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Cotransfecting norepinephrine transporter and vesicular monoamine transporter 2 genes for increased retention of metaiodobenzylguanidine labeled with iodine 131 in malignant hepatocarcinoma cells

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Frontiers of Medicine 2017年第1期11卷 120-128页

作者： Yanlin zhao Xiao Zhong Xiaohong Ou Huawei Cai Xiaoai Wu rui Huang Department of Nuclear Medicine West China Hospital Sichuan University Chengdu 610041 China

Norepinephrine transporter （NET） transfection leads to significant uptake of iodine-131-labeled metaiodobenzylguanidine （^131I-MIBG） in non-neuroendocrine tumors. However, the use of ^131I-MIBG is limited by its short retention time in target cells. To prolong the retention of ^131I-MIBG in target cells, we infected hepatocarcinoma （HepG2） cells with Lentivirus-encoding human NET and vesicular monoamine transporter 2 （VMAT2） genes to obtain NET-expressing, NET-VMAT2-coexpressing, and negative-control cell lines. We evaluated the uptake and efflux of 131I-MIBG both in vitro and in vivo in mice bearing transfected tumors. NET- expressing and NET-VMAT2-coexpressing cells respectively showed 2.24 and 2.22 times higher ^131I-MIBG uptake than controls. Two hours after removal of ^131I-MIBG-containing medium, 25.4% efflux was observed in NET- VMAT2-coexpressing cells and 38.6% in NET-expressing cells. In vivo experiments were performed in nude mice bearing transfected tumors; results revealed that NET-VMAT2-coexpressing tumors had longer ^131I-MIBG retention time than NET-expressing tumors. Meanwhile, NET-VMAT2-coexpressing and NET-expressing tumors displayed 0.54% and 0.19%, respectively, of the injected dose per gram of tissue 24 h after ^131I-MIBG administration. Cotransfection of HepG2 cells with NET and VMAT2 resulted in increased ^131I-MIBG uptake and retention. However, the degree of increase was insufficient to be therapeutically effective in target cells.

关键词： norepinephrine transporter vesicular monoamine transporter 2 ^131I-MIBG gene therapy lentivims vector

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Microwave assisted one-pot synthesis of novel molecular clefts with only one chiral arm based on deoxycholic acid

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Chinese Chemical Letters 2008年第1期19卷 33-36页

作者： BiTao Zeng zhi Gang zhao Xing Li Liu Yun Shi College of Chemistry and Environmental Protection Engineering Southwest University for Nationalities Chengdu 610041 China

A rapid, safe, and efficient method for the synthesis of novel molecular clefts based on deoxycholic acid was reported. Seven new molecular clefts have been synthesized in good yields （89-98%）. This method proved to be extremely simple and highly efficient. The structures of these receptors were confirmed by 1H NMR, IR, MS spectra and elemental analysis. 2007 zhi Gang zhao. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

关键词： Molecular cleft Deoxycholic acid Microwave irradiation Recognition

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三嗪类污染物光催化降解研究进展

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稀有金属 2023年第1期47卷 90-104页

作者：赵子龙闫蕊曲阳井立强黑龙江大学化学化工与材料学院功能无机化学教育部重点实验室黑龙江哈尔滨150080 哈尔滨师范大学化学化工学院黑龙江哈尔滨150500

三嗪类污染物是农业生产中广泛存在的环境激素类农药,其广泛且稳定的环境残留对生物体通常造成不可逆的伤害。利用光催化技术降解三嗪类污染物具有廉价、效率高、环保可持续等优势。研究发现,不同光催化剂材料降解不同结构的三嗪类污染... 详细信息

三嗪类污染物是农业生产中广泛存在的环境激素类农药,其广泛且稳定的环境残留对生物体通常造成不可逆的伤害。利用光催化技术降解三嗪类污染物具有廉价、效率高、环保可持续等优势。研究发现,不同光催化剂材料降解不同结构的三嗪类污染物的光催化机制各不相同。目前,对于三嗪类污染物的结构性质缺少总结,对于光催化降解机制,还缺乏系统的总结和归纳。基于此,本文系统总结了三嗪类污染物的理化性质,以活性物种(ROS)进行分类,归纳了羟基自由基(·OH)、超氧自由基(·O_(2)^(-))、空穴(h^(+))、单线态氧(1O_(2))及多活性物种协同的五种光催化降解机制,总结了光催化剂能带结构与所产生的活性物种之间的关联,以及不同活性物种对污染物降解机制的影响。探讨了降解三嗪类污染物的机制探究的欠缺及研究难点,展望了今后光催化降解三嗪类污染物可能的研究方向和重点。

关键词：三嗪类污染物光催化活性物种降解机制

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Deforming generalized cylinders without self-intersection by means of a parametric center curve

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Computational Visual Media 2018年第4期4卷 305-321页

作者： ruibin Ma Qingyu zhao rui Wang James Damon Julian Rosenman Stephen Pizer Computer Science University of North Carolina at Chapel Hill Mathematics University of North Carolina at Chapel Hill Radiation Oncology University of North Carolina at Chapel Hill

Large-scale deformations of a tubular object, or generalized cylinder, are often defined by a target shape for its center curve, typically using a parametric target curve. This task is non-trivial for free-form deformations or direct manipulation methods because it is hard to manually control the centerline by adjusting control points. Most skeleton-based methods are no better, again due to the small number of manually adjusted control points. In this paper, we propose a method to deform a generalized cylinder based on its skeleton composed of a centerline and orthogonal cross sections. Although we are not the first to use such a skeleton, we propose a novel skeletonization method that tries to minimize the number of intersections between neighboring cross sections by means of a relative curvature condition to detect intersections. The mesh deformation is first defined geometrically by deforming the centerline and mapping the cross sections. Rotation minimizing frames are used during mapping to control twisting. Secondly, given displacements on the cross sections, the deformation is decomposed into finely subdivided regions. We limit distortion at these vertices by minimizing an elastic thin shell bending energy,in linear time. Our method can handle complicated generalized cylinders such as the human colon.

关键词： generalized cylinder deformation skeleton self-intersection

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Slope excavation quality assessment and excavated volume calculation in hydraulic projects based on laser scanning technology

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Water Science and Engineering 2015年第2期8卷 164-173页

作者： Chao Hu Yi-hong Zhou Chun-ju zhao zhi-guo Pan School of Water Resources and Hydropower Engineering Wuhan University College of Hydraulic and Environmental Engineering China Three Gorges University Collaborative Innovation Center for Geo-Hazards and Eco-Environment in Three Gorges Area

Slope excavation is one of the most crucial steps in the construction of a hydraulic project. Excavation project quality assessment and excavated volume calculation are critical in construction management. The positioning of excavation projects using traditional instruments is inefficient and may cause error. To improve the efficiency and precision of calculation and assessment, three-dimensional laser scanning technology was used for slope excavation quality assessment. An efficient data acquisition, processing, and management workflow was presented in this study. Based on the quality control indices, including the average gradient, slope toe elevation, and overbreak and underbreak,cross-sectional quality assessment and holistic quality assessment methods were proposed to assess the slope excavation quality with laserscanned data. An algorithm was also presented to calculate the excavated volume with laser-scanned data. A field application and a laboratory experiment were carried out to verify the feasibility of these methods for excavation quality assessment and excavated volume calculation. The results show that the quality assessment indices can be obtained rapidly and accurately with design parameters and scanned data, and the results of holistic quality assessment are consistent with those of cross-sectional quality assessment. In addition, the time consumption in excavation quality assessment with the laser scanning technology can be reduced by 70%e90%, as compared with the traditional method. The excavated volume calculated with the scanned data only slightly differs from measured data, demonstrating the applicability of the excavated volume calculation method presented in this study.

关键词： Slope excavation Quality assessment Volume calculation Three-dimensional laser scanning technology

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Development potential and technical strategy of continental shale oil in China

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Petroleum Exploration and Development 2020年第4期47卷 877-887页

作者： HU Suyun zhao Wenzhi HOU Lianhua YANG zhi ZHU Rukai WU Songtao BAI Bin JIN Xu Research Institute of Petroleum Exploration&Development PetroChinaBeijing 100083China

Continental shale oil is a general term for liquid hydrocarbons and many kinds of organic matter in continental organic-rich shale series with vitrinite reflectance of more than 0.5%at buried depth of more than 300 m,and is an important type of source-rock oil and *** on the evolution model of oil generation and expulsion in organic-rich shale series controlled by maturity,continental shale oil is divided into two types:medium-high maturity and medium-low maturity.(1)The continental shale series in China develop high-quality source rocks of freshwater and saltwater lacustrine facies,as well as multiple types of reservoirs,including clastic rocks,carbonate rocks,diamictite,tuff and shale,forming a number of"sweet sections"and"sweet areas"of continuous distribution inside or near source rocks,which have large scale resources.(2)Experimental analysis of organic rich shale samples shows that the shale samples with wavy and horizontal beddings have good storage conditions,and the horizontal permeability of shale is tens to hundreds of times of its vertical permeability,which is conducive to the lateral migration and accumulation of shale oil in the source rocks.(3)After evaluation,the geological resources of medium-high maturity shale oil are about 10 billion tons,which can be effectively developed by horizontal drilling and volumetric fracturing,and will be a practical field of oil exploration in recent *** oil with medium and low maturity has huge resource potential,and technological recoverable resources of(70?90)billion tons,making it a strategic alternative resource of oil ***,economic development of this type of shale oil needs in-situ conversion technology *** shale oil is an inevitable choice in the process of Chinese continental petroleum exploration from"outside source"to"inside source".Making breakthroughs in the core technologies such as"sweet area"evaluation and optimization,horizontal well volume fracturing a

关键词： continental facies shale oil resource potential sweet section sweet area key technologies petroleum exploration inside source kitchen

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Landfill leachate production, quality and recirculation treatment in northeast China

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Journal of Environmental Sciences 2006年第4期18卷 625-628页

作者： zhao Qing-liang LIU Xue-yan QI Xu-dong LIU zhi-gang School of Municipal and Environment Engineering Harbin Institute of Technology Harbin 150090 China

Landfill leachate recirculation treatment process is a promising and economic way in northeast China due to the distinct season variation. In order to study the impact of recirculation on leachate production and its quality, two simulated sanitary landfill reactors, one with leachate recirculation and the other without, were placed outdoor in Harbin. The two-year experimental results indicated that leachate production was reduced by 86% with leachate recirculation and less or no facility for leachate treatment required. Recirculation could improve the leachate quality dramatically with lower COD, SS, NF4-N and higher pH level. Recirculation also could enhance waste degradation and stabilization and improve the efficiency of landfill. This study confirmed that leachate recirculation was a very feasible way for on-site landfill leachate treatment in cold areas.

关键词： cold area sanitary landfill leachate recirculation solid waste

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A methodology for 3D modeling and visualization of geological objects

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Science China Earth Sciences 2009年第7期52卷 1022-1029页

作者： ZHANG LiQiang TAN YuMin KANG zhiZhong rui XiaoPing zhao YuanYuan LIU Liu State Key Laboratory of Remote Sensing Science Sponsored by Beijing Normal University Beijing 100875China School of Transportation Science and Engineer Beijing University of Aeronautics and AstronauticsBeijing 100083China Department of Geodesy and Geomatics School of Land Science and TechnologyChina University of GeosciencesBeijing 100083China College of Resources and Environment Graduate University of Chinese Academy of SciencesBeijing 100049China

Geological body structure is the product of the geological evolution in the time dimension, which is presented in 3D configuration in the natural world. However, many geologists still record and process their geological data using the 2D or 1D pattern, which results in the loss of a large quantity of spatial data. One of the reasons is that the current methods have limitations on how to express underground geological objects. To analyze and interpret geological models, we present a layer data model to organize different kinds of geological datasets. The data model implemented the unification expression and storage of geological data and geometric models. In addition, it is a method for visualizing large-scaled geological datasets through building multi-resolution geological models rapidly, which can meet the demand of the operation, analysis, and interpretation of 3D geological objects. It proves that our methodology is competent for 3D modeling and self-adaptive visualization of large geological objects and it is a good way to solve the problem of integration and share of geological spatial data.

关键词： geological object geological model network transmission visualization

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ANALYTICAL STUDY ON FLOW PROCESS OF FLOATING-OIL RECOVERY DEVICE FROM OIL-CONTAMINATED SEAWATER BY MHD METHOD

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Journal of Hydrodynamics 2007年第2期19卷 195-200页

作者： ZHANG Guo-yan PENG Yan zhao Ling-zhi LI Ran SHA Ci-wen Institute of Electrical Engineering Chinese Academy of Sciences Beijing 100080 China

A new method of recovering maritime oil-spill based on electromagnetic force, the so-called MHD oil-spill recovery method was proposed in the IEECAS. The operating process of MHD channel was described in this article. Numerical study was carried out using a two-dimensional water-air two-phase model and the VOF method. The agreement between the numerical and the experimental results was reached.

关键词： numerical simulation water-air two phaseflow VOF method MHD

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Functions and Application of the AP2/ERF Transcription Factor Family in Crop Improvement

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Journal of Integrative Plant Biology 2011年第7期53卷 570-585页

作者： zhao-Shi Xu Ming Chen Lian-Cheng Li You-zhi Ma National Key Facility of Crop Gene Resources and Genetic Improvement (NFCRI) Key Laboratory of Crop Genetics and Breeding Ministry of Agriculture Institute of Crop Science Chinese Academy of Agriculture Sciences (CAAS) Beijing 100081 China

Plants have acquired sophisticated stress response systems to adapt to changing environments. It is important to understand plants＇ stress response mechanisms in the effort to improve crop productivity under stressful conditions. The AP2/ERF transcription factors are known to regulate diverse processes of plant development and stress responses. In this study, the molecular characteristics and biological functions of AP2/ERFs in a variety of plant species were analyzed. AP2/ERFs, especially those in DREB and ERF subfamilies, are ideal candidates for crop improvement because their overexpression enhances tolerances to drought, salt, freezing, as well as resistances to multiple diseases in the transgenic plants. The comprehensive analysis of physiological functions is useful in elucidating the biological roles of AP2/ERF family genes in gene interaction, pathway regulation, and defense response under stress environments, which should provide new opportunities for the crop tolerance engineering.

关键词： AP2/ERF gene regulation signal pathway stress tolerance transgenic plant

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