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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1717-1719页

作者： rui-lin zhu Xiao-Peng Gu Ya-Di Zhang Liu Yang Department of Ophthalmology Peking University First HospitalBeijing 100034China

Dear Editor,We write to report one case of focal choroidal excavation(FCE) complicated with choroidal neovascularization(CNV), and to review the literature on FCE. FCE is a newly recognized imaging finding with the development of optical coherence tomography(OCT) technology. FCE is defined as an area of macular choroidal excavation without evidence of posterior staphyloma or scleral ectasia[1].

关键词： choroidal technology. excavation

Absence of ephrin-A2/A3 increases retinal regenerative potential for Müller cells in Rhodopsin knockout mice

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Neural Regeneration Research 2021年第7期16卷 1317-1322页

作者： rui-lin zhu Yuan Fang Hong-Hua Yu Dong FChen Liu Yang Kin-Sang Cho Department of Ophthalmology Peking University First HospitalBeijingChina Schepens Eye Research Institute Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Ophthalmology and Visual Science Eye&ENT HospitalShanghai Medical CollegeFudan UniversityShanghaiChina Guangdong Eye Institute Department of OphthalmologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouGuangdong ProvinceChina

Müller cells(MC) are considered dormant retinal progenitor cells in *** studies demonstrated ephrin-As act as negative regulators of neural progenitor cells in the retina and *** remains unclear whether the lack of ephrin-A2/A3 is sufficient to promote the neurogenic potential of *** we investigated whether the MC is the primary retinal cell type expressing ephrin-A2/A3 and their role on the neurogenic potential of Müller *** this study, we showed that ephrin-A2/A3 and their receptor EphA4 were expressed in retina and especially enriched in *** level of ephrin As/EphA4 expression increased as the retina matured that is correlated with the reduced proliferative and progenitor cell potential of ***, we investigated the proliferation in primary MC cultures isolated from wild-type and A2~(–/–) A3~(–/–) mice by 5-ethynyl-2′-deoxyuridine(EdU) *** detected a significant increase of EdU~+ cells in MC derived from A2~(–/–) A3~(–/–) ***, we investigated the role of ephrin-A2/A3 in mice undergoing photoreceptor degeneration such as Rhodopsin knockout(Rho~(–/–)) *** further evaluate the role of ephrin-A2/A3 in MC proliferation in vivo, EdU was injected intraperitoneally to adult wild-type, A2~(–/–) A3~(–/–), Rho~(–/–) and Rho~(–/–) A2~(–/–) A3~(–/–) mice and the numbers of EdU~+ cells distributed among different layers of the *** As/EphA4 expression was upregulated in the retina of Rho~(–/–) mice compared to the wild-type *** addition, cultured MC derived from ephrin-A2~(–/–) A3~(–/–) mice also expressed higher levels of progenitor cell markers and exhibited higher proliferation potential than those from wild-type ***, we detected a significant increase of EdU~+ cells in the retinas of adult ephrin-A2~(–/–) A3~(–/–) mice mainly in the inner nuclear layer;and these EdU~+ cells were co-localized with MC marker, cellular retinaldehyde-binding protein, suggesting some proliferating cells are from

关键词： endogenous stem cell EphA4 ephrin-A2 ephrin-A3 ephrins Müller cell photoreceptor cell regeneration retinal degeneration retinal regeneration retinal stem cell

Glaucoma secondary to trabecular meshwork precipitates:a case report of Grant’s syndrome

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International Journal of Ophthalmology(English edition) 2021年第5期14卷 780-782页

作者： Ya-Hui Wei Tian Tian rui-lin zhu Mei Li Department of Ophthalmology Peking University First HospitalBeijing 100034China

Dear Editor,We write to report a case of glaucoma secondary to trabecular meshwork(TM)*** glaucoma is a common complication of uveitis,which usually presented as elevated intraocular pressure(IOP)with inflammatory sig... 详细信息

关键词： precipitates elevated meshwork

Paleoenvironmental reconstruction and organic matter accumulation of the paleogene shahejie oil shale in the Zhanhua Sag, Bohai Bay Basin, Eastern China

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Petroleum Science 2024年第3期21卷 1552-1568页

作者： Xiao-lin Wang Xiao-Min zhu Jin Lai Xing-Yue lin Xiang Wang Yu-Shan Du Chao Huang Yu-rui zhu State Key Laboratory of Petroleum Resources and Engineering China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Shengli Oilfield SINOPECDongying257000ShandongChina

The controlling factors of organic-rich shale accumulation is essential for the exploration and development of shale oil and gas *** sedimentary environment plays a vital role in the formation of organic-rich sediments in lacustrine *** article unravels the mineralogy,geochemistry,and paleoenvironmental evolution during the deposition of the Paleogene Shahejie Formation(Es_(3)^(L)).It discusses the effects of paleoclimate,paleosalinity,paleoredox conditions,paleowater depth,and paleoproductivity on organic matter(OM)***,the OM enrichment model was *** results show that the mineralogical compositions are mainly composed of calcite(avg.40.13%),quartz(avg.21.64%)and clay minerals(avg.24.07%),accompanied by dolomite(avg.7.07%),feldspar(avg.6.36%)and pyrite(avg.2.95%).The Es_(3)^(L) shale has a high abundance of OM,with total organic carbon(TOC)ranging from 1.07%to 5.12%.The organic matter type is mainly composed of type I-II_(1) kerogen,which is generally considered a good-quality source *** source of OM is a mixture of lower bacteria,algae,and *** the early sedimentary period,the paleoclimate was dry and cold,with high salinity,intense reducibility,and relatively low *** the late sedimentary period,the climate became warmer and more *** a result,the salinity decreased to a level that was suitable for biological reproduction,and productivity increased gradually due to the input of terrigenous *** and paleoclimate determined the environment of the sedimentary period,in addition,paleoproductivity and paleoredox condition indicated the formation and preservation conditions of *** warm and humid climate,brackish water,suitable reduction conditions and high productivity are the favorable conditions for the generation and preservation of organic *** research results may have implications for the genetic mechanisms of organic matter *** will provide theoret

关键词： Elemental geochemical Paleoenvironment Organic matter accumulation Paleogene shahejie formation Zhanhua Sag Bohai Bay Basin

Temporal retinal thinning might be an early diagnostic indicator in male pediatric X-linked Alport syndrome

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International Journal of Ophthalmology(English edition) 2022年第7期15卷 1142-1148页

作者： rui-lin zhu Liang Zhao Xiao-Peng Gu Ya-Di Zhang Fang Wang Yan-Qin Zhang Liu Yang Department of Ophthalmology Peking University First HospitalBeijing 100034China Department of Pediatrics Peking University First HospitalBeijing 100034China

AIM: To evaluate temporal retinal thinning changes in retinal layers using spectral-domain optical coherence tomography(SD-OCT) in pediatric X-linked Alport syndrome(XLAS) ***: A retrospective case-control study. SDOCT scans of pediatric patients diagnosed with XLAS and age-and sex-matched healthy control participants were reviewed. Automated segmentation of SD-OCT scans was induced to analyze the retinal thickness(RT) of different layers. The temporal thinning index(TTI) was calculated for each layer and compared between the patients and the control ***: Forty-three pediatric XLAS patients and 60 healthy controls were included. Temporal retinal thinning was present in 33 patients(76.74%), while 28 patients(65.11%) had severe pathological temporal retinal thinning and 5 patients(11.63%) had moderate thinning. The temporal inner sector RT(P<0.0001), the temporal outer sector RT(P<0.0001), and the nasal outer sector RT(P=0.0211) were significantly thinner in the XLAS male patients. The TTI of the total retina was significantly higher in the XLAS group than in the control group(P<0.0001). The TTI of the inner retina layers(P<0.0001), ganglion cell layer(P<0.0001), inner plexiform layer(P<0.0001), inner nuclear layer(P<0.0001), and outer nuclear layer(P<0.0001) were significantly higher in the XLAS group. The central RT of the XLAS group was significantly thinner than that of the control group(P<0.0001).CONCLUSION: Temporal retinal thinning appears early in XLAS patients, especially in male patients. The thinningis mainly caused by structural abnormalities of the inner retina. This suggests that temporal retinal thinning could be helpful for the early diagnosis and follow-up of XLAS with noninvasive SD-OCT examination.

关键词： Alport syndrome retinal thickness spectral domain optical coherence tomography segmentation

Crystal phase control and ignition properties of HNS/CL-20 composite microspheres prepared by microfluidics combined with emulsification techniques

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Particuology 2024年第2期85卷 241-251页

作者： Yi Liu Yunyan Guo rui zhu Jinqiang Zhou Zhengxu lin Kai Han Chongwei An Jingyu Wang Bidong Wu School of Environment and Safety Engineering North University of ChinaTaiyuan030051China School of Engineering Beijing Institute of TechnologyBeijing100081China Shanxi Province Ultrafine Powder Engineering Technology Research Center Taiyuan030051China

Improved controllability and energy density of ignition agents are of great significance for the devel-opment of energetic composite *** this study,droplet microfluidics and emulsification tech-niques were combined to prepare HNS/CL-20 composite microspheres with polyglycidyl azide polymer(GAP)as the *** influence of binder content on the morphology of microspheres was investi-gated,and the microspheres were characterized and tested for particle size,crystal structure,thermal decomposition,dispersibility,mechanical sensitivity,combustion behavior and detonation *** results showed that microspheres prepared with a binder content of 3%had higher sphericity and particle size *** microspheres retained the crystal structure of both HNS and CL-20(ε-type).Compared with raw HNS,the microspheres had higher apparent activation energy,better safety per-formance,and good *** ignition experiments and detonation performance tests show that HNS/CL-20 composite microspheres have excellent ignition performance,obvious combustion flame,and significant energy release effects,which are expected to achieve high energy and high-speed response of the igniter,thus improving the ignition reliability in special environments or systems.

关键词： Droplet microfluidics Emulsification technology Energetic materials Composite microspheres Crystal phase control Ignition

A two-field-scan harmonic Hall voltage analysis for fast,accurate quantification of spin-orbit torques in magnetic heterostructures

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 105-112页

作者： Xin lin Lijun zhu State Key Laboratory of Superlattices and Microstructures Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China

We report on the development of a“two-field-scan”harmonic Hall voltage(HHV)analysis,which collects the second HHVas a function of a swept in-plane magnetic field at 45°and 0°relative to the excitation current,for the determination of the spin-orbit torques of transverse spins in magnetic heterostructures without significant perpendicular spins,longitudinal spins,and longitudinal/perpendicular Oersted *** demonstrate that this two-field-scan analysis is as accurate as the well-established but time-consuming angle-scan HHV analysis even in the presence of considerable thermoelectric effects but takes more than a factor of 7 less measurement *** also show that the fit of the HHV data from a single field scan at 0°,which is commonly employed in the literature,is not reliable because the employment of too many free parameters in the fitting of the very slowly varying HHV signal allows erroneous conclusion about the spin-orbit torque efficiencies.

关键词： spin-orbit torque spin current spin-orbit coupling spintronics

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Optimal Energy Efficiency Based High-speed Flying Control Method for Hydraulic Quadruped Robot

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Journal of Bionic Engineering 2024年第3期21卷 1156-1173页

作者： Qingjun Yang Zhenyang Zhang rui zhu Dianxin Wang School of Mechatronics Engineering Harbin Institute of TechnologyHarbin150000China Nanjing Chenguang Group Co.Ltd Nanjing210006China

Herein,a control method based on the optimal energy efficiency of a hydraulic quadruped robot was proposed,which not only realizes the optimal energy efficiency of flying trot gait but also ensures the stability of high-speed ***,the energy consumption per unit distance was adopted as the energy efficiency evaluation index based on the constant pressure oil supply characteristics of the hydraulic system,and the global optimization algorithm was adopted to solve the optimal ***,the gait parameters that affect the energy efficiency of quadruped were analyzed and the mapping relationship between each parameter and energy efficiency was captured,so as to select the optimum combination of energy efficiency parameters,which is significant to improve endurance ***,to ensure the stability of the high-speed flying trot gait motion of the hydraulic quadruped robot,the active compliance control strategy was ***,the proposed method was successfully verified by simulations and *** experimental results reveal that the flying trot gait of the hydraulic quadruped robot can be stably controlled at a speed of 2.2 m/s.

关键词： Hydraulic quadruped robot Flying trot Energy efficiency Active compliance control

Reconfigurable mechanism-based metamaterials for ternary-coded elastic wave polarizers and programmable refraction control

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Applied Mathematics and Mechanics(English Edition) 2024年第7期45卷 1225-1242页

作者： Zhou HU Zhibo WEI Yan CHEN rui zhu School of Aerospace Engineering Beijing Institute of TechnologyBeijing100081China School of Mechanical Engineering Tianjin UniversityTianjin300350China Key Laboratory of Mechanism Theory and Equipment Design of Ministry of Education Tianjin UniversityTianjin300350China

Elastic metamaterials with unusual elastic properties offer unprecedented ways to modulate the polarization and propagation of elastic ***,most of them rely on the resonant structural components,and thus are frequency-dependent and ***,we present a reconfigurable 2D mechanism-based metamaterial which possesses transformable and frequency-independent elastic *** on the proposed mechanism-based metamaterial,interesting functionalities,such as ternarycoded elastic wave polarizer and programmable refraction,are ***,unique ternary-coded polarizers,with 1-trit polarization filtering and 2-trit polarization separating of longitudinal and transverse waves,are first ***,the strong anisotropy of the proposed metamaterial is harnessed to realize positive-negative bi-refraction,only-positive refraction,and only-negative ***,the wave functions with detailed microstructures are numerically verified.

关键词： elastic metamaterial elastic wave reconfigurable design zero mode ternary code programmable refraction

Indexing dynamic encrypted database in cloud for efficient secure k-nearest neighbor query

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Frontiers of Computer Science 2024年第1期18卷 187-198页

作者： Xingxin LI Youwen zhu rui XU Jian WANG Yushu ZHANG College of Computer Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016China Department of Mathematical Informatics University of TokyoTokyo 113-8654Japan Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China School of Computer Science China University of GeosciencesWuhan 430074China

Secure k-Nearest Neighbor(k-NN)query aims to find k nearest data of a given query from an encrypted database in a cloud server without revealing privacy to the untrusted cloud and has wide applications in many areas,such as privacy-preservingmachine elearning gand secure biometric *** solutions have been put forward to solve this challenging ***,the existing schemes still suffer from various limitations in terms of efficiency and *** this paper,we propose a new encrypt-then-index strategy for the secure k-NN query,which can simultaneously achieve sub-linear search complexity(efficiency)and support dynamical update over the encrypted database(flexibility).Specifically,we propose a novel algorithm to transform the encrypted database and encrypted query points in the *** indexing the transformed database using spatial data structures such as the R-tree index,our strategy enables sub-linear complexity for secure k-NN queries and allows users to dynamically update the encrypted *** the best of our knowledge,the proposed strategy is the first to simultaneously provide these two *** theoretical analysis and extensive experiments,we formally prove the security and demonstrate the efficiency of our scheme.

关键词： cloud computing secure k-NN query sub-linear complexity dynamicupdate