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Bone destruction of orbital wall in idiopathic orbital inflammatory pseudotumor:does it always imply malignancy?

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1681-1688页

作者： Qi-Han Guo Xuan Zhang An-Qi Huang Ben-Tao Yang rui Liu Nan Wang liang-Yuan Xu Jian-Min Ma Department of Ophthalmology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China The Affiliated Tai’an City Central Hospital of Qingdao University Tai’an 271000Shandong ProvinceChina Department of Pathology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Radiology Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China

AIM:To assess the clinical presentations and outcomes of idiopathic orbital inflammatory pseudotumor(IOIP)patients with orbital wall bone destruction(OWBD)and to propose an expanded classification system that includes bone ***:The study retrospectively reviewed clinical presentations,imaging findings,treatment modalities,and outcomes of six patients diagnosed histopathologically with IOIP and OWBD at the Beijing Tongren Hospital,Capital Medical University between October 2018 and June ***:Over two years,6(10%)of 60 IOIP patients at our hospital exhibited OWBD,but this may overrepresent severe *** cohort consisted of three men and three women,aged 17 to 60y(mean 35.5±16.1y).Presenting symptoms included proptosis,eyelid swelling,decreased visual acuity with pain,and palpable *** revealed multiple anatomical structures involved with the medial wall being the most common site of bone *** examination showed classic type in five patients and sclerosing type in one *** patients underwent surgical resection followed by methylprednisolone ***-up(mean 30.3±3.1mo)indicated three patients had no recurrence,while others had varying degrees of symptom persistence or ***:IOIP with bone destruction is a rare but significant subtype that mimics malignancy,leading to potential diagnostic and therapeutic *** findings suggest that complete surgical resection combined with adjunctive glucocorticoid therapy can yield favorable ***,larger-scale studies are needed to further optimize therapeutic approaches.

关键词： idiopathic orbital inflammatory pseudotumor bone destruction orbital disease

Isovalent co-alloying contributes to considerable improvement in thermoelectric performance of BiSe bulks with weak anisotropy

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Journal of Materiomics 2024年第5期10卷 965-974页

作者： Fu Li Chen Liu Mohammad Nisar Jian Zhao Chongbin liang Junze Zhang Ziyuan Wang Zhuanghao zheng Ping Fan Xilin Wang zhen-Hua Ge Yue-Xing Chen Shenzhen Key Laboratory of Advanced Thin Films and Applications Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen518060GuangdongChina Kunming University of Science and Technology Kunming650093China Tsinghua Shenzhen International Graduate School Tsinghua UniversityShenzhen518060GuangdongChina

BiSe with intrinsic low thermal conductivity has considered as a promising thermoelectric(TE)material at nearly room *** improve its low thermoelectric figure of merit(zT),in this work,Sb and Te isovalent co-alloying was performed and significantly optimized its TE property with weakly anisotropic *** substituting Sb on Bi sites,the carrier concentration is suppressed by introduction of Sbsingle bond Se site defects,which contributes to the increased absolute value of Seebeck coefficient(|S|).Further co-alloying Te on Se of the optimized composition Bi_(0.7)Sb_(0.3)Se,the carrier concentration increased without affecting the|S|due to the enhanced effective mass,which leads to a highest power factor of 12.8μW/(cm·K^(2))at 423 *** a result,a maximum zT of∼0.54 is achieved for Bi_(0.7)Sb_(0.3)Se_(0.7)Te_(0.3) along the pressing direction and the average zT(zTave)(from 300 K to 623 K)are drastically improved from 0.24 for pristine BiSe sample to ***,an energy conversion efficiency∼4.0%is achieved for a single leg TE device of Bi_(0.7)Sb_(0.3)Se_(0.7)Te_(0.3)when applied the temperature difference of 339 K,indicating the potential TE application.

关键词： BiSe Isovalent alloying zT Carrier modulation

Medcheck:A novel software for automated de-formulation of traditional Chinese medicine(TCM)prescriptions by liquid chromatography-mass spectrometry

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Journal of Pharmaceutical Analysis 2024年第6期14卷 930-932页

作者： Xiao-lan Li Jian-qing Zhang Yun Li Xuan-jing Shen Huan-ya Yang Lin Yang Meng Xu Qi-rui Bi Chang-liang Yao De-an Guo Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Research Center of TCM Standardization TechnologyShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China b University of Chinese Academy of Sciences Beijing100049China

Prescriptions are the main clinical application of traditional Chinese medicines(TCMs).Common forms include Chinese patent medicines,Kampo formulas,and hospital decoctions.A new pre-scription called“famous classical formulas”is recently developed and expected to boom in the *** constituent me-dicinal plants in prescriptions is critical for new drug development and quality control[1],which could avoid safety issues from adulteration or substandard ingredients,as seen in the notorious Longdan Xiegan Pill event.

关键词： medicines formulation prescription

The 2^(nd)Asian Conference on Porphyrins,Phthalocyanines and Related Materials

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Chinese Chemical Letters 2024年第7期35卷 1-3页

作者： Gaojie Zhu zhen Yang Shijun Li Weihua Zhu rui Cao Junlong Zhang Jianzhang Zhao Jonathan L.Sessler Xunjin Zhu Jianxin Song Yongshu Xie Jianzhuang Jiang Key Laboratory for Advanced Materials and Institute of Fine Chemicals School of Chemistry and Molecular EngineeringEast China University of Science&TechnologyShanghai 200237China College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013China Key Laboratory of Applied Surface and Colloid Chemistry Ministry of EducationSchool of Chemistry and Chemical EngineeringShaanxi Normal UniversityXi'an 710119China Beijing National Laboratory for Molecular Sciences State Key Laboratory of Rare Earth Materials Chemistry and ApplicationsCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Fine Chemicals Frontier Science Center for Smart MaterialsSchool of Chemical EngineeringDalian University of TechnologyDalian 116024China Department of Chemistry The University of TexasAustinTexas 78712-1224United States Department of Chemistry and Institute of Advanced Materials Hong Kong Baptist UniversityHong Kong 999077China Key Laboratory of Chemical Biology and Traditional Chinese Medicine(Ministry of Educational of China) Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan ProvinceCollege of Chemistry and Chemical EngineeringHunan Normal UniversityChangsha 410081China Beijing Advanced Innovation Center for Materials Genome Engineering Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline MaterialsDepartment of Chemistry and Chemical EngineeringSchool of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijing 100083China

In the past decades,porphyrins,phthalocyanines and related materials have attracted significant attention due to their diverse and brilliant structures[1,2],as well as their unique electronic structures and photophysi... 详细信息

关键词： cyanine phthalocyanine Porphyrin

Performance of water-coupled charge blasting under different in-situ stresses

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Journal of Central South University 2024年第7期31卷 2300-2320页

作者： ZHOU Zi-long WANG zhen CHENG rui-shan CAI Xin LAN Ri-yan School of Resources and Safety Engineering Central South UniversityChangsha 410083China Center for Infrastructural Monitoring and Protection School of Civil and Mechanical EngineeringCurtin UniversityBentleyAustralia Guangxi Xinfazhan Communication Group Co. Ltd.Nanning 530000China

Water-coupled charge blasting is a promising technique to efficiently break rock *** this study,numerical models of double boreholes with water-coupled charge are established using LS-DYNA and are calibrated by the tests of rock masses subjected to explosion loads to examine its *** crack levels of rock mass induced by water-coupled charge blasting and air-coupled charge blasting are first *** is found that water-coupled charge blasting is more appropriate to fracture deep rock mass than air-coupled charge *** addition,the effects of rock properties,water-coupled charge coefficients,and borehole connection angles on the performance of water-coupled charge blasting are *** results show that rock properties and water-coupled charge coefficients can greatly influence the crack and fragmentation levels of rock mass induced by water-coupled charge blasting under uniform and non-uniform in-situ ***,changing borehole-connection angles can only affect crack and fragmentation levels of rock mass under non-uniform in-situ stresses but barely affect those under uniform in-situ stresses.A formula is finally proposed by considering the above-mentioned factors to provide the design suggestion of water-coupled charge blasting to fracture rock mass with different in-situ stresses.

关键词： water-coupled blasting in-situ stress water-coupled charge coefficient rock type borehole-connection angle

Encoding and display technologies for combinatorial libraries in drug discovery:The coming of age from biology to therapy

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3362-3384页

作者： Yu Fan ruibing Feng Xinya Zhang zhen-liang Wang Feng Xiong Shuihua Zhang Zhang-Feng Zhong Hua Yu Qing-Wen Zhang Zhang Zhang Yitao Wang Guodong Li Macao Centre for Research and Development in Chinese Medicine State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoMacao SAR 999078China International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development Ministry of Education(MoE)of People’s Republic of ChinaCollege of PharmacyJinan UniversityGuangzhou 510632China Zhuhai UM Science and Technology Research Institute Zhuhai 519031China Department of Pharmacy Guangzhou Red Cross HospitalFaculty of Medical ScienceJinan UniversityGuangzhou 510632China Geriatric Medicine First People’s Hospital of XinXiang and the Fifth Affiliated Hospital of Xinxiang Medical CollegeXinxiang 453100China Shenzhen Innovation Center for Small Molecule Drug Discovery Co. Ltd.Shenzhen 518000China

Drug discovery is a sophisticated process that incorporates scientific innovations and cuttingedge *** to traditional bioactivity-based screening methods,encoding and display technologies for combinatorial libraries have recently advanced from proof-of-principle experiments to promising tools for pharmaceutical hit discovery due to their high screening efficiency,throughput,and resource *** review systematically summarizes the development history,typology,and prospective applications of encoding and displayed technologies,including phage display,ribosomal display,mRNA display,yeast cell display,one-bead one-compound,DNA-encoded,peptide nucleic acidencoded,and new peptide-encoded technologies,and examples of preclinical and clinical *** discuss the progress of novel targeted therapeutic agents,covering a spectrum from small-molecule inhibitors and nonpeptidic macrocycles to linear,monocyclic,and bicyclic peptides,in addition to *** also address the pending challenges and future prospects of drug discovery,including the size of screening libraries,advantages and disadvantages of the technology,clinical translational potential,and market *** review is intended to establish a comprehensive high-throughput drug discovery strategy for scientific researchers and clinical drug developers.

关键词： Drug screening Phage display DNA-encoded chemical libraries Peptide-encoded chemical libraries Clinical drugs

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高效稀土上转换纳米晶体合成

东南大学学报（自然科学版） 2024年第4期54卷 981-989页

作者：王睿梁高林东南大学数字医学工程全国重点实验室南京211189 东南大学生物科学与医学工程学院南京211189 邯郸诺曼科技有限公司邯郸057750

详细介绍了上转换纳米晶体的主要合成方法及其优缺点.共沉淀法具有产率高、易大规模制备等优点,但后续需要煅烧结晶,晶体形貌控制较差.水热/溶剂热法能够制备结晶性良好、尺寸均一的纳米晶体,但其发光性能的可调控性相对较差.热分解法... 详细信息

详细介绍了上转换纳米晶体的主要合成方法及其优缺点.共沉淀法具有产率高、易大规模制备等优点,但后续需要煅烧结晶,晶体形貌控制较差.水热/溶剂热法能够制备结晶性良好、尺寸均一的纳米晶体,但其发光性能的可调控性相对较差.热分解法能够获得粒径均一的纳米晶体,但需要使用预先制备的金属前驱体.晶种介导的高温生长法和阳离子交换法均可优化晶体的形貌与功能,易获得尺寸分布均一、光学性能优异的上转换纳米晶体.通过主体材料优化、纳米晶体结构设计和仿真设计指导等方法,可以有效提高纳米晶体的发光效率,优化后合成的纳米晶体在生物成像和疾病诊断中展示出良好的应用前景.

关键词：上转换纳米晶体发光性能优化纳米晶体合成水热法阳离子交换法

Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection:How to achieve a better outcome

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1833-1848页

作者： Fan Mu liang-Shuo Hu Kun Xu zhen Zhao Bai-Cai Yang Yi-Meng Wang Kun Guo Jian-Hua Shi Yi Lv Bo Wang Department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Anaesthesiology First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Gynaecology Wenzhou Medical University Affiliated Jiaxing Women and Children HospitalJiaxing 314000Zhejiang ProvinceChina

BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus(HBV)-related hepatocellular carcinoma(HCC)have been proven,researchers have not con-firmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time(at least 24 wk)and patients who received remedial antiviral therapy just before radical resection for HBV-related *** To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related *** A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was *** the history of antiviral therapy,patients were assigned to remedial antiviral therapy and preoperative antiviral therapy *** Kaplan–Meier analysis revealed significant differences in overall survival(P<0.0001)and disease-free survival(P=0.035)between the two *** analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival(hazard ratio=0.27;95%confidence interval:0.08-0.88;P=0.030).CONCLUSION In patients with HBV-related HCC,it is ideal to receive preoperative long-term antiviral therapy,which helps patients tolerate more extensive hepatectomy;however,remedial antiviral therapy,which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL,can also result in improved outcomes.

关键词： Hepatectomy Hepatitis B virus Antiviral therapy Hepatocellular carcinoma Hepatitis B virus-DNA

Endophthalmitis in silicone oil-filled eye: A case report

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World Journal of Clinical Cases 2024年第1期12卷 163-168页

作者： Hui-Chao Yan Ze-Lu Wang Wen-zhen Yu Ming-Wei Zhao Jian-Hong liang Hong Yin Xuan Shi Heng Miao Department of Ophthalmology Peking University People’s HospitalBeijing 100044China

BACKGROUND Endophthalmitis occurring in silicone oil-filled eyes is a very rare occurrence,with reported incidence rates ranging between 0.07%and 0.039%.Traditional methods of management of infectious endophthalmitis include the removal of silicone oil,washout of the vitreous cavity,administration of intravitreal antibiotics,and reinjection of silicone *** SUMMARY Herein,we report the case of a 39-year-old man with unilateral endophthalmitis after pars plana vitrectomy and silicone oil *** injections of full-dose antibiotics and anterior chamber washout were used to treat the *** signs of retinal toxicity were observed during the follow-up *** Intravitreal full-dose antibiotic injections and anterior chamber washout are promising alternatives to traditional therapies for endophthalmitis in silicone oilfilled eyes.

关键词： Endophthalmitis Intravitreal injection Silicone oil-filled eye Pars plana vitrectomy Washout Case report