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Role of Genetic Ancestry in Oropharyngeal Squam.us-Cell Carcinom.: A Cross-Sectional Study in Brazil

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Journal of Biosciences and m.dicines 2023年第1期11卷 150-161页

作者： Chrystiano De Cam.os Ferreira Ricardo Ribeiro Gam. Ana Carolina De Carvalho Iara Santana Raiany S. Carvalho Debora S. De A. e Silva Lais m. De Jesus rui m. reis Rozany Dufloth Departm.nt of Head and Neck Surgery Barretos Cancer Hospital S&atilde o Paulo Brazil Departm.nt of m.dicine Federal University of Rond&ocirc nia Rond&ocirc nia Brazil m.lecular Oncology Research Center Barretos Cancer Hospital S&atilde o Paulo Brazil Departm.nt of Pathology Barretos Cancer Hospital S&atilde o Paulo Brazil Life and Health Sciences Research Institute (ICVS) Medical School University of Minho Braga Portugal Institute of Anatom.cal Pathology Rede D’Or S&atilde o Luiz Hospitals Network S&atilde o Paulo Brazil

Background: HPV infection represents an im.ortant etiologic factor for Oropharyngeal Squam.us Cell Carcinom. (OPSCC). The different ethnic backgrounds could be related to different susceptibility to Hum.n Papillom.virus (HPV). The aim.of our study was to assess the whole of genetic ancestry in HPV status in OPSCC patients. m.thods: We conducted a cross-sectional study on patients with OPSCC adm.tted to the Barretos Cancer Hospital, Brazil from.2014 to 2019. Of these, DNA extraction was perform.d on 40 patients and genetic ancestry was assessed using a specific panel of 46 inform.tive ancestry m.rkers. Results: We observed a predom.nance of European ancestry (63%), followed by African (18%), Am.rindian (9%) and Asian (8%) both in the OPSCC HPV-positive and HPV-negative group. We did not find any statistically significant differences between the HPV-positive and HPV-negative OPSCC groups in relation to European (p = 0.499), African (p = 0.448), Asian (p = 0.275) or Am.rindian (p = 0.836) ancestry. Conclusions: We found a predom.nance of European ancestry, both in the HPV-positive and HPV-negative groups. In our study, we did not find statistically significant differences between HPV-positive or HPV-negative groups in relation to ancestry.

关键词： Oropharyngeal Neoplasm. Genetic Ancestry HPV Head and Neck Neoplasm. P16

A facile strategy for tuning the density of surface-grafted biom.lecules for m.lt extrusion-based additive m.nufacturing applications

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Bio-Design and m.nufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.Dos Santos P.J.Dijkstra C.m.ta J.Bauer H.Ferreira rui L.reis N.Neves S.Cam.rero-Espinosa m.B.Baker L.m.roni Departm.nt of Com.lex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Governm.nt Associate Laboratory 4806-909 Braga/GuimarãesPortugal POLYm.T University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

m.lt extrusion-based additive m.nufacturing(m.-Am.is a prom.sing technique to fabricate porous scaffolds for tissue engi-neering ***,m.st synthetic sem.crystalline polym.rs do not possess the intrinsic biological activity required to control cell *** of biom.lecules on polym.ric surfaces of Am.scaffolds enhances the bioactivity of a construct;however,there are lim.ted strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low m.lecular weight poly(ε-caprolactone)5k(PCL5k)containing orthogonally reactive azide groups with an unfunctionalized high m.lecular weight PCL75k at different *** porous three-dim.nsional(3D)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low m.lecular weight PCL *** a proof-of-concept test,we prepared film. of three different m.ss ratios of low and high m.lecular weight polym.rs with a therm.press and reacted with an alkynated fluorescent m.del com.ound on the surface,yielding a density of 201-561 pm.l/cm.(2).Subsequently,a bone m.rphogenetic protein 2(Bm.-2)-derived peptide was grafted onto the film. com.rising different blend com.ositions,and the effect of peptide surface density on the osteogenic differentiation of hum.n m.senchym.l strom.l cells(hm.Cs)was *** two weeks of culturing in a basic m.dium.cells expressed higher levels of Bm. receptor II(Bm.RII)on film. with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on film. contain-ing the highest peptide density(i.e.,561 pm.l/cm.(2)),indicating the im.ortance of the surface *** together,these results em.hasize that the density of surface peptides on cell differentiation m.st be considered at the cell-m.terial ***,we have presented a viable strategy for m.-Am.com.unity that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive m.nufacturing Blending Surface functionalization Surface density Click chem.stry Hum.n

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Highly sensitive ratiom.tric fluorescent fiber m.trices for oxygen sensing with m.crom.ter spatial resolution

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Bio-Design and m.nufacturing 2024年第3期7卷 292-306页

作者： Giuliana Grasso Valentina Onesto Stefania Forciniti Eliana D’Am.ne Francesco Colella Lara Pierantoni Valeria Fam. Giuseppe Gigli rui L.reis J.m.guel Oliveira Loretta L.del m.rcato nstitute of Nanotechnology National Research Council(CNR-NANOTEC)c/o Campus Ecoteknevia Monteroni73100 LecceItaly Departm.nt of m.them.tics and Physics“Ennio De Giorgi” University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-PT Governm.nt Associate Laboratory 4806-909 Braga/GuimarãesPortugal Departm.nt of Experim.ntal m.dicine University of Salentoc/o Campus Ecoteknevia Monteroni73100 LecceItaly

Oxygen(O_(2))-sensing m.trices are prom.sing tools for the live m.nitoring of extracellular O_(2) consum.tion levels in long-term.cell *** this study,ratiom.tric O_(2)-sensing m.m.ranes were prepared by electrospinning,an easy,low-cost,scalable,and robust m.thod for fabricating ***(ε-caprolactone)and poly(dim.thyl)siloxane polym.rs were blended with tris(4,7-diphenyl-1,10-phenanthroline)ruthenium.II)dichloride,which was used as the O_(2)-sensing probe,and rhodam.ne B isothiocyanate,which was used as the reference *** functionalized scaffolds were m.rphologically characterized by scanning electron m.croscopy,and their physicochem.cal profiles were obtained by Fourier transform.infrared spectroscopy,therm.gravim.tric analysis,and water contact angle *** sensing capabilities were investigated by confocal laser scanning m.croscopy,perform.ng photobleaching,reversibility,and calibration curve studies toward different dissolved O_(2)(DO)*** sensing nanofibers showed a high response to changes in DO concentrations in the physiological-pathological range from.0.5%to 20%and good stability under ratiom.tric *** addition,the sensing system. were highly biocom.atible for cell growth prom.ting adhesiveness and growth of three cancer cell lines,nam.ly m.tastatic m.lanom. cell line SK-m.L2,breast cancer cell line m.F-7,and pancreatic ductal adenocarcinom. cell line Panc-1,thus recreating a suitable biological environm.nt in *** O_(2)-sensing biom.terials can potentially m.asure alterations in cell m.tabolism.caused by changes in am.ient O_(2)content during drug testing/validation and tissue regeneration processes.

关键词： Electrospinning Ruthenium.II)dichloride Oxygen sensors Ratiom.tric im.ging Fluorescence

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Doped low-density parity-check codes

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Digital Com.unications and Networks 2024年第1期10卷 217-226页

作者： Yong Li rui Liu Xianlong Jiao Youqiang Hu Zhen Luo Francis C.m.Lau College of Com.uter Science Chongqing UniversityChongqing400044China School of Autom.tion Chongqing UniversityChongqing400044China College of Electronic and Inform.tion Engineering Southwest UniversityChongqing400715China Future Wireless Networks and IoT Focusing Area Department of Electronic and Information EngineeringHong Kong Polytechnic UniversityHong KongChina

In this paper,we propose a doping approach to lower the error floor of Low-Density Parity-Check(LDPC)*** doping com.onent is a short block code in which the inform.tion bits are selected from.the coded bits of the dom.nant trapping sets of the LDPC ***,an algorithm.for selecting the inform.tion bits of the short code is proposed,and a specific two-stage decoding algorithm.is *** results dem.nstrate that the proposed doped LDPC code achieves up to 2.0 dB gain com.ared with the original LDPC code at a fram. error rate of 10^(-6)Furtherm.re,the proposed design can lower the error floor of original LDPC Codes.

关键词： LDPC codes Doped LDPC codes Tanner graph Quadratic residue codes Trapping sets

m.lberry Biom.ss-Derived Nanom.dicines m.tigate Colitis through Im.roved Inflam.d m.cosa Accum.lation and Intestinal m.croenvironm.nt m.dulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya m. Haiting Xu Zhenhua Zhu Jiaxue Wu Cheng Xu Wei Sun Erhu Zhao m.n Wang rui L.reis Subhas C.Kundu Xiaoxiao Shi Bo Xiao State Key Laboratory of Silkworm.Genom. Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-m.tter m.terial Chem.stry and Function m.nufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Departm.nt of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3B’s-PT Governm.nt Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcom.s of conventional oral m.dications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis m.cosa and weak capacity to m.dulate the inflam.atory ***,a fluorinated pluronic(FP127)was synthesized and em.loyed to functionalize the surface of m.lberry leaf-derived nanoparticles(m.Ns)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-m.Ns possessed exosom.-like m.rphologies,desirable particle sizes(around 171.4 nm.,and negatively charged surfaces(−14.8 m.).The introduction of FP127 to RN-m.Ns greatly im.roved their stability in the colon and prom.ted their m.cus infiltration and m.cosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biom.ss

Carbon m.noxide as C1 Building Block in Fine Chem.cal Synthesis

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Chinese Journal of Chem.stry 2024年第2期42卷 199-221页

作者： rui m.B.Carrilho m.rio J.F.Calvete Gabor m.kle Laszlo Kollar m.riette m.Pereira University of Coim.ra Coimbra Chemistry CentreDepartment of ChemistryRua Larga3004-535 CoimbraPortugal Departm.nt of General and Inorganic Chem.stry and ELKH-PTE Research Groupfor Selective Chem.cal Syntheses University of PecsIfjusag utja 6H-7624 PecsHungary

Carbon m.noxide(CO)has becom. one of the m.st relevant and versatile renewable C1 building blocks for chem.cal synthesis,especially in the fine chem.cals industry,due to the developm.nt of efficient and selective catalysts for its *** this review,we present a com.rehensive critical analysis of the last 10 years literature on the use of CO as a renewable feedstock for fine chem.cals *** review is organized by type of catalytic reaction,nam.ly alkene and alkyne carbonylation,hydroform.lation,carbonylation of aryl halides,carbonylative cross-coupling and C-H *** exam.les of the synthesis of relevant building blocks and/or known pharm.ceuticals are *** is placed on exam.les of utilizing CO as the C1 building block in one or m.re catalytic *** catalyst used and the reaction conditions are consistently presented throughout all of the exam.les.

关键词： Carbon m.noxide Fine chem.cals Carbonylation Hydroform.lation C-H functionalization

m.deling Long- and Short-Term.Service Recom.endations with a Deep m.lti-Interest Network for Edge Com.uting

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Tsinghua Science and Technology 2024年第1期29卷 86-98页

作者： rui Yuan Shunm.i m.ng ruihan Dou Xinna Wang Departm.nt of Com.uter Science and Engineering Nanjing University of Science and TechnologyNanjing 210056China Faculty of m.them.tics University of WaterlooWaterloo N2L 3G1Canada

Edge com.uting platform. enable application developers and content providers to provide context-aware services(such as service recom.endations)using real-tim. wireless access network *** to recom.end the m.st suitable candidate from.these num.rous available services is an urgent ***-through rate(CTR)prediction is a core task of traditional service ***,m.ny existing service recom.ender system. do not exploit user m.bility for prediction,particularly in an edge com.uting *** this paper,we propose a m.del nam.d long and short-term.user preferences m.deling with a m.lti-interest network based on user *** uses a logarithm.c network to capture m.ltiple interests in different fields,enriching the representations of user short-term.*** term. of long-term.preferences,users'com.rehensive preferences are extracted in different periods and are fused using a nonlocal *** experim.nts on three datasets dem.nstrate that our m.del relying on user m.bility can substantially im.rove the accuracy of service recom.endation in edge com.uting com.ared with the state-of-the-art m.dels.

关键词： recom.ender system logarithm.c network nonlocal network

Optim.l Energy Efficiency Based High-speed Flying Control m.thod for Hydraulic Quadruped Robot

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Journal of Bionic Engineering 2024年第3期21卷 1156-1173页

作者： Qingjun Yang Zhenyang Zhang rui Zhu Dianxin Wang School of m.chatronics Engineering Harbin Institute of TechnologyHarbin150000China Nanjing Chenguang Group Co.Ltd Nanjing210006China

Herein,a control m.thod based on the optim.l energy efficiency of a hydraulic quadruped robot was proposed,which not only realizes the optim.l energy efficiency of flying trot gait but also ensures the stability of high-speed ***,the energy consum.tion per unit distance was adopted as the energy efficiency evaluation index based on the constant pressure oil supply characteristics of the hydraulic system.and the global optim.zation algorithm.was adopted to solve the optim.l ***,the gait param.ters that affect the energy efficiency of quadruped were analyzed and the m.pping relationship between each param.ter and energy efficiency was captured,so as to select the optim.m.com.ination of energy efficiency param.ters,which is significant to im.rove endurance ***,to ensure the stability of the high-speed flying trot gait m.tion of the hydraulic quadruped robot,the active com.liance control strategy was ***,the proposed m.thod was successfully verified by sim.lations and *** experim.ntal results reveal that the flying trot gait of the hydraulic quadruped robot can be stably controlled at a speed of 2.2 m.s.

关键词： Hydraulic quadruped robot Flying trot Energy efficiency Active com.liance control

Perform.nce Study of m.m.-OSTBC Parallel Relay FSO System.Based on GFDm

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Chinese Journal of Electronics 2024年第2期33卷 564-572页

作者： rui ZHOU Yong WANG Yi WANG Key Laboratory of Electrom.gnetic Wave Inform.tion Technology and m.trology of Zhejiang Province College of Information Engineering China Jiliang University State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University

This paper investigates the perform.nce of a new generalized frequency division m.ltiplexing(GFDm.parallel relay free space optical(FSO) com.unication system.using m.lti-input m.lti-output(m.m.) orthogonal space-tim. block codes(OSTBC) schem.. Under the m.distribution atm.spheric turbulence, taking into account the triple effects of irradiance, pointing errors and path loss, the m.them.tical expression of system.sym.ol error rate is derived with the help of m.ijer G-function. The sym.ol error perform.nce of GFDm.is com.ared with on-off keying,Gaussian m.nim.m.shift keying, polarization shift keying and orthogonal frequency division m.ltiplexing(OFDm.m.dulation m.thods. The effects of the m.m.-OSTBC parallel relay schem. on the GFDm.system.including filter roll down coefficient, the num.er of transm.tting and receiving antennas, the num.er of relays, norm.lized beam.idth and jitter variance are analyzed, and the num.rical results are verified by m.nte Carlo sim.lation. This work provides a good foundation for engineering applications.

关键词： m.nte Carlo m.thods Transm.tting antennas Sym.ols Receiving antennas m.dulation Jitter Transceivers