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Probabilistic and Hierarchical Quantum Information Splitting Based on the Non-Maximally Entangled Cluster State

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Computers, Materials & Continua 2021年第10期69卷 339-349页

作者： Gang Xu rui-ting shan Xiu-Bo Chen Mianxiong Dong Yu-Ling Chen School of Information Science and Technology North China University of TechnologyBeijing100144China Information Security Center State Key Laboratory of Networking and Switching TechnologyBeijing University of Posts and TelecommunicationsBeijing100876China Muroran Institution of Technology Muroran050-8585Japan State Key Laboratory of Public Big Data College of Computer Science and TechnologyGuizhou UniversityGuiyang550025China

With the emergence of classical communication security problems,quantum communication has been studied more *** this paper,a novel probabilistic hierarchical quantum information splitting protocol is designed by using a non-maximally entangled four-qubit cluster ***,the sender Alice splits and teleports an arbitrary one-qubit secret state invisibly to three remote agents Bob,Charlie,and *** agent David is in high grade,the other two agents Bob and Charlie are in low ***,the receiver in high grade needs the assistance of one agent in low grade,while the receiver in low grade needs the aid of all *** introducing an ancillary qubit,the receiver’s state can be inferred from the POVM measurement result of the ancillary ***,with the help of other agents,the receiver can recover the secret state probabilistically by performing certain unitary operation on his own *** addition,the security of the protocol under eavesdropping attacks is *** this proposed protocol,the agents need only single-qubit measurements to achieve probabilistic hierarchical quantum information splitting,which has appealing advantages in actual *** a probabilistic hierarchical quantum information splitting protocol hierarchical is expected to be more practical in multipartite quantum cryptography.

关键词： Cluster state hierarchical quantum information splitting probabilistic non-maximally entangled states

Design and implementation of reconfigurable CNN accelerator architecture based on elastic storage

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The Journal of China Universities of Posts and Telecommunications 2025年

作者： shan rui Xu Jianing Huo Ziqing College of Electronic Engineering， Xi'an University of Post and Telecommunications

With the rapid iteration of neural network algorithms， higher requirements was placed on the computational performance and memory access bandwidth of neural network accelerators. Simply increasing bandwidth cannot improve energy efficiency， so improving data reuse rate is a hot research topic. From the perspective of supporting data reuse， a reconfigurable convolutional neural networks (CNN) accelerator based on elastic storage was designed in this paper. By supporting elastic memory access and flexible data flow， it reduces data movement between the processor and memory， eases the bandwidth pressure and enhances CNN acceleration performance. The experimental results indicate that conducting 1×1 convolution and 3×3 convolution when performing convolution calculations， the execution speed increased by 25.00% and 61.61%， respectively. The 3×3 maximum pooling speed was increased by 76.04%.

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New Taub-NUT black holes with massive spin-2 hair

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 51-58页

作者： Yu-Qi Chen Hai-shan Liu Center for Joint Quantum Studies and Department of Physics School of ScienceTianjin UniversityTianjin 300350China

We consider Einstein gravity extended with quadratic curvature invariants,within which the well-known Ricci-flat Taub-NUT black hole remains a *** analysis of the unstable Lichnerowicz modes in the Taub-NUT background enables us to identify the mass and NUT parameters(m,n)where new Taub-NUT black holes can *** then adopt numerical techniques to construct these new Taub-NUT black holes,which bifurcate away from the Ricci-flat *** the Ricci-flat Taub-NUT,there can exist two new black holes for an appropriate given temperature,making it a total of three if we include the Ricci-flat one.

关键词： higher derivative gravity black hole solution Taub-NUT spacetime

The gut microbiome modulate response to immunotherapy in cancer

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Science China(Life Sciences) 2025年第2期68卷 381-396页

作者： shan-shan Jiang Zi-Ran Kang Ying-Xuan Chen Jing-Yuan Fang Division of Gastroenterologyand Hepatology Shanghai Instituteof Digestive DiseaseNHC KeyLaboratoryof Digestive DiseasesState KeyLaboratoryfor Oncogenesand Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200001China

Gut microbiota have been reported to play an important role in the occurrence and development of malignant ***,clinical studies have identified specific gut microbiota and its metabolites associated with efficacy of immunotherapy in multiple types of *** investigations have elucidated that gut microbiota modulate the antitumor immunity and affect the efficacy of cancer *** microbiota and its metabolites may favorably remodel the tumor microenvironment by engaging innate and/or adaptive immune *** how the gut microbiome interacts with cancer immunotherapy opens new avenues for improving treatment *** microbial transplants,probiotics,dietary interventions,and other strategies targeting the microbiota have shown promise in preclinical studies to enhance the *** clinical trials are evaluating these *** review presents the recent advancements in understanding the dynamic interplay among the host immunity,the microbiome,and cancer immunotherapy,as well as strategies for modulating the microbiome,with a view to translating into clinical applications.

关键词： cancer immunotherapy gut microbiota intratumoral microbiota microbiota-derived metabolites innate and adaptive immunity

Pressure induced superconducting dome in LaNiGa_(2)

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Science China(Physics,Mechanics & Astronomy) 2025年第2期68卷 161-166页

作者： Yanan Zhang Dajun Su Zhaoyang shan Yunshu Shi rui Li Jinyu Wu Zihan Yang Kaixin Ye Fei Zhang Yanchun Li Xiaodong Li Chao Cao Valentin Taufour Lin Jiao Michael Smidman Huiqiu Yuan Center for Correlated Matter and School of Physics Zhejiang UniversityHangzhou 310058China Department of Physics and Astronomy University of CaliforniaDavis 95616USA Beijing Synchrotron Radiation Facility Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Silicon and Advanced Semiconductor Materials Zhejiang UniversityHangzhou 310058China Collaborative Innovation Center of Advanced Microstructures Nanjing 210093China

LaNiGa_(2)is a time-reversal symmetry breaking superconductor with symmetry protected band crossings,making it an ideal platform for investigating the interplay between unconventional superconductivity and electronic structure *** we present a transport study of LaNiGa_(2)under *** application of pressure to LaNiGa_(2)induces a significant enhancement of the superconducting transition temperature Tcat a pressure of 7 *** contrast,powder X-ray diffraction(XRD)results show no evidence of structural phase transitions up to 26.3 ***,the ratio of band diffusivity shows a sudden increase at around 7 GPa,suggesting possible pressure-induced changes in the electronic structure that are closely linked to the evolution of superconductivity.

关键词： high pressure superconductivity time-reversal breaking

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P2Y1 receptor in Alzheimer’s disease

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Neural Regeneration Research 2025年第2期20卷 440-453页

作者： shan Luo Yifei Wang Tatsuhiro Hisatsune Department of Integrated Biosciences The University of TokyoKashiwaJapan

Alzheimer’s disease is the most frequent form of dementia characterized by the deposition of amyloid-beta plaques and neurofibrillary tangles consisting of hyperphosphorylated *** amyloid-beta plaques has been a primary direction for developing Alzheimer’s disease treatments in the last ***,existing drugs targeting amyloid-beta plaques have not fully yielded the expected results in the clinic,necessitating the exploration of alternative therapeutic *** evidence unravels that astrocyte morphology and function alter in the brain of Alzheimer’s disease patients,with dysregulated astrocytic purinergic receptors,particularly the P2Y1 receptor,all of which constitute the pathophysiology of Alzheimer’s *** receptors are not only crucial for maintaining normal astrocyte function but are also highly implicated in neuroinflammation in Alzheimer’s *** review delves into recent insights into the association between P2Y1 receptor and Alzheimer’s disease to underscore the potential neuroprotective role of P2Y1 receptor in Alzheimer’s disease by mitigating neuroinflammation,thus offering promising avenues for developing drugs for Alzheimer’s disease and potentially contributing to the development of more effective treatments.

关键词： astrocytes neuroinflammation P2Y1 receptor purinergic receptor

N^(6)-methyladenosine on the natural antisense transcript of NIA1 stabilizes its mRNA to boost NO biosynthesis and modulate stomatal movement

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Molecular Plant 2025年第1期18卷 151-165页

作者： Jie Li Wen Tian ting Chen Qing-Yan Liu Hua-Wei Wu Chuan-Hui Liu Yuan-Yuan Fang Hui-shan Guo Jian-Hua Zhao State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina

Nitric oxide(NO)is a crucial signaling molecule that regulates a wide range of metabolic pathways in different strata of *** plants,nitrate reductase(NR)is a key enzyme for NO *** are two NR-encoding genes in Arabidopsis genome,NIA1 and NIA2,which are precisely regulated and expressed in a tissue-specific *** this study,we found that the natural antisense transcript as-NIA1,transcribed from the 30 UTR of NIA1,stabilizes NIA1 mRNA to maintain its circadian oscillation in plants grown under the light/dark ***,as-NIA1-dependent NIA1 mRNA stability is indispensable for NIA1-mediated NO biosynthesis in guard cells and natural stomatal ***,we revealed that polypyrimidine tract-binding 3(PTB3)regulates the stabilization of NIA1 mRNA by directly binding to UC-rich elements of *** further found that MTA deposits N^(6)-methyladenosine(m6 A)on as-NIA1,facilitating the as-NIA1-PTB3 interaction in vivo,in agreement with RNA structure prediction in that m6 Amediated structural alterations expose the UC-rich elements to enhance the accessibility of *** together,these findings reveal a novel molecular mechanism by which plants precisely manipulate NO biosynthesis to modulate light/dark-regulated stomatal movement,highlighting the coupling of RNA epigenetic modifications and structures shaping RNA-protein interactions in the regulation of hormone biosynthesis.

关键词： natural antisense transcript,NO biosynthesis,N^(6)-methyladenosine,NIA1,stomatal movement

Immune cells:potential carriers or agents for drug delivery to the central nervous system

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Military Medical Research 2025年第1期12卷 121-153页

作者： shan-shan Zhang Ruo-Qi Li Zhong Chen Xiao-Ying Wang Aaron S.Dumont Xiang Fan School of Basic Medical Sciences Zhejiang Chinese Medical UniversityHangzhou 310053China Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province Zhejiang Chinese Medical UniversityHangzhou 310053China Clinical Neuroscience Research Center Department of Neurosurgery and NeurologyTulane University School of MedicineNew OrleansLA 70122USA

Drug delivery systems(DDS)have recently emerged as a promising approach for the unique advantages of drug protection and targeted ***,the access of nanoparticles/drugs to the central nervous system(CNS)remains a challenge mainly due to the obstruction from brain *** cells infiltrating the CNS in the pathological state have inspired the development of strategies for CNS foundation drug ***,we outline the three major brain barriers in the CNS and the mechanisms by which immune cells migrate across the blood–brain *** subsequently review biomimetic strategies utilizing immune cell-based nanoparticles for the delivery of nanoparticles/drugs to the CNS,as well as recent progress in rationally engineering immune cell-based DDS for CNS ***,we discuss the challenges and opportunities of immune cell-based DDS in CNS diseases to promote their clinical development.

关键词： Drug delivery systems Immune cells Blood-brain barrier Central nervous system

Relativistic hyperpolarizabilities of atomic H,Li,and Be^(+)systems

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Chinese Physics B 2025年第2期34卷 230-239页

作者： shan-shan Lu Hong-Yuan Zheng Zong-Chao Yan James F.Babb Li-Yan Tang State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhan 430071China University of Chinese Academy of Sciences Beijing 100049China Department of Physics University of New BrunswickFrederictonNew BrunswickE3B 5A3Canada ITAMP Center for Astrophysics|Harvard&Smithsonian60 Garden St.CambridgeMA 02138USA

For atoms in external electric fields,the hyperpolarizabilities are the coefficients describing the nonlinear interactions contributing to the induced energies at the fourth power of the applied electric *** evaluations of these coefficients for various systems are crucial for improving precision in advanced atom-based optical lattice clocks and for estimating field-induced effects in atoms for quantum information ***,there is a notable scarcity of research on atomic hyperpolarizabilities,especially in the relativistic *** work addresses this gap by establishing a novel set of alternative formulas for the hyperpolarizability based on the fourth-order perturbation *** formulas offer a more reasonable regrouping of scalar and tensor components compared to previous formulas,thereby enhancing their correctness and *** validate our formulas,we perform the calculations for the ground and low-lying excited pure states of few-electron atoms H,Li,and Be^(+).The highly accurate results obtained for the H atom could serve as benchmarks for further development of other theoretical methods.

关键词： hyperpolarizabilities Stark effect fourth-order perturbation few-electron atoms