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EGCG inhibits cardiomyocyte apoptosis in pressure overload-induced cardiac hypertrophy and protects cardiomyocytes from oxidative stress in rats

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Acta Pharmacologica Sinica 2007年第2期28卷 191-201页

作者： rui sheng~(2,3,4) zhen-iun gu~(2,3,4) mei-lin xie wen-xuan zhou~3 ci-yi guo~32 department of pharmacology,medical school of soochow university suzhou 215123 3 suzhou Institute of Chinese Materia Medica,suzhou 215007 China departmentofpharmacology MedicalSchoolofSoochowUniversitySuzhou215123 suzhouInstituteofChineseMateriaMedica Suzhou215007China

Aim:To investigate the effects of epigallocatechin gallate（EGCG）on pressureoverload and hydrogen peroxide（H2O2）induced cardiac myocyte ***:Cardiac hypertrophy was established in rats by abdominal *** 25,50 and 100 mg/kg were administered intragastrically（ig）.Cultured newborn rat cardiomyocytes were preincubated with EGCG,and oxida-tive stress injury was induced by ***:In cardiac hypertrophy inducedby AC in rats,relative to the model group,EGCG 25,50 and 100 mg/kg ig for 6weeks dose-dependently reduced systolic blood pressure（SBP）and heart weightindices,decreased malondialdehyde（MDA）content,and increased superoxidedismutase（SOD）and glutathione peroxidase（GSH-PX）activity,both in serumand in the ***,treatment with EGCG 50 and 100 mg/kg markedlyimproved cardiac structure and inhibited fibrosis in HE and van Gieson（VG）stain,and reduced apoptotic myocytes in the hypertrophic myocardium detected byterminal transferase-mediated dUTP-biotin nick end-labeling（TUNEL）*** Western blot analysis,EGCG significantly inhibited pressure overload-inducedp53 increase and bcl-2 *** H2O2-induced cardiomyocyte injury,whenpreincubated with myocytes for 6-48 h,EGCG 12.5-200 mg/L increased cell viabil-ity determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide（MTT）*** also attenuated H2O2-induced lactate dehydrogenase（LDH）release and MDA formation,Meanwhile,EGCG 50 and 100 mg/L significantlyinhibited the cardiomyocyte apoptotic rate in flow ***:EGCGinhibits cardiac myocyte apoptosis and oxidative stress in pressure overload in-duced cardiac ***,EGCG prevented cardiomyocyte apoptosisfrom oxidative stress in *** mechanism might be related to the inhibitoryeffects of EGCG on p53 induction and bcl-2 decrease.

关键词： epigallocatechin gallate hypertrophy apoptosis oxidative stress cardiac myocytes

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Expert consensus on the monitoring and treatment of sepsis-induced immunosuppression

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Military medical Research 2023年第3期10卷 281-298页

作者： Fei Pei Ren‑Qi Yao Chao Ren Soheyl Bahrami Timothy RBilliar Irshad HChaudry De‑Chang Chen Xu‑lin Chen Na Cui Xiang‑Ming Fang Yan Kang Wei‑Qin Li wen‑Xiong Li Hua‑Ping Liang Hong‑Yuan lin Ke‑xuan Liu Ben Lu Zhong‑Qiu Lu Marc Maegele Tian‑Qing Peng You Shang Lei Su Bing‑Wei Sun Chang‑Song Wang Jian Wang Jiang‑Huai Wang Ping Wang Jian‑Feng xie Li‑Xin xie Li‑Na Zhang Basilia Zingarelli Xiang‑Dong guan Jian‑Feng Wu Yong‑Ming Yao department of Critical Care Medicine the First Affiliated Hospital of Sun Yat-Sen University58 Zhongshan Er RoadYuexiu DistrictGuangzhou 510080GuangdongChina Translational Medicine Research Center Medical Innovation Research Division and Fourth Medical Center of the Chinese PLA General Hospital28 Fuxing RoadHaidian DistrictBeijing 100853China department of Burn Surgery the First Affiliated Hospital of Naval Medical UniversityShanghai 200433China Ludwig-Boltzmann Institute for Experimental and Clinical Traumatology 1200 ViennaAustria department of Surgery University of Pittsburgh Medical CenterPittsburghPA 15213USA Center for Surgical Research and department of Surgery University of Alabama at BirminghamBirminghamAL 35294USA department of Critical Care Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghai 200025China department of Burns the First Affiliated Hospital of Anhui Medical UniversityHefei 230022China department of Critical Care Medicine Peking Union Medical College HospitalChinese Academy of Medical Science and Peking Union Medical CollegeBeijing 100730China department of Anesthesiology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 31003China department of Critical Care Medicine West China Hospital of Sichuan UniversityChengdu 610041China department of Critical Care Medicine General Hospital of Eastern Theater Command of Chinese PLANanjing 210002China department of Surgical Intensive Critical Unit Beijing Chao‑Yang HospitalCapital Medical UniversityBeijing 100020China State Key Laboratory of Trauma Burns and Combined InjuryResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China department of Critical Care Medicine Fourth Medical Center of the Chinese PLA General HospitalBeijing 100048China department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China department of Critical Care Medicine and Hematology the Third Xiangya HospitalCentral South UniversityChangs

Emerged evidence has indicated that immunosuppression is involved in the occurrence and development of *** provide clinical practice recommendations on the immune function in sepsis,an expert consensus focusing on the monitoring and treatment of sepsis-induced immunosuppression was *** related to the immune monitoring and treatment of sepsis were retrieved from PubMed,Web of Science,and Chinese National Knowledge Infrastructure to design items and expert opinions were collected through an online ***,the Delphi method was used to form consensus opinions,and RAND appropriateness method was developed to provide consistency evaluation and recommendation levels for consensus *** consensus achieved satisfactory results through two rounds of questionnaire survey,with 2 statements rated as perfect consistency,13 as very good consistency,and 9 as good *** summarizing the results,a total of 14 strong recommended opinions,8 weak recommended opinions and 2 non-recommended opinions were ***,a face-to-face discussion of the consensus opinions was performed through an online meeting,and all judges unanimously agreed on the content of this *** summary,this expert consensus provides a preliminary guidance for the monitoring and treatment of immunosuppression in patients with sepsis.

关键词： Sepsis Immune function monitoring Immunomodulatory therapy Immunosuppression

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