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An unprotected vulnerable relict subtropical conifer-Keteleeria evelyniana: Its forests, populations, growth and endangerment by invasive alien plant species in China

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Plant Diversity 2024年第5期46卷 648-660页

作者： Cindy Q.Tang Min-rui Du huan-Chong Wang You-Cai Shi Jia-Le Zeng Shu-Li Xiao Peng-Bin Han Jian-Ran Wen Shi-Qian Yao Ming-Chun Peng Chong-Yun Wang Yong-Ping Li Jordi López-Pujol Institute of Ecology and Geobotany College of Ecology and Environmental ScienceYunnan UniversityBuilding#3Guozhong DalouDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Life Sciences Yunnan UniversityShengming Kexueyuan Building#2Chenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina College of Natural Resources Yunnan UniversityChenggong CampusDongwaihuan South RoadUniversity TownChenggong New DistrictKunming 650504YunnanChina Botanic Institute of Barcelona(IBB CSIC-CMCNC)Passeig del Migdia s/nBarcelona 08038CataloniaSpain Escuela de Ciencias Ambientales Universidad Espíritu Santo(UEES)Samborondon 091650Ecuador

Relict subtropical coniferous forests in China face severe fragmentation,resulting in declining populations,and some are under significant threat from invasive alien *** the crucial importance of understanding forest dynamics,knowledge gaps persist,particularly regarding the impact of invasive plants on vulnerable natives like Keteleeria *** this study,we investigated the impact of invasive plants on the regeneration of forests dominated by ***,a subtropical relict species in southwestern *** this purpose,we characterized forest dynamics of 160 forest plots featuring *** as the primary dominant species and determined whether the presence of invasive plants was correlated with regeneration of *** identified four distinct forest types in which *** was *** found that radial growth of *** trees is faster in younger ageclasses today than it was for older trees at the same *** population structure of *** in each forest type exhibited a multimodal age-class ***,three forest types lacked established saplings younger than 10 years old,a situation attributed to the dense coverage of the invasive alien Ageratina *** invasive species resulted in a reduction of understory species ***,our analysis uncovered a significant negative correlation in phylogenetic relatedness(net relatedness index)between native and invasive alien plant species in eastern *** suggests closely related invasive species face heightened competition,hindering successful *** together,our findings indicate that successful establishment and habitat restoration of *** seedling/saplings require effective measures to control invasive plants.

关键词： Keteleeria evelyniana Age structure Regeneration Species diversity Invasive alien species Phylogenetic relatedness

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Research 2024年第3期6卷 51-69页

作者： Jianan Lu Huaming Li guoqiang Zhangi Fan Yangi Xiaotao Zhangi An Pingi Zhouhan Xui Yichen gui rui Wangi Dan Yingi Jianjian Liui Jianmin Zhangi Ligen Shi Department of Neurosurgery Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangChina Clinical Research Center for Neurological Diseases of Zhejiang Province HangzhouChina.

Immunosenescence refers to the multifaceted and profound alterations in the immune system brought about by aging,exerting complex influences on the pathophysiological processes of diseases that manifest upon *** a combination of single-cell RNA sequencing,cytometry by time of flight,and various immunological assays,we investigated the characteristics of immunosenescence in the peripheral blood of aged mice and its impact on the cerebral immune environment after ischemic *** results revealed some features of *** observed an increase in neutrophil counts,concurrent with accelerated neutrophil aging,characterized by altered expression of aging-associated markers like CD62L and consequential changes in neutrophil-mediated immune ***/macrophages in aged mice exhibited enhanced antigen-presentation capabilities.T cell profiles shifted from naive to effector or memory states,with a specific rise in T helper 1 cells and T helper 17 cells subpopulations and increased regulatory T cell activation in CD4 T ***,regulatory CD8 T cells marked by Klra decreased with aging,while a subpopulation of exhausted-like CD8 T cells expanded,retaining potent immunostimulatory and proinflammatory ***,these inherent disparities not only persisted but were further amplified within the ischemic hemispheres following *** summary,our comprehensive insights into the key attributes of peripheral immunosenescence provide a vital theoretical foundation for understanding not only ischemic strokes but also other age-associated diseases.

关键词： alterations retaining Impact

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双酶法优化禄丰香醋糖化工艺

中国调味品 2024年第5期49卷 80-88页

作者：陈乾睿赵锐环徐志强谷大海云南农业大学食品科学技术学院昆明650201 云南农业大学云南省畜产品加工工程技术研究中心昆明650201

为提高禄丰香醋的生产效率,通过添加α-淀粉酶与糖化酶,对禄丰香醋生产过程中糖化工艺进行优化。糖化工艺包括液化工艺与糖化工艺两部分:液化实验以还原糖为指标;糖化实验以还原糖为主要指标,黄酮类物质、氨基酸态氮为次要指标。在单因... 详细信息

为提高禄丰香醋的生产效率,通过添加α-淀粉酶与糖化酶,对禄丰香醋生产过程中糖化工艺进行优化。糖化工艺包括液化工艺与糖化工艺两部分:液化实验以还原糖为指标;糖化实验以还原糖为主要指标,黄酮类物质、氨基酸态氮为次要指标。在单因素实验的基础上,采用响应面分析法对禄丰香醋糖化过程中的参数进行优化。研究结果表明,禄丰香醋的最佳糖化工艺参数为α-淀粉酶添加量2.272%、液化pH 4.9、液化温度50℃、液化时间43 min,此条件下还原糖含量为5.372 g/100 g。结合实际生产情况,当糖化酶添加量为2.336%、糖化pH为4、糖化温度为55℃、糖化时间为60 min、蒸煮时间为1 h、料液比为1∶3时得到还原糖含量为13.614 g/100 g,黄酮含量为6.867 mg/L,氨基酸态氮含量为0.101724 g/dL。

关键词：禄丰香醋糖化工艺优化双酶法响应面法

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Effectiveness and Safety of Qishen Yiqi Dripping Pill in Patients with Acute Coronary Syndrome after Percutaneous Coronary Intervention:3-Year Results from a Multicentre Cohort Study

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Chinese Journal of Integrative Medicine 2024年第10期30卷 877-885页

作者： BAI rui-na gu Feng CHE Qian-zi ZHANG Xuan CAI Ya-jie XI rui-xi ZHAO Yang guO Ming DONG guo-ju GAO Zhu-ye FU Chang-geng WANG Pei-li DU Jian-peng ZHANG Da-wu DUAN Wen-hui LI Li-zhi YANG Qiao-ning SHI Da-zhuo Department of Cardiovascular Xiyuan Hospital China Academy of Chinese Medical Sciences National Clinical Research Center for Chinese Medicine Cardiology Department of Evidence-Based Medicine Basic Research Laboratory Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Department of Traditional Chinese Medicine Beijing Shangdi Hospital National Medical Products Administration Key Laboratory for Clinical Research and Evaluation of Traditional Chinese Medicine

Objectives: To evaluate the effectiveness and safety of Qishen Yiqi Dripping Pill(QSYQ) in patients with acute coronary syndrome(ACS) after percutaneous coronary intervention(PCI). Methods: This multicentre prospective cohort study was conducted at 40 centers in China. Patients with ACS after PCI entered either the QSYQ or Western medicine(WM) groups naturally based on whether they had received QSYQ before enrollment. QSYQ group received QSYQ(0.52 g, 3 times a day for 12 months) in addition to WM. The primary endpoint included cardiac death, non-fatal myocardial infarction, and urgent revascularization. The secondary endpoint included rehospitalization due to ACS, heart failure, stroke, and other thrombotic events. Quality of life was assessed by the Seattle Angina Questionnaire(SAQ). Results: A total of 936 patients completed follow-up of the primary endpoint from February 2012 to December 2018. Overall, 487 patients received QSYQ and WM. During a median follow-up of 566 days(inter quartile range, IQR, 517–602), the primary endpoint occurred in 46(9.45%) and 65(14.48%) patients in QSYQ and WM groups respectively [adjusted hazard ratio(HR) 0.60, 95% confidence interval(CI) 0.41–0.90; P=0.013]. The secondary endpoint occurred in 61(12.53%) and 74(16.48%) patients in QSYQ and WM groups, respectively(adjusted HR 0.76, 95% CI 0.53–1.09; P=0.136). In sensitivity analysis, the results still demonstrated that WM combined with QSYQ reduced the risk of the primary endpoint(HR 0.67, 95% CI 0.46–0.98; P=0.039). Moreover, QSYQ improved the disease perception domain of the SAQ(P<0.05). Conclusions: In patients with ACS after PCI, QSYQ combined with WM reduced the incidence of the primary endpoint. These findings provide a promising option for managing ACS after PCI and suggest the potential treatment for reducing the risk of primary endpoint included cardiac death, non-fatal myocardial infarction, and urgent revascularization through intermittent administration of QSYQ.(Registra

关键词： Qishen Yiqi Dripping Pill acute coronary syndrome percutaneous coronary intervention primary and secondary endpoint

Profibrotic role of the SOX9-MMP10-ECM biosynthesis axis in the tracheal fibrosis after injury and repair

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Genes & Diseases 2024年第5期11卷 360-373页

作者： Lei gu Anmao Li Chunyan He rui Xiao Jiaxin Liao Li Xu Junhao Mu Xiaohui Wang Mingjin Yang Jinyue Jiang Yang Bai Xingxing Jin Meiling Xiao Xia Zhang Tairong Tan Yang Xiao Jing Lin Yishi Li Shuliang guo Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Soochow UniversitySuzhou 215006China Department of Respiratory and Critical Care Medicine The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Infection Disease The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang 325000China

Fibroblast activation and extracellular matrix(ECM)deposition play an important role in the tracheal abnormal repair process and *** a transcription factor,SOX9 is involved in fibroblast activation and ECM ***,the mechanism of how SOX9 regulates fibrosis after tracheal injury remains *** investigated the role of SOX9 in TGF-b1-induced fibroblast activation and ECM deposition in rat tracheal fibroblast(RTF)***9 overexpression adenovirus(Ad-SOX9)and siRNA were transfected into RTF *** found that SOX9 expression was up-regulated in RTF cells treated with ***9 overexpression activated fibroblasts and promoted ECM *** SOX9 inhibited cell proliferation,migration,and ECM deposition,induced G2 arrest,and increased apoptosis in RTF ***-seq and chromatin immunoprecipitation sequencing(ChIP-seq)assays identified MMP10,a matrix metalloproteinase involved in ECM deposition,as a direct target of SOX9,which promotes ECM degradation by increasing MMP10 expression through the Wnt/b-catenin signaling ***,in vivo,SOX9 knockdown ameliorated granulation proliferation and tracheal fibrosis,as manifested by reduced tracheal *** conclusion,our findings indicate that SOX9 can drive fibroblast activation,cell proliferation,and apoptosis resistance in tracheal fibrosis via the Wnt/b-catenin signaling *** SOX9eMMP10 eECM biosynthesis axis plays an important role in tracheal injury and *** SOX9 and its downstream target MMP10 may represent a promising therapeutic approach for tracheal fibrosis.

关键词： Extracellular matrix deposition Fibroblast activation MMP10 SOX9 Tracheal fibrosis

Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum

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World Journal of Gastrointestinal Oncology 2024年第8期16卷 3600-3623页

作者： Li-Li Yin Ping-Qian Qi Yun-Fei Hu Xiao-Jun Fu rui-Shan He Meng-Meng Wang Yan-Juan Deng Su-Yi Xiong Qi-Wen Yu Jin-Ping Hu Lv Zhou Zhi-Bin Zhou Ying Xiong huan Deng The Affiliated Rehabilitation Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Fourth Affiliated Hospital Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina The Second College of Clinical Medicine Jiangxi Medical CollegeNanchang UniversityNanchang 330006Jiangxi ProvinceChina Tumor Immunology Institute Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of General Medicine The Second College of Clinical MedicineJiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina The Ministry of Education Basic Research and Innovation Center for the Targeted Therapeutics of Solid Tumors Jiangxi Medical CollegeNanchang UniversityNanchang 330031Jiangxi ProvinceChina

BACKGROUND Colorectal polyps,which are characterized by a high recurrence rate,represent preneoplastic conditions of the *** to unclear mechanisms of pathogenesis,first-line therapies for non-hereditary recurrent colorectal polyps are limited to endoscopic *** recent studies suggest a mechanistic link between intestinal dysbiosis and polyps,the exact compositions and roles of bacteria in the mucosa around the lesions,rather than feces,remain *** To clarify the composition and diversity of bacteria in the mucosa surrounding or 10 cm distal to recurrent intestinal *** Mucosal samples were collected from four patients consistently with adenomatous polyps(Ade),seven consistently with non-Ade(Pol),ten with current Pol but previous Ade,and six healthy individuals,and bacterial patterns were evaluated by 16S rDNA *** discriminant analysis and Student’s t-tests were used to identify the genus-level bacteria differences between groups with different colorectal polyp ***’s correlation coefficients were used to evaluate the correlation between intestinal bacteria at the genus level and clinical *** The results confirmed a decreased level of probiotics and an enrichment of pathogenic bacteria in patients with all types of polyps compared to healthy *** changes were not restricted to the mucosa within 0.5 cm adjacent to the polyps,but also existed in histologically normal tissue 10 cm distal from the *** differences in bacterial diversity were observed in the mucosa from individuals with normal conditions,Pol,and *** abundance of Gram-negative bacteria,including Klebsiella,Plesiomonas,and Cronobacter,was observed in Pol group and Ade group,suggesting that resistance to antibiotics may be one risk factor for bacterium-related harmful ***,age and gender were linked to bacteria changes,indicating the potential involvement of sex hormone

关键词： Dysbiosis Biopsy Polyp Bacteria Colorectum

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利率市场化改革对企业数字化转型的影响

改革 2024年第7期 111-127页

作者：顾芳睿李清吉林大学商学与管理学院长春理工大学经济管理学院

利率市场化改革是金融体制改革的重要内容之一,其在微观层面对企业数字化转型的影响引起了学术界的关注。在阐述利率市场化促进企业数字化转型逻辑的基础上,实证检验利率市场化与企业数字化转型之间的关系。研究表明,利率市场化改革能... 详细信息

利率市场化改革是金融体制改革的重要内容之一,其在微观层面对企业数字化转型的影响引起了学术界的关注。在阐述利率市场化促进企业数字化转型逻辑的基础上,实证检验利率市场化与企业数字化转型之间的关系。研究表明,利率市场化改革能够显著促进企业数字化转型,随着金融机构存款利率上限及贷款利率下限的取消,进行数字化转型的企业显著增加,且企业数字化转型程度显著提升;利率市场化改革促进企业数字化转型的作用机制体现为降低融资约束、促进企业研发创新、提升企业生产率。同时,企业研发创新、数字化生产和管理系统引进强化了利率市场化对企业数字化转型的促进作用。进一步研究表明,利率市场化改革对企业数字化转型的促进效应在企业规模相对较小、非国有企业和非技术密集型行业的样本中尤为明显。

关键词：利率市场化改革企业数字化转型融资约束研发创新企业生产率

Physiochemical and biological characteristics of fouling on landfill leachate treatment systems surface

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Journal of Environmental Sciences 2024年第1期135卷 59-71页

作者： Zhourui Gong Shu Yang rui Zhang Yangqing Wang Xiaoqing Wu Liyan Song School of resources and environmental engineering Anhui UniversityHefei 230601China Anhui Shengjin Lake Wetland Ecology National Long-term Scientific Research Base Dongzhi 247230China Key Laboratory of Three Gorges Reservoir Region’s Eco-Environment Ministry of EducationChongqing UniversityChongqing 400045China Chongqing Institute of Green and Intelligent Technology Chinese Academy of SciencesChongqing 400714China Xing Lu huan Jing Co.LTD. Luzhou 646000China

Fouling of landfill leachate,a biofilm formation process on the surface of the collection system,migration pipeline and treatment system causes low efficiency of leachate transportation and treatment and increases cost for maintenance of those *** addition,landfill leachate fouling might accumulate pathogens and antibiotic resistance genes(ARGs),posing threats to the *** of the landfill leachate fouling and its associated environmental behavior is essential for the management of *** this study,physicochemical and biological properties of landfill leachate fouling and the possible accumulation capacity of pathogens and ARGs were investigated in nitrification(aerobic condition)and denitrification(anaerobic condition)process during landfill leachate biological treatment,*** show that microbial(bacterial,archaeal,eukaryotic,and viral)community structure and function(carbon fixation,methanogenesis,nitrification and denitrification)differed in fouling under aerobic and anaerobic conditions,driven by the supplemental leachate water *** fouling had a higher abundance of nitrification and denitrification functional genes,while anaerobic fouling harbored a higher abundance of carbon fixation and methanogenesis *** forms of leachate fouling had a higher abundance of pathogens and ARGs than the associated leachate,suggesting the accumulation capacity of fouling on biotic ***,aerobic fouling harbored three orders of magnitude higher multidrug resistance genes mex D than its associated *** finding provides fundamental knowledge on the biological properties of leachate fouling and suggests that leachate fouling might harbor significant pathogens and ARGs.

关键词： Landfill leachate fouling Biofilm Microbiome Carbon and nitrogen cycle Pathogens Antibiotic resistance genes

Gas microchannel plate-pixel detector for X-ray polarimetry

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Nuclear Science and Techniques 2024年第5期35卷 60-73页

作者： huan-Bo Feng Hong-Bang Liu Dong Wang Zi-Li Li Shu-Lin Liu Qian Liu Hang-Zhou Li Bin-Long Wang Yan-Jun Xie Zong-Wang Fan Hui Wang Ran Chen Di-Fan Yi rui-Ting Ma Fei Xie Bo Peng Xiang-Ming Sun Jin Li En-Wei Liang Present Address:guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China PLAC Key Laboratory of Quark and Lepton Physics(MOE)Central China Normal UniversityWuhan 430079China School of Science Huzhou UniversityHuzhou 313000China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China School of Physical Science University of Chinese Academy of SciencesBeijing 100049China The 13th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050057China

POLAR-2 is a gamma-ray burst(GRB)polarimeter that is designed to study the polarization in GRB radiation emissions,aiming to improve our knowledge of related ***-2 is expected to utilize an on-board polarimeter that is sensitive to soft X-rays(2-10 keV),called low-energy polarization *** have developed a new soft X-ray polari-zation detector prototype based on gas microchannel plates(GMCPs)and pixel chips(Topmetal).The GMCPs have bulk resistance,which prevents charging-up effects and ensures gain stability during *** detector is composed of low outgassing materials and is gas-sealed using a laser welding technique,ensuring long-term stability.A modulation factor of 41.28%±0.64% is obtained for a 4.5 keV polarized X-ray beam.A residual modulation of 1.96%±0.58% at 5.9 keV is observed for the entire sensitive area.

关键词： X-ray polarimetry Gas microchannel plate-pixel detector Gamma-ray bursts