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Comb-like Poly(N-(2-hydroxypropyl) methacrylamide) Doxorubicin Conjugates: The Influence of Polymer Architecture and Composition on the Biological Properties

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Chinese Journal of Polymer Science 2018年第11期36卷 1225-1238页

作者： Hao Tang Jin Tang Yi Shen Wen-Xuan Guo Min Zhou rui-hua wang Ni Jiang Zhi-hua Gan Qing-Song Yu The State Key Laboratory of Organic-inorganic Composites Beijing Laboratory of Biomedical Materials Beijing University of Chemical Technology College of Life Science and Technology Beijing University of Chemical Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology

The synthesis and structure-property correlation of poly（N-（2-hydroxypropyl） methacrylamide）（PHPMA） conjugates with various architectures including random, block, branched or star-like structures and compositions have been thoroughly explored. However, related synthesis and structure-property data are still lacking for comb-like PHPMA. In this work, we report the synthesis of comb-like PHPMA copolymer-doxorubicin （DOX） conjugates with different backbone/side-chain lengths and location of drug moieties. Well-defined comb-like PHPMA-DOX conjugates are obtained via the combination of controlled radical polymerization and fractional precipitation techniques. The influences of structural factors on the biological properties such as cellular uptake, blood circulation and tumor accumulation have been investigated. Long blood circulation and efficient tumor accumulation can be achieved by proper control of the comb number, length and location of drug moieties. These facile comb-like structures possess great potentials in future theranostics for brachytherapy or surgical navigation.

关键词： Poly(N-(2-hydroxypropyl) methacrylamide) Comb-like copolymer Anticancer drug delivery Synthesis Structure-property correlation

Measuring the space between vagina and rectum as it relates to rectocele

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World Journal of Gastroenterology 2009年第24期15卷 3051-3054页

作者： Jin Liu Li-Dong Zhai Yun-Sheng Li Wan-Xiang Liu rui-hua wang Department of Anatomy and Neurobiology Tianjian Medical University Tianjin 300070 China Radiology Division Tianjin Hongqiao Hospital Tianjin 300131 China

AIM:To measure the normal space between the posterior wall of the vagina and the anterior wall of the respectively rectum using computed tomography(CT) and reveal its were relationship to rectocele. METHODS:A total of twenty female volunteers without rectocele were examined by CT *** performed a middle level continuous horizontal pelvic scan from the upper part to the lower part and collected the measurement data to analyze the results using t-test. RESULTS:Twenty volunteers were enrolled in the study. The space between the posterior wall of the vagina and the anterior wall of the rectum was measured at three levels(upper 1/3,middle,lower 1/3 level of vagina). The results showed that the space from the posterior wall of the vagina to the anterior wall of the rectum at the upper 1/3 level and the middle level was 3.896 ±0.3617 mm and 4.6575±0.3052 mm,respectively. When the two groups of data were compared,we found the space at the upper 1/3 level was shorter than at the middle level(P<0.01).Moreover,at the lower 1/3 level the space measured was 10.058±0.4534 *** results revealed that the space at the lower 1/3 level was longer than that at the middle level(P<0.01). CONCLUSION:These measurement data may be helpful in assessing rectocele clinical diagnosis and functional outcomes of rectocele repair.

关键词： Measurement Space Rectocele Computed tomography

Surface　Acidic　Properties　of　Loaded　Heteropoly　Acid　and　Preparation　of　Dimethylether　by　Catalyzed　Dehydration　of　Methyl　Alcohol

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Chemical Research in Chinese Universities 1997年第1期13卷 3-8页

作者： hua rui nian, wang Yuan hong, GONG Jian, ZU Wei and QU Lun yu (Department of Chemistry, Northeast Normal University, Changchun, 130024)

The acidity and surface properties of H 4SiW 12 O 40 Ti(SO 4) 2 La 2O 3 HZSM 5(HTLH) were investigated by means of TEM, TPD and IR spectra. The activity and selectivity of the product as a catalyst for methanol to dimethylether were studied. The results show that there are Brnsted and Lewis acid sites in HTLH and that the total acidity is concerned with the conversion of methanol and the yield of dimethylether. The catalytic capacity of the acid at 453 K is the best. Keggin unit [SiW 12 O 40 ] 4- deposits on the external HZSM 5 surface only, and it can not permeate through the HZSM 5 pore system.

关键词： HZSM 5 12 Tungstosilicic acid Loading Acidity Dimethylether

Correlation of Commonly Used Anthropometric Parameters with FPG,FPG-CV and HbA1C

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Food Therapy and Health Care 2019年第1期1卷 2-7页

作者： Ya-Nan Zhao rui-hua wang Li-Juan Zhang Qiang Xu Yan-Fen Li Tianjin University of Traditional Chinese Medicine TianjinChina The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina Laiyuan Traditional Chinese Medicine Hospital BaodingHebeiChina

Objective:To investigate the relationship between body mass index(BMI),waist circumference(WC),hip circumference(HC),waist-hip ratio(WHR),waist height ratio(WHtR),fasting blood glucose(FPG),fasting blood glucose variation(FPG-CV)and glycosylated hemoglobin(HbA1C)to provide a reference for predicting the risk and development trend of diabetes ***:From October 2016 to December 2017,111 subjects from the Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine were selected to measure their height and ***,WHR and WHtR were calculated and the concentrations of FPG and HbA1C were *** analysis was carried out with SPSS21.0 software,and the data were processed by multiple linear regression ***:The concentration dependence of WHtR,FPG,FPG-CV and HbA1C were more closely *** was a significant difference between WHtR and FPG,FPG-CV and HbA1C by multiple linear regression analysis(t=8.531,6.910 and 6.905,respectively,P<0.01),and the correlation coefficient was 0.633,0.552 and 0.552 respectively(P<0.01).Conclusion:There is a significant correlation between WHtR and FPG,FPG-CV and ***,measuring the height and waist circumference for the predictive potential of diabetes needs to be emphasized and intensified.

关键词： Fasting blood glucose Fasting glucose variation Glycosylated hemoglobin Human parameters Correlation

Chinese patent medicine for stable angina pectoris:protocol for a systematic review and network meta-analysis

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TMR Integrative Medicine 2022年第1期6卷 1-9页

作者： Wei Mu Deng-Feng Kong Qiang Xu Xu-Fang Gu Jie Li Bao-He wang Ge Li Jin-hua Si rui-hua wang Yu-Hong huang Department of Clinical Pharmacology Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina.2Department of CardiologyWuan Hospital of Traditional Chinese MedicineHebeiChina.3Department of CardiologySecond Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina.4Second Affiliated Hospital of Tianjin University of Traditional Chinese MedicineTianjinChina.5Department of Public HealthTianjin University of Traditional Chinese MedicineTianjinChina.6LibraryTianjin University of Traditional Chinese MedicineTianjinChina

Stable angina pectoris is a common condition that affects a wide group of patients with coronary artery diseases.A number of Chinese patent drugs based on classic herbal formulations are available for angina management.A network meta-analysis is proposed to assess the relative efficacy and safety of commonly used drugs for stable angina and generate a clinically meaningful ranking for each important *** composed a list of 24 widely-used oral blood-quickening Chinese patent drugs from literature review and expert *** English and five Chinese electronic databases will be searched up to July 2021 for randomised clinical trials comparing between drugs on the list or with nitrates or placebo for stable *** data or grey literature will be sought through trial registries and correspondence to the report *** reviewers independently screen literature,extract data and assess clinical and methodological features of included *** WinBUGS software will be used to perform network meta-analysis and the Stata 13.0 software to generate graphic demonstrations of the *** outcomes are the incidence of cardiovascular events and changes in angina frequency,duration and *** will use the surface under the cumulative ranking curve and the mean value for the numeric presentation of efficacy and safety ranking probabilities of multiple *** and inconsistency will be assessed using appropriate statistical tests,and subgroup analysis and network meta-regression will be resorted when *** quality of evidence for each outcome will be graded with the web-based GRADEpro GDT.

关键词： Stable angina Blood-quickening Chinese patent medicine Network meta-analysis Systematic review

The concept of narrative evidence-based medicine and shared decision-making in traditional Chinese medical practice

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TMR Integrative Medicine 2018年第3期2卷 99-104页

作者： Wei Mu Hong-Cai Shang Xu-Fang Gu Li Zhang Yan-Fen Li Jie Li rui-hua wang Yu-Hong huang Bao-He wang Department of Clinical Pharmacology Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Tianjin China The second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine Cardiovascular Department Tianjin China Key Laboratory of Traditional Chinese Medical Sciences of Dongzhimen Hospital of Beijing University of Chinese Medicine Beijing China

For the explosive development of emerging diagnostic and therapeutic technologies brought by the advancement of precision medicine strategy, shared decision-making could improve the quality of clinical decision-making and promote the transformation of clinical research evidence in TCM. Paying attention to patients＇ narrative needs and strengthening medical humanistic concerns could improve clinical outcome and patient satisfaction. We described the origins and development of evidence-based medicine, narrative medicine and shared decision-making, and analyzed the existing problems in TCM clinical decision-making. Further, we put forward the model of shared decision-making between clinicians and patients under the guidance of narrative evidence-based medicine concepts and methods.

关键词： Narrative evidence-based medicine Clinical practice of TCM shared decision-making Decision aids

三甲氧基苯甲醛环丙沙星席夫碱诱导人肝癌SMMC-7721细胞凋亡的作用

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中国药学杂志 2016年第24期51卷 2082-2087页

作者：王蕊李晓华王颖胡国强刘彬河南大学护理学院神经生物学研究所河南开封475004 河南大学化学生物学研究所河南开封475004

目的探讨氟喹诺酮类化合物三甲氧基苯甲醛环丙沙星席夫碱诱导人肝癌SMMC-7721细胞凋亡作用。方法用不同浓度的1-环丙基-6-氟-7-(哌嗪^(-1)-基)-3-[5-苄硫基-4-(3,4,5-三甲氧苯甲叉基氨基)^(-1),2,4-三唑-3-基]-喹啉(1-H)-4-酮(M27)与人... 详细信息

目的探讨氟喹诺酮类化合物三甲氧基苯甲醛环丙沙星席夫碱诱导人肝癌SMMC-7721细胞凋亡作用。方法用不同浓度的1-环丙基-6-氟-7-(哌嗪^(-1)-基)-3-[5-苄硫基-4-(3,4,5-三甲氧苯甲叉基氨基)^(-1),2,4-三唑-3-基]-喹啉(1-H)-4-酮(M27)与人肝癌SMMC-7721细胞、结肠癌HCT^(-1)16细胞株、白血病JURKET细胞株体外培养。MTT法检测M27及其前体化合物环丙沙星盐酸盐对肿瘤细胞的增殖抑制作用;Hoechst 33258荧光染色法、TUNEL法检测细胞凋亡变化;以p BR322 DNA为底物,琼脂糖电泳法检测M27对拓扑异构酶Ⅱ的活性的影响;高内涵活细胞成像系统测定线粒体跨膜电位(△ψm)变化;Western blotting法检测p53、Caspase-9、Caspase-3、Caspase-8、Bcl-2和Bax等凋亡相关蛋白的表达以及细胞色素C在线粒体内外分布的变化。结果 M27在10~60μmol·L^(-1)内抑制肿瘤细胞增殖,呈浓度、时间依赖性。作用于SMMC-7721细胞、HCT^(-1)16细胞、JURKET细胞24 h IC50值分别为37.97、46.07、44.33μmol·L^(-1),而环丙沙星盐酸盐对SMMC-7721细胞增殖抑制作用不显著。各组M27作用于SMMC-7721细胞24 h,细胞凋亡率显著高于对照组(P<0.05),并伴有细胞线粒体膜电位(Δψm)降低。与对照组比较,M27能够抑制DNA拓扑异构酶Ⅱ的活性,使细胞p53、Bax、Caspase-8、Caspase-9和Caspase-3蛋白表达及活性片段增加,Bcl-2的表达量降低;线粒体细胞色素C减少,胞浆细胞色素C增多。结论三甲氧基苯甲醛环丙沙星席夫碱能够抑制拓扑异构酶Ⅱ的活性,造成DNA损伤,诱导人肝癌SMMC-7721细胞凋亡。

关键词：氟喹诺酮衍生物细胞凋亡拓扑异构酶Ⅱ 线粒体膜电位

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连退过程带钢热瓢曲指数及其影响因素

钢铁 2016年第12期51卷 94-102页

作者：王瑞白振华王云祥刘亚星钱承华长春燕山大学国家冷轧板带装备及工艺工程技术研究中心河北秦皇岛066004 燕山大学亚稳材料制备技术与科学国家重点实验室河北秦皇岛066004 燕山大学电气工程学院河北秦皇岛066004

针对带钢连退过程中的热瓢曲问题,充分考虑到连退机组的设备与工艺特点,从内力、外力两方面因素分析了热瓢曲以及横向压应力的产生机理,阐述了热瓢曲的发生规律,首次提出了瓢曲指数的新概念,给出了相应的瓢曲临界条件,建立了一套适合于... 详细信息

针对带钢连退过程中的热瓢曲问题,充分考虑到连退机组的设备与工艺特点,从内力、外力两方面因素分析了热瓢曲以及横向压应力的产生机理,阐述了热瓢曲的发生规律,首次提出了瓢曲指数的新概念,给出了相应的瓢曲临界条件,建立了一套适合于连退过程的带钢热瓢曲指数的计算模型,定量分析了不同工艺段内带钢瓢曲指数分布规律以及相同工艺段内来料板形、横向温差、炉辊辊型、摩擦因数、设定张力、通板速度等因素对带钢热瓢曲指数的影响,并将相关理论应用到生产实践,开发出了"连退机组通板过程带钢瓢曲预报软件",实现了对连退过程带钢瓢曲的在线预报,为瓢曲缺陷的预防和控制奠定了坚实的理论基础。

关键词：连续退火热瓢曲张力分布瓢曲指数计算模型

自拟脾胃调和汤治疗幽门螺杆菌相关性胃炎的疗效:一项前瞻性随机对照研究

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世界华人消化杂志 2021年第14期29卷 796-803页

作者：王瑞华王申宁波市镇海龙赛医院消化内科浙江省宁波市315200

背景世界上50%以上的人口感染幽门螺杆菌(Helicobacter pylori,***).临床主要通过四联疗法治疗***相关性胃炎,近年来,中西医联合疗法不断发展,使用自拟脾胃调和汤治疗幽门螺杆菌相关性胃炎能够在一定程度上提高治疗效果,值得临床进一步... 详细信息

背景世界上50%以上的人口感染幽门螺杆菌(Helicobacter pylori,***).临床主要通过四联疗法治疗***相关性胃炎,近年来,中西医联合疗法不断发展,使用自拟脾胃调和汤治疗幽门螺杆菌相关性胃炎能够在一定程度上提高治疗效果,值得临床进一步研究.目的探讨自拟脾胃调和汤辅助四联疗法治疗***相关性胃炎的疗效及对免疫-炎症、肠道菌群调控效应.方法采用随机信封法将2018-07/2020-05月我院收治的108例***相关性胃炎患者分为两组,各54例.对照组采用四联疗法,观察组采用自拟脾胃调和汤辅助四联疗法.比较两组总有效率、中医证候积分、免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+))、炎症指标转化生长因子-β1(TGF-β1)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)、白介素-32(IL-32)、C反应蛋白(CRP)、肠道菌群、不良反应.结果观察组总有效率为96.30%,高于对照组的81.48%(P0.05);观察组不良反应总发生率3.70%与对照组9.26%比较,差异无统计学意义(P>0.05).结论自拟脾胃调和汤辅助四联疗法治疗***相关性胃炎效果显著,能有效缓解临床症状,调节机体免疫、炎症反应,且具有良好肠道菌群调控效应,安全可靠,值得临床推广应用.

关键词：幽门螺杆菌相关性胃炎四联疗法自拟脾胃调和汤中医证候积分炎症指标肠道菌群免疫功能指标