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Antioxidant responses to benzo[a]pyrene,tributyltin and their mixture in the spleen of Sebasticus marmoratus

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Journal of Environmental Sciences 2007年第9期19卷 1129-1135页

作者： WU Yu-qiong WANG Chong-gang WANG Yun ZHAO Yang CHEN Yi-xin zuo Zheng-hong Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering School of Life Sciences Xiamen University Xiamen 361005 China. Bioengineering Department MinBei Vocational and Technical College Jianyang 354200 China

It has been reported that there is an interaction between Benzo[a]pyrene （BaP）, a widespread carcinogenic polycyclic aromatic hydrocarbon, and tributyltin （TBT）, an organometal used as an antifouling biocide. This study was therefore designed to examine the potential in vivo influence of BaP, TBT and their mixture on splenic antioxidant defense systems of Sebastiscus marmoratus. The fish were exposed to water containing environmentally relevant concentrations of BaP, TBT and their mixture. Spleens were collected for biochemical analysis after exposure for 7, 25, 50 d and after recovery for 7, 20 d. Cotreatment with BaP and TBT for 7 d potentiated the induction of glutathione peroxidase （GPx） activity by BaP or TBT alone. The cotreatment for 25 and 50 d resulted in inhibition of GPx activity, which was similar to the effect of TBT. Splenic glutathione S-transferase （GST） activities were significantly elevated in S. marmoratus exposed to BaP starting from 7 d and remained high up to 25 d. However, no further activity change was found with prolonged exposure. Cotreatment of BaP and TBT primarily inhibited the GST activity, which was similar to the effect of TBT. Cotreatment with BaP and TBT for 25 or 50 d potentiated the depletion of GSH （glutathione） by BaP or TBT alone. MDA （malondialdehyde） contents in spleen of S. marmoratus were not significantly altered compared with the control during the test period. Spleen, as an immune organ, is sensitive to exposure of BaP or TBT. It should have an effective mechanism to counteract oxidative damage. Antioxidative defense systems in spleen of S. marmoratus should be considered as potential biomarkers. Short-term exposure of BaP or TBT could result in induction of antioxidant defense system. A significant decrease of these indices, such as GSH, GST, GPx might indicate more severe contamination.

关键词： tributyltin benzo[a]pyrene antioxidant defense combined effect Sebastiscus marmoratus

Effects of Prior Corrosion with and Without Stress on the Mechanical Properties of 7475-T761 Aluminum Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第5期28卷 608-613页

作者： zuo-Yan Ye Dao-xin Liu Meng Yuan Xiao-Ming Zhang Zhi Yang Ming-Xia Lei Corrosion and Protection Research Laboratory Northwestern Polytechnical University Aviation Industry Corporation of China the First Aircraft Institute

The effect of prior corrosion on the mechanical properties of 7475-T761 aluminum alloy was investigated by immersion test, stress corrosion test, cathode charge method and electrochemical polarization test. Results show that prior corrosion in the solution with 3 wt% NaC1 and 0.5 wt% H202 leads to mechanical properties deterioration of 7475-T761 aluminum alloy. Moreover, the elongation decreases significantly. This is mainly attributed to electrochemical corrosion and hydrogen embrittlement, in which corrosion plays a major role. Tensile stress promotes the degradation of the mechanical properties by accelerating the pitting corrosion and hydrogen embrittlement.

关键词： Prior corrosion Corrosion with stress 7475 aluminum alloy Mechanical properties Hydrogen embrittlement

Recent advances and practical challenges of high-energy-density flexible lithium-ion batteries

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Frontiers of Chemical Science and Engineering 2024年第8期18卷 79-98页

作者： Guangxiang Zhang xin Chen Yulin Ma Hua Huo Pengjian zuo Geping Yin Yunzhi Gao Chuankai Fu State Key Laboratory of Space Power-Sources Harbin Institute of TechnologyHarbin 150001China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China

With the rapid iteration and update of wearable flexible devices,high-energy-density flexible lithium-ion batteries are rapidly ***,energy density,and safety are all important indicators for flexible lithium-ion batteries,which can be determined jointly by material selection and structural ***,recent progress on high-energy-density electrode materials and flexible structure designs are *** electrode materials and the next-generation high-energy-density electrode materials are analyzed in *** electrolytes with high safety and excellent flexibility are classified and *** strategies to increase the mass loading of active materials on the electrodes by designing the current collector and electrode structure are discussed with keys of representative *** the novel configuration structures to enhance the flexibility of batteries are *** the end,it is pointed out that it is necessary to quantify the comprehensive performance of flexible lithium-ion batteries and simultaneously enhance the energy density,flexibility,and safety of batteries for the development of the next-generation high-energy-density flexible lithium-ion batteries.

关键词： lithium-ion batteries flexibility high energy density safety

Effectiveness and Safety of Baidu Jieduan Granules for COVID-19: A Retrospective Observational Multicenter Study

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Chinese Journal of Integrative Medicine 2022年第10期28卷 885-893页

作者： XU Xiang-ru ZHANG Wen WU xin-xin HUANG Ting-rong zuo Jian-guo SHAO Zhong ZHOU Shuang FANG Bang-jiang Department of Emergency Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai(200032)China Department of Emergency Huangshi Hospital of Traditional Chinese Medicine(Infectious Disease Hospital)HuangshiHubei Province(435004)China Department of Emergency the First Hospital of LaohekouLaohekouHubei Province(441899)China Department of Emergency Fushun Third HospitalFushunLiaoning Province(113004)China Acupuncture and Massage College Shanghai University of Traditional Chinese MedicineShanghai(201203)China Institute of Critical Care Shanghai University of Traditional Chinese MedicineShanghai(201203)China

Objective: To evaluate the effectiveness and safety of Baidu Jieduan Granules(BDJDG) to treat common type coronavirus disease 2019(COVID-19). Methods: This multicenter, retrospective, and observational clinical trial included 230 common COVID-19 patients in Leishenshan, Huangshi, and Laohekou Hospitals in Wuhan from January 21 to March 26, 2020. The included patients were further divided into two subgroups according to the use of supplemental oxygen, mild and moderate groups. During the first 14 d of hospitalization, all patients were administered BDJDG combined with conventional Western medicine, and observed for continuous 28 d. Primary outcomes were disease progression rate and discharge rate. Secondary outcomes included negative conversion time of nucleic acid, hospitalization duration, clinical symptom subsidence time, and symptom regression rate. Results: A total of 230 common COVID-19 patients were analyzed(138 in moderate group and 92 in mild group). By day 28, the disease progression rate was 4.3% and the discharge rate was 95.7%. All mild cases recovered and were discharged from hospital. The median negative conversion time of nucleic acid of all 230 COVID-19 patients was 12 d [inter-quartile range(IQR) 3.5–17], the median hospitalization duration was 15 d(IQR 12–20). The median time to fever, cough, and fatigue recovery was 4 d(IQR 2–6), 8 d(IQR 5–12), and 8 d(IQR 5–11), respectively. The recovery rate of fever, cough, and fatigue was 94.6%, 90.5%, and 93.5%. The median time to clinical improvement was 12 d(IQR 10–17). Compared with the baseline, total leukocyte, neutrophil, lymphocyte, and platelet counts were all increased significantly on days 7 and 14(P<0.01). C-reactive protein markedly increased on day 3 and significantly decreased on days 7 and 14(P<0.01). No serious adverse events occurred during treatment. Conclusion: BDJDG may be effective and safe for treatment of common type COVID-19.(Registration No. ChiCTR2000030836)

关键词： COVID-19 common type Baidu Jieduan Granule integrated Chinese and Western medicine

Optimization of multiple attenuation mechanisms by cation substitution in imidazolic MOFs-derived porous composites for superior broadband electromagnetic wave absorption

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Journal of Materials Science & Technology 2024年第9期176卷 176-187页

作者： Hao Yu xin Kou Xueqing zuo Ding Xi Haijun Guan Pengfei Yin Lijia Xu Yongpeng Zhao College of Mechanical and Electrical Engineering Sichuan Agricultural UniversityYa’an 625000China College of Resources Sichuan Agricultural UniversityChengdu 610000China School of Physics Dalian University of TechnologyDalian 116024China College of Science Sichuan Agricultural UniversityYa’an 625000China

Metal-organic frameworks(MOFs)derived composites are extremely potential electromagnetic wave(EMW)***,the permittivity of absorbers directly derived from MOFs with solid structure is usually relatively low,inevitably limiting their further *** substitution can primely overcome the problem by regulating the morphology and atomic space occupation to enhance multiple loss mechanisms and impedance matching ***,universal mechanisms of the effect on EMW absorption performance influenced by cation substitution are still comparatively inadequate,which prospectively requires further ***,a series of imidazolic MOFs were fabricated by ultrasonic symbiosis method and tailored by subsequent cation substitution strategy to prepare target porous *** a low filling rate and thin thickness,the as-obtained samples reach the optimal reflection loss and effective absorption bandwidth values of–49.81 dB and 7.63 GHz,*** intercoupling between multiple atoms lays a significant foundation for abundant heterogeneous interfaces and defect vacancies,which effectively ameliorate the attenuation ***,the porous structure introduced by cation substitution reduces the bulk density to enhance the impedance matching and multiple reflections *** study provides a helpful idea to exceedingly improve the EMW absorbing performance of imidazolic MOFs-derived composites by cation substitution.

关键词： Multiple attenuation mechanisms Cation substitution Porous composites Electromagnetic wave absorption

Direct growth of Fe3O4-MoO2 hybrid nanofilm anode with enhanced electrochemical performance in neutral aqueous electrolyte

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Progress in Natural Science:Materials International 2016年第3期26卷 258-263页

作者： ruizhi Li xin Ba Yimeng Wang Wenhua zuo Chong Wang Yuanyuan Li Jinping Liu School of Chemistry Chemical Engineering and Life Science and State Key Laboratory of Advanced Technology for Materials Synthesis and ProcessingWuhan University of Technology Institute of Nanoscience and Nanotechnology Department of Physics Central China Normal University School of Optical and Electronic Information Huazhong University of Science and Technology

To enhance the electrochemical energy storage performance of supercapacitors（SCs）, the current researches are general directed towards the cathode materials. However, the anode materials are relatively less studied. In the present work, Fe3O4-MoO2（FO-MO） hybrid nano thin film directly grown on Ti substrate is investigated, which is used as high-performance anode material for SCs in Li2SO4electrolyte with the comparison to pristine Fe3O4nanorod array. The areal capacitance of FO-MO hybrid electrode was initially found to be 65.0 m F cm-2at 2 m Vs-1and continuously increased to 260.0% after 50 cycles of activation. The capacitance values were considerably comparable or higher than many reported thinfilm iron oxide-based anodes in neutral electrolyte. With the protection of MoO2shell, the FO-MO electrode developed in this study also exhibited excellent cyclic stability（increased to 230.8% after 1000cycles）. This work presents a promising way to improve the electrochemical performance of iron oxidebased anodes for SCs.

关键词： Magnetite MoO2 Supercapacitor Binder-free anode Hybridization

一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

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光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和S这两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为CaF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度

P-norm Regularized SVM Classifier by Non-convex Conjugate Gradient Algorithm

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P-norm Regularized SVM Classifier by Non-convex Conjugate Gr...

HFD-exacerbated Metabolic Side Effects of Olanzapine Are Suppressed by ER Stress Inhibitor

第25届中国控制与决策会议

作者： zuo xin HUANG Hailong LI Haien LIU Jianwei Research Institute of Automation China University of Petroleum

ISBN: (纸本)9781467355322

Classical classification algorithm of SVM via p norm regularization usually takes p as 0, 1 or 2. However, these parameters can’t always achieve the best classification results. Some scholars have discussed the situations of p∈{0,1, 2} , where the problem is transformed into the standard quadratic programming. However, when p∈(0,1], the object is non-convex, and the method of quadratic programming is not suitable. From the point of optimization, we use Conjugate Gradient Algorithm to solve the problem. In this paper, two different kinds of SVM have been discussed and the classification results are shown by the experiments on three cancer datasets. At last, we discussed the problem of feature selection. The experiment results show that, feature selection can not only keep the precision of the prediction but also reduce model complexity.

关键词： Lp-norm 0 SVM Conjugate gradient algorithm Feature Selection

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Current Medical Science 2023年第6期43卷 1116-1132页

作者： Yu-feng zuo Bao-hua ZHANG Ming-rui GUO Ben-ben LI Bao-cui WANG Deng DUAN Yu-xin WANG Jing XI Meng HE Tao-lei SUN School of Chemistry Chemical Engineering and Life SciencesWuhan University of TechnologyWuhan430070China The National Clinical Research Center for Mental Disorders&Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital&the Advanced Innovation Center for Human Brain ProtectionCapital Medical UniversityBeijing100069China Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases School of ChemistryChemical Engineering and Life ScienceWuhan University of TechnologyWuhan430070China

Objective Numerous schizophrenic patients are suffering from obesity primarily attributed to antipsychotic medication and poor dietary *** study investigated the progressive deterioration of olanzapine-induced metabolic disorders in the presence of a high-fat diet(HFD)and explored the involvement of endoplasmic reticulum(ER)*** Female Sprague-Dawley rats fed on a standard chow diet or HFD were treated with olanzapine(3 mg/kg/day)and the ER stress inhibitor 4-phenylbutyric acid(4-PBA,1 and 0.5 g/kg/day)for 8 *** in body weight,food intake,and plasma lipids were *** fat accumulation was evaluated using oil red O *** blotting and immunofluorescence assays were employed to examine the expression of ER stress markers,NOD-like receptor pyrin domain-containing protein 3(NLRP3),and proopiomelanocortin(POMC)in the hypothalamus or *** Compared to olanzapine alone,olanzapine+HFD induced greater weight gain,increased hyperlipidemia,and enhanced hepatic fat accumulation(P<0.05).Co-treatment with 4-PBA exhibited a dose-dependent inhibition of these effects(P<0.05).Further mechanistic investigations revealed that olanzapine alone activated ER stress,upregulated NLRP3 expression in the hypothalamus and liver,and downregulated hypothalamic POMC *** HFD exacerbated these effects by 50%–100%.Moreover,co-administration of 4-PBA dose-dependently attenuated the olanzapine+HFD-induced alterations in ER stress,NLRP3,and POMC expression in the hypothalamus and liver(P<0.05).Conclusion HFD worsened olanzapine-induced weight gain and lipid metabolic disorders,possibly through ER stress-POMC and ER stress-NLRP3 *** stress inhibitors could be effective in preventing olanzapine+HFD-induced metabolic disorders.

关键词： olanzapine high-fat diet obesity lipid metabolism endoplasmic reticulum stress proopiomelanocortin NOD-like receptor pyrin domain-containing protein 3