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Efficacy of different antibiotics in treatment of children with respiratory mycoplasma infection

World Journal of Clinical Cases 2021年第23期9卷 6717-6724页

作者： Mei-Ying zhang Yan Zhao Jin-Feng Liu Guo-Ping Liu rui-yun zhang Li-Min Wang Department of Pediatrics Qingdao Municipal HospitalQingdao 266011Shandong ProvinceChina Department of ICU Jinan City People’s HospitalJinan 271199Shandong ProvinceChina Department of Interventional Radiology Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

BACKGROUND Respiratory infections in children are common pediatric diseases caused by pathogens that invade the respiratory *** are considerably susceptible to Mycoplasma pneumoniae *** has been widespread clinical attention on treatment strategies for this *** To analyze the clinical efficacy of different antibiotics in treating pediatric respiratory mycoplasma *** We included 106 children with a confirmed diagnosis of respiratory mycoplasma infection who were admitted to our hospital from April 2017 to July 2019 and grouped them using a random number *** them,53 children each received clarithromycin or *** clinical efficacy of both drugs was evaluated and *** performed the multiplex polymerase chain reaction(MP-PCR)test and determined the MP-PCR negative rate in children after the end of the treatment *** compared the incidence of toxic and side effects,including nausea,diarrhea,and abdominal pain;further,we recorded the length of hospitalization,antipyretic time,and drug ***,we evaluated and compared the compliance of the children during *** The erythromycin group showed a significantly higher total effective rate of clinical treatment than the clarithromycin ***-PCR test results showed that the clarithromycin group had a significantly higher MP-PCR negative rate than the erythromycin ***,children in the clarithromycin group had shorter fever time,shorter hospital stays,and lower drug costs than those in the erythromycin *** clarithromycin group had a significantly higher overall drug adherence rate than the erythromycin *** incidence of toxic and side effects was significantly lower in the clarithromycin group than in the erythromycin group(P<0.05).CONCLUSION Our findings indicate that clarithromycin has various advantages over erythromycin,including higher application safety,stronger mycoplasma clearance,and higher medicatio

关键词： Clarithromycin Erythromycin Mycoplasma respiratory infection Children Clinical efficacy Drug compliance Toxic side effects

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Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population

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World Journal of Gastroenterology 2010年第36期16卷 4549-4557页

作者： zhang zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,rui zhang,yun-Bi Ni,Hong-Ying zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China Department of Pathology West China Hospital Sichuan University Guoxuexiang 37 Chengdu 610041 Sichuan Province China.

AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other ***:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed *** studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin ***:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by *** one patient,this presentation was accompanied by an initial severe *** symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were *** abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying *** tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal *** cases were surgically resected,three cases underwent biopsy and the two fetuses were ***,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and *** inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the *** patients are alive after a follow-up of 1-9 *** on immunohistochemistry,the endothelial cells in all cases were positiv

关键词： Infantile haemangioendothelioma Pediatrics Hepatic neoplasm Pathological diagnoses Chinese

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Neonatal biliary atresia combined with preduodenal portal vein:A case report

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World Journal of Clinical Cases 2021年第25期9卷 7542-7550页

作者： Xian-Lan Xiang Peng Cai Jun-Gang Zhao Hao-Wei Zhao Yu-Liang Jiang Meng-Lei Zhu Qi Wang rui-yun zhang Zhen-Wei Zhu Jian-Lei Chen Zhi-Cheng Gu Jie Zhu Department of Pediatric Surgery Children’s Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Congenital biliary atresia is a type of obstruction of the bile ducts inside and outside the liver,which can lead to cholestatic liver cirrhosis and eventually liver *** preduodenal portal vein(PD-PV)is a rare developmental malformation of the *** PV courses in front of the ***,very few cases of neonatal biliary atresia combined with PD-PV have been reported in the scientific *** SUMMARY A 1-mo-and-4-d-old child was admitted to the hospital in January because of yellowish *** surgical consultation,surgical intervention was *** child underwent Hilar-jejunal anastomosis,duodenal rhomboid anastomosis,and abdominal drainage under general *** the operation,the PV was located at the anterior edge of the *** Diagnoses:(1)Congenital biliary atresia;(2)PD-PV;and(3)Congenital cardiovascular ***:Recommendation for liver ***:The choice of treatment options for neonatal biliary atresia combined with PD-PV.

关键词： Neonatal Biliary atresia Preduodenal portal vein Treatment Case report

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期34卷 303-322页

作者： JU Dehao LIU rui ZHENG Liang DENG Jiahui zhang Wenzheng HUO Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

关键词： atomization dual-orifice nozzle nozzle structure spray flame asymmetry

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Coordinated Control Strategy of New Energy Power Generation System with Hybrid Energy Storage Unit

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Energy Engineering 2025年第1期122卷 167-184页

作者： yun zhang ZifenHan Biao Tian Ning Chen Yi Fan School of Mechano-Electronic Engineering Xidian UniversityXi’an710071China Electric Power Control Center State Grid Gansu Electric Power CompanyLanzhou730030China Electric Power Control Center State Grid Gansu Electric Power Company Zhangye Power Supply BranchZhangye734000China

The new energy power generation is becoming increasingly important in the power *** as photovoltaic power generation has become a research hotspot,however,due to the characteristics of light radiation changes,photovoltaic power generation is unstable and random,resulting in a low utilization rate and directly affecting the stability of the power *** solve this problem,this paper proposes a coordinated control strategy for a newenergy power generation system with a hybrid energy storage unit based on the lithium iron phosphate-supercapacitor hybrid energy storage ***,the variational mode decomposition algorithm is used to separate the high and low frequencies of the power signal,which is conducive to the rapid and accurate suppression of the power fluctuation of the energy storage ***,the fuzzy control algorithm is introduced to balance the power between energy *** this paper,the actual data is used for simulation,and the simulation results show that the strategy realizes the effective suppression of the bus voltage fluctuation and the accurate control of the internal state of the energy storage unit,effectively avoiding problems such as overshoot and over-discharge,and can significantly improve the stability of the photovoltaic power generation systemand the stability of the Direct Current *** is of great significance to promote the development of collaborative control technology for photovoltaic hybrid energy storage units.

关键词： Photovoltaic power suppression hybrid energy storage unit variationalmodal decomposition fuzzy control power distribution control

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Multi-receptive field interaction network for shape from polarization

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Science China(Information Sciences) 2025年第1期68卷 394-395页

作者： Yini PENG rui LIU Zhiyuan zhang Zhongyuan WANG Jiayi MA Xin TIAN Electronic Information School Wuhan University Computer Science School Wuhan University Wuhan Institute of Quantum Technology

Shape from polarization (SfP) method can use the polarization information in reflected light to estimate the surface normal of the target,which can further reconstruct the shape of the *** a simple image capture process,it can use low-cost equipment to meet a high precision imaging requirement,which can be used in remote scenes and other applications.

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NiCo_(2)O_(4)修饰N掺杂交联碳纳米纤维电极的制备及其电化学性能研究

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高分子学报 2022年第12期53卷 1484-1492页

作者：朱建华张倩张瑞云刘丽芳东华大学纺织学院上海201620 东华大学材料科学与工程学院上海201620

为有效改善碳纳米纤维导电性及柔性,以聚乙烯吡咯烷酮(PVP)为芯溶液,聚丙烯腈(PAN)和PVP为皮溶液,首先通过同轴静电纺丝技术制备偏心皮芯结构纳米纤维,然后在高温碳化过程中热塑性高聚物PVP发生熔融,在纤维间形成交联点,制得N掺杂的交... 详细信息

为有效改善碳纳米纤维导电性及柔性,以聚乙烯吡咯烷酮(PVP)为芯溶液,聚丙烯腈(PAN)和PVP为皮溶液,首先通过同轴静电纺丝技术制备偏心皮芯结构纳米纤维,然后在高温碳化过程中热塑性高聚物PVP发生熔融,在纤维间形成交联点,制得N掺杂的交联碳纳米纤维.进一步,通过水热合成反应在碳纳米纤维表面原位生长NiCo_(2)O_(4)纳米针获得NiCo_(2)O_(4)修饰的N掺杂交联碳纳米纤维电极.基于电极材料的结构优势以及碳纳米纤维与NiCo_(2)O_(4)纳米针的协同作用,所制备的NiCo_(2)O_(4)修饰N掺杂交联碳纳米纤维电极表现出优异的电化学行为,在0.5 A·g^(-1)电流密度下,质量比电容高达1186.4 F·g^(-1)(197.5 mA·h·g^(-1)),10000次充放电循环后电容保持率达74.5%,且将电极材料组装成非对称超级电容器可成功为电子器件进行供电.本文工作为柔性电极的开发提供了一种新的探究思路.

关键词：碳纳米纤维双金属氧化物 NiCo_(2)O_(4) 柔性电极超级电容器

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Liposomes as versatile agents for the management of traumatic and nontraumatic central nervous system disorders:drug stability,targeting efficiency,and safety

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Neural Regeneration Research 2025年第7期20卷 1883-1899页

作者： Mingyu zhang Chunyu Xiang Renrui Niu Xiaodong He Wenqi Luo Wanguo Liu rui Gu Department of Orthopedic Surgery China-Japan Union Hospital of Jilin UniversityChangchunJilin ProvinceChina

Various nanoparticle-based drug delivery systems for the treatment of neurological disorders have been widely ***,their inability to cross the blood–brain barrier hampers the clinical translation of these therapeutic *** are nanoparticles composed of lipid bilayers,which can effectively encapsulate drugs and improve drug delivery across the blood–brain barrier and into brain tissue through their targeting and ***,they can potentially treat traumatic and nontraumatic central nervous system *** this review,we outlined the common properties and preparation methods of liposomes,including thin-film hydration,reverse-phase evaporation,solvent injection techniques,detergent removal methods,and microfluidics ***,we comprehensively discussed the current applications of liposomes in central nervous system diseases,such as Alzheimer's disease,Parkinson's disease,Huntington's disease,amyotrophic lateral sclerosis,traumatic brain injury,spinal cord injury,and brain *** studies related to liposomes are still in the laboratory stage and have not yet entered clinical ***,their application as drug delivery systems in clinical practice faces challenges such as drug stability,targeting efficiency,and ***,we proposed development strategies related to liposomes to further promote their development in neurological disease research.

关键词： Alzheimer's disease amyotrophic lateral sclerosis brain tumors central nervous system Huntington's disease liposome drug delivery neurological disorders Parkinson's disease spinal cord injury traumatic brain injury

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Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： WEI zhang WEICHENG WANG rui WANG XIAO HAN LIJUN ZHU WENJIE GUO YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

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Postnatal development of rat retina:a continuous observation and comparison between the organotypic retinal explant model and in vivo development

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Neural Regeneration Research 2025年第3期20卷 900-912页

作者： Baoqi Hu rui Wang Hanyue zhang Xiou Wang Sijia Zhou Bo Ma Yan Luan Xin Wang Xinlin Chen Zhichao zhang Qianyan Kang Department of Ophthalmology The First Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Ophthalmology The First Affiliated Hospital of Northwest UniversityXi’anShaanxi ProvinceChina Institute of Neurobiology Xi’an Jiaotong University Health Science CenterXi’anShaanxi ProvinceChina

The organotypic retinal explant culture has been established for more than a decade and offers a range of unique advantages compared with in vivo experiments and cell ***,the lack of systematic and continuous comparison between in vivo retinal development and the organotypic retinal explant culture makes this model controversial in postnatal retinal development ***,we aimed to verify the feasibility of using this model for postnatal retinal development studies by comparing it with the in vivo *** this study,we showed that postnatal retinal explants undergo normal development,and exhibit a consistent structure and timeline with retinas in ***,we used SOX2 and PAX6 immunostaining to identify retinal progenitor *** then examined cell proliferation and migration by immunostaining with Ki-67 and doublecortin,***-67-and doublecortin-positive cells decreased in both in vivo and explants during postnatal retinogenesis,and exhibited a high degree of similarity in abundance and distribution between ***,we used Ceh-10 homeodomain-containing homolog,glutamate-ammonia ligase(glutamine synthetase),neuronal nuclei,and ionized calcium-binding adapter molecule 1 immunostaining to examine the emergence of bipolar cells,Müller glia,mature neurons,and microglia,*** timing and spatial patterns of the emergence of these cell types were remarkably consistent between in vivo and explant *** study showed that the organotypic retinal explant culture model had a high degree of consistency with the progression of in vivo early postnatal retina *** findings confirm the accuracy and credibility of this model and support its use for long-term,systematic,and continuous observation.

关键词： bipolar cells differentiation in vivo microglia Müller glia organotypic retinal explant culture postnatal retina development proliferation retinal progenitor cells

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