 2025年第1期40卷 67-78页

作者：孟繁泽曹锐胡冰秦磊李春清华大学化学工程系北京100084 清华大学工业生物催化教育部重点实验室北京100084 清华大学合成与系统生物学中心北京100084 新疆大学智能科学与技术学院(未来技术学院) 乌鲁木齐830049 北京理工大学化学与化工学院生物化工研究所/医药分子科学与制剂工程工信部重点实验室北京100081

绿色制造是一种综合考虑环境影响与资源效益的现代化制造模式,而绿色生物制造是绿色制造的重要方式之一,是新质生产力的重要组成部分。绿色生物制造以细胞工厂为核心,利用可再生资源,实现化学品的低碳、绿色、可持续的高效生产。其中,... 详细信息

绿色制造是一种综合考虑环境影响与资源效益的现代化制造模式,而绿色生物制造是绿色制造的重要方式之一,是新质生产力的重要组成部分。绿色生物制造以细胞工厂为核心,利用可再生资源,实现化学品的低碳、绿色、可持续的高效生产。其中,高性能细胞工厂的设计是实现高效绿色生物制造的重中之重。传统细胞工厂设计过程复杂,耗时耗力。随着人工智能领域的发展,数字化辅助细胞工厂设计节约了时间和成本。通过数据库构建与更新、代谢流调控数字化设计、目标分子逆合成途径数字化设计、基因线路数字化设计、发酵工艺数字孪生等技术的组合可实现全生命周期数字化细胞工厂的设计,指导高性能细胞工厂的快速构建与优化,赋能绿色生物制造。

关键词：新质生产力绿色生物制造细胞工厂数字化合成生物学

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