检索结果-南通市图书馆

Investigating the Potential Mechanism of Huazhi Rougan Granules Against Alcoholic Liver Disease by Network Pharmacology and Experiment

引用

World Journal of Traditional Chinese Medicine 2024年第2期10卷 191-203页

作者： Ying-Ying Tan Ying-Ying Liu Yi-Yan Zhai Yi-Xuan wang Zhi-shan wu Antony Stalin Guo-Liang Cheng Bing Li Chao wu Zhi-Hong Huang shan Lu Xiao-Tian Fan Zheng Zhao Jia-rui wu Department of Clinical Chinese Pharmacy School of Chinese Materia MedicaBeijing University of Chinese MedicineBeijingChina Department of Bioinformatics Institute of Fundamental and Frontier SciencesUniversity of Electronic Science and Technology of ChinaChengduChina Department of Traditional Chinese Medicine State Key Laboratory of Generic Manufacture Technology of Chinese Traditional MedicineLinyiChina Department of Clinical Medicine Beijing Zest Bridge Medical Technology Inc.BeijingChina

Objective: Huazhi Rougan granules(HRGs) are a promising drug to improve alcoholic liver disease(ALD), but its mechanism remains unclear. Materials and Methods: Network pharmacology, molecular docking, and animal experiments were used to reveal the potential mechanism of HRG against ALD. Results: A total of 245 potential targets of HRG against ALD were obtained. Functional enrichment analysis suggests that HRG could synergistically regulate various biological pathways to exert therapeutic effects on ALD. Molecular docking showed that the key targets exhibited the good binding ability with the key compounds. The in vivo experiments showed that HRG can effectively alleviate pathological changes in liver tissue, improve blood lipid levels, antioxidant stress ability, and liver function, and reduce the release of inflammatory cytokines in the liver. Conclusions: This study reflects that HRG is an effective strategy for treating ALD, providing a basis for revealing the prevention and treatment mechanisms of ALD.

关键词： Alcoholic liver disease Huazhi Rougan granules inflammatory response network pharmacology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Genes controlling grain chalkiness in rice

引用

The Crop Journal 2024年第4期12卷 979-991页

作者： Luo Chen Xiumei Li Minhua Zheng rui Hu Jingfang Dong Lingyan Zhou wuge Liu Dilin Liu wu Yang Rice Research Institute Guangdong Academy of Agricultural SciencesGuangdong Key Laboratory of New Technology in Rice BreedingGuangdong Rice Engineering LaboratoryKey Laboratory of Genetics and Breeding of High Quality Rice in Southern China(Co-construction by Ministry and Province)Ministry of Agriculture and Rural AffairsGuangzhou 510640GuangdongChina College of Agriculture and Biology Zhongkai University of Agriculture and EngineeringGuangzhou 510225GuangdongChina Guangdong Provincial Key Laboratory for Crop Germplasm Resources Preservation and Utilization Agro-biological Gene Research CenterGuangdong Academy of Agricultural SciencesGuangzhou 510640GuangdongChina

With rising living standards,there is an increasing demand for high-quality *** quality is mainly defined by milling quality,appearance quality,cooking and eating quality,and nutrition *** them,chalkiness is a key trait for appearance quality,which adversely affects cooking and eating quality,head rice yield,and commercial ***,chalkiness is undesirable,and reducing chalkiness is a major goal in rice quality ***,chalkiness is a complex trait jointly influenced by genetic and environmental factors,making its genetic study and precision improvement a huge *** the rapid development of molecular techniques,much knowledge has been gained about the genes and molecular networks involved in chalkiness *** present review describes the major environmental factors affecting chalkiness and summarizes the quantitative trait loci(QTL)associated with *** than 150 genes related to chalkiness formation have been *** functions of the genes regulating chalkiness,primarily those involved in starch synthesis,storage protein synthesis,transcription regulation,organelle development,grain shape regulation,and hightemperature response,are ***,we identify the challenges associated with genetic improvement of chalkiness and suggest potential ***,the review offers insight into the molecular dynamics of chalkiness and provides a strong basis for the future breeding of high-quality rice varieties.

关键词： Rice Grain quality Chalkiness QTL identification Gene

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

引用

World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： Huang Chen rui-Ying Jiang Zhan Hua Xiao-Wei wang Xiao-Li Shi Ye wang Qian-Qian Feng Jie Luo wu ning Yan-Fen Shi Da-Kui Zhang Bei wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly *** To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in *** We enrolled 2271 Chinese CRC patients at the China-Japan Friendship *** proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain *** status was determined using an MSI detection *** analyses were conducted using SPSS software and logistic *** The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,*** mutations were more likely to occur in patients with moderate-to-high *** mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural *** MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous ***,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,*** dMMR was more likely to occur in patients with a family history of CRC,agednical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

How territorial function determines CO_(2) emissions in China: An approach of spatial dimension

引用

Journal of Geographical Sciences 2024年第9期34卷 1677-1696页

作者： FAN Jie wang Zheng ZHOU Daojing GUO rui CHEN Dong LIU Baoyin LIU Hanchu QIAO Qin wu Jianxiong Key Laboratory of Regional Sustainable Development Modeling Institute of Geographic Sciences and Natural Resources ResearchCASBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China Institutes of Science and Development CASBeijing 100190China School of Architecture&Planning Anhui Jianzhu UniversityHefei 230022China State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

Regional CO_(2) emissions are closely related to their territorial function, which is the major role a region plays in sustainable processes on the earth's surface. Given that China is implementing a top-down emission allocation quota strategy, studying the impact of a territorial function on emissions addresses the research gap from a spatial integration *** investigating the effects of three basic functional territories(urbanization zones(UZ), food security zones(FSZ), and ecological security zones(ESZ)), horizontal spatial structure and vertical combinations of functional territories on CO_(2) emission patterns in China, we found that functional territory patterns were highly coupled with the spatial distribution of CO_(2) emissions, with a ratio of CO_(2) emissions from UZ–FSZ–ESZ was stable at around 5:2:1 from 2000 to 2017. Spatially, CO_(2) emissions in FSZ and ESZ were 1.06–2.12 times higher than the average value within 200 km from the UZ. As territorial function combination increased with spatial upscaling, the emission characteristics attributable to functional territories became indistinct. The findings above can provide a basis for the long-term prediction of CO_(2) emissions from spatial dimension, support scientific guidance for inter-zone cooperation and classified management of carbon emissions with the major function oriented zones as impetus.

关键词： CO_(2)emission pattern functional territory spatial structure function combination spatial dimension-based analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unique anti-angiogenic effects,pharmacological targets and therapeutic mechanisms of Chinese herbal medicines for endometriosis

引用

Genes & Diseases 2024年第5期11卷 63-65页

作者： Bo Liang rui Dong Sze Wan Hung Yiran Li Yuezhen Lin Ling wu Tao Zhang Gene Chi Wai Man Hui Xu Jacqueline Pui Wah Chung Chi Chiu wang Guangdong Provincial Key Laboratory of Marine Biotechnology Institute of Marine SciencesShantou UniversityShantouGuangdong 515063China Department of Obstetrics and Gynaecology The Chinese University of Hong KongHong Kong SARChina Reproduction and Development Laboratory Li Ka Shing Institute of Health SciencesThe Chinese University of Hong KongHong Kong SARChina School of Biomedical Sciences The Chinese University of Hong KongHong Kong SARChina Chinese University of Hong Kong-Sichuan University Joint Laboratory in Reproductive Medicine The Chinese University of Hong KongHong Kong SARChina

Endometriosis is a common and benign angiogenesisdependent gynecological disorder,which refers to the proliferation and growth of endometrium-like tissues with neovasculature formation outside of the uterus.1 Available medical treatments for endometriosis containing hormonal and non-hormonal treatments had been limited for longterm usage by their side effects.2 Ideal medical treatment for endometriosis with efficacy to relieve symptoms and suppress endometriotic lesion growth and minimal side effects has been longing for decades.3 Angiogenesis is a promising therapeutic target for endometriosis.

关键词： therapeutic endometriosis herbal

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Experimental study on photodegradation and leaching of typical pesticides in greenhouse soil from Shouguang, shandong Province, East China

引用

Ecological Processes 2024年第2期 32-47页

作者： Li-Ting Hua rui-Lin wu Cun-Lu Li Chao-Nan wang Yi-Long Li Fu-Liu Xu MOE Laboratory for Earth Surface Processes College of Urban and Envi-ronmental Sciences Peking University Department of Ecology and Environment of shanxi Province

Background Pesticide use contributes to national food security. The dissipation pathways and degradation mecha-nisms of pesticides have been widely studied and pesticide residues have remained a focus of public concern. How-ever, studies on the migration and transformation behaviors of pesticide residues in real-world greenhouse soils are insufficient. Therefore, in this study, we collected greenhouse soil from Shouguang, shandong Province, and investi-gated the photodegradation and leaching of 17 common pesticides, which leave residues in the soil and are the most frequently used pesticides in Shouguang. The environmental behavior of pesticides in greenhouse soils will provide new information on pesticide residues in the real environment and provide a scientific basis for the prevention and control of pesticide pollution in greenhouse *** The photodegradation of trifloxystrobin followed a first-order kinetic equation, whereas those of emamec-tin benzoate, chlorantraniliprole, buprofezin, difenoconazole, pyraclostrobin, boscalid, tebuconazole, isoprothiolane, metalaxyl, and oxadixyl followed second-order kinetics. The half-lives of 17 pesticides under light and dark conditions ranged from 2.5–104(mean: 36.2) and 2.6–110(mean: 31.4) days, respectively. The half-lives of emamectin benzoate, pyraclostrobin, and metalaxyl in the light were 86.6%, 68.5%, and 94.5% of their half-lives in the dark, respectively. Chlorantraniliprole, metalaxyl, nitenpyram, diethofencarb, acetamiprid, carbendazim, and oxadixyl were leached to ≥ 90% in aqueous solution. Six pesticides, avermectin B1A, emamectin benzoate, trifloxystrobin, difenoconazole, pyraclostrobin, and buprofezin, were difficult to leach from aqueous *** The degradation rate of some pesticides was higher in the light environment than in the dark. The leaching potential of the leachable pesticides was nitenpyram ? metalaxyl > acetamiprid > carbendazim > diethofen-carb ≈ chlorantraniliprole > iso

关键词：

来源：

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

2008~2022年我国湖泊有机质相关指标时空演变

引用

中国环境科学 2024年第3期44卷 1426-1435页

作者：付蕊刘沙沙索诚宇任艺吴丰昌北京科技大学能源与环境工程学院北京100083 中国环境科学研究院北京100012

基于2008~2022年中国湖泊长时间序列水质数据,采用Mann—Kendall检验(M-K检验),Pearson相关分析以及主成分分析(PCA)等对有机质及相关营养指标在长时间序列上的变化规律,空间异质性特征及指标之间的相关关系进行研究.结果表明:2008~2022... 详细信息

基于2008~2022年中国湖泊长时间序列水质数据,采用Mann—Kendall检验(M-K检验),Pearson相关分析以及主成分分析(PCA)等对有机质及相关营养指标在长时间序列上的变化规律,空间异质性特征及指标之间的相关关系进行研究.结果表明:2008~2022年,全国湖泊溶解氧(DO)浓度以每年0.19mg/L的速度增加(P0.50, P<0.05);BOD5与TP呈现显著正相关性(r=0.61, P<0.05);COD与TP(r=0.80,P<0.05)以及Chla(r=0.61,P<0.05)显著正相关,表明TP浓度和叶绿素浓度可能是影响我国湖泊有机质变化的关键因素.在空间尺度上,COD,COD-Mn与BOD5等有机质相关指标为影响全国湖泊水质空间异质性特征的主要因素,且有机质浓度较高的湖泊地理分布较为明显,主要集中于蒙新湖区和云贵高原湖区.

关键词：湖泊有机质营养水平时空变化相关分析主成分分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Temperature inversion enables superior stability for low-temperature Zn-ion batteries

引用

Journal of Energy Chemistry 2024年第4期91卷 245-253页

作者： Fu-Da Yu Zhe-Jian Yi rui-Yang Li Wei-Hao Lin Jie Chen Xiao-Yue Chen Yi-Ming Xie Ji-Huai wu Zhang Lan Lan-Fang Que Bao-Sheng Liu Hao Luo Zhen-Bo wang Engineering Research Center of Environment-Friendly Functional Materials Ministry of EducationInstitute of Materials Physical ChemistryHuaqiao UniversityXiamen 361021FujianChina b2 School of Electronic Engineering Guangxi University of Science and TechnologyLiuzhou 545006GuangxiChina School of Materials Science and Engineering Xiamen University of TechnologyXiamen 361024FujianChina School of Materials Science and Engineering Zhengzhou UniversityZhengzhou 450001HenanChina MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage State Key Laboratory of Space Power-SourcesSchool of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001HeilongjiangChina College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071GuangdongChina

It is challenging for aqueous Zn-ion batteries(ZIBs)to achieve comparable low-temperature(low-T)performance due to the easy-frozen electrolyte and severe Zn ***,an aqueous electrolyte with a low freezing point and high ionic conductivity is *** with molecular dynamics simulation and multi-scale interface analysis(time of flight secondary ion mass spectrometry threedimensional mapping and in-situ electrochemical impedance spectroscopy method),the temperature independence of the V_(2)O_(5)cathode and Zn anode is observed to be ***,dominated by the solvent structure of the designed electrolyte at low temperatures,vanadium dissolution/shuttle is significantly inhibited,and the zinc dendrites caused by this electrochemical crosstalk are greatly relieved,thus showing an abnormal temperature inversion *** the disclosure and improvement of the above phenomena,the designed Zn||V_(2)O_(5)full cell delivers superior low-T performance,maintaining almost 99%capacity retention after 9500 cycles(working more than 2500 h)at-20°*** work proposes a kind of electrolyte suitable for low-T ZIBs and reveals the inverse temperature dependence of the Zn anode,which might offer a novel perspective for the investigation of low-T aqueous battery systems.

关键词： Aqueous Zn-ion batteries Low-temperature performance Opposite temperature dependence Zndendrite growth Vanadium dissolution

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

An enhanced semi-supervised learning method with self-supervised and adaptive threshold for fault detection and classification in urban power grids

Energy and AI

引用

Energy and AI 2024年第3期17卷 65-79页

作者： Jiahao Zhang Lan Cheng Zhile Yang Qinge Xiao Sohail Khan rui Liang Xinyu wu Yuanjun Guo Taiyuan University of Technology TaiyuanShanxiChina Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhenGuangdongChina Guangdong Institute of Carbon Neutrality(shaoguan) ShaoguanGuangdongChina Sino-Pak Center for Artificial Intelligence Pak-Austria Fachhochschule–Institute of Applied Sciences and TechnologyHaripurKhyber PakhtunkhwaPakistan Chengxi Company State Grid Tianjin Electric Power CompanyTianjinChina

With the rapid development of urban power grids and the large-scale integration of renewable energy, traditional power grid fault diagnosis techniques struggle to address the complexities of diagnosing faults in intricate power grid systems. Although artificial intelligence technologies offer new solutions for power grid fault diagnosis, the difficulty in acquiring labeled grid data limits the development of AI technologies in this area. In response to these challenges, this study proposes a semi-supervised learning framework with self-supervised and adaptive threshold (SAT-SSL) for fault detection and classification in power grids. Compared to other methods, our method reduces the dependence on labeling data while maintaining high recognition accuracy. First, we utilize frequency domain analysis on power grid data to filter abnormal events, then classify and label these events based on visual features, to creating a power grid dataset. Subsequently, we employ the Yule–Walker algorithm extract features from the power grid data. Then we construct a semi-supervised learning framework, incorporating self-supervised loss and dynamic threshold to enhance information extraction capabilities and adaptability across different scenarios of the model. Finally, the power grid dataset along with two benchmark datasets are used to validate the model’s functionality. The results indicate that our model achieves a low error rate across various scenarios and different amounts of labels. In power grid dataset, When retaining just 5% of the labels, the error rate is only 6.15%, which proves that this method can achieve accurate grid fault detection and classification with a limited amount of labeled data.

关键词： Power grid fault detection Semi-supervised learning Data driven Deep learning Smart grid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microvascular alterations of the ocular surface and retina in connective tissue disease-related interstitial lung disease

引用

International Journal of Ophthalmology(English edition) 2024年第10期17卷 1869-1879页

作者： Li-Ming Chen Min Kang Jun-Yi wang San-Hua Xu Cheng Chen Hong Wei Qian Ling Liang-Qi He Jie Zou Yi-Xin wang Xu Chen Ping Ying Hui Huang Yi shao rui wu Department of Rheumatology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First School of Clinical Medicine of Nanchang University Jiangxi Medical College of Nanchang UniversityNanchang 330000Jiangxi ProvinceChina School of Optometry and Vision Science Cardiff UniversityCardiffCF244HQWalesUK Ophthalmology Centre of Maastricht University Maastricht 6200MSLimburg ProvincieNetherlands Department of Ophthalmology Eye&ENT Hospital of Fudan UniversityShanghai 200030China

AIM:To examine the disparities in macular retinal vascular density between individuals with connective tissue disease-related interstitial lung disease(CTD-ILD)and healthy controls(HCs)by optical coherence tomography angiography(OCTA)and to investigate the changes in microvascular density in abnormal ***:For a retrospective case-control study,a total of 16 patients(32 eyes)diagnosed with CTD-ILD were selected as the ILD *** 16 healthy volunteers with 32 eyes,matched in terms of age and sex with the patients,were recruited as control *** macular retina’s superficial retinal layer(SRL)and deep retinal layer(DRL)were examined and scanned using OCTA in each individual *** densities of retinal microvascular(MIR),macrovascular(MAR),and total microvascular(TMI)were calculated and *** in retinal vascular density in the macular region were analyzed using three different segmentation methods:central annuli segmentation method(C1-C6),hemispheric segmentation method[uperior right(SR),superior left(SL),inferior left(IL),and inferior right(IR)],and Early Treatment Diabetic Retinopathy Study(ETDRS)methods[superior(S),inferior(I),left(L),and right(R)].The data were analyzed using Version 9.0 of GraphPad prism and Pearson ***:The OCTA data demonstrated a statistically significant difference(Pnificantly lower surface density of MIR and TMI compared to the HCs group(P<0.05).Furthermore,using the hemispheric segmentation method,the ILD group showed notable reductions in SL,SR,and IL in the superficial retina(P<0.05),as well as marked decreases in SL and IR in the deep retina(P<0.05).Similarly,when employing the ETDRS method,the ILD group displayed substantial drops in superficial retinal S and I(P<0.05),along with notable reductions in deep retinal L,I,and R(P<0.05).In the central annuli segmentation m

关键词： connective tissue disease‑related interstitial lung disease optical coherence tomography angiography microvessel density ocular surface retina

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：