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Gut mucosal microbiota profiles linked to colorectal cancer recurrence

World Journal of Gastroenterology 2022年第18期28卷 1946-1964页

作者： rui-xue huo Yi-Jia Wang Shao-Bin Hou Wei Wang Chun-Ze Zhang xue-Hua Wan Department of Oncology Tianjin Union Medical CenterNankai UniversityTianjin 300121China Laboratory of Oncologic Molecular Medicine Tianjin Union Medical CenterNankai UniversityTianjin 300121China Advanced Studies in Genomics Proteomics and BioinformaticsUniversity of Hawaii at ManoaHonoluluHI 96822United States TEDA Institute of Biological Sciences and Biotechnology Nankai UniversityTianjin 300457China Department of Colorectal Surgery Tianjin Union Medical CenterNankai UniversityTianjin 300121China Tianjin Institute of Coloproctology Tianjin 300121China

BACKGROUND Emerging evidence links gut microbiota to various human diseases including colorectal cancer(CRC)initiation and ***,gut microbiota profiles associated with CRC recurrence and patient prognosis are not completely understood yet,especially in a Chinese *** To investigate the relationship between gut mucosal microbiota profiles and CRC recurrence and patient *** We obtained the composition and structure of gut microbiota collected from 75 patients diagnosed with CRC and 26 healthy *** patients were followed up by regular examination to determine whether tumors ***-paired samples from on-tumor,adjacent-tumor and off-tumor sites of patients diagnosed with/without CRC recurrence were analyzed to assess spatial-specific patterns of gut mucosal microbiota by 16S ribosomal RNA ***,we carried out bioinformatic analyses,Kaplan-Meier survival analyses and Cox regression analyses to determine the relationship between gut mucosal microbiota profiles and CRC recurrence and patient *** We observed spatial-specific patterns of gut mucosal microbiota profiles linked to CRC recurrence and patient prognosis.A total of 17 bacterial genera/families were identified as potential biomarkers for CRC recurrence and patient prognosis,including Anaerotruncus,Bacteroidales,Coriobacteriaceae,Dialister,Eubacterium,Fusobacterium,Filifactor,Gemella,Haemophilus,Mogibacteriazeae,Pyramidobacter,Parvimonas,Porphyromonadaceae,Slackia,Schwartzia,TG5 and *** Our work suggests that intestinal microbiota can serve as biomarkers to predict the risk of CRC recurrence and patient death.

关键词： Gut microbiota Colorectal cancer Prognosis Colorectal cancer recurrence Biomarker 16S rRNA sequencing analysis

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Concurrent chemoradiotherapy using gemcitabine and nedaplatin in recurrent or locally advanced head and neck squamous cell carcinoma

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World Journal of Clinical Cases 2022年第11期10卷 3414-3425页

作者： rui-xue huo Ying-Ying Jin Yong-xue Zhuo Xiao-Tong Ji Yu Cui Xiao-Jing Wu Yi-Jia Wang Long Zhang Wen-Hua Zhang Yu-Mei Cai Cheng-Cheng Zheng rui-xue Cui Qian-Ye Wang Zhen Sun Feng-Wei Wang Department of Oncology Tianjin Union Medical CenterTianjin 300000China School of Medicine Nankai UniversityTianjin 300000China Laboratory of Oncologic Molecular Medicine Tianjin Union Medical CenterTianjin 300000China

BACKGROUND Patients with recurrent or locally advanced head and neck squamous cell carcinoma(HNSCC)typically have limited treatment options and poor *** To evaluate the efficacy and safety of two drugs with potent radio-sensitization properties including gemcitabine and nedaplatin as concurrent chemoradiotherapy regimens in treating *** This single-arm prospective study enrolled patients with HNSCC to receive gemcitabine on days 1 and 8 and nedaplatin on days 1 to 3 for 21 *** radiation therapy with a conventional fraction was delivered 5 days per *** response rate(ORR),disease control rate,and toxicity were observed as primary *** survival(OS)and progression free survival were recorded and analyzed as secondary *** A total of 24 patients with HNSCC were *** the median 22.4-mo follow-up,both ORR and disease control rate were 100%.The one-year OS was 75%,and one-year progression-free survival(PFS)was 66.7%(median PFS was 15.1 mo).Recurrent HNSCC patients had a poorer prognosis than the treatment-naïve patients,and patients who achieved complete response had better survival than those in the PR group(all P<0.05).The most common grade 1-4(100%)or grade 3-4 toxicities(75%)were hematological,and the most common grade 3-4 non-hematological toxicity was mucositis in 17(71%)*** Gemcitabine plus nedaplatin with concurrent chemoradiotherapy is a therapeutic option for HNSCC with predictable *** the high adverse event rate,the optimized dose and schedule must be further explored.

关键词： Chemoradiotherapy Gemcitabine Nedaplatin Head and neck cancer Recurrent Locally advanced

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Investigating Müller glia reprogramming in mice: a retrospective of the last decade, and a look to the future

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Neural Regeneration Research 2025年第4期20卷 946-959页

作者： Zhiyuan Yin Jiahui Kang Xuan Cheng Hui Gao Shujia huo Haiwei Xu Key Lab of Visual Damage and Regeneration&Restoration of Chongqing Southwest Eye HospitalSouthwest HospitalThird Military Medical University(Army Medical University)ChongqingChina

Müller glia,as prominent glial cells within the retina,plays a significant role in maintaining retinal homeostasis in both healthy and diseased *** lower vertebrates like zebrafish,these cells assume responsibility for spontaneous retinal regeneration,wherein endogenous Müller glia undergo proliferation,transform into Müller glia-derived progenitor cells,and subsequently regenerate the entire retina with restored ***,Müller glia in the mouse and human retina exhibit limited neural reprogramming.Müller glia reprogramming is thus a promising strategy for treating neurodegenerative ocular disorders.Müller glia reprogramming in mice has been accomplished with remarkable success,through various *** in molecular,genetic,epigenetic,morphological,and physiological evaluations have made it easier to document and investigate the Müller glia programming process in ***,there remain issues that hinder improving reprogramming efficiency and ***,understanding the reprogramming mechanism is crucial toward exploring factors that will improve Müller glia reprogramming efficiency,and for developing novel Müller glia reprogramming *** review describes recent progress in relatively successful Müller glia reprogramming *** also provides a basis for developing new Müller glia reprogramming strategies in mice,including epigenetic remodeling,metabolic modulation,immune regulation,chemical small-molecules regulation,extracellular matrix remodeling,and cell-cell fusion,to achieve Müller glia reprogramming in mice.

关键词： cell fusion chemical small-molecules epigenetic extracellular matrix immune metabolic mice Müller glia neurodegenerative diseases reprogramming retina regeneration

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State Lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： xueyan Zhang Shichao Cheng Chuankai Fu Geping Yin Liguang Wang Yongmin Wu Hua huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,Li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability Li-ion conduction mechanism Characterization techniques

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Experimental Study on Diesel Spray and Flame Asymmetry Characteristics of Dual-Orifice Nozzles for a Medium-Speed Engine

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Journal of Thermal Science 2025年第1期 303-322页

作者： JU Dehao LIU rui ZHENG Liang DENG Jiahui ZHANG Wenzheng huo Jinlu HUANG Li Shanghai Marine Diesel Engine Research Institute National Key Laboratory of Marine Engine Science and Technology Key Laboratory for Power Machinery and Engineering Ministry of EducationShanghai Jiao Tong University

The asymmetry of the multi-orifice spray will cause uneven heat load of the marine diesel engine,thereby affecting its working performance and service ***,an in-depth understanding of the spray and flame characteristics of multi-orifice nozzles will guide the optimization of the nozzle structure,needle design and diesel atomization and combustion *** this reason,four groups of dual-orifice nozzles with different hole diameters(0.1-0.55 mm) and mass flow rates covering the typical marine medium-speed diesel injections are designed and customized,and the constant volume chamber(CVC) with high temperature and pressure is used to simulate the actual in-cylinder working conditions of the diesel engine for the spray visualization *** study the asymmetry of the fuel sprays discharged from a diesel injector,the multi-orifice nozzle is simplified as a dual-orifice nozzle in this *** with X-ray Computed Tomography(CT) imaging technology,the influences of the nozzle internal structure on the spray and flame asymmetry are studied in the constructed supercritical *** is found that the asymmetry of the inlet angle and the equivalent length-diameter ratio is positively correlated with the inconsistency of the dual *** an increase in the injection pressure and nozzle diameter,the asymmetry of the dual spray becomes more pronounced,resulting in greater disparities in the ignition delay times and ignition positions of the two ***,the increase in nozzle diameter also leads to combustion instability,resulting in a flame with a serrated *** the increase of ambient temperature,the proportion of liquid phase in the jet decreases and the relative density of spray front decreases.

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Influence of stir-frying on the lipid stability and flavor substances in oat flour during storage using HS-SPME-GC-MS and electronic nose

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Food Quality and Safety 2023年第1期7卷 30-39页

作者： Yuanyuan Zhang Meili Zhang xue Bai Yakun Zhang Jing Zhang rui huo College of Food Science and Engineering Inner Mongolia Agricultural UniversityHuhhotChina Agricultural and Livestock Products Processing Research Institute Inner Mongolia Academy of Agricultural and Animal Husbandry SciencesHuhhotChina

Objectives:We used stir-fried oat flour as experimental material and raw oat flour as a control to explore the influence of stir-frying on the *** and Methods:The HS-SPME-GC-MS method combined with electronic nose technology was used to understand the lipid stability and analyze the changes in the flavor of the substances during the entire storage ***:It was observed that during the storage period,stir-fried oat flour contained less water than raw oat *** former was characterized by a lower fatty acid value,lower acid value,and lower linoleic acid content,but higher oleic acid content and palmitic acid content compared to the *** the passage of storage time,the palmitic acid content significantly increased,and the linoleic acid content significantly decreased in raw and stir-fried oats flour(P

关键词： Stir-frying oat flour lipid stability flavor substances storage

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Recent advances in theoretical models of respiratory mechanics

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Acta Mechanica Sinica 2012年第1期28卷 1-7页

作者： Bo huo rui-Rong Fu Key Laboratory of Microgravity&Center for Biomechanicsand Bioengineering Institute of Mechanics Chinese Academy of Sciences100190 BeijingChina

As an important branch of biomedical engineering, respiratory mechanics helps to understand the physiology of the respiratory system and provides fundamental data for developing such clinical technologies as ventilators. To solve different clinical problems, researchers have developed numerous models at various scales that describe biological and mechanical properties of the respiratory system. During the past decade, benefiting from the continuous accumulation of clinical data and the dramatic progress of biomedical technologies （e.g. biomedical imaging）, the theoretical modeling of respiratory mechanics has made remarkable progress regarding the macroscopic properties of the respiratory process, complexities of the respiratory system, gas exchange within the lungs, and the coupling interaction between lung and heart. The present paper reviews the advances in the above fields and proposes potential future projects.

关键词： Respiratory mechanics Biomechanics Gas exchange

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The collision frequency of electron-neutralparticle in weakly ionized plasmas with non-Maxwellian velocity distributions

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Communications in Theoretical Physics 2021年第9期73卷 113-123页

作者： Hong Wang Jiulin Du rui huo Department of Physics School of ScienceTianjin UniversityTianjin 300350China

The collision frequencies of electron-neutral-particle in weakly ionized complex plasmas with the non-Maxwellian velocity distributions are *** average collision frequencies of electron-neutral-particle in plasmas are accurately *** find that these collision frequencies are significantly dependent on the power-law spectral indices of non-Maxwellian distribution functions and so they are generally different from the collision frequencies in plasmas with a Maxwellian velocity distribution,which will affect the transport properties of the charged particles in *** analyses are made to show the roles of the spectral indices in the average collision frequencies respectively.

关键词： non-Maxwellian velocity distribution collision frequency weakly ionized plasma

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The Vignetting Effect of a LAMOST-Type Schmidt Telescope

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Chinese Journal of Astronomy and Astrophysics 2008年第5期8卷 580-590页

作者： Yuan xue huo-Ming Shi National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Optical vignetting of a Schmidt reflector is caused mainly by the spherical primary mirror not being big enough and by the effective light-collecting area of the corrector, which depends on the direction of the star light. Calculations of the vignetting of LAMOST, a special reflecting Schmidt telescope, are made by ray-tracing methods. The results show various features due to LAMOST＇s structure and observing modes. The un-vignetted field is small compared with its field of view. In the outmost portions of the field vignetting in- creases rapidly with the distance to the field center. The vignetting at a general position within the field of view is a function of both its distance to the field center and its position angle. Vignetting varies when the telescope points at different declinations and during observations. There is difference in vignetting between direct imaging and multi-fiber spectroscopy. Vignetting distorts the relative intensity of celestial objects at different positions in a field and also affects accurate sky-estimation and sky-subtraction. The determined vignetting functions may be used to correct the vignetting effect; alternatively flat-fielding may be adopted for the calibration. The effective apertures, which affect the signal-to-noise ratio of the observations, depend on the different declinations the telescope is pointing at and also different positions within a field due to vignetting.

关键词： telescope - methods miscellaneous

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Thermally activated delayed fuorescent small molecule sensitized fuorescent polymers with reduced concentration‑quenching for efcient electroluminescence

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Frontiers of Optoelectronics 2023年第1期16卷 41-48页

作者： Qin xue Mingfang huo Guohua Xie Department of Physical Science and Technology Central China Normal UniversityWuhan 430079China Sauvage Center for Molecular Sciences Hubei Key Lab on Organic and Polymeric Optoelectronic MaterialsDepartment of ChemistryWuhan UniversityWuhan 430072China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhan 430074China

Thermally activated delayed fuorescence(TADF)small molecule bis-[3-(9,9-dimethyl-9,10-dihydroacridine)-phenyl]-sulfone(m-ACSO2)was used as a universal host to sensitize three conventional fuorescent polymers for maximizing the electroluminescent *** excitons were utilized via inter-molecular energy transfer and the non-radiative decays were successfully refrained in the condensed ***,the signifcant enhancement of the electroluminescent efciencies was *** instance,after doping poly(9,9-dioctylfuorene-co-benzothiadiazole)(F8BT)into m-ACSO2,the external quantum efciency(EQE)was improved by a factor of 17.0 in the solution-processed organic light-emitting device(OLED),as compared with the device with neat *** terms of the other well-known fuorescent polymers,i.e.,poly(para-phenylene vinylene)copolymer(Super Yellow,SY)and poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene](MEH-PPV),their EQEs in the devices were respectively enhanced by 70%and 270%,compared with the reference devices based on the conventional host 1,3-di(9H-carbazol-9-yl)benzene(mCP).Besides the improved charge balance in the bipolar TADF host,these were partially ascribed to reduced fuorescence quenching in the mixed flms.

关键词： Thermally activated delayed fuorescence(TADF) Organic light-emitting device(OLED) Sensitization Energy transfer Solution process

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