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Journal of Animal Science and Biotechnology 2024年第3期15卷 1119-1130页

作者： Tae Hong kang Sang In Lee Department of Animal Science and Biotechnology Kyungpook National UniversitySangjuGyeong‑Sangbuk‑Do 37224Republic of Korea Research Institute for Innovative Animal Science Kyungpook National University37224SangjuGyeong‑Sangbuk‑DoRepublic of Korea

Background Deoxynivalenol(DON)is a mycotoxin that has received recognition worldwide because of its ability to cause growth delay,nutrient malabsorption,weight loss,emesis,and a reduction of feed intake in *** DON-contaminated feedstuff is absorbed in the gastrointestinal tract,we used chicken organoids to assess the DON-induced dysfunction of the small *** We established a culture system using chicken organoids and characterized the organoids at passages 1 and *** confirmed the mRNA expression levels of various cell markers in the organoids,such as KI67,leucine-rich repeat containing G protein-coupled receptor 5(Lgr5),mucin 2(MUC2),chromogranin A(CHGA),cytokeratin 19(CK19),lysozyme(LYZ),and microtubule-associated doublecortin-like kinase 1(DCLK1),and compared the results to those of the small *** results showed that the organoids displayed functional similarities in permeability compared to the small *** damaged the tight junctions of the organoids,which resulted in increased *** Our organoid culture displayed topological,genetic,and functional similarities with the small intes-tine *** on these similarities,we confirmed that DON causes small intestine *** organoids offer a practical model for the research of harmful substances.

关键词： Barrier function Deoxynivalenol Organoids

Guest Editorial:Special Section on Battery Energy Storage Systems for Net-zero Power Systems and Markets

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Journal of Modern Power Systems and Clean Energy 2024年第2期12卷 321-322页

作者： Pierluigi Mancarella Nikos Hatziargyriou Chongqing kang The University of Melbourne MelbourneAustralia The University of Manchester ManchesterUK National Technical University of Athens(NTUA) AthensGreece Tsinghua University BeijingChina IEEE

Battery energy storage technologies have witnessed both dramatic cost reduction and technical evolution in recent *** is leading to widespread deployment of battery energy storage systems(BESSs)worldwide,particularly to support operation of power grids with already deep penetration of *** the development of new battery technologies with different power-to-energy ratios and for various engineering applications,BESSs could play a strategic role towards a net-zero energy *** opportunities are emerging for BESSs to participate in several markets,provide different grid services,and perform“value stacking”,eventually allowing development of new business cases and improved BESS *** configurations that are“behind the meter”,“in front of the meter”,hybrid plants co-located with renewables,and so forth,are only some of the exciting propositions that are being seen in different countries and at different scales,from highly distributed(virtual power plants),to neighbourhood-level(community batteries),to utility scale.

关键词： Battery battery eventually

Bioinspired nanocomposites with self-adaptive mechanical properties

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Nano Research 2024年第2期17卷 633-648页

作者： Grant Kitchen Bohan Sun Sung Hoon kang 13400 N Charles St Department of Materials Science and EngineeringJohns Hopkins UniversityBaltimore 21218USA 23400 N Charles St Department of Mechanical EngineeringJohns Hopkins UniversityBaltimore 21218USA 33400 N Charles St Hopkins Extreme Materials InstituteJohns Hopkins UniversityBaltimore 21218USA

Conventional synthetic materials have fixed mechanical properties and suffer defects,damage,and degradation over *** makes them unable to adapt to changing environments and leads to limited ***,self-adaptive materials inspired by natural materials have emerged as a solution to address these *** the ability to change their mechanical properties based on changing mechanical environments,repairing defects,and maintaining their mechanical properties,these materials can lead to improved performance while decreasing *** this review,we explore self-adaptive phenomena found in nature that have inspired the development of synthetic self-adaptive materials,and the mechanisms that have been employed to create the next generation of *** potential applications of these materials,the challenges that existing approaches face,and future research opportunities are also discussed.

关键词： nanocomposites self-adaptive materials bioinspired materials force-activated resilience

An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： Kazuki Shimura Hikaru Aono Chang-kwon kang Graduate School of Science and Technology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-vehicles(FWMAVs)have the potential to be useful aerial tools for gathering information in various *** recent advancements in manufacturing technologies and better understanding of aerodynamic mechanisms behind of the flapping flight,outdoor flights have become a ***,to fully realize the potential of FWMAVs,further improvements are necessary,particularly in terms of stability and robustness under gusty *** this study,the response and control of a tailless two-winged FWMAV under the wind gusts are *** experiments are conducted with a one-degree-of-freedom gimbal to focus on effects of wind gusts on the rotational motion of the ***-derivative and sliding-mode controls are adopted for the attitude *** present that the body angles changed in time and reached approximately 50°at the maximum due to the wing *** sliding-mode controller can more effectively control the rotational angle in the presence of disturbances and both the wing speed and changes in wind speed have an impact on the effectiveness of attitude *** results contribute to the development of of tailless two-winged,single-motor driven FWMAVs in terms of the design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air vehicles Sliding-mode control Pitch and roll angle-Wind gus

Steel-refractory reactions in lanthanum-,cerium-,and ytrium-added steels

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Journal of Iron and Steel Research International 2024年第6期31卷 1473-1485页

作者： Jian kang Hong-po Wang Yu Wang College of Materials Science and Engineering Chongqing UniversityChongqing 400044China The State Key Laboratory of Mechanical Transmissions Chongqing UniversityChongqing 400044China

A systematic experimental study was conducted on the similarities and differences in the reactions between commonly used rare earth elements(REEs)and frequently used refractories in the steelmaking *** results indicate that the reaction behaviors of La,Ce,and Y with MgO,Al_(2)O_(3),and MgO·Al_(2)O_(3) crucibles differed *** consumption rates of La,Ce,and Y in the molten steel were in descending order of La>Ce>Y for smelting with all three kinds of *** the REEs reacted with the crucible,the contents of Mg and Al showed a trend of first increasing and then *** laboratory-scale smelting conditions,the reactions related to REEs were dominated by steel-crucible reactions,and the contact area between the unit mass of molten steel and refractory materials mainly determined the consumption rates of ***-and Ce-crucible reactions generated loose and porous reaction interfaces;however,Y-crucible reactions generated a dense Y_(2)O_(3) layer,dramatically suppressing the consumption rate of *** calculation indicated that the reactions between rare earth and different refractory materials were first-order *** crucible materials significantly affected the product type and morphology of the steel-crucible reaction interfaces,thereby influencing the consumption rate of *** reactions between REEs and refractories must be seriously considered,especially for small-scale smelting.

关键词： Rare earth Inclusion Refractory Thermodynamics Dynamics

Morroniside from Corni Fructus ameliorates type 2 diabetes in mice by regulating intestinal microbiota dysbiosis

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Food Science and Human Wellness 2024年

作者： xueqi Tang Yilin Bai Yinxia Wu Yue Yang Xiaobo Yu Jing Chen Xiaochang xue Jiefang kang National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China The Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry， The Ministry of Education College of Life Sciences， Shaanxi Normal University

As one of the most common metabolic diseases， type 2 diabetes (T2D) has become a public health concern with rising global prevalence. Corni fructus (CF)， a traditional Chinese herb utilized for centuries as homologous medicinal and food resources， has been widely used to treat glucose and lipid metabolism disorders. However， as a core active ingredient of CF， whether and how morroniside (MOR) improves T2D is still unclear. This study aimed to explore the pathways by which MOR ameliorates T2D in mice induced by high-fat diet (HFD) and low-dose streptozotocin (STZ) through 16S rRNA gene sequencing. We found that MOR treatment significantly ameliorated body weight loss， hyperglycemia， hyperlipidemia and insulin resistance in T2D mice. In addition， MOR remarkably improved inflammation- and oxidative stress-driven hepatic and pancreatic injuries in the model mice. Mechanistically， MOR rehabilitated the dysregulated diversity and constitution of the gut microbiota in T2D mice， with significant changes in relative abundance in genus such as Lactobacillus， Lachnospiraceae＿NK4A136＿Group， and Lachnospiraceae＿UCG-006 which are believed to be highly correlated with serum parameters and insulin resistance in mice with T2D. Therefore， we infer that MOR improves T2D at least partially by maintaining the host microbiota homeostasis， and MOR may be a promising candidate for T2D treatment.

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QL1706 (anti-PD-1 IgG4/CTLA-4 antibody) plus chemotherapy with or without bevacizumab in advanced non-small cell lung cancer: a multi-cohort, phase II study

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Signal Transduction and Targeted Therapy 2024年第2期9卷 797-806页

作者： Yan Huang Yunpeng Yang Yuanyuan Zhao Hongyun Zhao Ningning Zhou Yaxiong Zhang Likun Chen Ting Zhou Gang Chen Ting Wu Lu Lu Shilin xue Xiaoyan kang Li Zhang Wenfeng Fang Department of Medical Oncology Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineNo.651 Dongfeng East RoadGuangzhouGuangdong 510060China Department of Medicine Qilu Pharmaceutical Co.Ltd.JinanChina

First-line chemoimmunotherapy(with or without bevacizumab)has improved outcomes in advanced non-small cell lung cancer(NSCLC).Here,this open-label,multi-cohort phase II study(NCT05329025)was done to investigate the safety and efficacy of QL1706(a single bifunctional MabPair product against PD-1 and CTLA-4)and chemotherapy with or without bevacizumab in this *** were enrolled into five different cohorts based on genotype(cohorts 1-4,epidermal growth factor receptor[EGFR]wild-type;cohort 5,EGFR-mutant and progressed on EGFR-tyrosine kinase inhibitors[TKIs]).Between June 11,2021 and December 29,2021,91 patients were *** frequent treatment-related adverse events(TRAEs)included decreased appetite(60[65.9%]),anemia(60[65.9%]),infusion-related reactions(48[52.7%]),and pruritus(44[48.4%]).Grade≥3 TRAEs occurred in 30(33.0%)***-seven(45%)patients with wild-type EGFR achieved partial response(PR)(objective response rate[ORR]=45%)and had a median progression-free survival(mPFS)of 6.8 months(95%CI:5.2-9.7).For 31 patients harboring mutated EGFR,17(54.8%)achieved PR(ORR=54.8%),with an mPFS of 8.5 months(95%CI:5.72-not evaluable).Overall,QL1706 plus chemotherapy,regardless of having bevacizumab,was generally tolerable and had promising antitumor activity for EGFR wild-type advanced NSCLC in first-line ***,QL1706 plus chemotherapy and bevacizumab showed favorable antitumor activity for patients who had EGFR mutated NSCLC but failed in TKI therapy,demonstrating a potential for treating this population.

关键词： bevacizumab chemotherapy phase

Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

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Science China Chemistry 2024年第3期67卷 755-758页

作者： Qinglin Zhang kang Liang Chang Guo Hefei National Research Center for Physical Sciences at the Microscale and Department of Chemistry University of Science and Technology of ChinaHefei 230026China

Electrosynthesis has gained widespread recognition for its extraordinary ability to precisely control the redox *** outstanding capability enables the direct conversion of non-functionalized substrates into reactive intermediates by utilizing easily accessible starting materials, eliminating the need for preliminary functionalization procedures and allowing for unconventional bond activations.

关键词： Confluence of asymmetric catalysis and electrosynthesis in sustainable chemical transformations

基于时序拓扑数据分析的电力电缆局部放电模式识别

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电子科技大学学报 2024年第3期53卷 440-446页

作者：李自强李睿孙抗河南理工大学电气工程与自动化学院焦作454003 许继电气股份有限公司许昌461000

在电力电缆局部放电(PD)模式识别时,相位图谱以及统计特征往往因区分度不足而影响识别精度。为此,提出了一种基于时序拓扑数据分析(TDA)的局放特征提取和识别方法。首先,提出一种符号熵和粒子群优化(PSO)相结合的重构参数选择方法,将预... 详细信息

在电力电缆局部放电(PD)模式识别时,相位图谱以及统计特征往往因区分度不足而影响识别精度。为此,提出了一种基于时序拓扑数据分析(TDA)的局放特征提取和识别方法。首先,提出一种符号熵和粒子群优化(PSO)相结合的重构参数选择方法,将预处理后的局放时域信号进行相空间重构,并生成三维局放数据点云;然后,基于TDA方法提取持续同调特征,据此生成持续散点图及持续条形码,计算并可视化表达为贝蒂曲线;最后,将贝蒂曲线输入1D-CNN模型,对4种典型局放缺陷模式进行识别并开展对比实验。实验结果表明,该方法对相空间重构时延参数的选取更加准确,且TDA特征具备良好的区分度,相比其他以相位图谱及统计特征为输入的模型,该方法整体识别准确率最高可提升15.34%,达到98.55%。

关键词：局部放电模式识别相空间重构拓扑数据分析卷积神经网络

Recent development and challenges in enhancing fire performance on wood and wood-based composites:A 10-year review from 2012 to 2021

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Journal of Bioresources and Bioproducts 2024年第1期9卷 27-42页

作者： Charles Michael Albert kang Chiang Liew Faculty of Tropical Forestry Universiti Malaysia SabahKota Kinabalu 88400Kota KinabaluSabah 88400Malaysia

Due to their durability,versatility,and aesthetic value,wood and wood-based composites are widely used as building *** fact that these materials are flammable,however,raises a major worry since they might cause fire hazards and significant loss of life and *** article investigates the variables that affect fire performance as well as the various fire-retardant treatments and their *** current developments and challenges in improving the fire performance of wood and wood-based composites treated with fire-retardant materials are summarized in this ***,organic chemicals,and densification are some recent developments in fire-retardant treatments that are also *** points from the review are summarized,along with potential areas for further research and development.

关键词： Fire performance Fire-retardant materials Wood Wood-based composite Nanoparticles coating Surface charring Bio-based fire retardant Densification