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Anabolic steroid-induced cardiomyopathy underlying acute liver failure in a young bodybuilder

World Journal of Gastroenterology 2009年第23期15卷 2920-2922页

作者： Miguel Bispo Ana Valente Rosário Maldonado rui palma Helena Glória Joo Nóbrega Paula Alexandrino Intensive Care Unit of Gastroenterology and Hepatology Santa Maria University Hospital 1069-166 Lisbon Portugal Department of Gastroenterology Egas Moniz Hospital 1349-019 Lisbon Portugal Coronary Care Unit Santa Maria University Hospital 1069-166 Lisbon Portugal

Heart failure may lead to subclinical circulatory disturbances and remain an unrecognized cause of ischemic liver injury. We present the case of a previously healthy 40-year-old bodybuilder, referred to our Intensive-Care Unit of Hepatology for treatment of severe acute liver failure, with the suspicion of toxic hepatitis associated with anabolic steroid abuse. Despite the absence of symptoms and signs of congestive heart failure at admission, an anabolic steroid-induced dilated cardiomyopathy with a large thrombus in both ventricles was found to be the underlying cause of the liver injury. Treatment for the initially unrecognized heart failure rapidly restored liver function to normal. To our knowledge, this is the f irst reported case of severe acute liver failure due to an unrecognized anabolic steroid-induced cardiomyopathy. Awareness of this unique presentation will allow for prompt treatment of this potentially fatal cause of liver failure.

关键词：肝功能衰竭蛋白合成类固醇心肌病急性健美充血性心力衰竭无法识别

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Size effect on the microstructure, phase transformation behavior, and mechanical properties of NiTi shape memory alloys fabricated by laser powder bed fusion

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Journal of Materials Science & Technology 2023年第26期157卷 200-212页

作者： Hao Jiang Xiebin Wang rui Xi Guichuan Li Huiliang Wei Jiangwei Liu Bo Zhang Sergey Kustov Kim Vanmeensel Jan Van Humbeeck Guoqun Zhao Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials(Ministry of Education) Shandong UniversityJinan 250061China Department of Materials Engineering University of Leuven(KU Leuven)Heverlee B3001Belgium School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Energy and Power Engineering Shandong UniversityJinan 250061China Shandong Institute of Medical Device and Pharmaceutical Packaging Inspection Jinan 250101China Departament de Física Universitat de les Illes BalearsCra Valldemossa km 7.5Palma de Mallorca E07122Spain

In this work,NiTi samples with different thicknesses(0.15-1.00 mm)were fabricated by laser powder bed fusion(LPBF)under variable scanning speeds(500-1200 mm s^(-1)).The densification behavior,phase transformation behavior,and mechanical properties of the sample with different thicknesses are *** results indicate a strong size effect in the LPBF-fabricated NiTi *** decrease of the sample thickness results in(i)the increase of porosity,(ii)the decrease of the number of adhered NiTi powder particles at the surface,(iii)the monotonous decrease of the martensitic transformation temperatures(MTTs),and(iv)the decrease of the shape recovery *** influence of sample thickness on the melt-pool behavior,and thus the microstructure and performance of NiTi alloys are *** is suggested that the melt-pool is deeper and narrower in the thin samples than in the thick *** conclude that,apart from the LPBF process conditions,the sample dimensions have also to be considered to fabricate NiTi structures with predictable properties.

关键词： Shape memory alloy NiTi Additive manufacturing Laser powder bed fusion Size effect

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大孔树脂对内生真菌Berkleasmium ***12中palmarumycins C_(12)和C_(13)积累的促进作用

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天然产物研究与开发 2015年第2期27卷 205-209,240页

作者：牟燕周开谊徐丹于瑞婷李京岳阳周立刚中国农业大学农学与生物技术学院北京100193

研究了3种大孔吸附树脂D3520、DS-8和DM-301对内生真菌Berkleasmium ***12中螺二萘类化合物palmarumycins C12和C13积累的影响。3种树脂均显著促进palmarumycin C12产量的提高,仅树脂DM-301同时有利于palmarumycins C12和C13产量的提高,总产量中81.3%~95.8%的palmarumycin C12被大孔树脂吸附。当树脂DM-301以浓度4.17%(g/m L)于第9 d添加到内生真菌Dzf12培养液、共培养112 h后,palmarumycins C12和C13的产量分别达到122.72 mg/L和55.99 mg/L,分别为对照(2.19 mg/L和29.86 mg/L)的56.04倍和1.88倍。结果表明,在内生真菌Dzf12液体发酵培养中添加大孔吸附树脂能有效提高螺二萘类化合物palmarumycins C12和C13的产量。

关键词：内生真菌 Berkleasmium sp.Dzf12 螺二萘类化合物 palmarumycins C12和C13 大孔树脂代谢调控

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