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Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape

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Cancer Communications 2024年第6期44卷 670-694页

作者： Xin-Yu Zhang Jian-Bo Shi Shu-Fang Jin rui-jie wang Ming-Yu Li Zhi-Yuan Zhang Xi Yang Hai-Long Ma Department of Oral Maxillofacial-Head and Neck Oncology Shanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghaiP.R.China National Clinical Research Center for Oral Diseases ShanghaiP.R.China Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology ShanghaiP.R.China Department of Second Dental Center Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineCollege of StomatologyShanghai Jiao Tong UniversityShanghaiP.R.China

Background:Metabolic reprograming and immune escape are two hallmarksof ***,how metabolic disorders drive immune escape in head andneck squamous cell carcinoma(HNSCC)remains ***,the aim ofthe present study was to investigate the metabolic landscape of HNSCC and itsmechanism of driving immune ***:Analysis of paired tumor tissues and adjacent normal tissues from69 HNSCC patients was performed using liquid/gas chromatography-mass spectrometry and *** tumor-promoting function of kynurenine(Kyn)was explored in vitro and in *** downstream target of Kyn wasinvestigated in CD8^(+)T *** regulation of CD8+T cells was investigatedafter Siglec-15 overexpression in *** engineering nanoparticle was establishedto deliver Siglec-15 small interfering RNA(siS15),and its association withimmunotherapy response were *** association between Siglec-15and CD8^(+)programmed cell death 1(PD-1)^(+)T cells was analyzed in a HNSCCpatient ***:A total of 178 metabolites showed significant dysregulation in HNSCC,including carbohydrates,lipids and lipid-like molecules,and amino *** these,amino acid metabolism was the most significantly altered,especiallyKyn,which promoted tumor proliferation and *** addition,most immune checkpoint molecules were upregulated in Kyn-high patientsbased on ***,tumor-derived Kyn was transferredinto CD8^(+)T cells and induced T cell functional exhaustion,and blockingKyn transporters restored its killing *** to the results,mechanistically,Kyn transcriptionally regulated the expression of Siglec-15 via arylhydrocarbon receptor(AhR),and overexpression of Siglec-15 promoted immuneescape by suppressing T cell infiltration and *** AhR in vivoreduced Kyn-mediated Siglec-15 expression and promoted intratumoral CD8^(+)Tcell infiltration and killing ***,a NH_(2)-modified mesoporous silicananoparticle was des

关键词： head and neck squamous cell carcinoma kynurenine Siglec-15 T cell exhaustion untargeted metabolomics

Cyano migration-mediated radical-polar crossover cyclopropanation

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Science China Chemistry 2025年第1期68卷 241-248页

作者： Ziqiang wang Yasu Chen jie Li Chen Zhu Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials ScienceSoochow University Frontiers Science Center for Transformative Molecules Zhangjiang Institute for Advanced Study and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs Shanghai Jiao Tong University

We report a novel cyano migration-mediated radical-polar crossover process, whereby both the sulfonylcyanation of aliphatic alkenes and the formation of cyclopropanes are concurrently achieved. This transformation yields a diverse array of multisubstituted cyclopropanes under mild photocatalytic conditions. Mechanistic studies elucidate that the reaction proceeds via intramolecular nucleophilic substitution, leading to the formation of the cyclopropane derivatives.

关键词： cyclopropanation cyano migration radical-polar crossover radical reactions

Photoinduced radical sulfur dioxide insertion with asymmetric cyclization of alkenes: accessing β-chiral sulfones bearing S-stereocentric cyclic sulfinamides

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Science China Chemistry 2025年第1期68卷 257-263页

作者： Jiapian Huang Chenxin wang Xu wang Xiaoyu Zhou Wei Xiao jie Wu School of Pharmaceutical and Chemical Engineering & Institute for Advanced Studies Taizhou University State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering Henan Normal University

The generation of various β-chiral sulfones bearing chiral cyclic sulfinamides through photoredox-catalyzed sulfur dioxide insertion with asymmetric radical cyclization is described. This method features a broad substrate scope and excellent stereospecificity. Computational studies reveal that the dispersion interaction between sulfinyl group and CH2SO2Ph group plays a crucial role in the stereoselectivity control.

关键词： β-chiral sulfones chiral cyclic sulfinamides sulfur dioxide insertion asymmetric radical cyclization stereoselectivity

A preliminary simulation study of influence of backsplash on the plastic scintillator detector design in HERD experiment

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Radiation Detection Technology and Methods 2021年第3期5卷 332-338页

作者： Peng Hu Zhi-gang wang Fabio Gargano Francesca Alemanno Corrado Altomare Tian-wei Bao Yong-wei Dong Valerio Formato Dimitrios Kyratzis Nicola Mori Lorenzo Pacini Zheng Quan Davide Serini Jun-jing wang rui-jie wang Ming Xu Bo-bing Wu Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China University of Chinese Academy of Sciences Beijing 100049China Istituto Nazionale di Fisica Nucleare(INFN) Sezione di Bari70126 BariItaly Gran Sasso Science Institute(GSSI) 67100 L’AquilaItaly Istituto Nazionale di Fisica Nucleare(INFN) Laboratori Nazionali del Gran Sasso67100 L’AquilaItaly Dipartimento Interateneo di Fisica dell’Universitàe del Politecnico di Bari 70125 BariItaly Istituto Nazionale di Fisica Nucleare(INFN) Sezione di Roma Tor Vergata00133 RomeItaly Istituto Nazionale di Fisica Nucleare(INFN) Sezione di Firenze50019 Sesto FiorentinoItaly

Background The plastic scintillator detector(PSD)is one of the detectors in the high energy cosmic radiation detection(HERD)facility,which is designed for gamma-ray detection and a redundant charge *** will lead to a decrease in PSD’s performance of gamma-ray detection and charge measurement,which should be carefully *** Two preliminary segmentation schemes of the PSD and two veto strategies have been proposed to suppress the backsplash *** this paper,we focus on the influence of the backsplash caused by gamma *** gamma-ray trigger efficiency and identification efficiency were studied in the case of different cell sizes and veto strategies,which can provide guidance on the PSD *** A Monte Carlo simulation based on Geant4 has been *** simplify the simulation,the PSD is segmented into 1 cm3 cubes which can be easily aggregated into cells with different sizes during *** and conclusion Side_Veto can be used as a baseline design of veto strategy,whereas Smart_Veto can be selected as an upgraded *** the PSD bar cell with a width of less than 11 cm and the PSD tile cell with a width of less than 20 cm can achieve a sufficiently high gamma-ray trigger efficiency(>80%),which realizes the primary goal of the ***,both the PSD bar cell with a width of less than 3 cm and the PSD tile cell with a width of less than 20 cm can ensure a sufficiently high gamma-ray identification efficiency(>80%)for photons up to 800 GeV.

关键词： Plastic scintillator detector Gamma-ray detection Backsplash Veto

Clinicopathological analysis of 14 patients with combined hepatocellular carcinoma and cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2011年第6期10卷 620-625页

作者： Xian-Huan Yu,Lei-Bo Xu,Hong Zeng,rui Zhang,jie wang and Chao LiuAuthor Affiliations:Department of Hepato-Pancreato-Biliary Surgery and Department of Pathology,Sun Yat-Sen Memorial Hospital,Sun Yat-Sen University,Guangzhou 510120,China Department of Hepato-Pancreato-Biliary Surgery Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China Department of Pathology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 China

BACKGROUND:Combined hepatocellular carcinoma and cholangiocarcinoma (cHCC-CC) is an uncommon subtype of primary hepatic carcinoma,and its prognosis is *** study was undertaken to investigate the prognosis and the clinicopathological characteristics of cHCC-CC,including their possible cellular ***:Among 852 patients with a primary hepatic carcinoma who underwent hepatectomy from January 1998 to April 2008 at our hospital,cHCC-CC was identified in 14 patients The clinicopathological characteristics of the 14 patients were analyzed *** expression of the liver stem cell markers (c-kit,CD90,CD133 and CK19) in the tumor tissue was detected by immunohistochemistry,and the Kaplan-Meier method was used to evaluate ***:Among the 14 patients,9 presented with abdominal pain,3 with anorexia and debilitation,and the remaining two patients were *** mean age was 53.6±3.0 (range 38-74) *** the included patients,11 had an elevated serum alpha-fetoprotein level,13 were infected with hepatitis B virus,9 had vascular invasion and 1 had lymph node metastasis The average diameter of the tumors was 9.9±1.1 (range 5.0-16.0) *** median overall survival time was 7.9±1.0 months In addition,the presence of the liver stem cell markers,c-kit CD90,CD133 and CK19 was 71.4%,85.7%,92.9% and 78.6% *** four markers were simultaneously expressed in eight ***:cHCC-CC has aggressive characteristics and the prognosis is extremely *** high expression of liver stem cell markers in the tumor tissue suggests that these tumors may derive from liver stem cells.

关键词： liver neoplasms hepatocellular carcinoma cholangiocarcinoma prognosis stem cells

Role of iron ore in enhancing gasification of iron coke:Structural evolution,influence mechanism and kinetic analysis

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 58-69页

作者： jie wang Wei wang Xuheng Chen Junfang Bao Qiuyue Hao Heng Zheng Runsheng Xu School of Chemistry and Materials Science Hubei Engineering UniversityXiaogan 432000China Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081China Institue of Ironmaking Technology Baosteel Central Research InstituteShanghai 201999China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

The utilization of iron coke provides a green pathway for low-carbon *** uncover the influence mechanism of iron ore on the behavior and kinetics of iron coke gasification,the effect of iron ore on the microstructure of iron coke was ***,a comparative study of the gasification reactions between iron coke and coke was conducted through non-isothermal thermogravimetric *** findings indicate that compared to coke,iron coke exhibits an augmentation in micropores and specific surface area,and the micropores further extend and *** provides more adsorption sites for CO_(2) molecules during the gasification process,resulting in a reduction in the initial gasification temperature of iron *** the heating rate in non-isothermal gasification can enhance the reactivity of iron *** metallic iron reduced from iron ore is embedded in the carbon matrix,reducing the orderliness of the carbon structure,which is primarily responsible for the heightened reactivity of the carbon *** kinetic study indicates that the random pore model can effectively represent the gasification process of iron coke due to its rich pore ***,as the proportion of iron ore increases,the activation energy for the carbon gasification gradually decreases,from 246.2 kJ/mol for coke to 192.5 kJ/mol for iron coke 15wt%.

关键词： low-carbon ironmaking iron coke gasification structural evolution kinetic model

直肠癌术前固定野容积旋转调强放疗剂量学比较

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中华肿瘤防治杂志 2017年第13期24卷 921-925,929页

作者：刘路王皓杨瑞杰王俊杰北京大学第三医院放射治疗科北京100191

目的比较5野调强放射治疗(5-field intensity modulated radiotherapy,5F-IMRT)、7野调强放射治疗(7-field intensity modulated radiotherapy,7F-IMRT)和容积旋转调强放射治疗(volumetric modulated arc therapy,VMAT)3种直肠癌术前放疗计划的靶区和危及器官剂量分布。分析各种放疗技术的特点,为临床放疗技术选择提供依据。方法顺序选取北京大学第三医院2016-03-01-2016-05-31收治的10例直肠癌术前放疗患者,分别设计5F-IMRT、7F-IMRT和VMAT计划。比较3组计划靶区和危及器官剂量分布。结果 VMAT的靶区适形性指数(conformity index,CI)优于5F-IMRT和7F-IMRT,7F-IMRT略优于5F-IMRT,CI分别为0.88、0.91和0.92;3种技术HI分别为1.08、1.06和1.08,VMAT比IMRT均匀性稍差,P<0.05。在危及器官剂量中,对于肠道和股骨头,VMAT都增加了低剂量区V_(10)、V_(20),但在中高剂量区V_(30),V_(40)和V_(50)上,受累体积减小;在膀胱剂量中,VMAT技术使得膀胱在低或高剂量受累体积上均低于其他两种技术,7F-IMRT中危及器官剂量介于VMAT和5F-IMRT之间。对于骨髓,VMAT技术30Gy以上体积比较5F-IMRT和7F-IMRT的体积降低,V_(30)(分别为14%、19%和17%)。结论对于直肠癌术前放疗患者,5F-IMRT、7F-IMRT和VMAT均可达到靶区处方剂量要求,靶区的剂量适形性和均匀性都有一定的差异。针对如膀胱、骨髓保护比较重要的患者可以采用VMAT技术减少高剂量的体积以减少放射性损伤,如放射性骨髓抑制;针对如肠道保护比较重要的患者可以选择IMRT技术,减少罹患腹泻等并发症的概率。

关键词：直肠癌危及器官调强放射治疗容积旋转调强放射治疗

Combination of fruquintinib with venetoclax for the treatment of colorectal cancer

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Oncology Research 2025年第1期33卷 225-234页

作者： WEI ZHANG WEICHENG wang rui wang XIAO HAN LIJUN ZHU WENjie GUO YANHONG GU Department of Oncology The First Affiliated Hospital of Nanjing Medical UniversityNanjing210029China State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing UniversityNanjing210023China Department of Oncology The Affiliated Taizhou People’s Hospital of Nanjing Medical UniversityTaizhou225300China

Background:As a novel blocker of vascular endothelial growth factor receptor(VEGFR),fruquintinib has been approved for treating colorectal cancer(CRC).However,its dosage and therapeutic efficacy are limited by its widespread adverse ***,recognized as the initial inhibitor of B-cell lymphoma protein 2(BCL2),has shown potential in boosting the effectiveness of immunotherapy against *** study investigated the efficacy and mechanisms of fruquintinib combined with venetoclax in treating *** and Materials:We developed a colon cancer mouse model with the CT26 colon cell line to demonstrate fruquintinib and venetoclax’s efficacy against *** we employed various techniques to evaluate different aspects of the experimental *** was used to detect cell proliferation and angiogenesis in tumor *** blot analysis was utilized to examine the occurrence of cell apoptosis,and flow cytometry to quantitate immune cells within the tumor ***,immunofluorescence was employed to measure cytokine ***:The strongest inhibition on tumor growth was achieved by the combination of fruquintinib with venetoclax,as opposed to individual drug *** was found to amplify the impact of fruquintinib,leading to decreased cancer cell proliferation,increased cancer cell apoptosis,lowered angiogenesis,better vascular structure normalization,and improved immune cell ***:Our findings indicate that the addition of venetoclax enhances the impact of fruquintinib on vascular normalization and modulation of the tumor immune *** study presents the justification for utilizing the fruquintinib and venetoclax combination in treating *** holds promise in being assimilated into anticancer medications for CRC.

关键词： Colorectal cancer(CRC) B-cell lymphoma protein 2(BCL2) Venetoclax Vascular endothelial growth factor receptor(VEGFR) Fruquintinib Anti-angiogenesis Immunotherapy

Multi-receptive field interaction network for shape from polarization

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Science China(Information Sciences) 2025年第1期68卷 394-395页

作者： Yini PENG rui LIU Zhiyuan ZHANG Zhongyuan wang Jiayi MA Xin TIAN Electronic Information School Wuhan University Computer Science School Wuhan University Wuhan Institute of Quantum Technology

Shape from polarization (SfP) method can use the polarization information in reflected light to estimate the surface normal of the target,which can further reconstruct the shape of the *** a simple image capture process,it can use low-cost equipment to meet a high precision imaging requirement,which can be used in remote scenes and other applications.

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