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Emergency Care for Children and Adolescents after Sexual Violence, in Brazil’s Capital, Brasilia

Open Journal of Epidemiology 2024年第2期14卷 397-403页

作者： Evaldo Lima Da costa Karla Simônia de Pádua Aníbal Faúndes rui Nunes Bioethics at the School of Medicine University of Porto/Federal Council of Medicine Porto Portugal Center for Research in Women’ s Reproductive Health (CEMICAMP) Center for Integral Attention to Women (CAISM) State University of Campinas Campinas Brazil Center for Research in Women’ s Reproductive Health (CEMICAMP) State University of Campinas (UNICAMP) Campinas Brazil. The Centre of Bioethics Faculty of Medicine University of Porto Porto Portugal

Objective: Sexual violence affects women of all ages but, more commonly, children and adolescents. This study aimed to identify the extent to which services are being provided at the hospitals responsible for the emergency care of children and adolescents who have suffered sexual violence and to determine whether there is any difference in the provision of such services as a function of the victim’s age. Method: This cross-sectional study investigated differences in the care received by female children and adolescents who are victims of sexual violence in a capital city, comparing the treatment given to girls under 15 with that given to adolescents of 15 to 19 years of age. The data were extracted from the State Department of Health database between 01/01/2012 and 31/12/2016. Results: Children under 15 were much less likely to receive prophylaxis against HIV, sexually transmitted infections and hepatitis B, with the number of adolescent girls treated adequately corresponding to between twice and almost three times the number of children treated prophylactically. Only 10% of girls under 15 received emergency contraception. Conclusion: The lack of standard care established by the Ministry of Health highlights the need for urgent debates both locally and probably throughout the country, as the situation may be similar in other regions of the country.

关键词： Aggressors Children Sexual Violence Teenagers

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Exercise training in the management of patients with resistant hypertension

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World Journal of Cardiology 2015年第2期7卷 47-51页

作者： Fernando Ribeiro rui costa José Mesquita-Bastos School of Health Sciences University of Aveiro Portugal and CINTESIS.UA 3810-193 Aveiro Portugal School of Health Sciences University of Aveiro3810-193 Aveiro Portuga

Hypertension is a very prevalent risk factor for cardiovascular disease. The prevalence of resistant hypertension, i.e., uncontrolled hypertension with 3 or more antihypertensive agents including 1 diuretic, is between 5% and 30% in the hypertensive population. The causes of resistant hypertension are multifactorial and include behavioral and biological factors, such as nonadherence to pharmacological treatment. All current treatment guidelines highlight the positive role of physical exercise as a non-pharmacological tool in the treatment of hypertension. This paper draws attention to the possible role of physical exercise as an adjunct non-pharmacological tool in the management of resistant hypertension. A few studies have investigated it, employing different methodologies, and taken together they have shown promising results. In summary, the available evidence suggests that aerobic physical exercise could be a valuable addition to the optimal pharmacological treatment of patients with resistant hypertension.

关键词： Exercise training Resistant hypertension Blood pressure Non-pharmacological Cardiovascular disease

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Polyphenol Oxidase Activity and Colour Changes of ‘Starking’ Apple Cubes Coated with Alginate and Dehydrated with Air

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Food and Nutrition Sciences 2011年第5期2卷 451-457页

作者： Susana Daniela Sousa Fernandes Catarina Araújo da Silva Ribeiro Maria Filomena de Jesus Raposo rui Manuel Santos costa de Morais Alcina Maria Miranda Bernardo de Morais 不详

The objective was to study the effect of alginate coating on polyphenol oxidase (PPO) activity and colour of ‘Starking’ apple cubes during dehydration with hot air. Apple cubes were dehydrated at 20oC, 35oC, or 40oC, with a parallel airflow. Analysis of PPO activity, colour (L*, a*, b*) and dry matter were performed along the dehydration process at each temperature. All samples presented a peak in relative PPO activity in the beginning of the drying. Exponential models fitted well the experimental data after the peak. Cubes without coating presented lower PPO activity, suggesting lower browning, than coated samples throughout the dehydration process, for all temperatures. Better results for coated samples were obtained with a perpendicular airflow drying at 40oC, after dipping the whole apple in water at 60oC for 10 min. In order to prevent coated samples from browning, drying by perpendicular airflow preceded by a thermal treatment of the whole apple is required.

关键词： Alginate Coating Apple Cubes Colour Hot Air Drying Polyphenol Oxidase

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尤文代签分析

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足球俱乐部 2005年第12期 45-45页

作者： rui costa1983

近段时间来,频繁听闻有信虫收到尤文的回信:一般都是一张带少量签名的全家福加一张打印信。信都是尤文的主席史蒂文斯先生回的。然而,众所周知,意大利球队普遍回信率极低,而尤文又是冷血中的代表,基本上对信虫置之不理,而现在一下子突... 详细信息

近段时间来,频繁听闻有信虫收到尤文的回信:一般都是一张带少量签名的全家福加一张打印信。信都是尤文的主席史蒂文斯先生回的。然而,众所周知,意大利球队普遍回信率极低,而尤文又是冷血中的代表,基本上对信虫置之不理,而现在一下子突然这么热

关键词：尤文维德内德

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Current advances in solid free-form techniques for osteochondral tissue engineering

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Bio-Design and Manufacturing 2018年第3期1卷 171-181页

作者： Joao Bebiano costa Joana Silva-Correia rui Luis Reis Joaquim Miguel Oliveira B's Research Group I3Bs - Research Institute onBiomaterials Biodegradables and Biomimetics University ofMinho Headquarters of the European Institute of Excellenceon Tissue Engineering and Regenerative Medicine AveParkParque de Ciencia e Tecnologia Zona Industrial da Gandra4805-017 Barco Guimaraes Portugal ICVS/3B's-PT Government Associate Laboratory Braga Guimarfies Portugal The Discoveries Centre for Regenerative and PrecisionMedicine Headquarters at University of MinhoAvepark 4805-017 Barco Guimaraes Portugal

Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds’ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro–macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.

关键词：软骨病变生物技术生物科学发展现状

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Association between EGF +61A/G polymorphism and gastric cancer in Caucasians

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World Journal of Gastroenterology 2011年第4期17卷 488-492页

作者： Ana Paula Araújo Bruno M costa Ana L Pinto-Correia Maria Fragoso Paula Ferreira Mário Dinis-Ribeiro Sandra costa rui M Reis rui Medeiros Molecular Oncology Group Portuguese Institute of Oncology of Porto Life and Health Sciences Research Institute (ICVS) School of Health Sciences Oncology Department Portuguese Institute of Oncology of Porto Gastroenterology Department Portuguese Institute of Oncology of Porto Portugal Cintesis/Faculty of Medicine University of Porto Centro de Estudos em Biomedicina Health Sciences Faculty-Fernando Pessoa University Instituto de Ciencias Biomédicas de Abel Salazar Abel Salazar Institute for the Biomedical Sciences

AIM: To investigate the association between epidermal growth factor (EGF) +61A/G polymorphism and susceptibility to gastric cancer, through a cross-sectional study. METHODS: Polymerase chain reaction resctriction fragment lenght polymorphism analyses were used to genotype EGF +61 in 207 patients with gastric lesions (162 patients with gastric adenocarcinomas, 45 with atrophy or intestinal metaplasia) and 984 controls. All subjects were Caucasian. RESULTS: Genotype distribution was 23.5% for GG and 76.5% for GA/AA in the control group, 18.4% for GG and 68.6% for GA/AA in the entire group with gastric lesions and 17.9% for GG and 82.1% for GA/AA in the group with gastric adenocarcinoma. No statistically significant associations were found between EGF +61 variants and risk for developing gastric cancer [odds ratios (OR) = 1.41, 95% confidence intervals (CI): 0.90-2.21, P = 0.116]. However, the stratification of individuals by gender revealed that males carrying A alleles (EGF +61A/G or AA) had an increased risk for developing gastric cancer as compared to GG homozygous males (OR = 1.55, 95% CI: 1.05-2.28, P = 0.021). CONCLUSION: In summary, we found that males who were A carriers for EGF +61 had an increased risk for developing gastric cancer. This result may be explained by the suggestion that women secrete less gastric acid than men.

关键词：多态性分析 EGF 白种人胃癌表皮生长因子协会聚合酶链反应片段长度

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Exosomal glypican-1 is elevated in pancreatic cancer precursors and can signal genetic predisposition in the absence of endoscopic ultrasound abnormalities

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World Journal of Gastroenterology 2022年第31期28卷 4310-4327页

作者： Pedro Moutinho-Ribeiro Ines A Batista Sofia T Quintas Bárbara Adem Marco Silva rui Morais Armando Peixoto Rosa Coelho Pedro costa-Moreira Renato Medas Susana Lopes Filipe Vilas-Boas Manuela Baptista Diogo Dias-Silva Ana L Esteves Filipa Martins Joanne Lopes Helena Barroca Fátima Carneiro Guilherme Macedo Sonia A Melo Serviço de Gastrenterologia Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Faculty of Medicine University of PortoPorto 4200Portugal Instituto de Investigacao e Inovacao em Saúde(i3S) Universidade do PortoPorto 4200Portugal IPATIMUP-Institute of Molecular Pathology and Immunology University of PortoPorto 4200Portugal Instituto de Ciencias Biomédicas Abel Salazar(ICBAS) University of PortoPorto 4050Portugal Servico de Cirurgia Geral Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal Unidade de Saúde Familiar Serpa Pinto ACeS Porto OcidentalPorto 4250Portugal Serviço de Anatomia Patológica Centro Hospitalar Universitário de Sao JoaoPorto 4200Portugal

BACKGROUND Individuals within specific risk groups for pancreatic ductal adenocarcinoma(PDAC)[mucinous cystic lesions(MCLs),hereditary risk(HR),and new-late onset diabetes mellitus(NLOD)]represent an opportunity for early cancer *** ultrasound(EUS)is a premium image modality for PDAC screening and precursor lesion *** no specific biomarker is currently clinically available for this purpose,glypican-1(GPC1)is overexpressed in the circulating exosomes(crExos)of patients with PDAC compared with healthy subjects or those harboring benign pancreatic *** To evaluate the capacity of GPC1+crExos to identify individuals at higher risk within these specific groups,all characterized by *** This cross-sectional study with a prospective unicentric cohort included 88 subjects:40 patients with MCL,20 individuals with HR,and 20 patients with NLOD.A control group(CG)was submitted to EUS for other reasons than pancreatic pathology,with normal pancreas and absence of hereditary risk factors(n=8).The inclusion period was between October 2016 and January 2019,and the study was approved by the Ethics Committee of Centro Hospitalar Universitário de São João,Porto,*** patients provided written informed *** and blood tests for quantification of GPC1+crExos by flow cytometry and carbohydrate antigen 19-9(CA 19-9)levels by ELISA were performed in all ***-guided tissue acquisition was done whenever *** statistical analysis,SPSS®27.0(IBM Corp.,Armonk,NY,United States)version was *** graphs were created using GraphPad Prism 7.00(GraphPad Software,San Diego,CA,United States).RESULTS Half of MCLs harbored worrisome features(WF)or high-risk stigmata(HRS).Pancreatic abnormalities were detected by EUS in 10.0%and 35.0%in HR and NLOD individuals,respectively,all considered non-malignant and“harmless.”Median levels of GPC1+crExos were statistically different:MCL[99.4%,interquartile range(IQR):94.9%-99.8%],HR(8

关键词： Glypican-1 Circulating exosomes Endoscopic ultrasound Pancreatic cancer risk groups Pancreatic cancer precursor lesions Genetic predisposition

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Septic shock 3.0 criteria application in severe COVID-19 patients:An unattended sepsis population with high mortality risk

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World Journal of Critical Care Medicine 2022年第4期11卷 246-254页

作者： JoséPedro Cidade LM Coelho Vasco costa rui Morais Patrícia Moniz Luís Morais Pedro Fidalgo António Tralhão Carolina Paulino David Nora Bernardino Valério Vítor Mendes Camila Tapadinhas Pedro Povoa Polyvalent Intensive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisboa 1449-005Portugal Polyvalent Intensive Care Unit Hospital Sao Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intensive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intesive Care Unit Hospital São Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal Polyvalent Intens Care Unit NOVA Medical SchoolHospital Sao Francisco XavierCentro Hospitalar Lisboa OcidentalLisbon 1449-005Portugal

BACKGROUND Coronavirus disease 2019(COVID-19)can be associated with life-threatening organ dysfunction due to septic shock,frequently requiring intensive care unit(ICU)admission,respi-ratory and vasopressor ***-fore,clear clinical criteria are pivotal for early recognition of patients more likely to need prompt organ *** most patients with severe COVID-19 meet the Sepsis-3.0 criteria for septic shock,it has been increasingly recognized that hyperlactatemia is frequently absent,possibly leading to an underestimation of illness severity and mortality *** To identify the proportion of severe COVID-19 patients with vasopressor support requirements,with and without hyperlactatemia,and describe their clinical outcomes and mortality METHODS We performed a single-center prospective cohort *** adult patients admitted to the ICU with COVID-19 were included in the analysis and were further divided into three groups:Sepsis group,without both criteria;Vasoplegic Shock group,with persistent hypotension and vasopressor support without hyperlactatemia;and Septic Shock 3.0 group,with both ***-19 was diagnosed using clinical and radiologic criteria with a severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)positive RT-PCR *** 118 patients(mean age 63 years,87%males)were included in the analysis(n=51 Sepsis group,n=26 Vasoplegic Shock group,and n=41 Septic Shock 3.0 group).SOFA score at ICU admission and ICU length of stay were different between the groups(P<0.001).Mortality was significantly higher in the Vasoplegic Shock and Septic Shock 3.0 groups when compared with the Sepsis group(P<0.001)without a significant difference between the former two groups(P=0.713).The log rank tests of Kaplan-Meier survival curves were also different(P=0.007).Ventilator-free days and vasopressor-free days were different between the Sepsis vs Vasoplegic Shock and Septic Shock 3.0 groups(both P<0.001),and similar in the last two groups(P=0.128

关键词： COVID-19 Critical care SARS-CoV-2 Septic shock Lactate Sepsis 3.0 criteria

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Fisher's perceptions about a marine protected area over time

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Aquaculture and Fisheries 2020年第5期5卷 273-281页

作者： Cristina Pita Barbara Horta e costa Gustavo Franco rui Coelho Inês Sousa Emanuel J.Gonçalves Jorge M.S.Gonçalves Karim Erzini Department of Environment and Planning&Centre for Environmental and Marine Studies(CESAM) University of AveiroPortugal Center of Marine Sciences CCMARUniversity of AlgarveCampus de Gambelas8005-139FaroPortugal MARE-Marine and Environmental Sciences Centre ISPAInstituto UniversitárioRua Jardim Do Tabaco 341149-041LisboaPortugal Instituto Português Do Mar a da Atmosfera IP(IPMA)-Polo OlhãoAv.5 de Outubro8700-305OlhãoPortugal

The perceptions of fishers towards the Arrábida Marine Park,a marine protected area(MPA)in the west coast of Portugal,were studied through face-to-face interviews in two different moments of the MPA life ***'perceptions about the MPA and the impact it had on the fishing activity over time were identified just before the full implementation of the zoning and regulations of the management plan and 10 years *** study aimed to investigate fishers'knowledge,acceptance and perceptions about the MPA changed with time,if support for the MPA was linked to the impact of the MPA on the fishing activity,and if fishers'perceptions about the impact of the MPA on the fishing activity match with local landings *** show that although knowledge about the marine park significantly improved over time,fishers'acceptance did not.A decrease on fishers'support was not substantial but *** such as the disagreement with regulations reinforced concerns raised during the implementation of the marine park,particularly in relation to the top-down decision-making,which commonly confers minor participation,recognition and legitimacy to ***,fisheries benefits were still not perceived by local fishers,though they are central for fishers'***,the perceived negative impacts of the park seemed to be more related to social aspects and individual interests than to impacts on *** adequate management,enforcement and participation of local fishers is still possible and are advocated here as to contribute to the expected socioecological outcomes and respective support,leading to the future successful performance of the Arrábida Marine *** fishers’perceptions towards an MPA over time is central and should be included on periodical socioecological monitoring and inform an effective adaptive management.

关键词： Arrabida Marine Park(AMP) Local fisheries Perceptions Attitudes Fishers'support Decision-making Marine protected area Changes over time

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What we have learned from urinary bladder cancer models

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Journal of Cancer Metastasis and Treatment 2016年第1期2卷 51-58页

作者： Carina Bernardo Céu costa Carlos Palmeira Rosário Pinto-Leite Paula Oliveira rui Freitas Francisco Amado Lúcio L.Santos Experimental Pathology and Therapeutics Group-Research Center Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Mass Spectrometry Group QOPNADepartment of ChemistryUniversity of AveiroCampus Universitário de Santiago3810-193 AveiroPortugal Department of Immunology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal School of Health Sciences Fernando Pessoa University4249-004 PortoPortugal Genetic Service Cytogenetic LaboratoryHospital Center of Trás-os-Montes e Alto Douro5000-508 Vila RealPortugal Department of Veterinary Sciences CITABUniversity of Trás-os-Montes e Alto Douro5001-801 Vila RealPortugal Department of Urology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal Department of Surgical Oncology Portuguese Oncology Institute-Porto(IPO-Porto)Rua Dr.António Bernardino de Almeida4200-072 PortoPortugal

Urinary bladder cancer(UBC)is a heterogeneous disease with highly variable clinical outcomes and responses to *** some advances in the molecular understanding of UBC,this knowledge still has not been translated to the clinic in terms of improvements in the prognosis and treatment of *** urinary bladder tumor models representative of the human disease in terms of histology and behavior are needed to study factors involved in tumor initiation,progression and ***,accurate model systems would facilitate identification of new therapeutic targets and predictive markers that could lead to optimization of existing therapies and development of new *** established cancer cell lines derived from human urinary bladder tumors representing different grades and stages have been used as experimental models for UBC *** cell lines reflect some of the genetic and morphologic alterations observed in human urothelial carcinoma and serve as simplified models to study the behavior of cancer cells in ***,their translational potential is limited due to the artificial conditions,in which the cells are maintained,grown and *** models offer a more complex and realistic model for the establishment,development,and progression of tumors as well as to evaluate new therapeutic *** the years,the authors'group has worked with several UBC cell lines,established and characterized chemically induced UBC models,and patient-derived xenografts *** this study,the authors will provide a summary of the UBC models developed by their group,analyze their translational potential and weaknesses,and define areas that remain to be explored.

关键词： Animal models cell lines tumor behavior urothelial bladder cancer xenografts

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