检索结果-南通市图书馆

在线全文

学校读者我要写书评

暂无评论

髡残在20世纪的传播与影响

美术 2023年第6期 76-85页

作者：吕晓北京画院理论研究部

从“二溪”到“二石”,再到“三高僧”“四僧”,随着“四僧”概念的建构,髡残在清代画史上的地位逐渐提高,至民国初年成为与清代“四王”对立的个性派的代表。由于作品存世较少,髡残的绘画在清代的影响有限。民国时期,一批深藏于私家的... 详细信息

从“二溪”到“二石”,再到“三高僧”“四僧”,随着“四僧”概念的建构,髡残在清代画史上的地位逐渐提高,至民国初年成为与清代“四王”对立的个性派的代表。由于作品存世较少,髡残的绘画在清代的影响有限。民国时期,一批深藏于私家的作品在报刊上发表,借助现代传播手段,为更多人了解,进而推动髡残绘画的研究,其画风也对黄宾虹、黄君璧、张大千、钱松嵒、黄秋园等大批画家产生深远影响。

关键词：髡残石谿四僧山水画黄宾虹

在线全文

学校读者我要写书评

暂无评论

轻骨料混凝土匀质性测试与评价方法研究

武汉理工大学学报 2020年第9期42卷 13-19页

作者：顾瑞丁庆军吕亚林谯理格武汉理工大学材料科学与工程学院武汉430070 中建商品混凝土有限公司武汉430074

针对目前常用的轻骨料混凝土匀质性测试与评价方法存在的局限性,提出了两种具有自主知识产权的、操作简便、可量化表征的混凝土匀质性测试与评价方法,并在长期的轻骨料混凝土生产中跟踪、采集相应的测试数据,通过大量的数据分析验证两... 详细信息

针对目前常用的轻骨料混凝土匀质性测试与评价方法存在的局限性,提出了两种具有自主知识产权的、操作简便、可量化表征的混凝土匀质性测试与评价方法,并在长期的轻骨料混凝土生产中跟踪、采集相应的测试数据,通过大量的数据分析验证两种匀质性测试与评价方法的可行性与准确性。结果表明,两种方法均能较好地表征轻骨料混凝土拌合物的匀质性,其中,对于静置的拌合物,基于重心偏移的匀质性测试方法更适用;而对于流动中的拌合物,基于分层度和流空速度的匀质性测试方法更适用。

关键词：轻骨料混凝土匀质性量化表征测试方法

Huai Qi Huang-induced Apoptosis via Down-regulating PRKCH and Inhibiting RAF/MEK/ERK Pathway in Ph+ Leukemia Cells

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2020年第2期40卷 354-362页

作者： Wen-fu XU Zhu-jun WANG Kun LI Ya-qing SHEN Ke LU Xuc-yan lv Yu-xi WEN Run-ming JIN Deparment of Pediatrics Union HospitalTongji Medical CollegeHuzhong University of Science and TechnologyWuhan 430022China

Imatinib mesylate(IM)is the first-line treatment for Philadelphia(Ph)chromosomal positive leukemia by inhibiting phosphorylation of substrates via binding to the ABL kinase *** of the drug resistance,side effects and the high cost of IM,it is necessary to find anti-cancer drugs with relatively low toxicity and cost,and enhanced efficacy,such as traditional Chinese medicines(TCMs).As one of TCMs,Huai Qi Huang(HQH)was chosen to treat BV173 and K562 *** concentrations of HQH were added to cells for 24-72 ***-treatment of HQH and trametinib,an MEK inhibitor,was used to verify the synergistic effects on cell viability and *** and overexpression of mitogen-activated protein kinase kinase 4(MEK4)were implemented to demonstrate the role of MEK in cell *** viability and apoptosis were measured by cell counting kit-8 assay(CCK8)and flow cytometry,*** blotting and real-time quantitative PCR(RT-qPCR)were used to assess protein and mRNA expression levels,*** results showed that HQH inhibited survival and promoted apoptosis of BV173 and K562 cells in a dose-dependent manner,accompanied with down-regulation of PRKCH mRNA as well as CRAF,MEK4,phospho-ERK(pERK)and BCL2 proteins,and up-regulation of cleaved caspase3 ***-treatment of HQH and trametinib had.a synergistic effect on inhibiting survival and promoting ***4 knockdown increased apoptosis,and had a synergistic effeet with *** contrast,MEK4 overexpression ***,and had the opposite efect with ***,the results of this study may identify a therapeutic mechanism of HQH on promoting apoptosis,and provide a potential option for treatment of Pht leukemia.

关键词： Huai Qi Huang leukemia apoptosis BCR-ABL RAF/MEK/ERK

Chlorite cement and its effect on the reservoir quality of sandstones from the Panyu low-uplift,Pearl River Mouth Basin

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2011年第2期8卷 143-150页

作者： Chen Guojun Du Guichao Zhang Gongcheng Wang Qi lv Chengfu Key Laboratory of Petroleum Resources Research Institute of Geology and Geophysics Chinese Academy of Sciences Lanzhou 730000 China CNOOC Research Center Beijing 100027 China Graduate University of the Chinese Academy of Sciences Beijing 100049 China

Based on porosity and permeability measurements, mercury porosimetry measurements, thin section analyses, SEM observations, X-ray diffraction （XRD） analysis and granulometric analyses, diagenetic features of reservoir sandstones taken from the Zhuhai formation in the Panyu low-uplift of the Pear River Mouth Basin were examined. This study shows that chlorite cements are one of the most important diagenetic features of reservoir sandstones. The precipitation of chlorite was controlled by multiple factors and its development occurred early in eo-diagenesis and continued till Stage A of middle diagenesis. The precipitation of chlorite at the early stage was mainly affected by the sedimentary environment and provenance. Abundant Fe- and Mg-rich materials were supplied during the deposition of distributary channel sediments in the deltaic front setting and mainly in alkaline conditions. With the burial depth increasing, smectite and kaolinite tended to be transformed into chlorite. Smectite cements were completely transformed into chlorite in sandstones of the studied area. Volcanic lithics rich in Fe and Mg materials were dissolved and released Fe2＋ and Mg 2＋ into the pore water. These cations precipitated as chlorite cements in middle diagenesis in an alkaline diagenetic environment. Chlorite coatings acted as porosity and permeability, thus helping preserve cements in the chlorite cemented sandstones. The reservoir quality of chlorite cemented sandstones is much better than sandstones without chlorite cements. Chlorite cements play an important role in the reservoir evolution that was mainly characterized by preserving intergranular porosity and forming better pore-throat structures of sandstones.

关键词： Chlorite cement diagenesis reservoir quality Panyu low-uplift Pearl River Mouth Basin

我国促进企业技术创新政策失灵问题研究——基于政策目标价值取向的测量设计与分析

在线全文

学校读者我要写书评

暂无评论

中国行政管理 2014年第12期 104-109页

作者：吕燕扬州大学商学院副教授硕士生导师扬州225009

我国企业技术创新能力普遍不足与技术创新主体地位之间的矛盾,已引起人们对促进企业技术创新政策失灵问题的研究。本研究运用数量统计法构建测量和统计模型量化分析我国促进企业技术创新政策体系特征及其失灵表现。研究发现,1992年以后... 详细信息

我国企业技术创新能力普遍不足与技术创新主体地位之间的矛盾,已引起人们对促进企业技术创新政策失灵问题的研究。本研究运用数量统计法构建测量和统计模型量化分析我国促进企业技术创新政策体系特征及其失灵表现。研究发现,1992年以后我国开始出现以企业为直接支持对象的技术创新政策,通过20多年的渐进式政策演进我国目前已基本形成了以提高企业技术创新能力为目标导向的政策体系,但这一体系还不够完善,政策失灵主要表现在政策制定者的博弈、政策连续性不足和政策工具结构的不合理等方面。

关键词：企业技术创新政策失灵政策目标导向政策工具政策效力

在线全文

学校读者我要写书评

暂无评论

构建基于企业社会责任的劳动工资增长机制

南京社会科学 2010年第1期 43-48页

作者：吕景春天津师范大学经济学院教授、经济学博士天津300387

构建基于企业社会责任的工资增长机制,应从两个方面入手:一是建立企业社会责任履行制度体系及其监督保障机制,二是建立依托于工资集体协商的劳动工资共同决定机制。这种"双重机制"是目前我国推行企业社会责任建设进程中一项重要的基础... 详细信息

构建基于企业社会责任的工资增长机制,应从两个方面入手:一是建立企业社会责任履行制度体系及其监督保障机制,二是建立依托于工资集体协商的劳动工资共同决定机制。这种"双重机制"是目前我国推行企业社会责任建设进程中一项重要的基础性工作。负有一定社会责任的经济组织,要在合法取得利润的前提下,切实保障企业员工的工资并使其随企业发展和利润的增长而增长,在此基础上进一步维护其他利益相关者的利益或为社会服务,这对发展和谐劳动关系以及对构建和谐社会,都将有着重大的现实意义。

关键词：企业基本社会责任劳动工资增长机制和谐劳动关系

桂枝茯苓汤联合超声引导下介入治疗卵巢巧克力囊肿疗效及对E_(2)、LH、FSH的影响

在线全文

学校读者我要写书评

暂无评论

中华中医药学刊 2022年第11期40卷 247-249页

作者：晁辉吕瑾荆治王锐运城市中心医院(东院) 山西运城044000

目的探讨桂枝茯苓汤联合超声引导下介入治疗卵巢巧克力囊肿(ovarian chocolate cyst, OEC)患者临床疗效及雌二醇(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)的影响。方法选取78例本院妇产科收治的卵巢巧克力囊肿患者进行回顾性分组实... 详细信息

目的探讨桂枝茯苓汤联合超声引导下介入治疗卵巢巧克力囊肿(ovarian chocolate cyst, OEC)患者临床疗效及雌二醇(E_(2))、黄体生成素(LH)、卵泡刺激素(FSH)的影响。方法选取78例本院妇产科收治的卵巢巧克力囊肿患者进行回顾性分组实验分析,纳入时间为2019年1月-2021年1月,对照组单纯予以超声引导下介入治疗+常规抗生素+孕三烯酮干预,实验组在对照组基础上联合桂枝茯苓汤干预,比较两组临床疗效及E_(2)、LH、FSH治疗前后差异。结果实验组总有效率97.44%(38/39),对照组82.05%(32/39),实验组总有效率较对照组更高(P0.05)。实验组患者治疗后CRP、TNF-α水平显著优于对照组(P<0.05)。结论桂枝茯苓汤联合超声引导下介入治疗能有效提高OEC患者的临床疗效,调节E_(2)、LH、FSH过表达,降低术后炎症反应,对卵巢功能恢复有益。

关键词：桂枝茯苓汤超声引导介入治疗卵巢巧克力囊肿雌二醇黄体生成素卵泡刺激

Systematic analysis of DNA polymerases as therapeutic targets in pan-cancers

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2024年第1期48卷 123-138页

作者： ZHENHUA LI HUILAI lv FAN ZHANG ZIMING ZHU QIANG GUO MINGBO WANG CHAO HUANG LIJUAN CHEN WENPAN ZHANG YUN LI ZIQIANG TIAN Department of Thoracic Surgery Fourth Hospital of Hebei Medical UniversityShijiazhuang050011China Department of Thoracic Surgery The First Hospital of XingtaiXingtai054001China Department of Thoracic Surgery Affiliated Hospital of Hebei UniversityBaoding050017China Shanghai OrigiMed Co. Ltd.Shanghai200000China Department of Thoracic Surgery The Seventh Affiliated Hospital of Sun Yat-sen UniversityShenzhen518107China

Introduction:DNA polymerases are crucial for maintaining genome stability and influencing ***,the clinical implications of DNA polymerases in tumorigenesis and their potential as anti-cancer therapy targets are not well ***:We conducted a systematic analysis using TCGA Pan-Cancer Atlas data and Gene Set Cancer Analysis results to examine the expression profiles of 15 DNA polymerases(POLYs)and their clinical *** also evaluated the prognostic value of POLYs by analyzing their expression levels in relation to overall survival time(OS)using Kaplan-Meier survival ***,we investigated the correlations between POLY expression and immune cells,DNA damage repair(DDR)pathways,and *** sensitivity analysis was performed to assess the relationship between POLY expression and drug ***:Our analysis revealed that 14 out of 15 POLYs exhibited significantly distinct expression patterns between tumor and normal samples across most cancer types,except for DNA nucleotidylexotransferase(DNTT).Specifically,POLD1 and POLE showed elevated expression in almost all cancers,while POLQ exhibited high expression levels in all cancer *** POLYs showed heightened expression in specific cancer subtypes,while others exhibited low ***-Meier survival curves demonstrated significant prognostic value of POLYs in multiple cancers,including PAAD,KIRC,and *** analysis further validated these *** patterns of POLYs varied significantly among different cancer types and were associated with poorer survival *** correlations were observed between the expression of POLY members and immune cells,DDR pathways,and *** sensitivity analysis indicated an inverse relationship between POLY expression and drug ***:Our comprehensive study highlights the significant role of POLYs in cancer development and identifies them as promising prognostic and

关键词： DNA polymerases(POLYs) Prognostic biomarker The Cancer Genome Atlas(TCGA) Ubiquitination network

一次具有党的代表会议性质的中央全会——纪念中共七届二中全会召开70周年

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

思想理论教育导刊 2019年第6期 32-37页

作者：吕臻中共中央党史和文献研究院第二研究部

1949年初在西柏坡召开的中共七届二中全会具有重大而深远的历史意义”全会为党在革命转变关头夺取全国胜利和建设新中国,在政治上、思想上和理论上做了重要准备。毛泽东提出这次全会"按其性质来说就是一次党的代表会议"。全会充分地讨... 详细信息

1949年初在西柏坡召开的中共七届二中全会具有重大而深远的历史意义”全会为党在革命转变关头夺取全国胜利和建设新中国,在政治上、思想上和理论上做了重要准备。毛泽东提出这次全会"按其性质来说就是一次党的代表会议"。全会充分地讨论了各方面的工作,取得一系列重要成果。

关键词：七届二中全会工作重心转移两个务必党委会的工作方法