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Expression of vascular endothelial growth factors A and C in human pancreatic cancer

World Journal of Gastroenterology 2006年第2期12卷 280-286页

作者： rui-feng tang Shu-Xia Wang Li Peng Shun-Xiang Wang Meng Zhang Zhi-feng Li Zhi-Ming Zhang Yan Xiao feng-rui Zhang Department of Hepatobiliary Surgery 4th Hospital Hebei Medical University Shijiazhuang 050011 Hebei Province China Department of Dermatology 4th Hospital Hebei Medical University Shijiazhuang 050011 Hebei Province China

AIM： To study the expression of vascular endothelial growth factor A （VEGF-A） and VEGF-C and to determine whether the presence of VEGF-A and VEGF-C was associated with the clinicopathologic characteristics of pancreatic cancer. METHODS： VEGF-A and VEGF-C mRNA transcripts were examined by Northern blot in 6 human pancreatic cancer cell lines and 8 normal pancreatic tissues and 8 pancreatic carcinoma specimens. The expression of VEGF-A and VEGF-C proteins was examined by Western blot in the tested cell lines and by immunohistochemical stain in 50 pancreatic carcinoma samples. RESULTS： VEGF-A and VEGF-C mRNA transcripts were present in all the 6 human pancreatic cancer cell lines. Immunoblotting revealed the presence of VEGF-A and VEGF-C proteins in all the cell lines. Northern blot analysis of total RNA revealed 3.0-fold and 3.6-fold increase in VEGF-A and VEGF-C mRNA transcript in the cancer samples, respectively. Immunohistochemical analysis confirmed the expression of VEGF-A and VEGF-C in cancer cells within the tumor mass. Immunohistochemical analysis of 50 pancreatic cancer tissue samples revealed the presence of VEGF-A and VEGF-C immunoreactivity in 50% and 80% of the cancer tissue samples, respectively. The presence of VEGF-A in these cells was associated with larger tumor size and enhanced local spread （x^2= 6.690, P= 0.035〈0.05） but was not associated with decreased patient survival. However, the presence of VEGF-C in the cancer cells was associated with increased lymph node metastasis （x^2= 5.710, P= 0.017〈0.05）,but was not associated with decreased patient survival. There was no correlation between the expression of VEGF-A and VEGF-C in the same cancer cells. CONCLUSION： VEGF-A and VEGF-C are commonly overexpressed in human pancreatic cancer and may contribute to tumor growth and lymph node metastasis, There is no relationship between the expression of VEGF-A and VEGF-C in pancreatic cancer.

关键词： Pancreatic cancer Vascular endothelial growth factor-A Vascular endothelial growth factor-C Survival

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The mechanism of microwave rock breaking and its potential application to rock-breaking technology in drilling

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Petroleum Science 2022年第3期19卷 1110-1124页

作者： Ming-Zhong Gao Ben-Gao Yang Jing Xie Si-Qi Ye Jun-Jun Liu Yi-Ting Liu rui-feng tang Hai-Chun Hao Xuan Wang Xiang-Yue Wen Xue-Min Zhou Guangdong Provincial Key Laboratory of Deep Earth Sciences and Geothermal Energy Exploitation and Utilization College of Civil and Transportation EngineeringShenzhen UniversityShenzhenGuangdong518060China State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource&HydropowerSichuan UniversityChengduSichuan610065China

The exploration and development of oil and gas resources have shifted from shallow to deep and *** difficulty of rock breaking has also increased,introducing new challenges to traditional rock-breaking ***,there is an urgent need to develop new rock-breaking technologies to improve the development efficiency of deep oil and gas ***,this study focused on the new microwave rock-breaking technology and conducted experimental and numerical simulation research on typical deep,hard rock *** research results showed that granite in the microwave field exhibited high-temperature melting and fracture,and the highest temperature could reach 550°*** the irradiation of circulating microwaves,a minimum irradiation time threshold of 3 min was needed to cause irreversible damage to the *** numerical simulation results showed that the interaction of thermal stress and in situ stress would cause the inside of the rock stratum to separate into a disturbed deterioration area,disturbed unloading area and initial stress *** results are expected to provide the necessary technical guidance and theoretical support for the research and development of high-efficiency rock-breaking drilling for deep hard rock.

关键词： Microwave Well drilling High efficiency Granite

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Revolutionizing breast cancer detection:Advances in fluorescent probe technology

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Nano Research 2025年第1期18卷 653-674页

作者： Qian Gao Lin tang Jun Zhan Yiyuan Xue feng Luo State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases West China Hospital of StomatologySichuan UniversityChengdu 610041China Emergency Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Obstetrics and Gynecology West China Second University HospitalSichuan UniversityChengdu 610041China Department of Prosthodontics West China School of StomatologySichuan UniversityChengdu 610041China

With the increasing incidence of breast cancer globally,there is an urgent demand for enhanced diagnostic and therapeutic *** comprehensive review explores advancements in fluorescent probe technology for breast cancer imaging and early *** probes offer unparalleled sensitivity and specificity in detecting cancer biomarkers,enabling early diagnosis and delineation of tumor margins during *** categorize these probes into molecular,nano,ratiometric,the second near-infrared window(NIR-II),and multifunctional varieties,each with unique capabilities for targeting specific cancer *** review highlights recent innovations in probe design,emphasizing their applications in pathogenesis studies,drug development,precision medicine,and fluorescence-guided *** their promising clinical potential,challenges such as safety,biomarker targeting accuracy,system compatibility,and clinical translation *** these hurdles is crucial for the integration of fluorescent probes into standard cancer care,aiming to improve treatment outcomes and patient quality of life.

关键词： breast cancer fluorescent probes imaging early diagnosis biomarker

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羊草草甸草原土壤微生物生物量碳氮对短期施氮的响应

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草地学报 2016年第3期24卷 553-558页

作者：朱瑞芬唐凤兰刘杰淋刘凤歧陈积山黑龙江省农业科学院草业研究所黑龙江哈尔滨150086

以松嫩草原羊草草甸为研究对象,通过测定4个不同施氮水平处理的土壤微生物生物量碳氮(Soil Microbial Biomass Carbon SMBC,Soil Microbial Biomass Nitrogen SMBN)探讨其对短期施氮的响应。结果表明,在一定范围内随着施氮量的增加,土... 详细信息

以松嫩草原羊草草甸为研究对象,通过测定4个不同施氮水平处理的土壤微生物生物量碳氮(Soil Microbial Biomass Carbon SMBC,Soil Microbial Biomass Nitrogen SMBN)探讨其对短期施氮的响应。结果表明,在一定范围内随着施氮量的增加,土壤微生物生物量碳氮显著增加(P<0.05);相关性分析表明,土壤微生物生物量碳(SMBC)与土壤有机质(SOM)含量呈极显著正相关关系(P<0.01),土壤微生物生物量氮(SMBN)与土壤全氮含量呈极显著正相关关系(P<0.01)。pH值与土壤微生物生物量碳氮(SMBC,SMBN)呈极显著负相关关系(P<0.01)。土壤微生物生物量碳(SMBC)与土壤有机质(SOM),土壤微生物生物量氮(SMBN)与土壤全氮呈显著正相关(P<0.05)。典范对应分析(CCA)排序图较好的解释了短期施氮处理与土壤微生物量碳氮、土壤环境因子3者之间的关系(78.5%)。

关键词：羊草草甸施氮微生物生物量碳氮

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低温胁迫下紫花苜蓿杂交代抗氧化酶及可溶性蛋白的动态聚类分析

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中国草地学报 2017年第2期39卷 53-58,70页

作者：亓春宇刘凤歧刘杰淋朱瑞芬唐凤兰哈尔滨师范大学生命科学与技术学院黑龙江哈尔滨150025 黑龙江省农业科学院草业研究所黑龙江哈尔滨150086

用人工低温胁迫的方法对肇东苜蓿(P_1)和WL323紫花苜蓿(P_2)杂交所得的190株F_2代幼苗进行24h和48h的4℃低温处理,研究F_2代群体SOD、POD活性和可溶性蛋白含量在低温胁迫下的动态变化,并对其进行综合聚类分析。结果表明:随着低温胁迫时... 详细信息

用人工低温胁迫的方法对肇东苜蓿(P_1)和WL323紫花苜蓿(P_2)杂交所得的190株F_2代幼苗进行24h和48h的4℃低温处理,研究F_2代群体SOD、POD活性和可溶性蛋白含量在低温胁迫下的动态变化,并对其进行综合聚类分析。结果表明:随着低温胁迫时间的延长,肇东苜蓿SOD活性呈先快速升高后下降的趋势,WL323紫花苜蓿及F_2代SOD活性呈逐渐升高的趋势;三者的POD活性均呈先升高后下降的趋势;可溶性蛋白含量呈逐渐增加的趋势。3个指标在F_2代群体中呈连续变异,分布频率总体接近正态分布,同时存在双向超亲分离现象,在聚类分析中,F_2群体间存在较大的遗传差异。

关键词：肇东苜蓿 WL323紫花苜蓿 F2代群体低温胁迫聚类分析

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： Zhi-Jian tang Yuan-Ming Pan Wei Li rui-Qiong Ma Jian-Liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Hypoxia-preconditioned bone marrow-derived mesenchymal stem cells protect neurons from cardiac arrest-induced pyroptosis

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Neural Regeneration Research 2025年第4期20卷 1103-1123页

作者： Xiahong tang Nan Zheng Qingming Lin Yan You Zheng Gong Yangping Zhuang Jiali Wu Yu Wang Hanlin Huang Jun Ke feng Chen Shengli Clinical Medical College of Fujian Medical University Fujian Medical UniversityFuzhouFujian ProvinceChina Department of Emergency Fujian Provincial HospitalFuzhouFujian ProvinceChina Fujian Provincial Key Laboratory of Emergency Medicine FuzhouFujian ProvinceChina The Second Department of Intensive Care Unit Fujian Provincial Hospital South BranchFuzhouFujian ProvinceChina

Cardiac arrest can lead to severe neurological impairment as a result of inflammation,mitochondrial dysfunction,and post-cardiopulmonary resuscitation neurological *** preconditioning has been shown to improve migration and survival of bone marrow–derived mesenchymal stem cells and reduce pyroptosis after cardiac arrest,but the specific mechanisms by which hypoxia-preconditioned bone marrow–derived mesenchymal stem cells protect against brain injury after cardiac arrest are *** this end,we established an in vitro co-culture model of bone marrow–derived mesenchymal stem cells and oxygen–glucose deprived primary neurons and found that hypoxic preconditioning enhanced the protective effect of bone marrow stromal stem cells against neuronal pyroptosis,possibly through inhibition of the MAPK and nuclear factor κB ***,we transplanted hypoxia-preconditioned bone marrow–derived mesenchymal stem cells into the lateral ventricle after the return of spontaneous circulation in an 8-minute cardiac arrest rat model induced by *** results showed that hypoxia-preconditioned bone marrow–derived mesenchymal stem cells significantly reduced cardiac arrest–induced neuronal pyroptosis,oxidative stress,and mitochondrial damage,whereas knockdown of the liver isoform of phosphofructokinase in bone marrow–derived mesenchymal stem cells inhibited these *** conclude,hypoxia-preconditioned bone marrow–derived mesenchymal stem cells offer a promising therapeutic approach for neuronal injury following cardiac arrest,and their beneficial effects are potentially associated with increased expression of the liver isoform of phosphofructokinase following hypoxic preconditioning.

关键词： bone marrow–derived mesenchymal stem cells cardiac arrest cardiac resuscitation hypoxic preconditioning liver isoform of phosphofructokinase mitochondria neuroinflammation oxidative stress pyroptosis reactive oxygen species

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Prediction and optimization of flue pressure in sintering process based on SHAP

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 346-359页

作者： Mingyu Wang Jue tang Mansheng Chu Quan Shi Zhen Zhang School of Metallurgy Northeastern UniversityShenyang 110819China Liaoning Low-Carbon Steelmaking Technology Engineering Research Center Northeastern UniversityShenyang 110819China Engineering Research Center of Frontier Technologies for Low-Carbon Steelmaking(Ministry of Education) Shenyang 110819China

Sinter is the core raw material for blast *** pressure,which is an important state parameter,affects sinter *** this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment ***,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction *** effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment *** operating parameter combination was then *** flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect.

关键词： sintering process flue pressure shapley additive explanation prediction optimization

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Impact of ocean data assimilation on the seasonal forecast of the 2014/15 marine heatwave in the Northeast Pacific Ocean

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 24-31页

作者： Tiantian tang Jiaying He Huihang Sun Jingjia Luo Institute for Climate and Application Research(ICAR)/Key Laboratory of Meteorological Disaster Nanjing University of Information Science and TechnologyNanjingChina

A remarkable marine heatwave,known as the“Blob”,occurred in the Northeast Pacific Ocean from late 2013 to early 2016,which displayed strong warm anomalies extending from the surface to a depth of 300 *** study employed two assimilation schemes based on the global Climate Forecast System of Nanjing University of Information Science(NUIST-CFS 1.0)to investigate the impact of ocean data assimilation on the seasonal prediction of this extreme marine *** sea surface temperature(SST)nudging scheme assimilates SST only,while the deterministic ensemble Kalman filter(EnKF)scheme assimilates observations from the surface to the deep *** latter notably improves the forecasting skill for subsurface temperature anomalies,especially at the depth of 100-300 m(the lower layer),outperforming the SST nudging *** excels in predicting both horizontal and vertical heat transport in the lower layer,contributing to improved forecasts of the lower-layer warming during the *** improvements stem from the assimilation of subsurface observational data,which are important in predicting the upper-ocean *** results suggest that assimilating ocean data with the EnKF scheme significantly enhances the accuracy in predicting subsurface temperature anomalies during the Blob and offers better understanding of its underlying mechanisms.

关键词： Seasonal forecast Ocean data assimilation Marine heatwave Subsurface temperature

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阿托伐他汀治疗对原发性高血压患者视觉电生理的影响

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中国动脉硬化杂志 2016年第10期24卷 994-1000页

作者：裴芳黄骥李锐锋李琳唐素琼黄婕肖睿陈诗佳王雅佗谷君中国人民武装警察部队重庆市总队医院心血管内科重庆市400061 中国人民武装警察部队重庆市总队医院眼科中心重庆市400061

目的观察在常规降压药物治疗的基础上加用阿托伐他汀对原发性高血压性视网膜病变(HR)患者视觉电生理的影响和疗效。方法将原发性高血压合并视网膜病变患者238例,随机分为阿托伐他汀组132例与常规治疗组106例。两组均给予相同的降压药物... 详细信息

目的观察在常规降压药物治疗的基础上加用阿托伐他汀对原发性高血压性视网膜病变(HR)患者视觉电生理的影响和疗效。方法将原发性高血压合并视网膜病变患者238例,随机分为阿托伐他汀组132例与常规治疗组106例。两组均给予相同的降压药物治疗,阿托伐他汀组在此基础上加用阿托伐他汀治疗。对比观察两组患者用药前和用药后6个月、12个月、24个月闪光视网膜电图(FERG)a波、b波和振荡电位(OP)的变化情况。结果两组患者治疗后收缩压(SBP)和舒张压(DBP)均较治疗前显著下降(P0.05)。自用药后12个月起,阿托伐他汀组FERG中a波、b波、OP及各子波潜伏期均显著短于常规治疗组(P<0.05或P<0.01),振幅均显著长于常规治疗组(P<0.05或P<0.01),用药后24个月上述差异更明显(P<0.01或P<0.001)。主成分Logistic回归分析显示SBP、DBP、总胆固醇、低密度脂蛋白胆固醇的下降幅度及阿托伐他汀的应用是影响HR患者视觉电生理改善的主要因素(P<0.05或P<0.001)。结论阿托伐他汀协同降压药物治疗提高了HR的疗效,使异常的视觉电生理得到改善。

关键词：阿托伐他汀高血压性视网膜病变闪光视网膜电图

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