检索结果-南通市图书馆

Alkaline sphingomyelinase(NPP7) in hepatobiliary diseases: A field that needs to be closely studied

在线全文

学校读者我要写书评

暂无评论

World Journal of Hepatology 2018年第2期10卷 246-253页

作者： rui-Dong duan Gastroenterology and Nutrition Lab Department of Clinical Sciences Lund University

Alkaline sphingomyelinase cleaves phosphocholine from sphingomyelin, platelet-activating factor, lysophosphatidylcholine, and less effectively phosphatidyl-choline. The enzyme shares no structure similarities with acid or neutral sphingomyelinase but belongs to ectonucleotide pyrophosphatase/phosphodiesterase(NPP) family and therefore is also called NPP7 nowadays. The enzyme is expressed in the intestinal mucosa in many species and additionally in human liver. The enzyme in the intestinal tract has been extensively studied but not that in human liver. Studies on intestinal alkaline sphingomyelinase show that it inhibits colonic tumorigenesis and inflammation, hydrolyses dietary sphingomyelin, and stimulates cholesterol absorption. The review aims to summarize the current knowledge on liver alkaline sphingomyelinase in human and strengthen the necessity for close study on this unique human enzyme in hepatobiliary diseases.

关键词： Sphingomyelin Alkaline sphingomyelinase Nucleotide pyrophosphatase/phosphodiesterase 7 Autotaxin Platelet-activating factor Cholangiocarcinoma Liver diseases Gallstone

A study of the mixed layer of the South China Sea based on the multiple linear regression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2012年第6期31卷 19-31页

作者： duan rui YANG Kunde MA Yuanliang HU Tao College of Marine Northwestern Polytechnical UniversityXi'an 710072China Key Laboratory of Underwater Acoustic Environment Institute of AcousticsChinese Academy of SciencesBeijing 100190China

Multiple linear regression （MLR） method was applied to quantify the effects of the net heat flux （NHF）, the net freshwater flux （NFF） and the wind stress on the mixed layer depth （MLD） of the South China Sea （SCS） based on the simple ocean data assimilation （SODA） dataset. The spatio-temporal distributions of the MLD, the buoyancy flux （combining the NHF and the NFF） and the wind stress of the SCS were presented. Then using an oceanic vertical mixing model, the MLD after a certain time under the same initial conditions but various pairs of boundary conditions （the three factors） was simulated. Applying the MLR method to the results, regression equations which modeling the relationship between the simulated MLD and the three factors were calculated. The equations indicate that when the NHF was negative, it was the primary driver of the mixed layer deepening; and when the NHF was positive, the wind stress played a more important role than that of the NHF while the NFF had the least effect. When the NHF was positive, the relative quantitative effects of the wind stress, the NHF, and the NFF were about i0, 6 and 2. The above conclusions were applied to explaining the spatio-temporal distributions of the MLD in the SCS and thus proved to be valid.

关键词： mixed layer multiple linear regression South China Sea vertical mixing model

Horizontal-Longitudinal Spatial Correlation of Acoustic Field with Deep Receiver in the Direct Zone in Deep Water

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2017年第2期34卷 47-51页

作者： Kun-De Yang Hui Li rui duan School of Marine Science and Technology Northwestern Polytechnical UniversityXi'an 710072 Key Laboratory of Ocean Acoustics and Sensing(Ministry of Industry and Information Technology) Northwestern Polytechnical UniversityXi'an 710072

The horizontal-longitudinal correlation of acoustic field for the receiver near the bottom is analyzed by using nu- merical modeling. An approximate analytical solution of horizontal-longitudinal correlation coefficient is derived based on the ray method. Combining the characteristic of Lloyd＇s mirror interference pattern, the variability of acoustic field and its effect on horizontal-longitudinal spatial correlation are discussed. The theoretical pre- diction agrees well with the numerical results. Experimental results confirm the validity of analytical solution. Finally, the applicability of the analytical solution is summarized. The conclusion is beneficial for the design of bottom-moored array and the estimation of integral time for moving source localization.

关键词： Horizontal-Longitudinal Spatial Correlation of Acoustic Field with Deep Receiver in the Direct Zone in Deep Water

Efficient P3HT：PC61BM Solar Cells Employing 1,2,4-Trichlorobenzene as the Processing Additives

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2017年第2期35卷 302-308页

作者： Wei-chao Chen Man-jun Xiao 杨春鹏 Lin-rui duan 阳仁强 Chinese Academy of Sciences Key Laboratory of Bio-based Materials Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China College of Textiles & Clothing Qingdao University Qingdao 266071 China

The efficiency of the poly（3-hexylthiophene）（P3HT） and [6,6]-phenyl C61-butyric acid methyl ester （PC61BM） based organic solar cells was enhanced by using 1,2,4-trichlorobenzene （TCB） as a processing additive to control the blend morphology. The addition of TCB improved the arrangement of P3HT which resulted in good phase separated blend films. Correspondingly, the optimized solar cells showed a power conversion efficiency （PCE） of 4.17% with a fill factor （FF） of 0.69, which were higher than those of common thermal annealing devices （PCE 3.84%, FF 0.67）. The efficiency was further improved to 4.74% by thermal annealing at 150 ℃for 10 min with a higher FF of 0.74.

关键词： Organic solar cells Crystallinity Additive Morphology

The Role of Consumer Privacy Concerns in Shaping Platform Strategy for Online Markets

在线全文

学校读者我要写书评

暂无评论

Journal of the Operations Research Society of China 2024年第2期12卷 363-386页

作者： Jin-Kun Yang Yong-rui duan Jia-Zhen Huo School Economics and Management Tongji UniversityShanghai 200092China

We investigate the effects of consumer privacy concerns on the pricing and personal data collection strategy of an online *** online platform derives revenues from disclosing consumer information to *** compete for the information in order to enable them to price discriminate and thus derive revenues from consumer purchases.A novel aspect of our research is that we allow the online platform to sell only a subset of consumer *** develop analytical models where consumers can/cannot protect their *** analysis yields three main ***,in the monopoly case,we find that when the consumer privacy disclosure aversion cost is relatively low,it is optimal for the platform to sell all consumer information to the ***,in the duopoly case,we illustrate that when the consumer privacy disclosure aversion cost is relatively low,the platform will sell all consumer information to only one firm;when the cost is moderate,the platform will choose to sell the information of only some consumers and to only one firm;when the cost is relatively high,the platform will select only some of the consumers and sell their information to both ***,it will be better for the platform to provide the information protection service for free when the privacy cost is low.

关键词： Price discrimination User privacy Consumer information Two-sided market Privacy disclosure aversion cost

Optical wireless network in home area based on white LED lights

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

High Technology Letters 2011年第3期17卷 277-284页

作者： Wang rui duan Jingyuan Shi Ancun Liu Yuliang Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 P. R. China

A new optical wireless network based on white LED lights in home area is proposed. It is a duplex channel communication system utilizing signal emitters of white LED lights in the downlink and infrared devices in the uplink. Strategies for the system construction are given. Performance for users＇ mobile access of different kinds of optical concentrators is investigated. Indoor channel band-width is analyzed considering white LED light distribution, wall reflection, and receivers field of view （FOV）. Various modulation methods are discussed. A demo point-to-point system for surfing the net is constructed using a new line code of 4B6B which is developed to stabilize the optical output, and a peak data rate of 1 Mbps is achieved. This system is built into the lighting infrastructure, therefore decreasing the cost and offering a solution for wireless access in places which are sensitive to radio frequency like hospitals.

关键词： optical wireless network white LED light optical concentrator mobile access indoor channel bandwidth

U-shaped microRNA expression pattern could be a new concept biomarker for environmental estrogen

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2016年第6期10卷 93-101页

作者： rui duan Yun Lu Lingyan Hou Lina Du Lequn Sun Xingfan Tang State Key Joint Laboratory of Environment Simulation and Pollution Control School of Environment Tsinghua University Beijing 100084 China

Many studies have focused on environmental estrogen-related diseases. However, no consistent gene markers or signatures for estrogenicity have been discovered in mammals. This study investigated the estrogenic effects of 17β-estradiol on the prostate in immature male mice. Consistent U-shaped responses were seen in bodyweight, ventral prostate epithelial morphology, and miRNA expression levels. Specifically, most estmdiol regulated miRNAs were downregulated at low doses of estradiol （0.2 and 2 μg. kg-1）, and whose expression returned to the control level at a larger dose （200 μg-kg-1）. The *** of these regulated miRNAs is related to the prostate cancer and PI3K-Akt signaling pathways, which is consistent with the function of estmdiol. Furthermore, the miRNA-processing machinery, Drosha, in the prostate was also regulated in a similar pattern, which could be a part of the U-shaped miRNA expression mechanism. All of these data indicate that the prostate is a reliable organ for evaluating estrogenic activity and that the typical nonmonotonic dose-response relationship could be used as a novel biomarker for estrogenicity.

关键词： miRNA Prostate Estradiol Nonmonotonic dose-response Estrogenicity Drosha

Microstructure-mechanical property relationship in Ti-Mo microalloyed steel with random and interphase precipitates

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2019年第8期26卷 838-845页

作者： Hai-long Yi Lu-ran Zhang rui-hai duan Xin-zeng Liang State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110819 Liaoning China

The relationship between microstructure and mechanical properties of Ti-Mo microalloyed steels composed of ferrite and bainite with nanometer-sized carbides and isothermally transformed at different temperatures and time was systematically investigated by tensile test, hardness test, and transmission electron microscopy. Ferrite formed at high temperatures exhibited both planar/curved sheet-like dispersions of interphase precipitates and random dispersion precipitates, with the interphase precipitates being the dominant morphology. In contrast, bainite formed at low temperatures exhibited only random dispersion precipitates. Furthermore, random dispersion precipitates and interphase precipitates were observed within the same ferrite grains. The mechanical properties of the ferrite specimen were superior to those of the bainite specimen. The stress-strain curves of both specimens indicated continuous yielding, high strength, and sufficient tensile elongation. The strengthening of the ferrite specimen was attributed to grain size strengthening, dislocation strengthening, and precipitation hardening, and the degree of precipitation strengthening was approximately 300 MPa.

关键词： Mechanical property Interphase precipitate Dispersion precipitate Precipitation strengthening Ti-Mo microalloyed stee

The Flow Behavior of Red Blood Cell Reduced Deformability in Microchannel

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

医用生物力学 2019年第A1期34卷 116-117页

作者： Fen Li rui duan Hui Li Institute of Applied Mechanics Taiyuan University of Technology

Blood cells are mainly(~99%)comprised of red blood *** most remarkable properties of are their high deformability,which allow they flow through microcapillaries of diameter even smaller than their *** RBC’s remarkable mechanical properties originate from the unique architecture of its *** study the mechanism of RBC’s deformability,a commonly adopted approach is to localize the cytoskeleton protein by immunofluorescence,followed by exploring the changes of cytoskeleton protein during cell *** this process,the fixed treatment of RBC using GA and PFA is of great ***,RBC’s deformability is reduced by the fixation process and skeletal protein of membrane is changed *** flow behavior of red RBCs through the microchannel also *** the difficulty of observing RBC flow in vivo,in vitro simulation by virtue of microfluidic devices provides a feasible *** important physiological phenomenon of the blood flow is the formation of cell free layer(CFL),with RBCs show a tendency to concentrate towards the central axis of the pipeline and move faster than the plasma ***,this phenomena is weaken if the stiffness of the membrane increase,which occurs in some disease,such as hereditary spherocytosis and hereditary *** study the effects of GA and PFA fix treatment on RBC deformability,a microfluidic platform is employed to measuring the CFL and flow velocity of blood flow in this *** PDMS micro flow channel used is 100 micrometers in width and 50 micrometers in *** RBC suspension is fed into the flow channel by the injection pump(***),and the experiments are observed and recorded by the inverted microscope(IX70,Olympus,Japan)and high-speed camera(Memrecam GX-1,NAC,Japan)*** GA concentrations,i.e.,0.000 5,0.000 75,and 0.001 wt.%were ***,the effect of PFA at a concentration of 2wt.%work with GA was also *** of the flowing RBCs are pr

关键词： red blood cell micro channel fixed treatment cell free layer velocity distribution