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Potential role of tanycyte-derived neurogenesis in Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1599-1612页

作者： Guibo Qi han Tang Jianian Hu Siying Kang Song qin Department of Anatomy Histologyand EmbryologySchool of Basic Medical SciencesFudan UniversityShanghaiChina State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Fudan UniversityShanghaiChina

Tanycytes, specialized ependymal cells located in the hypothalamus, play a crucial role in the generation of new neurons that contribute to the neural circuits responsible for regulating the systemic energy balance. The precise coordination of the gene networks controlling neurogenesis in naive and mature tanycytes is essential for maintaining homeostasis in adulthood. However, our understanding of the molecular mechanisms and signaling pathways that govern the proliferation and differentiation of tanycytes into neurons remains limited. This article aims to review the recent advancements in research into the mechanisms and functions of tanycyte-derived neurogenesis. Studies employing lineage-tracing techniques have revealed that the neurogenesis specifically originating from tanycytes in the hypothalamus has a compensatory role in neuronal loss and helps maintain energy homeostasis during metabolic diseases. Intriguingly,metabolic disorders are considered early biomarkers of Alzheimer's disease. Furthermore,the neurogenic potential of tanycytes and the state of newborn neurons derived from tanycytes heavily depend on the maintenance of mild microenvironments, which may be disrupted in Alzheimer's disease due to the impaired blood–brain barrier ***, the specific alterations and regulatory mechanisms governing tanycyte-derived neurogenesis in Alzheimer's disease remain unclear. Accumulating evidence suggests that tanycyte-derived neurogenesis might be impaired in Alzheimer's disease, exacerbating neurodegeneration. Confirming this hypothesis, however, poses a challenge because of the lack of long-term tracing and nucleus-specific analyses of newborn neurons in the hypothalamus of patients with Alzheimer's disease. Further research into the molecular mechanisms underlying tanycyte-derived neurogenesis holds promise for identifying small molecules capable of restoring tanycyte proliferation in neurodegenerative diseases. This line of investigation could pro

关键词： Alzheimer's disease blood–brain barrier ependymoglial cells hypothalamus metabolic diseases neural stem cells neurogenesis neuroinflammatory diseases neurons tanycyte

Multi boron-doping effects in hard carbon toward enhanced sodium ion storage

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Journal of Energy Chemistry 2025年第1期100卷 730-738页

作者： Peng Zheng Wang Zhou Ying Mo Biao Zheng Miaomiao han qin Zhong Wenwen Yang Peng Gao Lezhi Yang Jilei Liu College of Materials Science and Engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean Energy Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Greater Bay Area Institute for Innovation Hunan University Changsha Research Institute of Mining & Metallurgy Co. LTD.

Hard carbon （HC） has been considered as promising anode material for sodium-ion batteries （SIBs）.The optimization of hard carbon’s microstructure and solid electrolyte interface （SEI） property are demonstrated effective in enhancing the Na+storage capability,however,a one-step regulation strategy to achieve simultaneous multi-scale structures optimization is highly ***,we have systematically investigated the effects of boron doping on hard carbon’s microstructure and interface chemistry.A variety of structure characterizations show that appropriate amount of boron doping can increase the size of closed pores via rearrangement of carbon layers with improved graphitization degree,which provides more Na+storage ***-situ Fourier transform infrared spectroscopy/electrochemical impedance spectroscopy （FTIR/EIS） and X-ray photoelectron spectroscopy （XPS） analysis demonstrate the presence of more BC3and less B–C–O structures that result in enhanced ion diffusion kinetics and the formation of inorganic rich and robust SEI,which leads to facilitated charge transfer and excellent rate *** a result,the hard carbon anode with optimized boron doping content exhibits enhanced rate and cycling *** general,this work unravels the critical role of boron doping in optimizing the pore structure,interface chemistry and diffusion kinetics of hard carbon,which enables rational design of sodium-ion battery anode with enhanced Na+storage performance.

关键词： X ray photoelectron spectroscopy

Improving postoperative outcomes in patients with pancreatic cancer:Inflammatory and nutritional biomarkers

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World Journal of Clinical Oncology 2025年第1期16卷 59-64页

作者： Chun-han Cheng Wen-rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305Taiwan Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561Taiwan Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002Taiwan Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404328Taiwan

This editorial assesses the prognostic value of preoperative inflammatory and nutritional biomarkers in patients undergoing surgical resection for pancreatic *** et al evaluated the ability of seven biomarkers to predict postoperative recovery and long-term *** biomarkers were albumin-to-globulin ratio,prognostic nutritional index(PNI),systemic immune-inflammation index,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,nutritional risk index,and geriatric nutritional risk *** PNI was found to be a strong predictor of both overall and recurrence-free survival,underscoring its clinical relevance in managing patients with pancreatic cancer.

关键词： Pancreatic cancer Prognostic nutritional index Systemic immune-inflammation index Postoperative recovery Prognosis

Radiomics and molecular analysis:Bridging the gap for predicting hepatocellular carcinoma prognosis

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World Journal of Clinical Cases 2025年第4期13卷 56-60页

作者： Chun-han Cheng Wen-rui Hao Tzu-Hurng Cheng Department of Medical Education Linkou Chang Gung Memorial HospitalTaoyuan 33305TaiwanChina Division of Cardiology Department of Internal MedicineShuang Ho HospitalMinistry of Health and WelfareTaipei Medical UniversityNew Taipei 23561TaiwanChina Division of Cardiology Department of Internal MedicineSchool of MedicineCollege of MedicineTaipei Medical UniversityTaipei 11002TaiwanChina Department of Biochemistry School of MedicineCollege of MedicineChina Medical UniversityTaichung 404333TaiwanChina

This editorial examines a recent study that used radiomics based on computed tomography(CT)to predict the expression of the fibroblast-related gene enhancer of zeste homolog 2(EZH2)and its correlation with the survival of patients with hepatocellular carcinoma(HCC).By integrating radiomics with molecular analysis,the study presented a strategy for accurately predicting the expression of EZH2 from CT *** findings demonstrated a strong link between the radiomics model,EZH2 expression,and patient *** noninvasive approach provides valuable insights into the therapeutic management of HCC.

关键词： Hepatocellular carcinoma Computed tomography Radiomics Enhancer of zeste homologue 2 expression Non-invasive imaging

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相变混凝土抗压强度与储热能力试验及分析

河南城建学院学报 2024年第4期33卷 33-38页

作者：张经双缪鹏秦瑞汉安徽理工大学土木建筑学院安徽淮南232001

为研究硅藻土相变混凝土在建筑围护结构中的应用,进行了相变储能骨料的封装方式试验和相变混凝土的抗压强度、保温性能试验,得到不同封装方式下相变储能骨料的质量损失率、不同相变储能骨料掺量下相变混凝土的抗压强度和储热能力的变化... 详细信息

为研究硅藻土相变混凝土在建筑围护结构中的应用,进行了相变储能骨料的封装方式试验和相变混凝土的抗压强度、保温性能试验,得到不同封装方式下相变储能骨料的质量损失率、不同相变储能骨料掺量下相变混凝土的抗压强度和储热能力的变化规律。结果表明:用水泥净浆封装相变储能骨料,操作简便且封装效果好,相变储能骨料在50次高低温循环后,质量损失率仅为1.97%;当相变储能骨料的掺量为20%时,抗压强度和保温性能综合效果最优,抗压强度达到31.48 MPa,温度阻尼率达到0.538 5。

关键词：相变混凝土相变储能骨料封装方式抗压强度保温性能

Evaluation and Projection of Population Exposure to Temperature Extremes over the Beijing−Tianjin−Hebei Region Using a High-Resolution Regional Climate Model RegCM4 Ensemble

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Advances in Atmospheric Sciences 2024年第6期41卷 1132-1146页

作者： Peihua qin Zhenghui XIE rui han Buchun LIU State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural Sciences(CAAS)Beijing 100081China

Temperature extremes over rapidly urbanizing regions with high population densities have been scrutinized due to their severe impacts on human safety and *** of all,the performance of the regional climate model RegCM4 with a hydrostatic or non-hydrostatic dynamic core in simulating seasonal temperature and temperature extremes was evaluated over the historical period of 1991–99 at a 12-km spatial resolution over China and a 3-km resolution over the Beijing−Tianjin−Hebei(JJJ)region,a typical urban agglomeration of *** of spatial distributions of temperature extremes over the JJJ region using RegCM4 with hydrostatic and non-hydrostatic cores showed high spatial correlations of more than 0.8 with the *** a warming climate,temperature extremes of annual maximum daily temperature(TXx)and summer days(SU)in China and the JJJ region showed obvious increases by the end of the 21st century while there was a general reduction in frost days(FD).The ensemble of RegCM4 with different land surface components was used to examine population exposure to temperature extremes over the JJJ *** exposure to temperature extremes was found to decrease in 2091−99 relative to 1991−99 over the majority of the JJJ region due to the joint impacts of increases in temperature extremes over the JJJ and population decreases over the JJJ region,except for downtown ***,changes in population exposure to temperature extremes were mainly dominated by future population ***,we quantified changes in exposure to temperature extremes with temperature increase over the JJJ *** study helps to provide relevant policies to respond future climate risks over the JJJ region.

关键词： CMIP6 convection-permitting population exposure RegCM4 temperature extremes

上海市一级医院35岁以上首诊病人测血压现状调查

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上海预防医学 2002年第6期14卷 258-259页

作者：王振果李锐韩阿琴上海市疾病预防控制中心上海200336

[目的 ]　了解上海市一级医院首诊测血压执行情况。　 [方法 ]　采用问卷及查阅病史的方法进行横断面的流行病学研究 ,共调查 19家一级医院 ,76位门诊医生、92 6份门诊病历。　 [结果 ]　各医院在该项工作的执行中存在不平衡现象 ,医生... 详细信息

[目的 ]　了解上海市一级医院首诊测血压执行情况。　 [方法 ]　采用问卷及查阅病史的方法进行横断面的流行病学研究 ,共调查 19家一级医院 ,76位门诊医生、92 6份门诊病历。　 [结果 ]　各医院在该项工作的执行中存在不平衡现象 ,医生对 35岁首诊测压的认识也不尽相同 ;门诊被调查就诊人群中高血压患病率高达 44.18% ,且随年龄逐渐递增 ,各年龄组血压水平亦呈现随年龄递增趋势 ;高血压患者新检出率为 2 6 .0 1% ,新检出高血压患者中 78%血压水平处于 14 0～ 15 9和 /或 90～ 99mmHg范围。　[结论 ]　 35岁以上门诊病人中 ,高血压患病率较高 ,尤其以轻型高血压居多。加强落实和规范一级医院中 35岁首诊测压工作 ,可以提高高血压患者的早期检出率和预防并发症的发生 ,同时建议有关部门应尽快在二、三级医院开展此项工作。

关键词：上海一级医院首诊高血压检出率

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

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Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan Sun Lingxiao Deng Melissa Walker Chen Chen Heqiao Dai Qi han Ying Ding Yongzhi Xia George Smith rui Li Nai-Kui Liu Xiao-Ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA Department of hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA Department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

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广东普通野生稻调查、收集与保护建议

植物遗传资源学报 2017年第2期18卷 372-379页

作者：范芝兰潘大建陈雨陈建酉李晨孙炳蕊周汉钦陈文丰刘维广东省农业科学院水稻研究所/广东省水稻育种新技术重点实验室广州510640

为了全面了解广东省普通野生稻自然生存现状,更好地为我国野生稻资源的长远保护提供决策依据,2005-2016年我们对广东普通野生稻自然生存状况进行了实地调查。结果查明,目前广东共有25个县(市)尚存普通野生稻,尚有分布点118个,其中103个... 详细信息

为了全面了解广东省普通野生稻自然生存现状,更好地为我国野生稻资源的长远保护提供决策依据,2005-2016年我们对广东普通野生稻自然生存状况进行了实地调查。结果查明,目前广东共有25个县(市)尚存普通野生稻,尚有分布点118个,其中103个有历史资料记载,15个为本次调查新发现。根据历史资料统计,广东省原有普通野生稻分布点1083个,但截至目前野生稻已全部消失的分布点有980个,分布点丧失率90.49%,呈现严重濒危的趋势。调查发现,造成野生稻大量消失的原因主要有垦荒造田、水利建设、城镇建设、养殖业发展、除草剂使用、环境污染和外来物种侵袭等。调查的同时,从118个点共收集了1371份种茎样本进行异位保存,为普通野生稻资源持续利用提供了更大的物质保障。此外,对广东普通野生稻的长远保护提出了建议。

关键词：广东普通野生稻调查收集保护