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Cardiometabolic and panvascular multimorbidity associated with motoric cognitive risk syndrome in older adults

Journal of Geriatric Cardiology 2024年第10期21卷 944-953页

作者： rui she Zhong-rui YAN Peng WANG Ya-Jun LIANG Cheng-Xuan QIU Department of Rehabilitation Sciences the Hong Kong Polytechnic UniversityHong KongChina Department of Ne-urology Jining No.1 People’s HospitalJiningChina Department of Global Public Health Karolinska InstitutetStock-holmSweden Aging Research Center and Center for Alzheimer Research Department of NeurobiologyCare Sciences and SocietyKarolinska Institutet-Stockholm UniversityStockholmSweden Department of Neurology Shandong Pr-ovincial Hospital Affiliated to Shandong First Medical UniversityJinanChina

Background Motoric cognitive risk(MCR)syndrome as a pre-dementia syndrome often co-occurring with chronic health *** study aims to investigate the prevalence of MCR and its association with cardiometabolic and panvascular multimorb-idity among older people living in rural *** This population-based study included 1450 participants who were aged≥60 years(66.2%women)and who underto-ok the second wave examination of the Confucius Hometown Aging Project in Shandong,China when information to define MCR was *** were collected through in-person interviews,clinical examinations,and laboratory *** and pa-nvascular multimorbidity were defined following the international *** was defined as subjective cognitive complaints and slow gait speed in individuals free of dementia and functional *** logistic regression models were used to exa-mine the associations of MCR with *** MCR was present in 6.3%of all participants,and the prevalence increased with advancing *** disea-se,ischemic heart disease,heart failure,and increased serum cystatin C were associated with increased likelihoods of MCR(mult-ivariable-adjusted odds ratio range:1.90-3.02,P<0.05 for all).Furthermore,there was a dose-response relationship between the nu-mber of cardiometabolic diseases and panvascular diseases and the likelihood of *** multivariable-adjusted odds ratio(95%CI)of MCR associated with cardiometabolic and panvascular multimorbidity were 2.47(1.43-4.26)and 3.85(2.29-6.47),*** Older adults with cardiometabolic and panvascular multimorbidity are at a higher likelihood of *** fin-dings may have implications for identifying older adults at pre-dementia state as targets for early preventive interventions to delay dementia onset.

关键词： morbidity likelihood older

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Domestic trends in malaria research and development in China and its global influence

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Infectious Diseases of Poverty 2017年第1期6卷 25-33页

作者： Yang-Mu Huang Lu-Wen Shi rui she Jing Bai Shi-Yong Jiao Yan Guo School of Public Health Peking University Health Science CenterXueyuan Road 38Haidian DistrictBeijing 100191China School of Pharmaceutical Science Peking University Health Science CenterXueyuan Road 38Haidian DistrictBeijing 100191China Department of Health Policy and Management School of Public HealthPeking University Health Science CenterXueyuan Road 38Haidian DistrictBeijing 100191China Patent Examination Cooperation Center of the Patent Office SIPOBeijingChina

Background:Though many countries,including China,are moving towards malaria elimination,malaria remains a major global health *** to the spread of antimalarial drug resistance and the need for innovative medical products during the elimination phase,further research and development(R&D)of innovative tools in both epidemic and elimination areas is *** study aims to identify the trends and gaps in malaria R&D in China,and aims to offer suggestions on how China can be more effectively involved in global malaria R&***:Quantitative analysis was carried out by collecting data on Chinese malaria-related research programmes between 1985 and 2014,invention patents in China from 1985 to 2014,and articles published by Chinese researchers in PubMed and Chinese databases from 2005 to *** data were screened and extracted for numerical analysis and were categorized into basic sciences,drug/drug resistance,immunology/vaccines,or diagnostics/detection for chronological and subgroup ***:The number of malaria R&D activities have shown a trend of increase during the past 30 years,however these activities have fluctuated within the past few *** the past 10 years,R&D on drug/drug resistance accounted for the highest percentages of research programmes(32.4%),articles(55.0%in PubMed and 50.6%in Chinese databases)and patents(45.5%).However,these R&D activities were mainly related to artemisinin.R&D on immunology/vaccines has been a continuous interest for China’s public entities,but the focus remains on basic science.R&D in the area of high-efficiency diagnostics has been rarely seen or reported in ***:China has long been devoted to malaria R&D in multiple areas,including drugs,drug resistance,immunology and vaccines.R&D on diagnostics has received significantly less attention,however,it should also be an area where China can make a *** focus on malaria R&D is needed,especially in the area of diagnostics,if China

关键词： Research and development R&D Malaria Antimalarial China

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Hepatitis associated with hepatitis B virus in broilers

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Journal of Integrative Agriculture 2016年第1期15卷 191-199页

作者： ZHAO Yue MAO Jing-jing she rui-ping HU Feng-jiao Majid H Soomro LIANG rui-ping YANG Yi-fei DU Fang WANG Tong-tong GUO Zhao-jie CHENG Min-heng Laboratory of Animal Pathology and Public Health/Key Laboratory of Zoonosis Ministry of Agriculture/College of Veterinary Medicine China Agricultural University Beijing 100193 P.R. China National Shanghai Center for New Drug Safety Evaluation Research Center Shanghai 201203 P.R. China

Infection by hepatitis B virus （HBV） results in acute and chronic liver damages in humans. Liver products of broilers as a primary food consumed in our daily life have a close connection with public health. The prevalence of the virus in livers and serum of broilers is of great significance, owning to the potential transmission between chickens and humans. Liver tissues and serum samples were tested to investigate the prevalence of hepatitis B virus infection in slaughtered broilers, for expression of HBV antigens and antibodies. The distribution and positive rate of hepatitis B surface antigen （HBsAg）, hepatitis B core antigen （HBcAg） and hepatitis B e antigen （HBeAg） in liver samples were examined using immunohistochemistry. HBsAg was mainly located in the cytoplasm of hepatocytes with a positivity of 81.61% whereas HBeAg and HBcAg were primarily located in the nucleus of hepatocytes with a positivity of 40.13 and 49.10%, respectively. Enzyme-linked immunosorbent assay （ELISA） analysis of serum for HBV serological markers demonstrated a high prevalence of hepatiits B surface antibody （HBsAb, 54.91%） and hepatitis B core antibody （HBcAb, 27.68%）, whereas HBeAb, HBsAg and HBeAg were rarely detectable. Classic hepatitis pathological changes, including swollen hepatocytes, focal parenchymal necrosis, lymphocytic infiltration and hyperplasia of fibrous connective tissues were observed using histopathological analysis. Some of the liver samples were found positive for HBV DNA using nested PCR. Sequence comparison confirmed that all sequences shared 97.5-99.3% identity with human HBV strains. These results demonstrated the existence of HBV in livers and serums of broilers. Animals or animal products contaminated with HBV could raise an important public health concern over food safety and zoonotic risk.

关键词： broilers hepatitis B virus detection prevalence investigation

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Induction of Apoptosis in the Immature Mouse Testes by a Mixture of Melamine and Cyanuric Acid

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Journal of Integrative Agriculture 2012年第12期11卷 2058-2066页

作者： YOU Hua ZHU Jin-feng she rui-ping CHANG Ling-ling SHI rui-han DING Ye CHI Li-juan LIU Bin YUE Zhuo TIAN Ji-jing MAO Jing-jing SU Li-fang Key Laboratory of Zoonosis Ministry of Agriculture/Department of Veterinary Pathology College of Veterinary Medicine China Agricultural University China Animal Disease Control Center National Animal Husbandry Service

The toxicity of melamine has attracted much attention since the recent outbreaks of renal injury in pets and infants. Previous studies indicated that melamine by itself had low toxicity, whereas a mixture of melamine and cyanuric acid （M＋CA） could cause serious renal damage. At present, most researches on the toxicity of M＋CA are focused on the kidney. However, little is known about the adverse effects of this mixture on the reproductive system. In the present study, the toxicity of M＋CA to testes was investigated. Immature male mice were orally dosed with 0, 0.6, 3, and 15 mg kg-1 d-1 of a 1：1 M＋CA for 28 d. Pathological changes occurred in germ cells, such as loose arrangement, reduced numbers and karyopyknosis, indicating that this mixture was toxic to spermatogenesis. Compared with the control group, the TUNEL- positive germ cells increased significantly and the ratio of Bcl-2 to Bax, total antioxidant capacity and superoxide dismutase activity decreased significantly in the 3 and 15 mg kg-1 d- M＋CA treated group, while the activities of caspase-3, caspase- 8 and caspase-9 remained unchanged. The results suggest that M＋CA can induce apoptosis in the mice testes. The downregulation of Bcl-2/Bax and oxidative stress may play a pivotal role in the induction of apoptosis by M＋CA in mice testes.

关键词： melamine/cyanuric acid mixture testes injury caspase-independent apoptosis

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Detection and characterization of Hepatitis E virus from commercial rabbit livers in Hebei, China

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Journal of Integrative Agriculture 2021年第12期20卷 3270-3276页

作者： XIAO Peng TIAN Ji-jing MAO Jing-jing GUO Zhao-jie ZHAO Yue LIU Tian-long CHEN Jian WANG Tong-tong MA Long-huan she rui-ping Laboratory of Animal Pathology and Public Health/Key Laboratory of Zoonosis of Ministry of Agriculture and Rural Affairs College of Veterinary MedicineChina Agricultural UniversityBeijing 100193P.R.China Shanghai InnoStar Bio-Tech Co. Shanghai 201203P.R.China Institute of Laboratory Animal Science Jinan UniversityGuangzhou 510632P.R.China

Rabbit hepatitis E virus(HEV)has been reported for years and is thought to have the potential for zoonotic transmission from rabbits to *** reported,HEV genotype 3(gt3)is the most prevalent form of HEV in *** determine the prevalence of HEV in commercial rabbit livers,176 liver samples were collected from an abattoir in Hebei Province,***(1.7%)samples tested positive for RNA of HEV-0RF2(open reading frames-2).Sequence analysis showed that the three isolates shared high identities with each other(94.08-98.85%).Further analysis showed that all the rabbit strains clustered together in the branch of HEV *** study by immunohistochemistry(IHC)assays showed that 131(74.4%)liver samples were positive for HEV ORF2 *** changes including cell degeneration,inflammatory cell infiltration and bile duct epithelial cell hyperplasia were observed under *** findings indicated the presence of HEV in commercial livers of *** studies should be conducted to investigate the infectivity of rabbit HEV(rHEV)and the potential risks of zoonotic transmission of rHEV from rabbits to human beings.

关键词： hepatitis E virus IHC RT-nPCR commercial rabbits livers

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强脊四穴深刺治疗腰椎间盘突出症疗效观察

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中国针灸 2008年第5期28卷 341-344页

作者：佘瑞平如皋市中医院针灸科江苏226500

目的:比较强脊四穴深刺与常规针刺治疗腰椎间盘突出症的疗效差异。方法:将279例腰椎间盘突出症患者随机分为2组,深刺组140例,常规组139例。深刺组采用深刺强脊四穴治疗;常规组选取气海俞、大肠俞、关元俞、小肠俞,针刺常规深度。观察2... 详细信息

目的:比较强脊四穴深刺与常规针刺治疗腰椎间盘突出症的疗效差异。方法:将279例腰椎间盘突出症患者随机分为2组,深刺组140例,常规组139例。深刺组采用深刺强脊四穴治疗;常规组选取气海俞、大肠俞、关元俞、小肠俞,针刺常规深度。观察2组疗效并进行比较。结果:第1疗程末,深刺组痊愈率为42.1%,常规组痊愈率为28.1%,2组差异有显著性意义(P<0.05);第2疗程末,深刺组痊愈率为82.9%,常规组痊愈率为46.8%,2组差异有非常显著性意义(P<0.005)。结论:强脊四穴深刺治疗腰椎间盘突出症疗效明显优于常规针刺疗法。

关键词：椎间盘移位/针灸疗法腰椎针刺深度强脊四穴

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基于SWIPT的双向中继CR-NOMA系统研究

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华中科技大学学报（自然科学版） 2019年第10期47卷 111-115,132页

作者：鲍慧佘蕊赵伟华北电力大学电气与电子工程学院

针对现有研究中CR-NOMA(认知无线电非正交多址接入)系统均配置单向中继,频谱利用率和能源利用率低的缺点,提出在CR-NOMA系统中通过双向中继辅助用户传输,并且中继采用无线信息和能量同时传输的方式.推导出在用户服务质量和最小能量捕获... 详细信息

针对现有研究中CR-NOMA(认知无线电非正交多址接入)系统均配置单向中继,频谱利用率和能源利用率低的缺点,提出在CR-NOMA系统中通过双向中继辅助用户传输,并且中继采用无线信息和能量同时传输的方式.推导出在用户服务质量和最小能量捕获等约束条件下的次用户传输能效,将目标函数转化为单目标问题分别求解;利用交替迭代算法,对中继发射功率和功率分配因子等单目标最优解进行联合优化,以最大化次用户系统传输能效.仿真结果表明:与传统单向中继系统相比,所提方案在提高频谱利用率的同时,次用户传输能效也提高了45%.

关键词：认知无线电非正交多址接入双向中继能源效率功率分配无线信息和能量同时传输

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电针颈枕八穴治疗脑干梗死后延髓麻痹临床观察

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中国针灸 2014年第6期34卷 539-542页

作者：佘瑞平葛春晖如皋市中医院针灸科江苏如皋226500

目的：比较电针颈枕八穴与常规取穴治疗脑干梗死后延髓麻痹之语言、吞咽功能障碍的疗效差异。方法：将72例患者随机分为颈枕组和经穴组，每组36例。颈枕组取颈枕八穴（颈1～4穴、枕1～4穴），经穴组取廉泉、扶突、通里、合谷等穴，两组... 详细信息

目的：比较电针颈枕八穴与常规取穴治疗脑干梗死后延髓麻痹之语言、吞咽功能障碍的疗效差异。方法：将72例患者随机分为颈枕组和经穴组，每组36例。颈枕组取颈枕八穴（颈1～4穴、枕1～4穴），经穴组取廉泉、扶突、通里、合谷等穴，两组均行电针疗法，断续波，留针30min，每日1次，每周5次，共治疗4周。观察治疗前后两组患者语言、吞咽功能症状评分变化，并比较两组疗效。结果：治疗后两组语言和吞咽功能评分均显著改善（P〈0．05，P〈0．01），且颈枕组优于经穴组（均P〈0．01）；颈枕组语言功能障碍临床痊愈率、吞咽功能障碍临床痊愈率分别为30．6％（11／36）、22．2％（8／36），优于经穴组的11．1％（4／36）、5．6％（2／36），组间差异有统计学意义（P〈0．01，P〈0．05）。结论：电针颈枕八穴治疗脑干梗死后延髓麻痹之语言、吞咽功能障碍疗效优于电针常规取穴，且定位更准确、操作更安全。

关键词：脑干梗死延髓麻痹颈枕八穴电针

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基于Citespace的新乡贤文化知识生产探讨

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湘潭大学学报（哲学社会科学版） 2024年第3期48卷 187-192,F0003页

作者：刘社瑞赵钰欣湖南大学新闻与传播学院湖南长沙410000

学界发表了大量的新乡贤文化研究论文,知识生产成果丰硕。运用Citespace软件对该领域知识生产进行探讨,在其生成的系统视觉图谱中,可以发现新乡贤文化知识生产的主要贡献表现为:拓宽新乡贤文化整体知识版图,形成新乡贤文化多种知识关联... 详细信息

学界发表了大量的新乡贤文化研究论文,知识生产成果丰硕。运用Citespace软件对该领域知识生产进行探讨,在其生成的系统视觉图谱中,可以发现新乡贤文化知识生产的主要贡献表现为:拓宽新乡贤文化整体知识版图,形成新乡贤文化多种知识关联,产生新乡贤文化知识赋能效应。新乡贤文化知识生产的未来在于立足新乡贤文化的系统性与规范性,注重传播视角下的新乡贤文化知识生产,深嵌新乡贤文化的实践场域。

关键词： Citespace 新乡贤文化知识生产乡村振兴

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CR-NOMA双向中继自干扰能量回收传输方法

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华中科技大学学报（自然科学版） 2019年第12期47卷 121-126页

作者：鲍慧佘蕊石梦倩骆亚菲华北电力大学电气与电子工程学院

针对单向中继自干扰能量收集的认知无线电系统中,窃听用户的接入概率增加,从而影响次用户物理层安全性能的问题,在认知无线电非正交多址接入系统中通过双向中继辅助次用户传输,同时在中继能量捕获受限等约束条件下,最大化弱用户物理层... 详细信息

针对单向中继自干扰能量收集的认知无线电系统中,窃听用户的接入概率增加,从而影响次用户物理层安全性能的问题,在认知无线电非正交多址接入系统中通过双向中继辅助次用户传输,同时在中继能量捕获受限等约束条件下,最大化弱用户物理层安全速率.由于优化问题为复杂的非凸问题,因此根据半定松弛理论将其转化为凸问题,并通过迭代算法对信号协方差矩阵、中继发送和接收的功率分配因子进行联合优化,进而得到弱用户物理层安全速率的全局最优解.仿真结果表明:与单向中继自干扰能量收集相比,在保证中继节点收集能量和强用户安全传输条件下,弱用户物理层安全速率提高了15.4%.

关键词：自干扰双向中继安全速率认知无线电非正交多址功率分配

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