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Predictive value of a serum tumor biomarkers scoring system for clinical stage Ⅱ/Ⅲ rectal cancer with neoadjuvant chemoradiotherapy

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World Journal of Gastrointestinal Oncology 2022年第10期14卷 2014-2024页

作者： Jie-Yi Zhao Qing-Qing Tang Yu-Ting Luo Shu-Min Wang xiao-rui Zhu xiao-Yu Wang Department of Neurosurgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Medical School Sichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Multiple classes of molecular biomarkers have been studied as potential predictors for rectal cancer(RC)response.Carcinoembryonic antigen(CEA)is the most widely used blood-based marker of RC and has proven to be an effective predictive marker.Cancer antigen 19-9(CA19-9)is another tumor biomarker used for RC diagnosis and postoperative monitoring,as well as monitoring of the therapeutic effect.Using a panel of tumor markers for RC outcome prediction is a practical approach.AIM To assess the predictive effect of pre-neoadjuvant chemoradiotherapy(NCRT)CEA and CA19-9 levels on the prognosis of stage II/III RC patients.METHODS CEA and CA19-9 levels were evaluated 1 wk before NCRT.According to the receiver operating characteristic curve analysis,the optimal cut-off point of CEA and CA19-9 levels for the prognosis were 3.55 and 19.01,respectively.The novel serum tumor biomarker(NSTB)scores were as follows:score 0:Pre-NCRT CEA3.55 and CA19-9>19.01;score 1:Other situations.Pathological information was recorded according to histopathological reports after the operation.RESULTS In the univariate analysis,pre-NCRT CEA<3.55[P=0.025 for overall survival(OS),P=0.019 for disease-free survival(DFS)],pre-NCRT CA19-9<19.01(P=0.014 for OS,P=0.009 for DFS),a lower NSTB score(0-1 vs 2,P=0.009 for OS,P=0.005 for DFS)could predict a better prognosis.However,in the multivariate analysis,only a lower NSTB score(0-1 vs 2;for OS,HR=0.485,95%CI:0.251-0.940,P=0.032;for DFS,HR=0.453,95%CI:0.234-0.877,P=0.019)and higher pathological grade,node and metastasis stage(0-I vs II-III;for OS,HR=0.363,95%CI:0.158-0.837,P=0.017;for DFS,HR=0.342,95%CI:0.149-0.786,P=0.012)were independent predictive factors.CONCLUSION The combination of post-NCRT CEA and CA19-9 was a predictive factor for clinical stage II/III RC patients receiving NCRT,and the combined index had a stronger predictive effect.

关键词： Rectal cancer Neoadjuvant chemoradiotherapy Scoring system Carcinoembryonic antigen Carbohydrate antigen 19-9 Predictive

鼠伤寒沙门菌PipD蛋白结构及抗原表位的生物信息学分析

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医学信息 2024年第4期37卷 1-7页

作者：宋晓蕊刘玉春丁聪贾蕊李瑞静马嘉悦李利锋郑州大学附属儿童医院河南省儿童感染性疾病国际联合实验室郑州大学附属儿童医院耳鼻咽喉头颈外科

目的用生物信息学方法预测分析沙门菌PipD蛋白的结构和抗原表位，为沙门菌相关疾病的诊疗和疫苗的研发提供理论依据。方法通过NCBI数据库获得沙门菌典型致病血清型：鼠伤寒沙门菌（Salmonella typhimurium）ATCC 14028S标准菌株STM14... 详细信息

目的用生物信息学方法预测分析沙门菌PipD蛋白的结构和抗原表位，为沙门菌相关疾病的诊疗和疫苗的研发提供理论依据。方法通过NCBI数据库获得沙门菌典型致病血清型：鼠伤寒沙门菌（Salmonella typhimurium）ATCC 14028S标准菌株STM14＿1240基因的核苷酸序列及其编码蛋白PipD的氨基酸序列，运用ProtParam、ProtScale、SignalP 4.1 Server、TMHMM Serverv.2.0、Netphos 3.1 Server、NetNGlyc-1.0、NCBI BLAST、SOMPA、SWISSMODEL、ABCpred、SYFPEITHI和UniProt等生物信息学工具分别对鼠伤寒沙门菌PipD蛋白的理化性质、亲疏水特性、信号肽、跨膜区、磷酸化位点、糖基化位点、结构域、二级结构、三级结构、B细胞抗原表位、T细胞抗原表位及蛋白同源性进行预测分析。结果 PipD是由520个氨基酸组成的亲水蛋白，分子式为C2608H3963N721O780S16，理论相对分子质量为58.4 kDa，理论等电点为7.34，脂溶指数为67.81，平均亲水系数为-0.508。PipD蛋白无信号肽序列，在其35～57氨基酸残基位置含1个长度为23个氨基酸的跨膜螺旋，属于跨膜蛋白。预测PipD蛋白含有57个磷酸化位点和1个糖基化位点。PipD蛋白二级结构以无规则卷曲居多，占36.35%，其次为α螺旋、β折叠、β转角分别占15.77%、3.27%、44.62%。预测PipD蛋白可形成22个B细胞优势抗原表位，17个CTL细胞优势表位和30个Th细胞优势表位。PipD蛋白与人类基因BCLA3、SCRN2和MRPL4的编码蛋白同源性分别为29%、24.6%和31.8%，同源性较低。结论 PipD蛋白为亲水蛋白，热稳定性好；存在多个B细胞和T细胞抗原表位，与人类宿主蛋白同源性低，不易发生交叉免疫反应，可作为鼠伤寒沙门菌血清学诊断和疫苗候选蛋白。

关键词：鼠伤寒沙门菌 PipD 生物信息蛋白结构抗原表位

Non-synchronous bulk photovoltaic effect in two-dimensional interlayer-sliding ferroelectrics

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npj Computational Materials 2022年第1期8卷 1328-1335页

作者： rui-Chun xiao Yang Gao Hua Jiang Wei Gan Changjin Zhang Hui Li Institute of Physical Science and Information Technology and Information Materials and Intelligent Sensing Laboratory of Anhui Province Anhui UniversityHefei230601China Department of Physics University of Science and Technology of ChinaHefei230026China School of Physical Science and Technology Soochow UniversitySuzhou215006China High Magnetic Field Laboratory Chinese Academy of SciencesHefei230031China

Spontaneous polarization and bulk photovoltaic effect(BPVE)are two concomitant physical properties in ferroelectric materials.The flipping of ferroelectric order usually accompanies the switching of BPVE in all directions because both of them are reversed under the inversion symmetry.In this study,we report the non-synchronous BPVE in two-dimensional(2D)interlayer-sliding ferroelectric materials featuring unswitchable in-plane BPVE(light-induced photocurrent in the xy plane)and switchable out-of-plane BPVE(light-induced polarization along the z-direction).Symmetry analysis within the abstract bilayer crystal model and first-principles calculations validate these BPVE properties.It is because the positive and negative ferroelectric states caused by interlayer sliding are related by mirror symmetry which cannot flip all the BPVE tensor elements.This finding extends the understanding of the relationship between ferroelectricity and BPVE.On one hand,the switchable out-of-plane BPVE can be used to design switchable photoelectric devices.On the other hand,the in-plane BPVE is robust against the ferroelectric flipping,and the unswitchable character is beneficial to construct larger-scale photoelectric devices.

关键词： polarization ferroelectric interlayer

Numerical simulation of multi-scale cavitating flow with special emphasis on the influence of vortex on micro-bubbles

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Journal of Hydrodynamics 2022年第6期34卷 1032-1043页

作者： Ming-zhe Zhou Zi-yang Wang xiao-rui Bai Huai-yu Cheng Bin Ji State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan430072China

A multi-scale Euler-Lagrange method is applied in the current paper to investigate the characteristics of turbulent cloud cavitating flow around a Clark-Y hydrofoil,in which macroscopic cavitating structures are simulated by volume of fluid(VOF)approach,while micro-scale bubbles are modelled based on Rayleigh-Plesset equation and bubble motion equation.The numerical results are in reasonable agreement with the available experiments,and the transition between multi-scale structures is captured clearly.The evolution of microscopic bubble behaviors is statistically investigated.During one typical cycle,numbers and Sauter mean radius of the bubbles show a similar variation tendency which both sharply spike to their maxima after the breakup of the sheet cavity,and then decrease continuously to their minima before the next breakup.Discrete bubbles are mainly concentrated at the tail of the attached cavity,in front of the cloud cavity and in the region quite close to the hydrofoil suction side.Furthermore,vortices are extracted to account for the micro-scale hydrodynamics.It is found that intense vortices aggravate turbulence fluctuation,thus spalling cavity to generate massive micro bubbles.Meanwhile,the vortices provide microscopic bubbles low pressure and detain them so that numerous bubbles are able to grow.These effects are remarkable after the breakup of attached sheet cavity,owing to the violent vortices generated.On the contrary,when sheet cavity develops,the flow field becomes comparatively stable since the strong vortices travel downstream.Few micro-scale bubbles are produced,and their volume is generally small.

关键词： Cloud cavitation Euler-Lagrange method bubble-vortex interaction bubble dynamics

DCE-MRI血流动力学参数在高、低级别胶质瘤鉴别中的应用及其与分子生物学标记物水平的相关性

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川北医学院学报 2024年第2期39卷 177-181页

作者：李建丽张晓瑞李莹邯郸市中心医院CT/MR室河北邯郸056001

目的:探讨动态增强磁共振成像(DCE-MRI)血流动力学参数在高、低级别胶质瘤鉴别中的应用,分析其与分子生物学标记物水平的相关性。方法:选取86例脑胶质瘤患者为研究对象。以病理结果作为金标准,按WHO肿瘤分类标准,将其分为低级别组(n=41... 详细信息

目的:探讨动态增强磁共振成像(DCE-MRI)血流动力学参数在高、低级别胶质瘤鉴别中的应用,分析其与分子生物学标记物水平的相关性。方法:选取86例脑胶质瘤患者为研究对象。以病理结果作为金标准,按WHO肿瘤分类标准,将其分为低级别组(n=41)、高级别组(n=45),获得常规和动态增强MRI扫描参数数值,通过受试者工作特征曲线(ROC)分析DCE-MRI血流动力学参数对高、低级别胶质瘤的鉴别价值,Pearson分析各血流动力学参数与癌组织分子生物学标志物的相关性。结果:高级别组DCE-MRI血流动力学参数Ktrans、Kep、Ve水平均高于低级别组(P0.05);DCE-MRI血流动力学参数Ktrans、Kep、Ve联合检测鉴别高、低级别脑胶质瘤ROC曲线下面积(AUC)为0.927,高于单独检测AUC(0.822、0.803、0.785),敏感度为91.11%、特异度为80.49%(P<0.05);高级别组脑胶质瘤分子生物学标记物VEGF mRNA、Ki-67 mRNA表达水平高于低级别组(P<0.05);Pearson相关性分析显示,脑胶质瘤DCE-MRI血流动力学参数Ktrans、Kep、Ve水平与癌组织VEGF mRNA、Ki-67 mRNA表达水平正相关(r=0.522、0.415、0.323、0.483、0.376、0.274,P<0.05)。结论:高级别脑胶质瘤DCE-MRI血流动力学参数Ktrans、Kep、Ve水平均高于低级别胶质瘤,且与癌组织分子生物学标记物VEGF、Ki-67表达水平正相关,可用于临床高、低级别脑胶质瘤鉴别。

关键词：脑胶质瘤病理分级动态增强磁共振成像分子生物学标记物

“一带一路”沿线国家金融市场对我国金融市场的影响研究——基于制度环境差异的调节效应

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哈尔滨学院学报 2024年第1期45卷 30-35页

作者：唐自元王小蕊孙德皓厦门理工学院经济与管理学院福建厦门361024 厦门大学管理学院福建厦门361012 厦门工学院商学院福建厦门361021

文章以2011—2020年中国上证指数与六个签署“一带一路”合作谅解备忘录国家股票市场周收益率的面板数据为样本,通过建立多元回归模型分析了“一带一路”沿线主要国家金融市场对我国金融市场的影响。结果显示:(1)“一带一路”合作备忘... 详细信息

文章以2011—2020年中国上证指数与六个签署“一带一路”合作谅解备忘录国家股票市场周收益率的面板数据为样本,通过建立多元回归模型分析了“一带一路”沿线主要国家金融市场对我国金融市场的影响。结果显示:(1)“一带一路”合作备忘录签署以来,沿线各主要国家的金融市场对我国金融市场的影响显著增强;(2)通过建立制度距离指数发现,以政府效率、公众市场话语权和金融市场监管质量为代表的综合监督体系差异对金融市场的影响有显著负向调节作用,即与我国监督体系差异越小的国家对我国的金融市场影响更强。

关键词： “一带一路” 金融风险传染制度距离监督体系

血清同型半胱氨酸与颅内动脉斑块易损特征和负荷的关系

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河北医科大学学报 2024年第6期45卷 646-653页

作者：严雪娇施笑蕊汤敏高洁张小玲李玲陕西省人民医院MRI室陕西西安710068

目的利用高分辨血管壁成像评估同型半胱氨酸水平与颅内症状性斑块中易损特征和负荷之间的关系。方法选取因脑缺血症状接受颅脑高分辨血管壁成像检查的118例患者。根据血清同型半胱氨酸病理生理水平将分为高同型半胱氨酸(high homocyst... 详细信息

目的利用高分辨血管壁成像评估同型半胱氨酸水平与颅内症状性斑块中易损特征和负荷之间的关系。方法选取因脑缺血症状接受颅脑高分辨血管壁成像检查的118例患者。根据血清同型半胱氨酸病理生理水平将分为高同型半胱氨酸(high homocysteine, HHcy)组(Hcy>15μmol/L),正常同型半胱氨酸(normal homocysteine, NHcy)组(Hcy≤15μmol/L)。获取患者颅内症状性斑块的面积、狭窄程度、重塑率、标准化管壁指数(normalized wall index, NWI)以及斑块内存在的易损特征,包括对比增强、斑块内出血(intracranial hemorrhage, IPH)、表面不规则或阳性重塑。根据每个斑块中易损特征的数量作为易损负荷并进行分级。采用Logistic回归模型和Spearman相关分析评价同型半胱氨酸水平与斑块易损特征及负荷的关系。结果在调整人口统计学、血管危险因素和斑块测量指标后,高同型半胱氨酸水平是颅内症状性斑块IPH[校正比值比(OR)=3.051,95%CI:1.065~8.738,P=0.038]和表面不规则性(校正OR=2.745,95%CI:1.024~7.363,P=0.045)的独立预测因子。血清同型半胱氨酸浓度与症状性斑块易损负荷呈正相关(r=0.524,P<0.001)。结论同型半胱氨酸水平升高与缺血性患者颅内斑块的IPH和表面不规则独立相关,并可能在颅内斑块易损负荷中起作用。

关键词：颅内动脉硬化同型半胱氨酸磁共振成像

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基于局部回归模型的森林生物量动态变化分析

西南林业大学学报（自然科学） 2024年第3期44卷 148-156页

作者：卢士欣贾炜玮孙毓蔓张小勇吴思敏肖锐东北林业大学林学院森林生态系统可持续经营教育部重点实验室黑龙江哈尔滨150040 黑龙江省林业科学研究所黑龙江哈尔滨150040

基于丰林县地区4期Landsat影像和对应气象站点数据,结合该地区248块固定样地数据,利用全局回归模型(多元线性模型)和2种局部回归模型(地理加权回归模型、时空地理加权回归模型)建立研究区乔木地上生物量和遥感因子之间的关系,选出最优... 详细信息

基于丰林县地区4期Landsat影像和对应气象站点数据,结合该地区248块固定样地数据,利用全局回归模型(多元线性模型)和2种局部回归模型(地理加权回归模型、时空地理加权回归模型)建立研究区乔木地上生物量和遥感因子之间的关系,选出最优模型来研究丰林县乔木地上生物量时空变化。结果表明:根据3种模型的模拟结果数据与实测值的分析对比可以发现,局部回归模型的拟合效果要优于全局模型,加入时间特征的时空地理加权回归模型的拟合效果最好,模型评价指标与地理加权回归模型相比更为理想。统计得到研究区4个时期内总的乔木地上生物量分别为1.63×10^(7)、2.05×10^(7)、2.32×10^(7)、3.37×10^(7)t,4个时期的平均乔木地上生物量分别为54.82、68.98、77.87、113.46 t/hm2,乔木地上生物量呈现出逐期增加的趋势。利用遥感因子估测丰林地区的地上生物量,为未来该地区生物量分布的估计提供了依据。

关键词：时空地理加权回归模型地上生物量时空动态变化遥感估算

A Study of Detecting Student Engagement Modes in an Online Learning Platform

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Frontiers of Education in China 2022年第1期17卷 23-45页

作者： xiao rui LIU Qianhui SHANG Junjie HUANG Win-bin Learning Science Laboratory Graduate School of EducationPeking UniversityBeijing 100871China Department of Information Management Peking UniversityBeijing 100871China

In this paper,we used the platform log data to extract three features(proportion of passive video time,proportion of active video time,and proportion of assignment time)aligning with different learning activities in the Interactive-Constructive-Active-Passive(ICAP)framework,and applied hierarchical clustering to detect student engagement modes.A total of 840 learning rounds were clustered into four categories of engagement:passive(n=80),active(n=366),constructive(n=75)and resting(n=319).The results showed that there were differences in the performance of the four engagement modes,and three types of learning status were identified based on the sequences of student engagement modes:difficult,balanced and easy.This study indicated that based on the ICAP framework,the online learning platform log data could be used to automatically detect different engagement modes of students,which could provide useful references for online learning analysis and personalized learning.

关键词： online learning platform online learning student engagement Interactive-Constructive-Active-Passive(ICAP)framework hierarchical clustering learning analytics log analysis