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Pathologic response after preoperative therapy predicts prognosis of Chinese colorectal cancer patients with liver metastases

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Chinese Journal of Cancer 2017年第11期36卷 537-547页

作者： Yun Wang Yun-Fei Yuan Hao-cheng Lin Bin-Kui Li Feng-Hua Wang Zhi-Qiang Wang Pei-Rong Ding Gong Chen Xiao-Jun Wu Zhen-Hai Lu Zhi-Zhong Pan De-Sen Wan Peng Sun Shu-Mei Yan rui-Hua Xu Yu-Hong Li Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 Guangdong P. R. China Department of Medical Oncology Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Hepatobiliary Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Colorectal Surgery Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Department of Pathology Sun Yat-sen University Cancer Center Guangzhou 510060 Guangdong P. R. China

Background: Pathologic response is evaluated according to the extent of tumor regression and is used to estimate the efficacy of preoperative treatment. Several studies have reported the association between the pathologic response and clinical outcomes of colorecal cancer patients with liver metastases who underwent ***, to date, no data from Chinese patients have been reported. In this study, we aimed to evaluate the association between the pathologic response to pre-hepatectomy chemotherapy and prognosis in a cohort of Chinese *** and methods: In this retrospective study, we analyzed the data of 380 liver metastases in 159 *** pathologic response was evaluated according to the tumor regression grade(TRG).The prognostic role of pathologic response in recurrence-free survival(RFS) and overall survival(OS) was assessed using Kaplan-Meier curves with the log-rank test and multivariate Cox models. Factors that had potential influence on pathologic response were also analyzed using multivariate logistic regression and Kruskal-Wallis/Mann-Whitney U ***: Patients whose tumors achieved pathologic response after preoperative chemotherapy had significant longer RFS and OS than patients whose tumor had no pathologic response to chemotherapy(median RFS: 9.9 vs.6.5 months, P = 0.009; median OS: 40.7 vs. 28.1 months, P = 0.040). Multivariate logistic regression and Kruskal-Wallis/Mann-Whitney U tests showed that metastases with small diameter, metastases from the left-side primary tumors,and metastases from patients receiving long-duration chemotherapy had higher pathologic response rates than their control metastases(all P < 0.05). A decrease in the serum carcinoembryonic antigen(CEA) level after preoperative chemotherapy predicted an increased pathologic response rate(P < 0.05). Although the application of targeted therapy did not significantly influence TRG scores of all cases of metastases, the addition of cetuximab to chemoth

关键词： Colorectal cancer Liver metastases Chemotherapy Pathologic response

基于AFLP分子标记技术的黑花韭与多星韭遗传多样性与亲缘关系分析

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广西植物 2011年第3期31卷 295-299页

作者：王锦何承中党承林黄瑞复西南林业大学昆明650224 云南大学生命科学学院昆明650031

采用AFLP分子标记技术分析了分布在滇中、滇西、滇西北的3个黑花韭居群、3个二倍体多星韭居群和6个四倍体多星韭居群的遗传多样性与亲缘关系。结果表明,12个居群在DNA水平上已发生明显分化。居群间的基因分化系数（GST）为0.444。由GST... 详细信息

采用AFLP分子标记技术分析了分布在滇中、滇西、滇西北的3个黑花韭居群、3个二倍体多星韭居群和6个四倍体多星韭居群的遗传多样性与亲缘关系。结果表明,12个居群在DNA水平上已发生明显分化。居群间的基因分化系数（GST）为0.444。由GST计算的居群间基因流（Nm）为0.625,表明居群间部分基因流动受阻。12个居群间的遗传距离（D）在0.019~0.298之间,平均为0.185。UPGMA聚类结果表明居群聚类关系与地理分布相近似。四倍体多星韭与黑花韭的遗传距离较与二倍体多星韭的遗传距离要小。二倍体多星韭与黑花韭的遗传距离最大,它们之间的亲缘关系最远。

关键词：黑花韭多星韭遗传多样性亲缘关系

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LaCoO_3中自旋态转变现象的超声研究

物理学报 2005年第9期54卷 4379-4383页

作者：张士龙孔辉岑诚苏金瑞朱长飞中国科学技术大学材料科学与工程系先进功能材料与器件实验室合肥230026

测量了LaCoO3单相多晶样品的纵波与横波超声声速和衰减随温度的变化关系,在材料的自旋态转变温度附近(≈90K),纵波声速出现明显的软化并伴随一个尖锐的衰减峰,但是在横波的测量中却没有出现类似的超声异常,分析认为LaCoO3在90K附近的自... 详细信息

测量了LaCoO3单相多晶样品的纵波与横波超声声速和衰减随温度的变化关系,在材料的自旋态转变温度附近(≈90K),纵波声速出现明显的软化并伴随一个尖锐的衰减峰,但是在横波的测量中却没有出现类似的超声异常,分析认为LaCoO3在90K附近的自旋态转变是由于Co3+离子是从低自旋态(LS,t62ge0g)转变到中等自旋态(IS,t52ge1g),而不是高等自旋态(HS,t42ge2g).随着温度的升高,在200K附近纵波和横波测量上都观察到一个伴随着微小声速软化的宽大的衰减峰,这可能是随机分布的IS态Co3+离子的JahnTeller效应导致的局域晶格扭曲所造成的.

关键词：超声声速与衰减自旋态转变 Jahn—Teller 效应 LaCoO3 低自旋态超声声速 Co^3+ 转变温度纵波声速多晶样品 er效应随机分布

Bone marrow-derived CXCR4-overexpressing MSCs display increased homing to intestine and ameliorate colitis-associated tumorigenesis in mice

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Gastroenterology Report 2019年第2期7卷 127-138,I0002页

作者： Xiao-Bin Zheng Xiao-Wen He Long-Juan Zhang Hua-Bo Qin Xu-Tao Lin Xuan-Hui Liu Chi Zhou Hua-Shan Liu Tuo Hu Hai-Chun cheng Xiao-Sheng He Xian-rui Wu Yu-Feng Chen Jia Ke Xiao-Jian Wu Ping Lan Department of Colorectal Surgery The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655P.R.China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655P.R.China Laboratory of Surgery The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510080P.R.China Department of Gastrointestinal Endoscopy The Sixth Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong 510655P.R.China Department of Gastrointestinal Surgery Shenzhen Baoan Shajing People’s HospitalGuangzhou Medical UniversityShenzhenGuangdong 518104P.R.China

Background and Objective:Increasing interest has developed in the therapeutic potential of bone marrow-derived mesenchymal stem cells(MSCs)for the treatment of inflammatory bowel disease(IBD)and IBD-induced ***,whether MSCs have the ability to suppress or promote tumor development remains *** stromal cell-derived factor 1(SDF-1)/C-X-C chemokine receptor type 4(CXCR4)axis is well known to play a critical role in the homing of *** this study,we aimed to evaluate the role of CXCR4-overexpressing MSCs on the tumorigenesis of ***:MSCs were transduced with lentiviral vector carrying either CXCR4 or green fluorescent protein(GFP).Chemotaxis and invasion assays were used to detect CXCR4 expression.A mouse model of colitis-associated tumorigenesis was established using azoxymethane and dextran sulfate sodium(DSS).The mice were divided into three groups and then injected with phosphate buffer saline(PBS),MSC-GFP or ***:Compared with the mice injected with MSC-GFP,the mice injected with MSC-CXCR4 showed relieved weight loss,longer colons,lower tumor numbers and decreased tumor load;expression of pro-inflammatory cytokines decreased,and signal transducer and activator of transcription 3(STAT3)phosphorylation level in colon tissue was ***:CXCR4-overexpressing MSCs exhibited effective anti-tumor function,which may be associated with enhanced homing to inflamed intestinal tissues.

关键词： Inflammatory bowel disease tumorigenesis mesenchymal stem cells CXCR4 mice

维普期刊数据库评论

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末端治理对工业涂装行业VOCs排放的影响

中国环境科学 2022年第2期42卷 593-600页

作者：王瑞鹏王晓琦程水源程龙蔡斌沈泽亚北京工业大学区域大气复合污染防治北京市重点实验室北京100124

选取河北省4类典型工业涂装行业开展车间与末端排口VOCs样品采集,检测分析了102种VOCs组分,获得了4类行业车间与排口处VOCs排放特征.结果表明,不同行业由于涂料类型、使用量等因素影响,VOCs排放浓度存在较大差异;芳香烃与含氧挥发性有机... 详细信息

选取河北省4类典型工业涂装行业开展车间与末端排口VOCs样品采集,检测分析了102种VOCs组分,获得了4类行业车间与排口处VOCs排放特征.结果表明,不同行业由于涂料类型、使用量等因素影响,VOCs排放浓度存在较大差异;芳香烃与含氧挥发性有机物(OVOCs)是家具制造、车辆制造与专用设备制造行业的主要组分,占比分别为14.7%~88.3%与10.1%~64.7%;卤代烃在金属制品行业的占比高达59.2%~86.9%.末端治理对芳香烃的影响最大,甲苯、乙苯、二甲苯、三甲苯、乙酸丁酯与2-丁酮在排口处占比明显低于车间.芳香烃对臭氧生成潜势(OFP)与二次有机气溶胶生成潜势(SOAP)的贡献最高,末端治理对OFP、SOAP及源反应活性(SR)具有显著削减作用.各类源SR差异明显,建议加强对SR值较大行业的管控力度.

关键词：工业涂装挥发性有机物(VOCs) 源成分谱末端治理化学反应活性

水泥砂浆面层加固法抗震受剪承载力计算公式的适用性讨论

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工业建筑 2016年第1期46卷 179-185页

作者：罗瑞唐曹明程绍革中国建筑科学研究院北京100013

水泥砂浆面层加固法是砌体结构抗震加固常用的方法之一,但是按照GB 50003—2011《砌体结构设计规范》和JGJ 116—2009《建筑抗震加固技术规程》计算得到的加固后砖墙抗震受剪承载力设计值存在一定差异,某些情况下差异还较大。通过收集... 详细信息

水泥砂浆面层加固法是砌体结构抗震加固常用的方法之一,但是按照GB 50003—2011《砌体结构设计规范》和JGJ 116—2009《建筑抗震加固技术规程》计算得到的加固后砖墙抗震受剪承载力设计值存在一定差异,某些情况下差异还较大。通过收集相关文献中基于试验数据提出的13个计算公式,并基于这些计算公式对两种规范的计算方法进行适用性分析,给出部分可供工程设计人员参考的一些建议。

关键词：砌体结构水泥砂浆面层加固法适用性分析

Research Progress of Treating Chronic Atrophic Gastritis by Non-Drug Therapy

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World Journal of Integrated Traditional and Western Medicine 2020年第12期6卷 18-25页

作者： ZHANG rui-qing LIU Li ZHOU cheng YANG Yong-feng ZHANG Cong-wei WANG Liang Shaanxi University of Chinese Medicine Xianyang 712000China The Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000China

Modern medicine believes that the incidence and detection rate of chronic atrophic gastritis(CAG)are positively correlated with *** detection,monitoring and intervention are helpful to reduce the incidence and mortality of gastric ***-drug therapy has many unique methods,wide range of application,simple operation,easy to popularize *** the process of using non-drug therapy to treat CAG syndrome differentiation,the principle of"treating the same disease with different methods"and"treating different diseases with the same method"must be *** recent years,in order to improve the quality of life of CAG patients and optimize treatment methods,some research progress has been made in the treatment of chronic atrophic gastritis with non-drug *** paper summarized mainly from the basic function principle and the characteristic of Chinese medicine non-drug therapy,the mechanism of various kinds of non-drug therapy treatment of chronic atrophic gastritis and its respective application.

关键词： Chronic atrophic gastritis Non-drug therapy Reviews

Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study

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Biomedical and Environmental Sciences 2015年第1期28卷 80-84页

作者： YANG Yi LANG Jing He WANG You Fang cheng Xue Mei CAI Yu Pin LI Hui ZHU Bao Li ZHANG rui Fen Department of Obstetrics and Gynaecology Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Key Laboratory of Pathogenic Microbiology & Immunology Institute of Microbiology Chinese Academy of Sciences

This study compared HPV testing and liquid-based cytology （LCT） as performance indicators for cervical cancer screening in a hospital-based study. A total of 61,193 outpatients were screened initially by LCT. Samples with screening results showing atypical squamous cells of undetermined significance （ASC-US） or worse were referred for colposcopy, and some samples were tested for high-risk HPV types with the Hybrid Capture II system （HC II）. Data on LCT （n=61,193） and HC II （n=1056） results were analysed. Overall test positivity for LCT was 2.53% using an ASC-US threshold, 3.11% using a low-grade squamous intraepithelial lesion （LSIL） threshold, and 0.67% using a high-grade squamous intraepithelial lesion （HSIL） threshold. A total of 1839 women （84% of the 3893 patients with abnormal cytology） underwent colposcopy-directed biopsy. HPV was positive in 80.3% of women with cervical intraepithelial neoplasia 1 （CIN1）, 88.3% of those with CIN2, 79.2% of women with CIN3 and 50% （2 of 4） of women with invasive cancer. There was a significant increase in the detection of CIN2 or worse with adjunct HPV testing of women with ASC-US and LSIL However, there were detection of CIN2＋ cases no differences in the with adjunct HPV testing of women with HSlI.. The results indicate that HPV testing for HSlL triage should not be recommended in cervical cancer screening.

关键词： HPV HSIL Assessing the Effectiveness of a Cervical Cancer Screening Program in a Hospital-based Study

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备件满足率约束下的备件模型

系统工程与电子技术 2007年第8期29卷 1314-1316页

作者：程海龙康锐肖波平龙军北京航空航天大学工程系统工程系北京100083

针对如何确定备件数量的问题,在以可用度为中心的备件供应分析的基础上,通过对备件特征参数和备件满足率的研究,运用边际效应分析方法对备件数量的确定进行建模,从而在优化费用的同时满足规定的装备备件满足率,进而达到系统可用度的要... 详细信息

针对如何确定备件数量的问题,在以可用度为中心的备件供应分析的基础上,通过对备件特征参数和备件满足率的研究,运用边际效应分析方法对备件数量的确定进行建模,从而在优化费用的同时满足规定的装备备件满足率,进而达到系统可用度的要求。最后通过具体案例的应用,对该备件模型进行进一步的说明和检验。

关键词：备件满足率边际效应费用