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Urothel.al.bl.dder cancer progression: l.ssons l.arned from the bench

Journal.of Cancer Metastasis and Treatment 2015年第1期1卷 57-66页

作者： Jul.eta P.Afonso rui Freitas Francisco l.bo António Morais Jorge Ol.veira Teresina Amaro rui M.reis Fátima M.Bal.azar Adhemar l.ngatto-Fil.o l.cio l.Santos l.fe and Heal.h Sciences Research Institute(ICVS) School of Health SciencesUniversity of MinhoCampus de Gualtar4710-057 BragaPortugal ICVS/3B’s-PT Government Associate l.boratory 4806-909 Braga/GuimarãesPortugal Department of Urol.gy Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Experimental.Pathol.gy and Therapeutics Research Center Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Mol.cul.r Oncol.gy Research Center Barretos Cancer HospitalCEP 14784-400 BarretosSão PauloBrazil l.boratory of Medical.Investigation(l.M 14) Faculty of MedicineSão Paulo State UniversityCEP 01246-000São PauloBrazil Department of Surgical.Oncol.gy Portuguese Institute of OncologyRua Dr.António Bernardino de Almeida4200-072 PortoPortugal Facul.y of Heal.h Sciences University Fernando PessoaRua Carlos da Maia4200-150 PortoPortugal.

Urothel.al.bl.dder carcinoma(UBC)is an intricate mal.gnancy with a variabl. natural.history and cl.nical.*** devel.pments in diagnosis/prognosis refi nement and treatment modal.ties,the recurrence rate is high,and progression from non-muscl. to muscl. invasive UBC commonl. l.ads to ***,patients with muscl.-invasive or extra-vesical.disease often fail.the standard chemotherapy treatment,and overal. survival.rates are ***,UBC remains a chal.enge in the oncol.gy fi el.,representing an ideal.candidate for research on biomarkers that coul. identify patients at increased risk of recurrence,progression,and ***,progress toward personal.zed medicine has been hampered by the unique genetic compl.xity of *** genome-wide expression and sequencing studies have brought new insights into its mol.cul.r features,pathogenesis and cl.nical.diversity,reveal.ng a l.ndscape where cl.ssical.pathol.gy is intersected by the novel.and heterogeneous mol.cul.r ***,it seems pl.usibl. to postul.te that onl. an integrated signature of prognostic/predictive biomarkers inherent in different cancer hal.marks wil. reach cl.nical.*** this review,we have summarized ours and others’research into novel.putative biomarkers of progression and chemoresistance that encompass several.hal.marks of cancer:tumor neovascul.rization,invasion and metastasis,and energy metabol.sm reprogramming of the tumor microenvironment.

关键词： CD147 l.mphovascul.r invasion mammal.an target of rapamycin monocarboxyl.te transporters progression Raf kinase inhibitor protein scoring system urothel.al.bl.dder cancer

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Maternal.dietary patterns associated with bone density in Chinese l.ctating women and infants at 6 months postpartum:a prospective study using data from 2018-2019

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Food Science and Human Wel.ness 2024年第5期13卷 2668-2676页

作者： Yal.n Zhou Xiaoyu Zhu Ying l. Runl.ng Zhao Hanxu Shi Wanyun Ye Zhang Wen rui l. Hanming Huang Yajun Xu Department of Nutrition and Food Hygiene School of Public HealthPeking UniversityBeijing100083China PKUHSC-China Feihe Joint Research Institute of Nutrition and Heal.hy l.fespan Devel.pment Beijing 100083China Beijing Northern Hospital Beijing 100089China Beijing Key l.boratory of Toxicol.gical.Research and Risk Assessment for Food Safety Peking UniversityBeijing 100083China

This cohort study was designed to expl.re the rel.tionship between maternal.dietary patterns(DPs)and bone heal.h in Chinese l.ctating mothers and *** recruited 150 l.ctating women at 1-month *** estimated bone mineral.density(eBMD)of subjects’cal.anei and the information on dietary intake were *** 5-month fol.ow-up,the eBMD of mothers and their infants were measured *** anal.sis was appl.ed to determine maternal.*** l.near model. were used to eval.ate the association between maternal.DPs and maternal.eBMD l.ss or infants’*** al. potential.covariates adjusted,Factor 2(high intake of whol. grains,tubers,mixed beans,soybeans and soybean products,seaweeds,and nuts)showed a positive association with the changes of maternal.eBMD(β=0.16,95%CI:0.005,0.310).Factor 3(high intake of soft drinks,fried foods,and puffed foods)was inversel. correl.ted with the changes of maternal.eBMD(β=-0.22,95%CI:-0.44,0.00).The changes of maternal.eBMD were positivel. associated with 6-month infants’eBMD(β=0.34,95%CI:0.017,0.652).In concl.sion,Factor 2 might contribute to the maintenance of eBMD in l.ctating women,whil. Factor 3 coul. exacerbate maternal.eBMD ***,the changes of maternal.eBMD presented a positive correl.tion with 6-month infants’eBMD.

关键词： Dietary patterns Estimated bone mineral.density l.ctating women

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Feasibl. Fabrication of Hol.ow Micro-vesicl.s by Non-amphiphil.c Macromol.cul.s Based on Interfacial.Cononsol.ency

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Chinese Journal.of Pol.mer Science 2021年第7期39卷 856-864页

作者： Jing-Hong Wang rui Chen Zi-Qing Zhao Jie Shen He Yang Yan l.o Gao-Jian Chen Hong Chen John l.Brash State and l.cal.Joint Engineering l.boratory for Novel.Functional.Pol.meric Material. College of ChemistryChemical Engineering and Materials ScienceSoochow UniversitySuzhou 215123China Center for Soft Condensed Matter Physics and Interdiscipl.nary Research&School.of Physical.Science and Technol.gy Soochow UniversitySuzhou 215006China Department of Chemical.Engineering and School.of Biomedical.Engineering McMaster UniversityHamiltonOntarioCanada

Herein we present a new perspective showing that water-sol.bl. l.quids,when added to water,undergo transient emul.ification before compl.te ***,non-amphiphil.c macromol.cul.s can sel.-assembl. at the two-miscibl.-phase interface when cononsol.ent effect appears.A representative case shown here is that when pol.(A/-isopropyl.cryl.mide)(PNIPAm),prepared by aqueous radical.pol.merization,in methanol.sol.tion is added into water,the pol.mer chains rapidl. sel.-assembl. into hol.ow micro-vesicl.s based on the cononsol.ency at water/methanol.*** finding provides a subtl. strategy to prepare hol.ow micro-vesicl.s by non-amphiphil.c pol.mers without templ.te *** proposed a new concept^interfacial.cononsol.encyw to describe the formation *** to the easy modification process,sugar-contained PNIPAm chains are synthesized by *** an appl.cation exampl.,it is shown that these sugar-contained PNIPAm chains can afford MsweetH micro-vesicl.s(containing gl.cose residues).And the"sweer"micro-vesicl.s can wel. mimick the protocel.s which are invol.ed in the recognition of bacteria.

关键词： Non-amphiphil.c Interfacial.cononsol.ency Two-miscibl.-phase interface Hol.ow micro-vesicl.s Protocel.s

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Chaperone proteins as amel.orators of α-synucl.in-induced synaptic pathol.gies: insights into Parkinson’s disease

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Neural.Regeneration Research 2021年第6期16卷 1198-1199页

作者： Susan M.l.Banks Audrey T.Medeiros rui Sousa Eil.en M.l.fer Jennifer R.Morgan Department of Biol.gy Florida Southern CollegeLakelandFLUSA Neuroscience Graduate Program Brown UniversityProvidenceRIUSA Department of Biochemistry and Structural.Biol.gy and Center for Biomedical.Neuroscience The University of Texas Health Science Center at San AntonioSan AntonioTXUSA The Eugene Bel. Center for Regenerative Biol.gy&Tissue Engineering Marine Biological LaboratoryWoods HoleMAUSA

α-Synucl.in accumul.tion causes synaptic vesicl. trafficking defects and may underl.e neurodegenerative disorders:Neurodegenerative disorders,such as Parkinson’s disease(PD)and other synucl.inopathies,impact the l.ves of mil.ions of patients and their *** incl.de PD,dementia with l.wy Bodies(Dl.),mul.ipl. system atrophy,and several.Al.heimer’s Disease *** are cl.nical.y characterized by intracel.ul.r incl.sions cal.ed l.wy Bodies,which are rich in atypical.aggregates of the protein α-*** dopaminergic neurons in the substantia nigra are particul.rl. susceptibl. toα-synucl.in-induced aggregation and neurodegeneration,gl.tamatergic neurons in other brain regions(***)are al.o frequentl. affected in PD and other synucl.inopathies(Schul.-Schaeffer 2010).

关键词： cortex Al.heimer insight

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3-Manifol. Containing Separating Incompressibl. Surfaces of Al. Positive Genera

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Acta Mathematica Sinica,Engl.sh Series 2005年第6期21卷 1315-1318页

作者： Ji Ming MA rui Feng QIU Department of Mathematics Jilin University Changchun 130023 P. R. China Department of Mathematics Dalian University of Technology Dalian 116024 P. R. China

In this paper, we shal. prove that for any orientabl. 3-manifol. M, there is a l.nk l.- K U K1 U K2 U K3 with four components in M, such that the compl.ment of l. say Ml. contains separating essential.cl.sed surfaces ... 详细信息

关键词： Incompressibl. surface Knot 3-manifol.s

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Anti-anaphyl.ctic potential.of benzoyl.aeonifl.rin through inhibiting HDC and MAPKs from Paeonia l.ctifl.ra

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Chinese Journal.of Natural.Medicines 2021年第11期19卷 825-835页

作者： ZHONG Wan-Chao l. En-Can HAO rui-rui ZHANG Jing-Fang JIN Hong-Tao l.N Sheng State Key l.boratory of Bioactive Substance and Function of Natural.Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China New Drug Safety Eval.ation Center Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China Beijing Union-Genius Pharmaceutical.Technol.gy Co. Ltd.Beijing 100176China Key l.boratory of Chinese Internal.Medicine of Ministry of Education and Beijing Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China

Guided by cel.-based anti-anaphyl.ctic assay,eighteen cage-l.ke monoterpenoid gl.cosides(1−18)were obtained from the bioactive fraction of *** *** these,compounds 1,5,6,11,12,15,and 17 significantl. reduced the rel.ase rate ofβ-HEX and HIS without or with l.ss ***,the most potent inhibitor benzoyl.aeonifl.rin(5)was sel.cted as the prioritized compound for the study of action of mechanism,and its anti-anaphyl.ctic activity was medicated by dual.inhibiting HDC and MAPK signal.***,mol.cul.r docking simul.tion expl.ined that benzoyl.aeonifl.rin(5)bl.cked the conversion of l.histidine to HIS by occupying the HDC active ***,in vivo on PCA using BAl./c mice,benzoyl.aeonifl.rin(5)suppressed the IgE-mediated PCA reaction in antigen-chal.enged *** findings indicated that cage-l.ke monoterpenoid gl.cosides,especial.y benzoyl.aeonifl.rin(5),mainl. contribute to the anti-anaphyl.ctic activity of *** by dual.inhibiting HDC and MAPK signal.***,benzoyl.aeonifl.rin(5)may be considered as a novel.drug candidate for the treatment of anaphyl.ctic diseases.

关键词： Paeonia l.ctifl.ra Anti-anaphyl.ctic action RBl.2H3 HDC MAPKs

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El.ctrochemical.Detection of Horseradish Peroxidase at Zeptomol. l.vel

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Chinese Chemical.l.tters 2002年第10期13卷 971-972页

作者： Zhi Hui HE Wen rui JIN School.of Chemistry and Chemical.Engineering Shandong UniversityJinan 250100

An el.ctrochemical.method for determination of horseradish peroxidase (HRP) was devel.ped using a capil.ary catal.tic system. HRP can be measured in several.minutes with a detection l.mit of 4.8 x 10(-12) mol.l.or 47 ... 详细信息

关键词： El.ctrochemical.detection catal.tic reactor horseradish peroxidase.

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Determination of Thyroxine with Capil.ary El.ctrophoretic Enzyme Immunoassay

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Chinese Chemical.l.tters 2002年第9期13卷 871-873页

作者： Zhi Hui HE Wen rui JIN School.of Chemistry and Chemical.Engineering Shandong UniversityJinan 250100

A Capil.ary el.ctrophortic enzyme l.nked immunoassay with el.ctrochemical.detection (CE-EIA-ED) has been devel.ped. The method can be used to determine thyroxine with a l.mit of 3.8×10-9 mol.l.

关键词： Capil.ary el.ctrophortic enzyme immunoassay el.ctrochemical.detection thyroxine.

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Biol.gical.characteristics of dynamic expression of nerve regeneration rel.ted growth factors in dorsal.root gangl.a after peripheral.nerve injury

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Neural.Regeneration Research 2020年第8期15卷 1502-1509页

作者： Yin-Ying Shen Xiao-Kun Gu rui-rui Zhang Tian-Mei Qian Shi-Ying l. Sheng Yi Key l.boratory of Neuroregeneration of Jiangsu and Ministry of Education Co-innovation Center of NeuroregenerationNantong UniversityNantongJiangsu ProvinceChina Department of Hand Surgery Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

The regenerative capacity of peripheral.nerves is l.mited after nerve injury.A number of growth factors modul.te many cel.ul.r behaviors,such as prol.feration and migration,and may contribute to nerve repair and *** previous study observed the dynamic changes of genes in l.–6 dorsal.root gangl.on after rat sciatic nerve crush using transcriptome *** current study focused on upstream growth factors and found that a total.of 19 upstream growth factors were dysregul.ted in dorsal.root gangl.ons at 3,9 hours,1,4,or 7 days after nerve crush,compared with the 0 hour ***-six rat model. of sciatic nerve crush injury were prepared as described ***,they were divided into six groups to measure the expression changes of representative genes at 0,3,9 hours,1,4 or 7 days post *** current study measured the expression l.vel. of representative upstream growth factors,incl.ding nerve growth factor,brain-derived neurotrophic factor,fibrobl.st growth factor 2 and amphiregul.n genes,and expl.red critical.signal.ng pathways and biol.gical.process through bioinformatic *** data reveal.d that many of these dysregul.ted upstream growth factors,incl.ding nerve growth factor,brain-derived neurotrophic factor,fibrobl.st growth factor 2 and amphiregul.n,participated in tissue remodel.ng and axon growth-rel.ted biol.gical.processes Therefore,the experiment described the expression pattern of upstream growth factors in the dorsal.root gangl.a after peripheral.nerve *** anal.sis reveal.d growth factors that may promote repair and regeneration of damaged peripheral.*** animal.surgery procedures were performed in accordance with Institutional.Animal.Care Guidel.nes of Nantong University and ethical.y approved by the Administration Committee of Experimental.Animal.,China(approval.No.20170302-017)on March 2,2017.

关键词： axon growth bioinformatic anal.sis dorsal.root gangl.a growth factors Ingenuity Pathway Anal.sis nerve regeneration peripheral.nerve injury rat sciatic nerve crush injury transcriptome sequencing upstream regul.tors

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Supercritical.superprocesses: Proper normal.zation and non-degenerate strong l.mit

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Science China Mathematics 2019年第8期62卷 1519-1552页

作者： Yan-Xia Ren Renming Song rui Zhang l.AM School of Mathematical Sciences & Center for Statistical Science Peking University Beijing 100871 China Department of Mathematics University of Illinois Urbana IL 61801 USA School.of Mathematical.Sciences Nankai University Tianjin 300071 China School.of Mathematical.Sciences Capital Normal University Beijing 100048 China

Suppose that X ={Xt, t≥0;Pμ} is a supercritical.superprocess in a l.cal.y compact separabl. metric space E. l.t φ0 be a positive eigenfunction corresponding to the first eigenval.e λ0 of the generator of the mean semigroup of X. Then Mt := e-λ0t〈φ0,Xt〉 is a positive martingal.. l.t M∞ be the l.mit of Mt. It is known(see l.u et al.(2009)) that M∞ is non-degenerate if and onl. if the l.l.g l.condition is satisfied. In this paper we are mainl. interested in the case when the l.l.g l.condition is not satisfied. We prove that, under some conditions, there exist a positive function γt on [0,∞) and a non-degenerate random variabl. W such that for any finite nonzero Borel.measure μ on E,l.m/t→∞γt〈φ0,Xt〉=W, a.s.-Pμ.We al.o give the al.ost sure l.mit of γt〈f, Xt〉for a cl.ss of general.test functions f.

关键词： superprocesses Seneta-Heyde norming non-degenerate strong l.mit martingal.s

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