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DNA Cleavage by Copper (Ⅱ) Complexes Without added Coreactants

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Chinese Chemical Letters 1999年第5期10卷 383-386页

作者： rui ren {2. yang Gao Yi HAN(Institute of coordination chemistry. state key laboratory of coordination chemistry.{12. university. nanjing 2.0093Institute of Molecular science. shanxi university. taiyuan 030006) Institute of coordination {2. State Key Lab. of Coord. Chemistry Nanjing University Nanjing 210093 China Institute of Molecular science Shanxi University Taiyuan 030006 China

The cleavage activity of complexes between copper (Ⅱ) and four different amino acidor amino acid methyl ester on DNA was tested at physioloical pH and temperature., It was found that Cu (Ⅱ)-L-His and Cu (Ⅱ)-L-His methyl ester complexes could cleane DNA. The extent ofDNA cleavage is largely dependent on the metal ion-to-ligand ratio. The cleavage of doublestranded DNA mediated by Cu (Ⅱ)-L-His complexes occurs via a hydrolytie mechanism.

关键词： Copper (Ⅱ) complexes DNA hydrolytic cleavage

Studies　on　the　Binding　of　Tris(1,10-phenanthroline)　Nickel(Ⅱ)　to　Calf　Thymus　DNA

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Chemical Research in Chinese Universities 1997年第3期13卷 201-206页

作者： JIN Lan , yang pin . . and LI Qing-shan ({2. key laboratory of coordination chemistry, nanjing university , Nnjing 2. 0093 ) yang Bin-sheng (Institute of Molecular science , shanxi university , {12. , 030006 )

Absorbance and fluorescence methods were used to study the interaction of - and A-tris (phenanthroline) nickel ( Ⅱ) complex with calf thymus DNA. It was con- cluded that -Ni(phen). preferentially bound to DNA. Especially the fluorescence Scatchard plots were discussed for the binding of EthBr to calf thymus DNA in the presence of varying concentrations of the metal complex. Theses studies indicated that both the isomers bound to DNA by two acting types , namely , intercalative and electrostatic bound modes.

关键词： Chiral metal complexe DNA . Binding mode

Synthesis and Structure of the Copper(I) Complex Containing Bis(diphenylphosphino)ethane

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Chinese Journal of Structural chemistry 2002年第1期21卷 51-54页

作者： LIN Kun-Hua1,2.XIE Qing1 yang rui-Na1② XING Li-{2.g1 JIN Dou-Man3 (1Henan Institute of chemistry, Zhengzhou 450002. China) (2.hengzhou university, Zhengzhou 450006, China) (3state key laboratory of coordination chemistry, nanjing university {12., Chin Henan Institute of chemistry Zhengzhou 450002 配位化学国家重点实验室配位化学国家重点实验室 Nanjing 210093

The mononuclear copper(I) complex, [Cu(dppe)2.(PF6)(CH3COCH3) [dppe = bis-(diphenylphosphino)ethane] has been synthesized and characterized by X-ray crystallography. The crystal belongs to monoclinic, Mr=1062.3, space group P2./n with cell parameters a =14.741(2., b =19.354(8), c =18.587(3) ? = 91.41(1)°, V = 5301.5 3, Z = 4, Dc=1.302.g/cm3, F(000)= 2.00, = 6.16cm-1, R=0.062. Rw = 0.068. A total of 9679 independent reflections were collected, of which 4574 reflections with I >3σ(I) were observed. The central Cu atom is coordinated by four P atoms from dppe to form a distorted tetrahedral environment. In the coordination sphere the bond lengths of CuP(1), CuP(2., CuP(3) and CuP(4) are 2.2.8(2., 2.305(2., 2.311(2. and 2.2.5? respectively; and the PCuP bond angles vary from 87.52.9) to 12..12.9)?

关键词： copper complex crystal structure synthesis

Crystal and Molecular Structure of Copper（Ⅰ） Complex 〔Cu（PPh3）2.NO3）〕

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Chinese Journal of Structural chemistry 2000年第2期19卷 126-130页

作者： yang rui Na * LI Tian Xian SUN Yu An 1 HU Xiao Yuan JIN Dou Man LUO Bao Sheng 2.(Henan I{2. of chemistry, Zhengzhou 450003) (state key laboratory of coordination chemistry, nanjing university 2.0093) 1(Zhengzhou I{2. of 河南省化工所河南郑州 450 0 0 3 郑州轻工业学院河南郑州 450 0 0 1 南京大学配位化学国家重点实验室江苏南京 2 1 0 0 93 武汉大学湖北武汉 470 0 53

Mononuclear copper(Ⅰ) complex 〔Cu(PPh 3) 2.NO 3)〕 has been synthesized by ligand reduction of cupric nitrate with PPh 3 in methanol and characterized by elemental analyses, molecular weight determination, IR spectra and X ray single crystal analysis; its molar conductivity has also been measured. The crystal is monoclinic, space group C2.c, a=2..52.5), b=9.187(2., c=15.489(3) ; β=116.69(3)°, V=3118.7(11) 3, Z=4, F(000) =152., D c =1.584 g/cm 3, R=0.02.6, R w =0.032.. The results show that PPh 3 coordinates as a monodentate ligand to the Cu(Ⅰ) atoms, and (NO 3) behaves as a bidentate ligand in the prepared complex.

关键词： reduction copper crystal structure

Efficient DNA Cleavage by Copper(Ⅱ) Complex Derived from 1, 1′-Dimethyl-2. 2.-biimidazole Ligand

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Chinese Chemical Letters 2005年第10期16卷 1397-1400页

作者： rui Li SANG pin {2. Institute of Molecular science Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University Taiyuan 030006

The cleavage of DNA （pBR32.） by [Cu（Dime-biim）2.H2.）]（ClO4）2.（Dime-biim=1, 1＇- dimethyl-2. 2.-biimidazole） was investigated. The results showed that the complex could cleave DNA efficiently at pH=8.0 and 3... 详细信息

关键词： Copper(Ⅱ) complex DNA efficient cleavage biimidazol derivative.

Rapid, Catalytic Hydrolysis of DNA by Copper(Ⅱ) Complexes

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Chemical Research in Chinese Universities 1999年第2期15卷 104-107页

作者： ren rui {2. pin GAO Dong Institute of coordination {2. State Key Laboratory of Coordination ChemistryNanjing UniversityNanjing210093 Institute of Molecular science Shanxi UniversityTaiyuan030006

ＩｎｔｒｏｄｕｃｔｉｏｎＮｕｃｌｅａｓｅｓｗｈｉｃｈｃａｔａｌｙｚｅｔｈｅｈｙｄｒｏｌｙｔｉｃｃｌｅａｖａｇｅｏｆｔｈｅｐｈｏｓｐｈｏｄｉｅｓｔｅｒｂａｃｋｂｏｎｅｏｆＤＮＡａｎｄＲＮＡｐｌａｙａｎｉｍｐｏｒｔａｎｔ... 详细信息

ＩｎｔｒｏｄｕｃｔｉｏｎＮｕｃｌｅａｓｅｓｗｈｉｃｈｃａｔａｌｙｚｅｔｈｅｈｙｄｒｏｌｙｔｉｃｃｌｅａｖａｇｅｏｆｔｈｅｐｈｏｓｐｈｏｄｉｅｓｔｅｒｂａｃｋｂｏｎｅｏｆＤＮＡａｎｄＲＮＡｐｌａｙａｎｉｍｐｏｒｔａｎｔｒｏｌｅｉｎｔｈｅｍｏｌｅｃｕｌａ...

关键词： Copper complex DNA Cleavage efficiency

Identification of the highly active Zn-N4 sites with pyrrole/pyridine-N synergistic coordination by dz2.s-band center for electrocatalytic H2.2.production

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Journal of Energy chemistry 2024年第11期 105-113页

作者： rui Chen Wei Liu Zhiyuan Sang Jingjing Jia Zhenxin Li Jiahuan Nie Qiao Jiang Zixian Mao Baitong Guo Qiuying Wang Feng Hou Lichang Yin De'an yang Ji Liang key laboratory of Advanced Ceramics and Machining Technology of Ministry of Education School of Materials {2. and Engineering Tianjin University Shenyang National laboratory for Materials {2. Institute of Metal Research Chinese Academy of Science

Single metal atoms anchored on nitrogen-doped carbon materials（M-N4） have been identified as effective active sites for catalyzing the two-electron oxygen reduction reaction（2.-ORR）.However,the relationship between the local atomic/electronic environments of the M-N4sites（metal atoms coordinated with different types of N species） and their catalytic activity for 2.-ORR has rarely been elaborated clearly,which imposes significant ambiguity for the rational design of ***,guided by the comprehensive density-functional theory calculations and predictions,a series of Zn-N4single-atom catalysts（SACs） are designed with pyrrole/pyridine-N(NPo/NPd) synergistic coordination and prepared by controlling the pyrolysis temperature（600,700,and 800℃）,Among them,the dominated Zn-N4configurations with rationally combined NPo/NPdcoordination show*OOH adsorption strength close to the optimal value,much superior to those with mono N ***,the as-prepared catalyst exhibits a high H2.2.electivity of over 90% both in neutral and alkaline environments,with a superb H2.2.ield of up to 33.63 mol g-1h-1in an alkaline with flow *** importantly,a new descriptor,dz2.s band center,has been proposed,which is especially feasible for predicting the activity for metal types with fully occupied s and d *** work thus presents clear guidance for the rational design of highly active SACs toward ORR and provides a complement to the d-band theory for more accurately predicting the catalytic activity of the materials.

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Synthesis, structure and characterization of binuclear copper(Ⅱ) complexes

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Chinese Journal of chemistry 1997年第1期15卷 76-83页

作者： yang, rui-Na XUE, Bao-Yu WANG, Dong-Mei JIN, Dou-Man Henan I{2. of chemistry, Zhengzhou, Henan 450003, ChinaCHEN, Jun LI, Ming-Xing Department of chemistry, Fudan university, Shanghai 2.0433, China

At room temperature, dibenzoyl peroxide undergoes oxidative addition reaction with metallic copper powder and pyridine N-oxide (triphenylphosphine oxide or 2.9-dimethyl-4,7-diphenyl-1,10-phenanthrolin) which affords the last products as binuclear copper(II) complexes, [Cu(C5H5NO)-(C6H5COO)2.2.1), [Cu(OPPh3)(C6H5COO)2.2.2. and [Cu(C6H5COO)(C2.H2.N2.](3, C2.H2.N2.is 2.9-dimethyl-4,7-diphenyl-1,10-phenanthrolin). The structure of the complexes were characterized by elemental analyses, IR spectra, TG-DTA and magnetic property. Crystals(1) are triclinic, space group P1,a=0.92.17(36),b=1.06973(17), c=1.08813(2.) nm, a=59.60(2.°, β=74.83(3)°,γ=72.80(2.°, V=0.880 nm3, Dc=1.52. g/cm3, Z=1, R=0.044, Rw=0.048, Mr=805.78, 3477 reflections with I > 3σ(I). Each copper(Ⅱ) ion is coordinated by two bridging bidentate benzoate ligands and one pyridine N-oxide or triphenylphosphine oxide to form dimeric binuclear molecules. The structure of the compound(1) shows a clear centre of symmetry.

关键词： Copper binuclear complex oxidative addition

Functionalize d 3D-printe d porous titanium scaffold induces in situ vascularized bone regeneration by orchestrating bone microenvironment

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Journal of Materials science & Technology 2023年第22期153卷 92-105页

作者： Bo Yuan pin Liu rui Zhao Xiao {2. Zhanwen Xiao Kai Zhang Xiangdong Zhu Xingdong Zhang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Biomedical Engineering Sichuan UniversityChengdu 610064China

Titanium(Ti)and its alloys have been extensively explored for treating load-bearing bone ***-ever,high-stress shielding,weak osteogenic activity,and insufficient vascularization remain key chal-lenges for the long-term clinical outcomes of Ti-based ***,inspired by structural and func-tional cues of bone regeneration,a silicon-doped nano-hydroxyapatite(nSiHA)/titanium dioxide(TiO_(2.)composite coating with a hierarchical micro/nano-network structure is constructed on the surface of a 3D-printed porous Ti scaffold via a combined strategy of acid-alkali(AA)treatment and electrochemi-cal deposition technique,which not only endows the scaffold with excellent osteoinduction ability but can also effectively immobilize and release vascular endothelial growth factor(VEGF).The results of the in vitro cell experiments show that the functionalized Ti scaffold significantly promotes osteogenesis in bone marrow mesenchymal stem cells(BMSCs)and angiogenesis in human umbilical vein endothelial cells(HUVECs)by activating the extracellular signal-regulated protein kinase(ERK)and HIF-1αsignaling *** being implanted into a rat femoral condyle defect model,the functionalized Ti scaffold can induce in situ vascularized bone regeneration by orchestrating the two coupled processes of angio-genesis and *** findings indicate that the functionalized Ti scaffold has great potential in bone tissue regeneration and is a promising candidate for load-bearing bone defect repair.

关键词： Porous titanium 3D-printing Hierarchical micro/nano-structure Bone microenvironment Vascularization Bone regeneration