检索结果-南通市图书馆

Clinical effects of apatinib mesylate for treatment of multiple brain micrometastases:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第7期8卷 1326-1336页

作者： Jun-Hui Guo Yuan-Yuan Wang Jiang-Wei Zhang Pei-Min Liu Yan-Jun Hao hai-rui duan Department of Oncology The Second Affiliated Hospital of Henan University of Chinese MedicineHenan Province Hospital of TCMZhengzhou 450002Henan ProvinceChina

BACKGROUND Apatinib is a small-molecule multitargeted tyrosine kinase *** has demonstrated encouraging antitumor *** study aimed to observe the efficacy and safety of apatinib for the treatment of multiple brain *** SUMMARY We report two patients with multiple brain micrometastases after failure of second-line *** patients had extracerebral *** the patients took 250 mg/d apatinib orally,the intracerebral lesions *** extracerebral lesions were partially *** patients had a progressionfree survival of more than 12 mo and were still *** safety was *** main adverse events(AEs)were mild hypertension and proteinuria,which could be *** Apatinib has clear efficacy and good tolerance in patients with multiple brain micrometastases after failure of second-line treatment.

关键词： Esophageal squamous cell carcinoma Cervical adenocarcinoma Brain micrometastases Apatinib Tyrosine kinase inhibitor Vascular endothelial growth factor

Projectile fragment emission in the fragmentation of 56Fe on Al,C,and CH2 targets

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2019年第12期30卷 119-129页

作者： Luo-Huan Wang Liang-Di Huo Jia-Huan Zhu hai-rui duan Jing-Ya Wu Hui-Ling Li Jun-Sheng Li S.Kodaira N.Yasuda Dong-hai Zhang Institute of Modern Physics Shanxi Normal UniversityLinfen 041004China Radiation Measurement Research Section National Institute of Radiological ScienceChiba 263-8555Japan Research Institute of Nuclear Engineering University of FukuiFukui 914-0055Japan

The emission angle distribution of projectile fragments(PFs)and the temperature of PF emission sources for fragmentation of 56Fe on polyethylene,carbon,and aluminum targets at the highest energy of 497 A MeV are investigated on the basis of corrected data,using a CR-39 plastic nuclear track *** is found that the average emission angle of PFs increases with the decrease in PF charge for the same target,and no obvious dependence of angular distribution on the mass of the target nucleus is found for the same *** cumulative squared transverse momentum distribution of PFs can be well represented by a single Rayleigh *** temperature of PF emission sources is extracted from the distribution,and it is about 1.0-8.0 MeV and does not depend on the mass of the target for PFs with charges of 9≤Z≤25.

关键词： Heavy-ion collision Projectile fragmentation Nuclear temperature CR-39 plastic nuclear track detector

维普期刊数据库

Encapsulating lipase on the surface of magnetic ZIF-8 nanosphers with mesoporous SiO2 nano-membrane for enhancing catalytic performance

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第2期36卷 279-283页

作者： Guang-Xu duan Queting Chen rui-rui Shao Hui-Huang Sun Tong Yuan Dong-Hao Zhang College of Pharmaceutical Science Hebei University Affiliated Hospital of Hebei University Key Laboratory of Pharmaceutical Quality Control of Hebei Province College of Pharmaceutical ScienceHebei University Institute of Life Science and Green Development Hebei University

The preparation of immobilized enzyme with excellent performance is one of the difficulties that restrict the application of enzyme catalysis technology. Here, Candida rugosa lipase（CRL） was firstly adsorbed on the surface of magnetic zeolitic imidazolate framework-8（ZIF-8） nanospheres, which was further encapsulated with a mesoporous SiO2nano-membrane formed by tetraethyl orthosilicate（TEOS） polycondensation. Consequently, lipase could be firmly immobilized on carrier surface by physical binding rather than chemical binding, which did not damage the active conformation of enzyme. There were mesopores on the silica nano-membrane, which could improve the accessibility of enzyme and its apparent catalytic activity. Moreover, silica membrane encapsulation could also improve the stability of enzyme, suggesting an effective enzyme immobilization strategy. It showed that TEOS amount and the encapsulation time had significant effects on the thickness of silica membrane and the enzyme activity. The analysis in enzyme activity and protein secondary structure showed that lipase encapsulated in silica membrane retained the active conformation to the greatest extent. Compared with the adsorbed lipase, the encapsulated lipase increased its thermostability by 3 times and resistance to chemical denaturants by 7 times. The relative enzyme activity remained around 80% after 8 repetitions, while the adsorbed lipase only remained at7.3%.

关键词： Encapsulation Enzyme immobilization Lipase activity Mesoporous silica membrane ZIF-8

Mechanism study of the molluscicide candidate PBQ on Pomacea canaliculata using a viscosity-sensitive fluorescent probe

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2025年第1期36卷 447-452页

作者： Lanyun Zhang Weisi Wang Yu-Qiang Zhao rui Huang Yuxun Lu Ying Chen Liping duan Ying Zhou Yunnan Characteristic Plant Extraction Laboratory College of Chemical Science and TechnologyYunnan UniversityKunming 650091China National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionChinese Center for Tropical Diseases ResearchWHO Centre for Tropical DiseasesNational Key Laboratory of Inteligent Tracking and Forecasting for Infectious DiseasesKey Laboratory on Parasite and Vector Biology MinistryofHealthShanghai200025China

PBQ[1-(4-chlorophenyl)-3-(pyridin-3-yl)urea],an enormous potent molluscicide,showed excellent Pomacea canaliculata(***)control activity and low toxicity for other aquatic organisms,but its snail-killing mechanisms are still not fully *** employed an optical method to elucidate PBQ action via a novel fluorescent viscosity probe,*** the viscosity in the test solutions increased,compared with that in pure ethanol,a 54-fold fluorescence intensity enhancement of NCV was observed in 310 cP of 90%***,NCV successfully exhibited a selective fluorescence response towards monensin-induced cellular viscosity changes in HepG2 *** liver,stomach,and foot plantar of the tested snails were frozen and sectioned for fluorescent imaging experiments after the treatment with different PBQ concentrations over various times.A significant fluorescent increase in the snail's liver was observed upon exposure to 0.75 mg/L PBQ for 72 h,which highlighted an increase in *** and eosin(HE)staining further supported PBQ-induced liver damage with a viscosity increase in *** study provides a new rapid optical visualization method to study the killing mechanisms of PBQ and may help discover new chemicals that control snail populations.

关键词： Fluorescence sensor Viscosity Pomacea canaliculata Molluscicide mechanisms Bio-imaging

维普期刊数据库

Predicting the efficiency of arsenic immobilization in soils by biochar using machine learning

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2025年第1期147卷 259-267页

作者： Jin-Man Cao Yu-Qian Liu Yan-Qing Liu Shu-Dan Xue hai-Hong Xiong Chong-Lin Xu Qi Xu Gui-Lan duan State Key Lab of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou 450052China University of Chinese Academy of Sciences Beijing 100049China

Arsenic(As)pollution in soils is a pervasive environmental *** immobilization offers a promising solution for addressing soil As *** efficiency of biochar in immobilizing As in soils primarily hinges on the characteristics of both the soil and the ***,the influence of a specific property on As immobilization varies among different studies,and the development and application of arsenic passivation materials based on biochar often rely on empirical *** enhance immobilization efficiency and reduce labor and time costs,a machine learning(ML)model was employed to predict As immobilization efficiency before biochar *** this study,we collected a dataset comprising 182 data points on As immobilization efficiency from 17 publications to construct three ML *** results demonstrated that the random forest(RF)model outperformed gradient boost regression tree and support vector regression models in predictive *** importance analysis and partial dependence plots based on the RF model were conducted to identify the most crucial factors influencing As *** findings highlighted the significant roles of biochar application time and biochar pH in As immobilization efficiency in ***,the study revealed that Fe-modified biochar exhibited a substantial improvement in As *** insights can facilitate targeted biochar property design and optimization of biochar application conditions to enhance As immobilization efficiency.

关键词： Biochar Arsenic immobilization Soil Machine learning

Effect of h-BN rods on high-temperature properties of alumina-carbon refractory

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2025年第1期32卷 115-128页

作者： Ya-ge Li Shuai-bing Wu Feng Liang Zhong Huang Tu Long Long Dong Jun-yi Lv Hong-juan duan Biao Wen Yong Liu hai-jun Zhang The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan430081HubeiChina Sinosteel Luoyang Institute of Refractories Research Co. Ltd.Luoyang471039HenanChina

h-BN rods modified low-carbon alumina-carbon(Al_(2)O_(3)-C)refractories were prepared,and the effect of h-BN rod addition on the high-temperature properties was investigated and compared with commercial h-BN flake,carbon black,and carbon nanotubes *** results demonstrated that Al_(2)O_(3)-C refractories containing h-BN rods exhibited optimal high-temperature service performances,including 25%higher hot modulus of rupture,21.3%higher thermal shock strength residual ratio,20.9%lower in oxidation and 44.3%less in slag corrosion,compared to the counterpart specimens without ***,benefiting from the synergistic enhancement of the rod-like h-BN and in-situ generated SiC whiskers,the high-temperature service performances of h-BN rods containing specimens outperformed counterpart specimens containing commercial h-BN flake,carbon black,and carbon nanotubes,respectively.

关键词： Al_(2)O_(3)-C refractory h-BN rod Microstructure High-temperature service performance

Spin-modulated near-infrared-Ⅰ emission in a xanthene-decorated Fe(Ⅱ) spin-crossover complex

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Cheng Yi Duyong Chen Shihui Zhang rui Cai Chunying duan Yinshan Meng Tao Liu State Key Laboratory of Fine Chemicals Frontier Science Center for Smart Materials and Chemical Engineering School of Chemical Engineering Dalian University of Technology Instrumental Analysis Center Dalian University of Technology School of Chemistry Dalian University of Technology Liaoning Binhai Laboratory

Molecular materials showing synergetic coupling of near-infrared （NIR） fluorescence and spin-crossover （SCO） are promisingly applicable in in-vivo bioimaging,temperature sensing,and spintronic *** the related study faces formidable *** this work we graft the NIR fluorophore xanthene onto the dipyridyl substituted triazole ligand and construct a new Febased SCO material,{FeⅡ（ddxc-abpt）2[N（CN）2]2}(1,ddxc-abpt:（E）-4-(((3,5-di（pyridin-2-yl）-4H-1,2,4-triazol-4-yl)imino)methyl)-N,N-diethyl-2,3-dihydro-1H-xanthen-6-amine).Magnetic studies indicate that compound 1 exhibits thermally induced SCO property in both the solid and solution ***-temperature fluorescence emission spectra reveal a remarkable 7-fold increase in photoluminescence intensity upon the transition from the low-spin state at 110 K to the high-spin state at 280 K,which is the record of all reported coupled fluorescence-SCO ***-temperature ultraviolet-visible （UV-Vis）absorption spectra show a significant change in absorption intensity within the fluorescence emission window,consistent with the F?rster resonance energy transfer （FRET） ***-dependent density functional theory （TD-DFT） calculations demonstrate that the strong coupling is attributed to disrupted energy transfer between the xanthene fluorophore and high-spin *** work provides a feasible approach for expanding the synergetic SCO-fluorescence materials to the NIR-Iwavelength region,and hopefully contributes to the applications of tunable NIR-SCO molecule-based sensors and devices.

关键词：

Network pharmacology and in vivo study:Unraveling the therapeutic mechanisms of Panax ginseng in potentially treating ulcerative colitis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第9期31卷 83-99页

作者： Yan Qin rui-Ya Zhang Yu Zhang Yi-Qing Zhao hai-Feng Hao Jun-Ping Wang Department of Gastroenterology Shanxi Provincial People’s Hospital Affiliated to Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina Department of Urology The First Hospital of Shanxi Medical UniversityTaiyuan 030012Shanxi ProvinceChina

BACKGROUND Ulcerative colitis(UC),a chronic and challenging condition,necessitates the development of more effective treatments owing to the unsatisfactory efficacy and side effects associated with current *** Chinese medicine(TCM),known for its multi-stage and multi-targeted approach,has a long history in treating gastrointestinal diseases and offering a promising alternative UC *** ginseng(***),a commonly used remedy for UC in TCM,exemplifies this potential,although the specific components and mechanisms through which its therapeutic effects are exerted remain to be fully elucidated,highlighting the need for further research to unlock its full potential as a treatment *** To investigate the key constituents and biological pathways through which *** exerts therapeutic effects on *** Network pharmacology investigated the UC-alleviating mechanism of ***,including“active ingredient-target-disease”network analysis,and Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment ***(PD;active ingredient of ***)was tested in a mouse model of 3%dextran sulfate sodium-induced UC,with assessments of body weight,Disease Activity Index scores,and colon *** and intestinal barrier integrity were analyzed via hematoxylin-eosin and Alcian blue and periodic acid-Schiff staining,immunohistochemistry,real time-quantitative PCR,and western *** By integrating and analyzing the targets of *** and UC,15 critical hub genes were *** Encyclopedia of Genes and Genomes pathway analysis revealed the mechanisms involved to be linked to MAPK and PI3K-Akt *** the 10 main active ingredients identified as potentially effective,PD was most abundant and was validated in vivo to mitigate weight loss,reduce Disease Activity Index scores,and prevent colon *** also reduced inflammation and suppressed expression of pro-inflammatory cytokines and me

关键词： Ulcerative colitis Panax ginseng Network pharmacology Panaxadiol MAPK NF-κB AMPK NRF2

Risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Surgery 2025年第3期17卷 240-248页

作者： Jia-rui Liu Jin Zhang Xiang-Long duan The Second Department of General Surgery Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Health Science Center Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of Clinical Nutrition Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina Institute of Medical Research Northwestern Polytechnical UniversityXi'an 710072Shaanxi ProvinceChina Second Department of General Surgery Third Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710068Shaanxi ProvinceChina

BACKGROUND The surgical management of rectal cancer is continuously advancing,with a current emphasis on minimising the need for a permanent *** the risk factors influencing sphincter preservation is crucial for guiding clinical decision-making and optimising preoperative patient *** To examine the risk factors influencing sphincter preservation in laparoscopic radical rectal cancer *** A retrospective analysis of the demographics,preoperative and intraoperative data,and pathological findings of 179 patients with rectal cancer who underwent laparoscopic radical rectal cancer surgery at our hospital between January 2022 and December 2023 was *** clinical data were compared between two groups:Patients with sphincter preservation and those without,categorised as the sphincter-preserved and sphincter-unpreserved groups,*** Of the 179 patients analysed,150 were in the sphincter-preserved group and 29 were in the sphincter-unpreserved *** height was significantly greater in the sphincter-preserved group compared to the sphincter-unpreserved ***,elevated levels of carcinoembryonic antigen,carbohydrate antigen 19-9,and plasma D-dimer were significantly higher in the sphincter-unpreserved *** differences were also observed between the two groups in terms of place of residence,presence of colonic polyps,neoadjuvant chemotherapy,preoperative radiotherapy,mucinous adenocarcinoma,nerve invasion,and tumour *** significant differences were observed for other *** regression analysis identified colonic polyps,mucinous adenocarcinoma,nerve invasion,and tumour height as independent risk factors for sphincter *** Several risk factors influencing sphincter preservation in laparoscopic radical rectal cancer surgery were *** factors could be valuable tools for guiding clinical decision-making and optimising preoperative patient eva

关键词： Rectal cancer Laparoscopic surgery Sphincter preservation Risk factors Preoperative evaluation