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Function and biomedical implications of exosomal microRNAs delivered by parenchymal and nonparenchymal cells in hepatocellular carcinoma

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World Journal of Gastroenterology 2023年第39期29卷 5435-5451页

作者： Hai-Chen Wang Wen-xuan Yin meng Jiang Jia-Yi Han Xing-Wang Kuai rui Sun Yu-Feng Sun Ju-Ling Ji Department of Pathology Medical School of Nantong UniversityNantong 226001Jiangsu ProvinceChina Key Laboratory of Microenvironment and Translational Cancer Research Science and Technology Bureau of Nantong CityNantong 226001Jiangsu ProvinceChina Department of Pathology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu Province

Small extracellular vesicles(exosomes)are important components of the tumor *** are small membrane-bound vesicles derived from almost all cell types and play an important role in intercellular *** transmit biological molecules obtained from parent cells,such as proteins,lipids,and nucleic acids,and are involved in cancer ***(miRNAs),the most abundant contents in exosomes,are selectively packaged into exosomes to carry out their biological *** studies have revealed that exosome-delivered miRNAs play crucial roles in the tumorigenesis,progression,and drug resistance of hepatocellular carcinoma(HCC).In addition,exosomes have great industrial prospects in the diagnosis,treatment,and prognosis of patients with *** review summarized the composition and function of exosomal miRNAs of different cell origins in HCC and highlighted the association between exosomal miRNAs from stromal cells and immune cells in the tumor microenvironment and the progression of ***,we described the potential applicability of exosomal miRNAs derived from mesenchymal stem cells in the treatment of HCC.

关键词： Hepatocellular carcinoma MicroRNA Exosomes Extracellular vesicles Nonparenchymal cells

Contrast-enhanced ultrasound imaging for intestinal lymphoma

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World Journal of Gastroenterology 2021年第32期27卷 5438-5447页

作者： Ning-Yi Cui xuan-Tong Gong Yan-Tao Tian Yong Wang rui Zhang meng-Jia Liu Jie Han Bo Wang Di Yang Department of Ultrasound National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Ultrasound Fatou Community Health Service Center Chaoyang District BeijingBeijing 100023China Pancreatic and Gastric Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

BACKGROUND Intestinal lymphoma is a rare ***-enhanced ultrasound(CEUS)findings of intestinal lymphoma have not been reported previously,and the relationship between CEUS and clinicopathological features and prognostic factors is still *** To describe the B-mode US and CEUS features of intestinal lymphoma and investigate the correlation of CEUS and histopathological *** This was a single-center retrospective *** patients with histologically confirmed intestinal lymphoma underwent B-mode US and CEUS examinations between October 2016 and November *** summarized the features of Bmode US and CUES imaging of intestinal lymphoma and compared the frequency of tumor necrosis in intestinal lymphomas with reference to different pathological subtypes(aggressive or indolent)and clinical stage(early or advanced).The time–intensity curve parameters of CEUS were also compared between patients with normal and elevated serum lactate *** In B-mode imaging,four patterns were observed in intestinal lymphoma:Mass type(12/18,66.7%),infiltration type(1/18,5.6%),mesentery type(4/18,22.2%)and mixed type(1/18,5.6%).All cases were hypoechoic and no cystic areas were *** CEUS,most cases(17/18,94.4%)showed arterial hyperechoic *** cases showed arterial enhancement followed by venous wash out.A relatively high rate of tumor necrosis(11/18,61.1%)was observed in this *** necrosis on CEUS was more frequent in aggressive subtypes(10/13,76.9%)than in indolent subtypes(1/5,20.0%)(P=0.047).There were no correlations between tumor necrosis and lesion size and Ann Arbor *** was no significant difference in time–intensity curve parameters between normal and elevated lactate dehydrogenase *** B-mode US and CEUS findings of intestinal lymphoma are *** observed a high rate of tumor necrosis,which appeared more frequently in aggressive pathological subtypes of intestinal lymphoma.

关键词： Intestinal lymphoma Contrast enhanced ultrasound B-mode ultrasound Histopathological features Lactate dehydrogenase Quantitative diagnosis

复合膳食抗氧化指数与6~11岁儿童认知功能的相关性分析

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河北医科大学学报 2024年第10期45卷 1139-1148页

作者：温瑞裴焕婷乔思梦刘奕秋柳宣伊马玉霞河北医科大学公共卫生学院营养与食品卫生学教研室河北省环境与人群健康重点实验室河北石家庄050017

目的探讨膳食抗氧化指数(composite dietary antioxidant index,CDAI)与6~11岁儿童认知功能的关系。方法基于美国国家健康与营养调查的公开数据(National Health and Nutrition Examination Survey,NHANESⅢ),以及和英国利兹大学合作项目“中国儿童营养不良双重负担及其相关微量营养素缺乏的食物系统解决方案”收集的数据(简称中国数据),构建CDAI,采用多元Logistic回归模型分析6~11岁儿童CDAI水平和认知功能之间的关系。膳食调查分别采用24 h膳食回顾法和24 h膳食称重法,NHANESⅢ采用韦氏智力测验(Wechsler Intelligence Scale for Children,WICS)测试中的语言部分测试(Wide Range Achievement Test-Revised,WRAT-R)和表现测试(Wechsler Intelligence Scale for Children,WISC-R);中国数据采用基本认知能力测验(Primary Cognitive Abilities Test,PCAT)和WISC-R中的推理测试(perceptual reasoning,PR)。结果共纳入470名中国儿童和2968名美国儿童。在中国儿童中,男性224名,占47.70%,女性246名,占52.30%;在NHANESⅢ调查对象中,男性1494名,占50.30%,女性1474名,占49.7%。多元Logistics回归分析结果显示,在调整了性别、年龄、种族、体重指数、能量后,6~11岁儿童CDAI是工作记忆(working memory,WM)的影响因素(中国数据:OR=1.04,95%CI:1.00~1.20,P=0.047;NHANESⅢ:OR=1.13,95%CI:1.01~1.28,P=0.038);6~11岁儿童摄入的抗氧化剂中,维生素C、锌摄入量对WM的影响最为显著(中国数据:锌P=0.009,维生素C P=0.030;NHANESⅢ:维生素C P=0.040)。结论CDAI与儿童认知功能中的WM的影响因素,组成CDAI的各成分中,锌、维生素C的作用更加明显,研究结果提示通过提高膳食抗氧化营养素的摄入,可能会促进儿童工作记忆的发展。

关键词：复合膳食抗氧化指数认知儿童

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基于OpenFDA数据库的普拉格雷相关不良事件信号检测与分析

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中国药物应用与监测 2024年第1期21卷 63-67页

作者：侯梦雨尹航李江硕张美娟吴竞轩董瑞华首都医科大学附属北京友谊医院研究型病房北京100050

目的分析普拉格雷上市后药品不良事件(ADE)信号,为其临床安全合理用药提供依据。方法收集美国食品药品监督管理局公共数据开放项目(OpenFDA)数据库中普拉格雷上市后(2009年1月1日—2023年1月30日)的ADE报告,采用报告比数比法进行信号挖... 详细信息

目的分析普拉格雷上市后药品不良事件(ADE)信号,为其临床安全合理用药提供依据。方法收集美国食品药品监督管理局公共数据开放项目(OpenFDA)数据库中普拉格雷上市后(2009年1月1日—2023年1月30日)的ADE报告,采用报告比数比法进行信号挖掘,根据《国际医学用语词典》将各信号映射得到其对应的系统器官分类(SOC),并与药品说明书做出对比与分析。结果共提取普拉格雷相关ADE报告10872例,挖掘到涉及11类SOC的44项有效信号,其中23项为未被药品说明书记录的潜在不良反应信号。结论目前可认为普拉格雷的安全性较好,但需密切关注和评估普拉格雷临床使用过程中患者发生胃肠系统疾病、血管假性动脉瘤、心脏器官疾病与肾脏泌尿系统不良事件的风险。

关键词：普拉格雷药物不良事件信号挖掘

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地震波动方程的局部间断有限元方法数值模拟

地球物理学报 2013年第10期56卷 3507-3513页

作者：廉西猛张睿璇中国石油化工股份有限公司胜利油田分公司物探研究院山东东营257022

近年来,随着地震波数值模拟对计算精度和效率的要求越来越高,间断有限元方法开始受到越来越多的关注.本文中,针对具有吸收边界条件的二维地震声波波动方程,作者提出了一种基于局部间断有限元方法的数值模拟算法.该算法在空间上使用局部... 详细信息

近年来,随着地震波数值模拟对计算精度和效率的要求越来越高,间断有限元方法开始受到越来越多的关注.本文中,针对具有吸收边界条件的二维地震声波波动方程,作者提出了一种基于局部间断有限元方法的数值模拟算法.该算法在空间上使用局部间断有限元方法进行离散,在时间上采用了显式蛙跳格式.在这种时空离散的组合方式下,每个时间步上,此算法在空间剖分的每个单元上的求解计算是相互独立的,因而具有极高的并行性.通过数值算例,我们将该算法与连续有限元方法进行了比较.结果表明,本算法不仅具有对起伏构造的良好适应性,而且在计算效率和计算精度等方面,都具有优越性.

关键词：声波方程局部间断有限元方法数值模拟并行性计算效率精度

Collagen derived species-specific peptides for distinguishing donkey-hide gelatin(Asini Corii Colla)

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Chinese Herbal Medicines 2021年第2期13卷 261-266页

作者： Shuo Cai Ke-xuan Zhao meng-tong Jiang Shu-ying Han Yun-feng Zheng Xun Liu Ming Zhao Jin-ao Duan rui Liu National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing 210023China School of Pharmacy Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Key Laboratory of Research and Development in Marine Bio-resource Pharmaceutics Nanjing University of Chinese MedicineNanjing 210023China Suzhou Vocational Health College Suzhou 215009China

Objective:As an important food therapy product with traditional Chinese medicine(TCM) applications,donkey-hide gelatin(Asini Corii Colla,ACC) has been used for thousands of ***,till now few effective strategy had been proposed to distinguish ACC from other animal hide gelatins,especially closely related horse-and mule-hide gelatins,which was an embarrassment of ACC quality ***:Combined mass spectrometry and bioinformatic methods have been applied to identify and verify two ACC-specific peptides(Pep-1 and Pep-2) capable of distinguishing ACC from other closely related animal gelatins with high ***:It confirmed that these two peptides could be not only used for distinguishing ACC from highly homologous horse-hide and mule-hide gelatins as well as other animal hide ***:The present study provides a simple method for species-specific peptides discovery,which can be used for assessing the quality of animal gelatin products,and ensure they are authenticable and traceable.

关键词： Asini Corii Colla Biomarkers collagen peptidomics species-specific peptides

A reinvestigation of low molecular weight components in SOA produced by cyclohexene ozonolysis

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Nuclear Science and Techniques 2018年第11期29卷 238-246页

作者： Jun Chen Zhao-Hui Li Ye-Peng Yu xuan Lin Hang Zhang Yan-Bo Li Huan-Huan Wang rui-rui Sun Qing-Hui meng Chao-Qun Huang Xiao-Bin Shan Fu-Yi Liu Chang-Jin Hu Wei-Jun Zhang Liu-Si Sheng National Synchrotron Radiation Laboratory School of Nuclear Science and TechnologyUniversity of Science and Technology of China Laboratory Medical Optical and Mass Spectrometry Center of Medical Physics and TechnologyHefei Institutes of Physical ScienceChinese Academy of Sciences Laboratory of Atmospheric Physico-Chemistry Anhui Institute of Optics and Fine MechanicsChinese Academy of Sciences School of Environmental Science and Optoelectronic Technology University of Science and Technology of China

The ozonolysis of cyclohexene is an important model system for understanding the more complex reaction of O_3 with monoterpenes; however, many previous studies have come to qualitatively different conclusions about the composition of the secondary organic aerosol(SOA)formed in this system. In the present study, the composition of the SOA produced by cyclohexene ozonolysis in the absence of seed aerosols has been investigated online and off-line using synchrotron-based thermal desorption/tunable vacuum ultraviolet photoionization time-of-flight aerosol mass spectrometry(TD-VUV-TOF-PIAMS) in conjunction with a custom-built smog chamber. On the basis of the molecular ions observed by mass spectrometry at 11.5 e V, it was found that dicarboxylic acids, dialdehydes, and cyclic anhydrides are the predominant low molecular weight components in the particle phase. The results also indicated that TD-VUV-TOF-PIAMS coupled with filter sampling is a potentially useful tool for the investigation of SOA composition both in the field and in the laboratory.

关键词： Cyclohexene Ozonolysis SOA Smog chamber Aerosol mass spectrometry

Endovascular treatment of Budd-Chiari syndrome

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Chinese Medical Journal 2011年第20期124卷 3289-3292页

作者： meng Qing-yi SUN Nian-feng WANG Jia-xiang WANG rui-hua LIU Zhao-xuan Department of Surgery First Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China Department of Vascular Surgery Affiliated Jinan Central Hospital of Shandong University Jinan Shandong 250013 China

Background Budd-Chiad syndrome （BCS） is a posthepatic portal hypertension caused by the obstruction of the lumen of the hepatic veins or the proximal inferior vena cava （IVC）. This study aimed to evaluate the clinical experience of interventional therapy for Budd-Chiari syndrome. Methods IVC venography was carried out first, the obliteration or stenosis in the IVC was opened or dilated with the hard guided wire or Rupsl00 puncture needle and balloon, then a stent was routinely implanted for the type of obliteration or stenosis. Results The procedure was successful in 821 out of 903 cases including IVC intervention in 760 cases, and hepatic vein intervention in 61 cases. An IVC stent was used in 517 cases and hepatic vein stent in 19 cases. There were no pulmonary embolisms, but acute renal failure occurred in eight cases, hepatic coma in two cases and acute heart failure in 43 cases. Two patients died in this group and five cases were complicated with acute IVC thrombosis. Follow up of 7 to 124 months was made in 679 cases with recurrence found in 59 cases. Conclusions Interventional therapy is safe and effective with a fast recovery for most types of BCS. It is gradually becomine the first therapeutic choice.

关键词： Budd-Chiari syndrome angioplasty stents

基于有调节的中介模型分析突发公共卫生事件中信息疫情对社会焦虑的影响

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现代预防医学 2024年第6期51卷 1105-1111页

作者：王群凯孟楠王可欣刘欢诸葛瑞倩王雨璇马云霞高珊珊刘沼悦许峤吴群红哈尔滨医科大学卫生管理学院南方医科大学第五附属医院

目的研究通过有调节的中介模型干预信息疫情对公众焦虑的影响过程，旨在探究信息疫情与焦虑情绪之间的关系及其作用机制，以期更好的解决其带来的难题，消弭突发公共卫生事件下信息疫情笼罩的公众焦虑氛围，进一步扼杀社会风险危机产... 详细信息

目的研究通过有调节的中介模型干预信息疫情对公众焦虑的影响过程，旨在探究信息疫情与焦虑情绪之间的关系及其作用机制，以期更好的解决其带来的难题，消弭突发公共卫生事件下信息疫情笼罩的公众焦虑氛围，进一步扼杀社会风险危机产生的可能性。方法采用方便抽样和滚雪球抽样相结合的方法，在全国范围内调查有效问卷1 580份，进行描述性统计分析、回归分析和有中介的调节效应分析。结果信息疫情对焦虑程度有正向预测作用(β=0.14,P<0.001);心理韧性在信息疫情与焦虑程度间起部分中介效应，中介效应值为0.30(95%CI:0.10～0.52),间接效应占总效应的15.4%;受教育程度在前述中介模型的后半路径起到调节作用(β=-0.36,P<0.001)。结论突发公共卫生事件背景下，建议通过提升公众心理韧性及受教育程度来缓解信息疫情造成的不良冲击，继而降低社会公众焦虑的负性情绪。

关键词：信息疫情焦虑情绪心理韧性中介效应调节效应