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Assay of Biomarkers for Alzheimer's Disease by Surface Plasmon Resonance

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Journal of Analysis and Testing 2024年第3期8卷 251-261页

作者： Xinyao yi Huihui chen Yuhan He Jianxiu Wang Hunan Provincial Key Laboratory of Micro and Nano Materials Interface Science College of Chemistry and Chemical EngineeringCentral South University

Alzheimer's disease(AD) is one of the neurodegenerative diseases characterized by cognitive dysfunction and behavioral impairment. Early diagnosis of AD serves as a viable means to avoid the onset and progression of the disease. Due to the remarkably lower expression levels of AD biomarkers in cerebrospinal fluids and serum samples, sensitive and specific analytical methods are highly demanded. Surface plasmon resonance(SPR) is ultrasensitive to the refractive index or thickness change at the metal surface, which enables real-time and label-free assay of target biomolecules. In this review, we summarize the advances on assay of AD biomarkers including amyloid beta, tau protein, apoE proteins and apoE genes, and BACE1 by SPR, with emphasis on the analytical performances concerning anti-fouling and signal amplification strategies and real sample applications.

关键词： Alzheimer’s disease amyloid beta apoE BACE1 Surface plasmon resonance Tau protein

Flux phases in the extended Hubbard model on the triangular lattice

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 148-153页

作者： Yuge chen Kun Jiang yi Zhang Jiangping Hu Beijing National Laboratory for Condensed Matter Physics and Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China Department of Physics and Institute for Quantum Science and Technology Shanghai UniversityShanghai 200444China Shanghai Key Laboratory of High Temperature Superconductors and International Center of Quantum and Molecular Structures Shanghai UniversityShanghai 200444China Kavli Institute of Theoretical Sciences University of Chinese Academy of SciencesBeijing 100190China New Cornerstone Science Laboratory Beijing 100190China

Using the unrestricted Hartree-Fock variational method,we study the extended Hubbard model in the triangular lattice at 3/4 *** to the nesting instability of the Fermi surface,various density wave states compatible with the 2×2 supercell are found as the ground state by tuning the onsite and nearest neighbor repulsions U and ***,the flux phases with complex bond order parameters are realized in a wide range of the U-V phase *** also acquire nontrivial topological properties due to the spontaneous breaking of the time-reversal *** study suggests that the flux phases can be stabilized by the interplay between short-range repulsive interactions in correlated electron systems.

关键词： flux state triangular lattice Hubbard model

Preparation of vanadium-based electrode materials and their research progress in solid-state flexible supercapacitors

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Rare Metals 2024年第2期43卷 431-454页

作者： rui-Jie Zhu Jiang Liu Chao Hua Hao-Yu Pan yi-Jun Cao Meng Li Zhongyuan Critical Metals Laboratory Zhengzhou UniversityZhengzhou450001China School of Chemical Engineering Zhengzhou UniversityZhengzhou450001China

Solid-state flexible supercapacitors(SCs)have many advantages of high specific capacitance,excellent flexibility,fast charging and discharging,high power density,environmental friendliness,high safety,light weight,ductility,and long cycle *** are the ideal choice for the development of flexible energy storage technology in the future,and provide a good prospect for energy storage *** present,solid-state flexible SCs are widely used for portable electronic equipment and wearable energy storage equipment,the research of them has become the focus of a growing number of *** material is the key part of SCs and always determines the electrochemical performance of *** has been a hotspot and focus of ***-based compounds are considered to be a promising electrode material for SCs because of variable valence,open structure,high theoretical capacity,and low ***,this study first gives an overview of solid-state flexible SCs,then reviews the current research status of vanadium-based electrode materials in solid-state flexible SCs,and proposes some strategies to solve some problems of vanadium-based electrode materials.

关键词： Vanadium-based materials Flexible energy storage Specific capacitance Supercapacitors(SCs)

Testicular volume is a noninvasive predictor of sperm retrieval failure in idiopathic nonobstructive azoospermia

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Asian Journal of Andrology 2024年第4期26卷 421-425页

作者： Hong Xiao Song-Xi Tang rui-Jie Yao yi-Lang Ding Peng Yang Qiang chen Hai-Lin Huang Xi chen Hui-Liang Zhou Department of Andrology and Sexual Medicine First Affiliated Hospital of Fujian Medical UniversityFuzhou 350005China.

We investigated the prognostic importance of noninvasive factors in predicting sperm retrieval failure in idiopathic nonobstructive azoospermia(iNOA).We studied 193 patients with nonobstructive azoospermia who underwent microsurgical testicular sperm *** Chi-square test and Mann–Whitney U tests for clinical parameters and seminiferous tubule distribution were used for between-group comparisons.A logistic regression analysis was conducted to identify predictors of retrieval *** under the receiver operating characteristic curve for each variable was evaluated,and the net clinical benefit was calculated using a clinical decision *** with iNOA had a lower sperm retrieval rate than those with known ***,testicular volume was an independent factor affecting sperm extraction outcomes(odds ratio=0.79,P<0.05).The testicular volume cut-off value was 6.5 ml(area under the curve:0.694).The patients with iNOA were categorized into two groups on the basis of the distribution of seminiferous tubules *** sperm retrieval rate and testicular volume were significantly different between the groups with a uniform or heterogeneous tubule *** was also a significant association between a uniform tubule distribution and testicular *** conclusion,a testicular volume of more than 6.5 ml effectively predicts microsurgical testicular sperm extraction failure due to a uniform tubule distribution in patients with iNOA.

关键词： idiopathic nonobstructive azoospermia microsurgical testicular sperm extraction sperm retrieval failure testicular volume

Energy-Saving Distributed Flexible Job Shop Scheduling Optimization with Dual Resource Constraints Based on Integrated Q-Learning Multi-Objective Grey Wolf Optimizer

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1459-1483页

作者： Hongliang Zhang yi chen Yuteng Zhang Gongjie Xu School of Management Science and Engineering Anhui University of TechnologyMa’anshan243032China Laboratory of Multidisciplinary Management and Control of Complex Systems of Anhui Higher Education Institutes Anhui University of TechnologyMa’anshan243032China Department of Industrial Engineering School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an710072China

The distributed flexible job shop scheduling problem(DFJSP)has attracted great attention with the growth of the global manufacturing *** DFJSP research only considers machine constraints and ignores worker *** one critical factor of production,effective utilization of worker resources can increase ***,energy consumption is a growing concern due to the increasingly serious environmental ***,the distributed flexible job shop scheduling problem with dual resource constraints(DFJSP-DRC)for minimizing makespan and total energy consumption is studied in this *** solve the problem,we present a multi-objective mathematical model for DFJSP-DRC and propose a Q-learning-based multi-objective grey wolf optimizer(Q-MOGWO).In Q-MOGWO,high-quality initial solutions are generated by a hybrid initialization strategy,and an improved active decoding strategy is designed to obtain the scheduling *** further enhance the local search capability and expand the solution space,two wolf predation strategies and three critical factory neighborhood structures based on Q-learning are *** strategies and structures enable Q-MOGWO to explore the solution space more efficiently and thus find better Pareto *** effectiveness of Q-MOGWO in addressing DFJSP-DRC is verified through comparison with four algorithms using 45 *** results reveal that Q-MOGWO outperforms comparison algorithms in terms of solution quality.

关键词： Distributed flexible job shop scheduling problem dual resource constraints energy-saving scheduling multi-objective grey wolf optimizer Q-learning

Data-driven real-time prediction for attitude and position of super-large diameter shield using a hybrid deep learning approach

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Underground Space 2024年第2期15卷 275-297页

作者： Yanbin Fu Lei chen Hao Xiong Xiangsheng chen Andian Lu yi Zeng Beiling Wang Key Laboratory of Coastal Urban Resilient Infrastructures(MOE) Shenzhen UniversityShenzhen 518060GuangdongChina College of Civil and Transportation Engineering Shenzhen UniversityShenzhen 518060GuangdongChina Shenzhen Key Laboratory of Green Efficient and Intelligent Construction of Underground Metro StationShenzhen UniversityShenzhen 518060GuangdongChina Guangdong Yuehai Pearl River Delta Water Supply Limited Company Guangzhou 511458China Shanghai Tunnel Engineering and Rail Transit Design and Research Institute Shanghai 200235China

The presented research introduces a novel hybrid deep learning approach for the dynamic prediction of the attitude and position of super-large diameter shields-a critical consideration for construction safety and tunnel lining *** study proposes a hybrid deep learning approach for predicting dynamic attitude and position prediction of super-large diameter *** approach consists of principal component analysis(PCA)and temporal convolutional network(TCN).The former is used for employing feature level fusion based on features of the shield data to reduce uncertainty,improve accuracy and the data effect,and 9 sets of required principal component characteristic data are *** latter is adopted to process sequence data in predicting the dynamic attitude and position for the advantages and potential of convolution *** approach’s effectiveness is exemplified using data from a tunnel construction project in *** obtained results show remarkable accuracy in predicting the global attitude and position,with an average error ratio of less than 2 mm on four shield outputs in 97.30%of ***,the approach displays strong performance in accurately predicting sudden fluctuations in shield attitude and position,with an average prediction accuracy of 89.68%.The proposed hybrid model demonstrates superiority over TCN,long short-term memory(LSTM),and recurrent neural network(RNN)in multiple *** additive exPlanations(SHAP)analysis is also performed to investigate the significance of different data features in the prediction *** study provides a real-time warning for the shield driver to adjust the attitude and position of super-large diameter shields.

关键词： Shield attitude and position Super-large diameter shield PCA-TCN Deep learning Real-time warning

Narrowband blue emitter based on fused nitrogen/carbonyl combination with external quantum efficiency approaching 30%

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Science China Chemistry 2024年第1期67卷 351-359页

作者： Long chen Jia-Heng Cai You-Jun Yu Yang-Kun Qu Sheng-yi Yang Sheng-Nan Zou rui-Hong Liu Dong-ying Zhou Liang-Sheng Liao Zuo-Quan Jiang Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials&DevicesSoochow UniversitySuzhou 215123China Macao Institute of Materials Science and Engineering Macao University of Science and TechnologyMacao 999078China

Multi-resonance thermally activated delayed fluorescence(MR-TADF)emitters can enable narrowband emission with high color purity and electroluminescence ***/carbonyl(N/C=O)system is receiving increasing attention while the nitrogen/boron(N/B)system has been widely *** decoration is an effective approach for N/B type MR-TADF system but always leads to broadening and red-shifting of the emission band in N/C=O MR-TADF *** attribute these unfavorable phenomena to the formation of intramolecular charge transfer between the MR-core and peripheral *** address this issue,we have developed a new strategy by decorating DMQAO(a fused N/C=O MR-core)with a triazine acceptor and a neutral terphenyl group to construct MTDMQAO and MBDMQAO,*** introduction of the triazine acceptor not only realizes efficient narrowband emission in MTDMQAO,but also accelerates the reverse intersystem crossing process through enhanced spin-orbital *** a result,MTDMQAO exhibits a significantly higher external quantum efficiency of 29.4%compared to the referent emitters,validating the rationality of our derivation *** study highlights the potential of the N/C=O system for MR-TADF emitters and provides important insights for understanding the difference between N/B and N/C=O systems.

关键词： carbonyl group narrowband acceptor decoration thermally activated delayed fluorescence OLEDs

Intra-Oceanic Subduction Termination and Reinitiation of the Eastern Neo-Tethys in Myanmar

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Journal of Earth Science 2024年第3期35卷 1053-1058页

作者： yi chen Qinghua Zhang Lin chen Kaihui Shi Kyaing Sein State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China University of Chinese Academy of Sciences Beijing 100049China Myanmar Geosciences Society Hlaing University CampusYangon 11062Myanmar

Subduction initiation and termination represent the birth and death of a subduction zone and are inevitable elements of terrestrial plate *** evidence demonstrates that subduction zone processes did not operate continuously and might involve multiple initiation and termination stages(Stern,2004),characterized by sustained subduction-zone death and *** geological and numerical studies focus on subduction initiation processes/mechanisms(see reviews in Yang,2022);however,subduction termination is often studied numerically at continental margins(Gerya,2022).How subduction termination proceeds in intra-oceanic settings remains enigmatic due to lacking geological records.

关键词： Eastern terrestrial continental

Ablative behavior and mechanism of SiC_(f) /SiBCZr composites prepared by PIP process

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Journal of Advanced Ceramics 2024年第1期13卷 124-134页

作者： Mingwei chen Yuliang Zhao Haipeng Qiu Shijian Liu Weijie Xie yi chen Qiyue Zhang AVIC Manufacturing Technology Institute Beijing 100130China

SiC_(f)/SiBCZr composites were prepared by polymer precursor impregnation and pyrolysis process with near stoichiometric ratio SiC fiber preform as reinforcement phase and SiBCZr multiphase ceramic precursor as impregnating *** results highlighted that the SiC_(f)/SiBCZr composites exhibited excellent ablative properties after ablative tests at 1200℃/3600 s and 1400℃/3600 s,and the strength retention rates of the composites reached 90%and 85%,*** was mainly due to the liquid sealing effect of the ablative products represented by B2O_(3) and SiO_(2)∙B_(2)O_(3),which inhibited the ablative reaction by reducing the diffusion rate of the oxidation medium,and the solid pinning effect of the substances represented by SiO_(2),ZrO_(2),and ZrSiO_(4),which could play high viscosity and high strength characteristics to improve anti-erosion *** above-mentioned SiC_(f)/SiBCZr composites with corrosion resistance,oxidation resistance,and ablative resistance provided a solid material foundation and technical support for the development of reusable spacecraft hot-end components.

关键词： near stoichiometric ratio SiC fiber SiC_(f)/SiBCZr composite liquid sealing effect solid pinning effect