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A strategic flight conflict avoidance approach based on a memetic algorithm

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Chinese Journal of Aeronautics 2014年第1期27卷 93-101页

作者： Guan Xiangmin Zhang Xuejun Han dong Zhu Yanbo lv Ji Su Jing School of Electronic and Information Engineering Beihang University National Key Laboratory of CNS/ATM Beihang University Aviation Data Communication Corporation

Conflict avoidance （CA） plays a crucial role in guaranteeing the airspace safety. The cur- rent approaches, mostly focusing on a short-term situation which eliminates conflicts via local adjust- ment, cannot provide a global solution. Recently, long-term conflict avoidance approaches, which are proposed to provide solutions via strategically planning traffic flow from a global view, have attracted more attentions. With consideration of the situation in China, there are thousands of flights per day and the air route network is large and complex, which makes the long-term problem to be a large-scale combinatorial optimization problem with complex constraints. To minimize the risk of premature convergence being faced by current approaches and obtain higher quality solutions, in this work, we present an effective strategic framework based on a memetic algorithm （MA）, which can markedly improve search capability via a combination of population-based global search and local improve- ments made by individuals. In addition, a specially designed local search operator and an adaptive local search frequency strategy are proposed to improve the solution quality. Furthermore, a fast genetic algorithm （GA） is presented as the global optimization method. Empirical studies using real traffic data of the Chinese air route network and daily flight plans show that our approach outper- formed the existing approaches including the GA .based approach and the cooperative coevolution based approach as well as some well-known memetic algorithm based approaches.

关键词： Air traffic control Combinatorial optimization Conflict avoidance Genetic algorithm Memetic algorithm

Additive-free synthesis of S-substituted isothioureas via visible-light-induced four-component reaction ofα-diazoesters,aryl isothiocyanates,amines and cyclic ethers

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Chinese Chemical Letters 2024年第2期35卷 415-419页

作者： Yufen lv Hongyu Ding Jinmao You Wei Wei dong Yi Key Laboratory of Catalytic Conversion and Clean Energy in Universities of Shandong Province School of Chemistry and Chemical EngineeringQufu Normal UniversityQufu 273165China College of Chemistry and Chemical Engineering Shaoxing UniversityShaoxing 312000China School of Pharmacy Southwest Medical UniversityLuzhou 646000China

An additive-free and environmentally friendly strategy has been realized for the construction of S-substituted isothioureas through visible-light-induced multicomponent reaction starting fromα-diazoesters,aryl isothiocyanates,amines and cyclic *** methodology features simple operation,mild reaction conditions,favorable functional group tolerance,easily available starting materials and high efficiency.

关键词： Visible-light Additive-free Four-component reaction S-Substituted isothioureas

A Rhodamine-based fluorescent sensor for chromium ions and its application in bioimaging

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Chinese Chemical Letters 2017年第6期28卷 1258-1261页

作者： Xue-Mei Li rui-rui Zhao Yan Yang Xue Wei lv Yu-Ling Wei rui Tan Jun-Feng Zhang Ying Zhou Department of Safety Evaluation Technology Center of China Tobacco Yunnan Industrial Co.Ltd. College of Chemical Science and Technology Yunnan University College of Chemistry and Chemical Engineering Yunnan Normal University

A rhodamine-based sensor（1） has been developed for the detection of chromium ***-（3＋）-induced opening of the rhodamine spirocycle in sensor（1） led to the distinct colorimetric and fluorescence *** all the tested ions,only Cr-（3＋） generated a significant fluorescence enhancement of up to13-fold,which indicated the high selectivity of ***（1） was successfully applied in the in vivo fluorescence imaging of Cr-（3＋） in *** results provided solid evidences for the future estimation of Cr-（3＋） in environmental applications and tobacco samples.

关键词： Sensor Chromium Rhodamine Colorimetric Fluorescence In vivo imaging

Mechanism of high temperature reduction on iron carbide preparation with low-grade siderite

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Journal of Iron and Steel Research International 2022年第9期29卷 1357-1367页

作者： dong Chen Ya-nan lv Wei Zhao Fei-bao Wu Wei-ang Ying School of Iron and Steel Soochow UniversitySuzhou 215021JiangsuChina Department of Mechanical and Electrical Engineering Suzhou Institute of Industrial TechnologySuzhou 215104JiangsuChina

The carburization roasting followed by magnetic separation is a feasible method to utilize low-grade siderite *** order to enhance the carburization efficiency and separation effciency,high temperature reduction was carried out,and its mechanism was demonstrated by measuring carburization index,phase change,and microstructure under a carbon-sulfur infrared analyzer,an X-ray diffractometer,and a metallurgical *** results show that both the carburization effciency of siderite pellet and the separation efficiency of iron carbide from gangue are very ***,high temperature reduction is a useful way to enhance the carburization efficiency,as it can accelerate the reduction reaction rate and carburization reaction ***,high temperature reduction can improve the growth of iron carbide particle,promote the carburization efficiency,and strengthen the sodium modification reactions,thereby greatly accelerating the separation efficiency of iron carbide and *** the siderite pellets were reduced at 1050℃ for 90 min and carburized at 650℃ for 120 min,the carburization index of carburized pellets reached *** magnetic separation treatment,an electric furnace burden assaying 83.12 wt.%Fe and 6.96 wt.%C was prepared,and the corresponding iron recovery rate was 95.43%.The high temperature reduction is promisingly adopted to promote the utilization of low-grade siderite ores using carburization-magnetic separation technology.

关键词： Siderite High temperature reduction Carburization-Separation Iron carbide

Leaching process of phosphorus and iron from steelmaking slag into malic acid solution

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Journal of Iron and Steel Research International 2022年第6期29卷 951-960页

作者： Ning-ning lv Chang Su Hui Kong Hai-chuan Wang Yuan-chi dong Key Laboratory of Metallurgical Emission Reduction and Resources Recycling Ministry of EducationAnhui University of TechnologyMa’anshan 243002AnhuiChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243002AnhuiChina

In order to remove phosphorus element from steelmaking slag and decrease iron loss,malic acid was selected as the leaching agent to dissolve steelmaking ***,the influences of different factors,such as malic acid concentration,slag particle size,temperature,liquid/solid ratio and stirring speed,on the leaching ratios of phosphorus and iron were ***,the kinetics for the leaching process of phosphorus was *** results showed that the leaching ratios of phosphorus and iron increase significantly with increasing the malic acid solution concentration and liquid/solid *** the concentration of malic acid solution increases up to 0.01492 mol/L,about 80%phosphorus can be dissolved,and iron leaching ratio is less than 17%.In addition,decreasing slag particle size can obviously increase the leaching ratio of ***,temperature and stirring speed have no significant effect on the dissolution of phosphorus and *** leaching kinetics of phosphorus follows the unreacted shrinking core *** through product layer is the rate-limiting step of the leaching process,and the corresponding apparent activation energy is determined to be 3.32 kJ/***,a semi-empirical kinetic equation was established.

关键词： Leaching process Steelmaking slag Phosphorus Iron Malic acid solution

Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/β-catenin interaction

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Acta Pharmaceutica Sinica B 2021年第11期11卷 3481-3492页

作者： rui Huang Lijun Zhang Jinmei Jin Yudong Zhou Hongwei Zhang Chao lv dong Lu Ye Wu Hong Zhang Sanhong Liu Hongzhuan Chen Xin Luan Weidong Zhang Institute of Interdisciplinary Integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmacy Second Military Medical UniversityShanghai 200433China Department of Chemistry and Biochemistry College of Liberal ArtsUniversity of MississippiUniversityMS 38677-1848USA

Hepatocellular carcinoma(HCC)is one of the leading causes of cancer-related deaths,characterized by highly hypoxic tumor ***-inducible factor-1α(HIF-1α)is a major regulator involved in cellular response to changes of oxygen levels,supporting the adaptation of tumor cells to *** D(BD)is an isolated natural quassinoid with multiple anti-cancer ***,we identified BD could significantly inhibit the HIF-1α expression and its subsequently mediated HCC cell *** biophysical proteomics approaches,we identified inhibitor of β-catenin and T-cell factor(ICAT)as the functional target of *** targeting ICAT,BD disrupted the interaction of bcatenin and ICAT,and promoted β-catenin degradation,which in turn induced the decrease of HIF-1α ***,BD could inhibit HCC cells proliferation and tumor growth in vivo,and knockdown of ICAT substantially increased resistance to BD treatment in *** data highlight the potential of BD as a modulator of β-catenin/HIF-1α axis mediated HCC metabolism.

关键词： Hepatocellular carcinoma Bruceine D HIF-1α Metabolism ICAT β-Catenin Tumor microenvironment Hypoxia

Double network self-healing hydrogel based on hydrophobic association and ionic bond for formation plugging

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Petroleum Science 2022年第5期19卷 2150-2164页

作者： Ying-rui Bai Qi-Tao Zhang Jin-Sheng Sun Guan-Cheng Jiang Kai-He lv School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina CNPC Engineering Technology R&D Company Limited Beijing102206China College of Petroleum Engineering China University of Petroleum(Beijing)Beijing102249China

Self-healing hydrogels have attracted tremendous attention in the field of oil and gas drilling and production engineering because of their excellent self-healing performance after physical *** this study,a series of double network self-healing(DN_(SA))hydrogels based on hydrophobic association and ionic bond were prepared for plugging pores and fractures in formations in oil and gas drilling and production *** mechanical,rheological,and self-healing properties of the DN_(SA)hydrogels were *** revealed that the DN_(SA)hydrogels exhibited excellent mechanical properties with a tensile stress of 0.67 MPa and toughness of 7069 kJ/cm^(3) owing to the synergistic effect of the double *** addition,the DN_(SA)hydrogels exhibited excellent compression resistance,notch insensitivity,and self-healing *** DN_(SA)-2 hydrogel was granulated and made into gel particles with different particle sizes and used as a plugging *** self-healing mechanism of DN_(SA)-2 hydrogel particles in fractures was explored,and it’s plugging effect on fractures of different widths and porous media of different permeabilities were *** results revealed that the plugging capacity of the DN_(SA)-2 hydrogel particles for a fracture with width of 5 mm and a porous medium with a permeability of 30μm^(2) was 3.45 and 4.21 MPa,respectively,which is significantly higher than those of commonly used plugging agents in the *** DN_(SA)hydrogels with excellent mechanical and self-healing properties prepared in this study will provide a new approach for applying hydrogels in oil and gas drilling and production engineering.

关键词： Self-healing hydrogel Hydrophobic association Ionic bond Mechanical property Rheological property Formation plugging

Microstructure and wear behaviors of TiB/TiC reinforced Ti2Ni/α(Ti) matrix coating produced by laser cladding

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Rare Metals 2020年第3期39卷 304-315页

作者： Jin-Zhong Shao Jun Li rui Song lv-Lin Bai Jia-Li Chen Cui-Cui Qu School of Materials Engineering Shanghai University of Engineering ScienceShanghai201620China

A Ti2Ni/a(Ti)matrix composite coating reinforced by TiC and TiB was prepared on a Ti6A14V substrate by laser *** microstructure of the coating was examined and *** wear behavior of the coating at various sliding speeds was investigated from the perspective of energy dissipation,and the relationship between accumulated dissipated energy(ΣE)and accumulated wear volume(ΣV)was *** indicate a good linear relationship betweenΣE andΣV at low sliding speed(0.1 m·s-1);at higher sliding speed(0.2 m·s-1),the relationship between these parameters follows a quadratic *** results may be explained from the perspective of energy transformation,wherein the friction heat and plastic deformation of the coating surface consume a substantial amount ofΣE at high sliding speed(0.2 m·s-1)and the remainder of the energy is used to produce worn coating *** wear mechanism of the coating involves a combination of microcutting and brittle debonding accompanied by oxidization of the worn surface and formation of Al2O3 adherents.

关键词： Wear behaviors Coating Laser cladding Accumulated dissipated energy

Lonicerin targets EZH2 to alleviate ulcerative colitis by autophagy-mediated NLRP3 inflammasome inactivation

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Acta Pharmaceutica Sinica B 2021年第9期11卷 2880-2899页

作者： Qi lv Yao Xing Jian Liu dong dong Yue Liu Hongzhi Qiao Yinan Zhang Lihong Hu Jiangsu Key Laboratory for Functional Substance of Chinese Medicine Stake Key Laboratory Cultivation Base for TCM Quality and EfficacySchool of PharmacyNanjing University of Chinese MedicineNanjing 210023China

Aberrant activation of NLRP3 inflammasome in colonic macrophages strongly associates with the occurrence and progression of ulcerative *** targeting NLRP3 inflammasome has been considered to be a potential therapy,the underlying mechanism through which pathway the intestinal inflammation is modulated remains *** focusing on the flavonoid lonicerin,one of the most abundant constituents existed in a long historical anti-inflammatory and anti-infectious herb Lonicera japonica Thunb.,here we report its therapeutic effect on intestinal inflammation by binding directly to enhancer of zeste homolog 2(EZH2)histone ***2-mediated modification of H3 K27 me3 promotes the expression of autophagy-related protein 5,which in turn leads to enhanced autophagy and accelerates autolysosome-mediated NLRP3 *** of EZH2 residues(His 129 and Arg685)indicated by the dynamic simulation study have found to greatly diminish the protective effect of *** importantly,in vivo studies verify that lonicerin dose-dependently disrupts the NLRP3-ASC-pro-caspase-1 complex assembly and alleviates colitis,which is compromised by administration of EZH2 overexpression ***,these findings together put forth the stage for further considering lonicerin as an anti-inflammatory epigenetic agent and suggesting EZH2/ATG5/NLRP3 axis may serve as a novel strategy to prevent ulcerative colitis as well as other inflammatory diseases.

关键词： Lonicerin Colitis NLRP3 inflammasome Autophagy EZH2