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Interleukin-4 affects microglial autophagic flux

Neural Regeneration Research 2019年第9期14卷 1594-1602页

作者： Run-Hong Tang rui-Qun Qi Hua-Yan Liu Department of Neurology the First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina Department of Dermatology Key Laboratory of Immunodermatologythe First Hospital of China Medical UniversityShenyangLiaoning ProvinceChina

Interleukin-4 plays an important protective role in Alzheimer’s disease by regulating microglial phenotype,phagocytosis of amyloid-β,and secretion of anti-inflammatory and neurotrophic ***,increasing evidence has suggested that autophagy regulates innate immunity by affecting M1/M2 polarization of microglia/***,the role of interleukin-4 in microglial autophagy is *** view of this,BV2 microglia were treated with 0,10,20 or 50 ng/mL interleukin-4 for 24,48,or 72 ***,light chain 3-II and p62 protein expression levels were detected by western blot ***2 microglia were incubated with interleukin-4(20 ng/mL,experimental group),3-methyladenine(500μM,autophagy inhibitor,negative control group),rapamycin(100 nM,autophagy inductor,positive control group),3-methyladenine+interleukin-4(rescue group),or without treatment for 24 hours,and then exposed to amyloid-β(1μM,model group)or vehicle control(control)for 24 ***3-II and p62 protein expression levels were again detected by western blot *** addition,expression levels of multiple markers of M1 and M2 phenotype were assessed by real-time fluorescence quantitative polymerase chain reaction,while intracellular and supernatant amyloid-βprotein levels were measured by enzyme-linked immunosorbent *** results showed that interleukin-4 induced microglial autophagic flux,most significantly at 20 ng/mL for 48 ***-4 pretreated microglia inhibited blockade of amyloid-β-induced autophagic flux,and promoted amyloid-βuptake and degradation partly through autophagic flux,but inhibited switching of amyloid-β-induced M1 phenotype independent on autophagic *** results indicate that interleukin-4 pretreated microglia increases uptake and degradation of amyloid-βin a process partly mediated by autophagy,which may play a protective role against Alzheimer’s disease.

关键词： nerve regeneration Alzheimer’s disease interleukin-4 amyloid-β microglial autophagy microglial polarization microglia M1 phenotype M2 phenotype peptide degradation neural regeneration

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不同生活环境下小熊猫皮质醇和肠道微生物的变化规律

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兽类学报 2024年第4期44卷 427-435页

作者：赵星马锐吴蔚李明喜陈超周延山洪明生齐敦武西华师范大学西南野生动植物资源保护教育部重点实验室南充637002 成都大熊猫繁育研究基地四川省濒危野生动物保护生物学重点实验室成都610081

肠道微生物群落易受环境压力的影响,其结构的相对稳定对维持动物机体健康至关重要。皮质醇作为一种应激激素不仅能反映动物应激状况还影响动物的肠道微生物结构,然而小熊猫肠道菌群和粪便皮质醇之间的共变机制尚未被研究。为此,我们通... 详细信息

肠道微生物群落易受环境压力的影响,其结构的相对稳定对维持动物机体健康至关重要。皮质醇作为一种应激激素不仅能反映动物应激状况还影响动物的肠道微生物结构,然而小熊猫肠道菌群和粪便皮质醇之间的共变机制尚未被研究。为此,我们通过比较不同生活环境下(圈养、散养和野生)小熊猫粪便皮质醇和肠道微生物结构的差异,以期阐明其皮质醇和肠道微生物的变化规律。结果发现:(1)圈养环境下皮质醇浓度最低(71.1±21.6)ng/g,散养环境下其浓度为(111.3±5.6)ng/g,而野生环境下最高,为(5094.8±5383.9)ng/g。同时,散养环境下的小熊猫肠道微生物Shannon指数最高(6.178),其次是野生环境下(5.535),圈养环境下最低(3.449)。(2)圈养小熊猫皮质醇浓度与大肠杆菌志贺氏菌属(Escherichia⁃Shigella)呈显著负相关(P<0.001),与难辨梭菌属(Clostridium_sensu_stricto_1)呈显著正相关(P<0.001)。综上所述,不同生活环境显著影响小熊猫的肠道微生物组成和粪便皮质醇浓度,减少环境的变化频率和强度能有效降低其应激性,维持肠道菌群的健康稳定,这将为小熊猫种群的健康管理提供技术支撑。

关键词：小熊猫肠道微生物 16S rRNA测序皮质醇应激

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Interventions for preventing influenza: An overview of Cochrane systematic reviews and a Bayesian network meta-analysis

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Journal of Integrative Medicine 2021年第6期19卷 503-514页

作者： Yi Yuan rui-ting Wang Jun Xia Hui-juan Cao Department of Tuina and Pain Management Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Department of Cardiology Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Nottingham Ningbo GRADE Centre The University of Nottingham NingboNingbo 315100Zhejiang ProvinceChina Division of Epidemiology and Public Health School of MedicineUniversity of NottinghamNottingham NG72RDUK Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing 100029China

Background:Influenza places a heavy public health burden in numerous countries every *** addition to vaccines,there are some interventions that are effective in preventing ***:This overview of systematic reviews(SRs)aimed to evaluate the efficacy and safety of interventions for influenza *** strategy:We searched the Cochrane Database of Systematic Reviews,2020,Issue 1 for relevant Cochrane SRs using the keywords‘‘common cold,"‘‘influenza,"and‘‘flu."Inclusion criteria:Cochrane SRs that investigated the prevention of influenza were *** included the general population without influenza or influenza-like symptoms,who were treated with preventative interventions and compared to individuals receiving no treatment or *** extraction and analysis:Two reviewers independently screened citations against pre-defined inclusion criteria and extracted *** methodological quality of these SRs was evaluated using the Assessing the Methodological Quality of Systematic Reviews-II(AMSTAR-II)*** primary outcome of our analysis was the incidence of influenza,and the secondary outcomes were the incidence of influenza-like illness and *** addition to the narrative summary of SR findings,we also pooled data from homogeneous trials among these SRs and produced evidence *** conducted a network meta-analysis to compare the effect across interventions and used the Cochrane approach to grading of recommendations,assessment,development,and evaluation(GRADE)to assess the quality of ***:Eleven Cochrane SRs were included,covering five medications,eleven vaccinations and four complementary *** these SRs,73%scored"high"quality on AMSTAR-II *** found that eight interventions,including amantadine,garlic,and six different vaccines,were beneficial for reducing the incidence of influenza compared to placebo,while oseltamivir,zanamivir,Ganmao capsule,Echinacea,and another three typ

关键词： Influenza Preventive measure Overview Network meta-analysis Evidence mapping Systematic review

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Forecasting method of monthly wind power generation based on climate model and long short-term memory neural network

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Global Energy Interconnection 2020年第6期3卷 571-576页

作者： rui Yin Dengxuan Li Yifeng Wang Weidong Chen State Grid Hebei Electric Power Company Shijiazhuang 050022P.R.China China Electric Power Research Institute Nanjing 210003P.R.China

Predicting wind power gen eration over the medium and long term is helpful for dispatchi ng departme nts,as it aids in constructing generation plans and electricity market *** study presents a monthly wind power gen eration forecast!ng method based on a climate model and long short-term memory(LSTM)n eural n etwork.A non linear mappi ng model is established between the meteorological elements and wind power monthly utilization *** considering the meteorological data(as predicted for the future)and new installed capacity planning,the monthly wind power gen eration forecast results are output.A case study shows the effectiveness of the prediction method.

关键词： Wind power Monthly generation forecast Climate model LSTM neural network

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Labor Market Dynamics and Structural Change： Evidence from China

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China & World Economy 2015年第4期23卷 60-83页

作者： rui Mao Jianwei Xu School of Management Zhejiang University Hangzhou China School of Finance Beijing Normal University Beijing China

Structural change theories usually assume agents are homogeneous. However, because of demand-side or supply-side heterogeneities, the probability of switching among sectors differs across people. This paper reveals these differences through restoring a long-period, individual-level panel dataset from China＇s Urban Household Survey for 1986-2009. We find that both for people who started working for the first time and those who switched jobs, the sector choice depends on personal characteristics. In particular, women and people with higher educational attainment or a previous white- collar job are more likely to join the tertiary sector and less likely to join the primary sector. These effects are substantial even if the macroeconomic variables used in conventional structural change theories are controlled. They are also robust in various periods and at more detailed industry levels. Our research suggests that it is important to pay greater attention to the labor composition when mal^ng policy related to economic structural change.

关键词： labor market dynamics personal characteristics sectoral switch structural change

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The novel male meiosis recombination regulator coordinates the progression of meiosis prophase Ⅰ

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Journal of Genetics and Genomics 2020年第8期47卷 449-464页

作者： Miao Li Haiwei Feng Zexiong Lin Jiahuan zh.ng Dongteng Liu rui Guo Junshi Li Raymond H.W.Li Ernest H.Y.ng Michael S.Y.Huen P.Jeremy Wang William S.B.Yeung Kui Liu Shenzhen Key Laboratory of Fertility Regulation Center of Assisted Reproduction and EmbryologyThe University of Hong Kong-Shenzhen HospitalShenzhen518000China Department of Obstetrics and Gynecology Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China Department of Biomedical Sciences University of Pennsylvania School of Veterinary MedicinePhiladelphiaPA19104USA School of Biomedical Sciences Li Ka Shing Faculty of MedicineThe University of Hong KongHong Kong999077China

Meiosis is a specialized cell division for producing haploid gametes in sexually reproducing *** this study,we have independently identified a novel meiosis protein male meiosis recombination regulator(MAMERR)/4930432 K21 Rik and showed that it is indispensable for meiosis prophase I progression in male *** super-resolution structured illumination microscopy,we found that MAMERR functions at the same double-strand breaks as the replication protein A and meiosis-specific with OB domains/spermatogenesis associated 22 *** generated a Mamerr-deficient mouse model by deleting exons 3 e6 and found that most of Mamerrà/àspermatocytes were arrested at pachynema and failed to progress to diplonema,although they exhibited almost intact synapsis and progression to the pachytene stage along with XY body *** mechanistic studies revealed that the recruitment of DMC1/RAD51 and heat shock factor 2 ebinding protein in Mamerrà/àspermatocytes was only mildly impaired with a partial reduction in double-strand break repair,whereas a substantial reduction in ubiquitination on the autosomal axes and on the XY body appeared as a major phenotype in Mamerrà/à*** propose that MAMERR may participate in meiotic prophase I progression by regulating the ubiquitination of key meiotic proteins on autosomes and XY chromosomes,and in the absence of MAMERR,the repressed ubiquitination of key meiotic proteins leads to pachytene arrest and cell death.

关键词： Meiosis 4930432K21Rik Recombination Ubiquitination

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NiCo-LDH/Ti3C2 MXene hybrid materials for lithium ion battery with high-rate capability and long cycle life

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Journal of Energy Chemistry 2020年第11期29卷 143-153页

作者： rui zh.ng zhe Xue Jiaqian Qin Montree Sawangphnjk Xinyu zh.ng Riping Liu State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004HebeiChina Research Unit of Advanced Materials for Energy Storage Metallurgy and Materials Science Research InstituteChulalongkorn UniversityBangkok 10330Thailand Centre of Excellence for Energy Storage Technology(CEST) Department of Chemical and Biomolecular EngineeringSchool of Energy Science and EngineeringVidyasirimedhi Institute of Science and TechnologyRayo ng 21210Thailand

Nickel/cobalt-layered double hydroxides(Ni Co-LDH) have been attracted increasing interest in the applications of anode materials for lithium ion battery(LIB), but the low cycle stability and rate performance are still limited its practice applications. To achieve high performance LIB, the surface-confined strategy has been applied to design and fabricate a new anode material of NiCo-LDH nanosheet anchored on the surface of Ti3C2 MXene(Ni Co-LDH/Ti3C2). The ultra-thin, bended and wrinkled α-phase crystal with an interlayer spacing of 8.1 ? can arrange on the conductive substrates Ti3C2 MXene directly, resulting in high electrolyte diffusion ability and low internal resistance. Furthermore, chemical bond interactions between the highly conductive Ti3C2 MXene and Ni Co-LDH nanosheets can greatly increase the ion and electron transport and reduce the volume expansion of NiCo-LDH during Li ion intercalation. As expected,the discharge capacity of 562 m Ah g-1 at 5.0 A g-1 for 800 cycles without degradation can be achieved,rate capability and cycle performance are better than that of NiCo-LDH(~100 mAh g-1). Furthermore, the density function theory(DFT) calculations were performed to demonstrate that Ni Co-LDH/Ti3C2 system can be used as a highly desirable and promising anode material for lithium ion battery.

关键词： MXene Ti3C2 NiCo-LDH Lithium ion battery First-principles calculation

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MSPE-GC-BID同时测定白酒中16种邻苯二甲酸酯含量

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食品科技 2024年第7期49卷 300-307页

作者：贾鹏禹陈爽孙蕊李良玉闫岩张丽媛黑龙江八一农垦大学食品学院黑龙江大庆163319 黑龙江八一农垦大学国家杂粮工程技术研究中心黑龙江大庆163319 黑龙江八一农垦大学动物科技学院黑龙江大庆163319

文章建立了磁固相萃取结合气相色谱-介质阻挡放电等离子体检测器(Barrier discharge ionization detector, BID)对白酒中16种邻苯二甲酸酯含量的检测方法,优化了磁固相萃取条件。该方法采用50.0 mg磁性吸附剂,在50℃下萃取10 min,目标... 详细信息

文章建立了磁固相萃取结合气相色谱-介质阻挡放电等离子体检测器(Barrier discharge ionization detector, BID)对白酒中16种邻苯二甲酸酯含量的检测方法,优化了磁固相萃取条件。该方法采用50.0 mg磁性吸附剂,在50℃下萃取10 min,目标物萃取后经2.0 mL丙酮/乙酸乙酯混合溶液(9:1,V/V),在50℃下解吸15 min后上机检测。气相色谱进样口温度为270℃,色谱分离柱采用CD-5(30 m×0.25 mm×0.25μm,5%苯基-聚二甲基硅氧烷)石英毛细管柱,在程序升温模式下分离组分,BID检测器温度为290℃,放电气体流量为25.0 mL/min,不分流进样体积为1μL。结果表明,16种邻苯二甲酸酯在20.0~3000.0 ng/mL的浓度范围内线性关系良好,相关系数为0.9989~0.9998,加标回收率为62.4%~127.1%,检出限为0.12~0.49 ng/mL。所建方法操作简单、准确度高、精密度好,可用于白酒样品中16种邻苯二甲酸酯的测定。

关键词：磁固相萃取气相色谱介质阻挡放电等离子体检测器邻苯二甲酸酯白酒

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条件变化对海口湾风暴增水的影响分析——以海鸥台风为例

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海洋工程 2018年第4期36卷 147-154页

作者：丁瑞朱良生华南理工大学土木与交通学院广东广州510641

以海口湾为例,通过建立天文潮与风暴潮耦合数值模型,以典型强台风海鸥为基础,对未来台风增强、海平面上升和填海工程对海口湾风暴潮的影响分别进行了诊断分析,并计算了三者的共同作用在未来100年对风暴增水最大值的变化幅度。结果表明:1... 详细信息

以海口湾为例,通过建立天文潮与风暴潮耦合数值模型,以典型强台风海鸥为基础,对未来台风增强、海平面上升和填海工程对海口湾风暴潮的影响分别进行了诊断分析,并计算了三者的共同作用在未来100年对风暴增水最大值的变化幅度。结果表明:1)台风强度增强大幅度增加海口湾沿岸风暴增水最大值,台风强度增强10%时,海口湾沿岸控制点风暴增水最大值增加12%~18%;2)海口湾地区在海平面上升的影响下风暴增水最大值反而减小,仅有部分岸段风暴增水值最大增加,不同海域风暴增水变化对海平面上升的响应不同;3)不合理的人工岛建设方案会显著增加对岸风暴最大增水值;4)在台风增强、海平面上升和不合理的海湾填海共同影响下,未来100年风暴增水最大值将增加12%~28%。显然这样的风暴增水变化会引起严重的灾害和后果,本研究可为海口湾防灾减灾工作提供依据。

关键词：风暴增水最大值台风强度增强海平面上升海湾填海

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人血清中全氟和多氟烷基化合物及典型异构体的暴露特征与健康风险评估

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环境科学学报 2024年第2期44卷 432-440页

作者：崔建升杨瑞于玉洁杨臣强何礼王占辉金航标刘大喜河北科技大学环境科学与工程学院石家庄050018 河北省污染防治生物技术实验室石家庄050018 河北省生活饮用水安全检测技术创新中心承德067000 浙江工业大学环境学院杭州310032

为探究全氟和多氟烷基化合物(PFASs)及典型异构体在人血清中的暴露特征,利用高效液相色谱串联质谱法(HPLC-MS/MS)分析检测了60个人类血清样本中包括全氟辛烷羧酸(PFOA)与全氟辛烷磺酸(PFOS)异构体在内的16种PFASs.结果表明,除PFOA的异构... 详细信息

为探究全氟和多氟烷基化合物(PFASs)及典型异构体在人血清中的暴露特征,利用高效液相色谱串联质谱法(HPLC-MS/MS)分析检测了60个人类血清样本中包括全氟辛烷羧酸(PFOA)与全氟辛烷磺酸(PFOS)异构体在内的16种PFASs.结果表明,除PFOA的异构体4m-PFOA与5m-PFOA外,所有目标PFASs均被检出.ΣPFASs的血清浓度为2.15~77.22 ng·mL^(-1),n-PFOS是血清中贡献率最高的PFASs,其次为3+5mPFOS、4m-PFOS、n-PFOA及全氟己烷磺酸(PFHxS),PFOS所有的异构体与PFHxS、PFNA之间均存在显著的正相关关系.探究不同性别和年龄段的人类血清的PFASs发现,男性血清中的PFASs浓度显著高于女性,高年龄段人群血清中的PFASs浓度高于低年龄段人群.健康风险表征显示,血清中所有的PFASs单体的风险熵值HQ均小于1,PFASs的总和危险指数HI也小于1,血清中的现有浓度的PFASs对造成人类肝毒性和生殖毒性的风险程度较低,肝毒性与生殖毒性HI的主要贡献者均为n-PFOS,其次为3+5m-PFOS与4m-PFOS.

关键词：全氟和多氟烷基化合物(PFASs) 异构体人类血清浓度水平分布特征风险评估

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