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Mutual antagonism of mouse-adaptation mutations in HA and PA proteins on H9N2 virus replication

Virologica Sinica 2024年第1期39卷 56-70页

作者： Liping Ma Huabin Zheng Xianliang Ke rui gui Zhongzi Yao Jiasong Xiong Quanjiao Chen CAS Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of VirologyChinese Academy of SciencesWuhan430207China Center for Biosafety Mega-Science Wuhan Institute of VirologyChinese Academy of SciencesWuhan430207China Hubei Jiangxia Laboratory Wuhan430207China University of Chinese Academy of Sciences Beijing100049China

Avian H9N2 viruses have wide host range among the influenza A ***,knowledge of H9N2 mammalian adaptation is *** explore the molecular basis of the adaptation to mammals,we performed serial lung passaging of the H9N2 strain A/chicken/Hunan/8.27 YYGK3W3-OC/2018(3W3)in mice and identified six mutations in the hemagglutinin(HA)and polymerase acidic(PA)*** L226Q,T511I,and A528V of HA were responsible for enhanced pathogenicity and viral replication in mice;notably,HA-L226Q was the key *** T97I,I545V,and S594G of PA contributed to enhanced polymerase activity in mammalian cells and increased viral replication levels in vitro and in ***-T97I increased viral polymerase activity by accelerating the viral polymerase complex *** findings revealed that the viral replication was affected by the presence of PA-97I and/or PA-545V in combination with a triple-point HA ***,the double-and triple-point PA mutations demonstrated antagonistic effect on viral replication when combined with ***,any combination of PA mutations,along with double-point HA mutations,resulted in antagonistic effect on viral *** also observed antagonism in viral replication between PA-545V and PA-97I,as well as between HA-528V and *** findings demonstrated that several antagonistic mutations in HA and PA proteins affect viral replication,which may contribute to the H9N2 virus adaptation to mice and mammalian *** findings can potentially contribute to the monitoring of H9N2 field strains for assessing their potential risk in mammals.

关键词： Influenza Avirus(IAV) H9N2 HA PA Antagonism Mouse adaptation

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减磷施肥配施生物炭对南方酸性稻作土壤磷素形态的影响

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中国土壤与肥料 2024年第1期 19-27页

作者：苏贵锐荣飞龙张薇张满云吴爱平陈法霖洞庭湖区农村生态系统健康湖南省重点实验室湖南农业大学资源环境学院湖南长沙410128 湖南农业大学农学院湖南长沙410128

针对南方酸性稻作土壤专性吸附和固定磷素能力强的问题,采用微区试验,以正常施磷(75 kg/hm^(2))不施生物炭为对照,探讨不同磷肥水平(P2O575、60、45、30 kg/hm^(2))和生物炭配施(40、60、80 t/hm^(2))对土壤不同形态磷素含量的影响。结... 详细信息

针对南方酸性稻作土壤专性吸附和固定磷素能力强的问题,采用微区试验,以正常施磷(75 kg/hm^(2))不施生物炭为对照,探讨不同磷肥水平(P2O575、60、45、30 kg/hm^(2))和生物炭配施(40、60、80 t/hm^(2))对土壤不同形态磷素含量的影响。结果表明:(1)减磷施肥配施生物炭后全磷、有效磷、树脂磷、碳酸氢钠无机磷及稀盐酸磷的含量显著增加,残留态磷的含量显著降低。(2)磷肥水平≥45 kg/hm^(2)时,配施生物炭处理的全磷和有效磷含量较对照分别显著提高17.1%~46.7%和32.5%~76.3%。(3)磷肥水平≥45 kg/hm^(2)时,配施生物炭处理的树脂磷和碳酸氢钠无机磷的含量较对照分别显著增加50.8%~160.3%和36.1%~118.3%。(4)减磷施肥导致氢氧化钠有机磷含量较对照下降38.4%~39.8%;处理间氢氧化钠无机磷的含量无显著差异。(5)配施生物炭后稀盐酸磷含量较对照显著提高57.9%~352.1%;减磷施肥处理的浓盐酸有机磷含量显著低于正常施磷的处理组合;施磷量为30 kg/hm^(2)时,浓盐酸无机磷的含量显著低于其他处理组合;配施生物炭显著降低残留态磷的含量。(6)土壤全磷、有效磷的含量与树脂磷、碳酸氢钠无机磷、稀盐酸磷的含量呈显著正相关。综上所述,添加生物炭有利于提高南方酸性稻作土壤的磷素含量,促进有机磷向无机磷的转化,提高土壤磷素有效性,在此基础上磷肥施用可低至45 kg/hm^(2)。

关键词：生物炭减磷施肥水稻土磷分级

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早熟梨新品种‘蜀都蜜’的选育

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北方园艺 2024年第2期 158-160,F0002页

作者：桂瑞张勇李山林刘勇强张云婷汤浩茹四川农业大学园艺学院四川成都611130

‘蜀都蜜’是由‘金花’×‘早酥’杂交选育出的早熟砂梨新品种。该品种树势中庸,树姿半开张;一年生枝条呈黄褐色,皮孔小且分布稀疏;叶片长椭圆形,叶缘锐锯齿;每花序5~9朵花,花药浅粉红色,花柱高于花药,以短果枝结果为主。果实呈纺锤形... 详细信息

‘蜀都蜜’是由‘金花’×‘早酥’杂交选育出的早熟砂梨新品种。该品种树势中庸,树姿半开张;一年生枝条呈黄褐色,皮孔小且分布稀疏;叶片长椭圆形,叶缘锐锯齿;每花序5~9朵花,花药浅粉红色,花柱高于花药,以短果枝结果为主。果实呈纺锤形,果面光洁,黄绿色,果点小;平均单果质量231.5 g;果肉白色,肉质细脆,石细胞少,风味甜蜜浓郁,可溶性固形物含量13.7%,可溶性糖含量8.43%,可滴定酸含量0.22%,果实硬度8.34 kg·cm^(-2)。在成都崇州地区于3月上旬开花,7月上旬果实成熟,果实发育期约115 d;适应性与抗性较好,生物学性状和经济性状稳定,适宜在四川、重庆等平原和丘陵砂梨生态区种植。

关键词：梨新品种蜀都蜜早熟鲜食

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Regional coupled C-N-H2O cycle processes and associated driving mechanisms

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Science China Earth Sciences 2020年第9期63卷 1227-1236页

作者： Yang GAO gui-rui YU Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China

From a molecular level to an ecosystem scale,different coupling mechanisms take place during coupled carbonnitrogen-water(C-N-H2O)cycle,of which essential are water flux and related biogeochemical processes through physicochemical reactions associated with terrestrial and aquatic ***,regional coupled C-N-H2O cycle will subsequently impact regional gross primary productivity(GPP)and C and N exchanges during air-water interactions that occur downstream of *** study aimed to first synthetically analyze the regional dynamics of C,N and H2O cycles in ecosystems and determine their interactional relationships;second,to specify regional C-N-H2O coupled relationships of ecosystems and their theoretical ecological principles;third,to classify coupled regional response and adaptation of the C-N-H2O cycle to climatic and environmental changes under anthropogenic activities,providing a theoretical basis to fully understand and make adjustments to interactional C,N and H2O cycling relationships at different ecosystem scales and under associated coupling processes.

关键词： Regional C-N-H2O cycle Coupled relationship C cycle N cycle Water cycle Driving mechanisms

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Plutonium utilization in a small modular molten-salt reactor based on a batch fuel reprocessing scheme

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Nuclear Science and Techniques 2024年第4期35卷 15-28页

作者： Xue-Chao Zhao rui Yan gui-Feng Zhu Ya-Fen Liu Jian Guo Xiang-Zhou Cai Yang Zou Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China CAS Innovative Academies in TMSR Energy System Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

A molten salt reactor(MSR)has outstanding features considering the application of thorium fuel,inherent safety,sustainability,and resistance to ***,fissile material^(233)U is significantly rare at the current stage,thus it is difficult for MSR to achieve a pure thorium-uranium fuel ***,using plutonium or enriched uranium as the initial fuel for MSR is more *** this study,we aim to verify the feasibility of a small modular MSR that utilizes plutonium as the starting fuel(SM-MSR-Pu),and highlight its advantages and ***,the structural design and fuel management scheme of the SM-MSR-Pu were ***,the neutronic characteristics,such as the graphite-irradiation lifetime,burn-up performance,and coefficient of temperature reactivity were calculated to analyze the physical characteristics of the *** results indicate that plutonium is a feasible and advantageous starting fuel for a SM-MSR;however,there are certain shortcomings that need to be *** a 250 MWth SM-MSR-Pu,approximately 288.64 kg^(233)U of plutonium with a purity of greater than 90% is produced while 978.00 kg is burned every ten *** temperature reactivity coefficient decreases from -4.0 to -6.5 pcm K^(-1) over the 50-year operating time,which ensures a long-term safe ***,the amount of plutonium and accumulation of minor actinides(MAs)would increase as the burn-up time increases,and the annual production and purity of^(233)U will *** achieve an optimal burn-up performance,setting the entire operation time to 30 years is ***,more than 3600 kg of plutonium eventually accumulate in the *** research is required to effectively utilize this accumulated plutonium.

关键词： Molten salt fuel Plutonium utilization ^(233)U TRUs mole fraction Temperature feedback coefficient

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Effect of Arbuscular Mycorrhizal Inoculation on Plant Growth and Phthalic Ester Degradation in Two Contaminated Soils

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Pedosphere 2005年第2期15卷 263-269页

作者： CHENrui-rui YINrui LINXian-gui CAOZhi-Hong InstituteofSoilScience ChineseAcademyofSciencesNanjing210008（China）

A 60-day pot experiment was carried out using di-(2-ethylhexyl) phthalate (DEHP) as a typical organic pollutant phthalic ester and cowpea (Vigna sinensis) as the host plant to determine the effect of arbuscular mycorrhizal inoculation on plant growth and degradation of DEHP in two contaminated soils, a yellow-brown soil and a red soil. The air-dried soils were uniformly sprayed with different concentrations of DEHP, inoculated or left uninoculated with an arbuscular mycorrhizal (AM) fungus, and planted with cowpea seeds. After 60 days the positive impact of AM inoculation on the growth of cowpea was more pronounced in the red soil than in the yellow-brown soil, with significantly higher (P ＜ 0.01)mycorrhizal colonization rate, shoot dry weight and total P content in shoot tissues for the red soil. Both in the yellowbrown and red soils, AM inoculation significantly (P ＜ 0.01) reduced shoot DEHP content, implying that AM inoculation could inhibit the uptake and translocation of DEHP from roots to the aboveground parts. However, with AM inoculation no positive contribution to the degradation of DEHP was found.

关键词：灌木菌根真菌接种方法植物生长土壤污染邻苯二甲酸酯

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Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 414-435页

作者： You-Wang Lu Zhao-Li Ding rui Mao gui-Gang Zhao Yu-Qi He Xiao-Lu Li Jiang Liu Department of Dermatology and Venereology The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina Kunming Biological Diversity Regional Center of Large Apparatus and Equipments Public Technical Service CenterKunming Institute of ZoologyKunming 650223Yunnan ProvinceChina School of Stomatology Kunming Medical UniversityKunming 650500Yunnan ProvinceChina Genome Center of Biodiversity Kunming Institute of ZoologyChinese Academy of ScienceKunming 650223Yunnan ProvinceChina Department of Reproduction and Genetics The First Affiliated Hospital of Kunming Medical UniversityKunming 650032Yunnan ProvinceChina

BACKGROUND Aberrant methylation is common during the initiation and progression of colorectal cancer(CRC),and detecting these changes that occur during early adenoma(ADE)formation and CRC progression has clinical *** To identify potential DNA methylation markers specific to ADE and *** Here,we performed SeqCap targeted bisulfite sequencing and RNA-seq analysis of colorectal ADE and CRC samples to profile the epigenomic-transcriptomic *** Comparing 22 CRC and 25 ADE samples,global methylation was higher in the former,but both showed similar methylation patterns regarding differentially methylated gene positions,chromatin signatures,and repeated ***-grade CRC tended to exhibit elevated methylation levels in gene promoter regions compared to those in low-grade *** with RNA-seq gene expression data,we identified 14 methylation-regulated differentially expressed genes,of which only AGTR1 and NECAB1 methylation had prognostic *** Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC,suggesting prognostic biomarkers for CRC.

关键词： Colorectal cancer Epigenomic alteration Transcriptome Methylation-regulated differentially expressed genes

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自然生态价值、生态资产管理及价值实现的生态经济学基础研究--科学概念、基础理论及实现途径

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应用生态学报 2022年第5期33卷 1153-1165页

作者：于贵瑞杨萌中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室中国生态系统研究网络综合研究中心北京100101 中国科学院大学资源与环境学院北京100049

自然界的生态系统为人类繁衍发展提供各式各样的生活、生产和生计的环境条件与自然资源。基于自然规律的生态系统管理是人类社会不断认知自然生态价值、保护利用自然环境和资源、创造积累生态资产、维持社会经济系统永续发展的基本途径... 详细信息

自然界的生态系统为人类繁衍发展提供各式各样的生活、生产和生计的环境条件与自然资源。基于自然规律的生态系统管理是人类社会不断认知自然生态价值、保护利用自然环境和资源、创造积累生态资产、维持社会经济系统永续发展的基本途径。以此为核心认知的区域生态经济学或经济生态学,正在成为探讨人类世地球系统演变及社会经济可持续发展问题的科学研究前沿。本文以大尺度区域宏观生态系统科学为学术视角,以生态系统的多功能性与多元价值观为基础,综合论述了自然生态价值、生态资产、生态产品等基本概念;从生态学、社会学和经济学融合角度,分析讨论了生态资产形成与变化、生态产品生产与消费、生态投资与生态资产损益等过程原理;提出了区域生态资产的系统经营与生态价值实现途径,期望为我国及区域生态系统价值及生态资产的评估,生态产业及生态价值实现体系的发展提供理论和方法学参考。

关键词：生态价值生态资产生态产品价值实现生态经济学

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中国干旱半干旱区土壤CO_(2)与CH_(4)通量的耦联解耦及其对温度的响应

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植物生态学报 2022年第12期46卷 1497-1507页

作者：杨萌于贵瑞中国科学院地理科学与资源研究所生态系统网络观测与模拟重点实验室中国生态系统研究网络综合研究中心北京100101 中国科学院大学资源与环境学院北京100049

干旱半干旱区是一类典型的生态脆弱区,同时又对全球变暖具有重要影响。其土壤以氧化型土壤为主,被认为是重要的CH_(4)汇,然而研究发现随着土壤吸收CH_(4)速率的升高,排放CO_(2)的速率也升高。为验证该消长现象是否广泛存在以及是否发生... 详细信息

干旱半干旱区是一类典型的生态脆弱区,同时又对全球变暖具有重要影响。其土壤以氧化型土壤为主,被认为是重要的CH_(4)汇,然而研究发现随着土壤吸收CH_(4)速率的升高,排放CO_(2)的速率也升高。为验证该消长现象是否广泛存在以及是否发生于特定环境条件下,该研究基于中国干旱半干旱地区的土壤温室气体通量与相关环境数据整合,首次开展了多站点的土壤CO_(2)与土壤CH_(4)通量季节变化耦联与日变化耦联分析。结果显示,土壤CO_(2)与土壤CH_(4)通量间存在协同(正相关)、消长(负相关)及随机(不相关)3种模式,其中随机变化的比例更高,季节尺度与日尺度上分别占比83%与54%。相对于水分和植被状况,温度与通量间相关性的关系更强,呈现为随气温升高通量间相关性下降的二次函数关系。季节尺度上,采样期间平均气温对通量间相关关系的判别准确率为92%,通量间耦联解耦的气温阈值为12.5℃;日尺度上,日气温差对通量间相关关系的判别准确率为79%,通量间耦联解耦的温度阈值为15.2℃。此外,日尺度上土壤为吸收CH_(4)状态时,土壤CH_(4)与土壤CO_(2)通量之间并非呈现为负相关关系,而更多呈现为正相关关系,这一现象难以仅用温度进行解释,我们推测土壤呼吸和CH_(4)氧化在竞争O2过程中形成了不对等的耦联关系,即土壤呼吸可通过消耗O2抑制CH_(4)氧化,从而出现土壤CO_(2)排放增加而CH_(4)吸收降低的现象。该研究表明,土壤CO_(2)和CH_(4)通量间可能存在温度调控嵌套O2竞争调控的耦联解耦机制,气候变暖可能导致两种通量在更广的空间上以及更长的时间上发生解耦,增加区域碳循环的复杂性以及碳通量评估的不确定性。

关键词：耦联解耦土壤CO_(2)通量土壤CH_(4)通量温度干旱半干旱区

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Suppressing Wnt signaling of the blood-tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2716-2731页

作者： Yang Tong Pei An Puxian Tang rui Mu Yuteng Zeng Hang Sun Mei Zhao Ziyan Lv Pan Wang Wanjun Han Chunshan gui Xuechu Zhen Liang Han Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow UniversitySuzhou 215123China Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow UniversitySuzhou 215123China

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid *** inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood-tumor barrier(BTB).BTB activates its Wnt signaling to maintain barrier properties,e.g.,Mfsd2a-mediated BTB low ***,we reported VCAM-1-targeting nano-wogonin(W@V-NPs)as an adjuvant of nano-orlistat(O@V-NPs)to intensify drug delivery and inhibit lipogenesis of brain metastases.W@V-NPs were proven to be able to inactivate BTB Wnt signaling,downregulate BTB Mfsd2a,accelerate BTB vesicular transport,and enhance tumor accumulation of O@*** the ability to specifically kill cancer cells in a lipid-deprived environment with IC_(50) at 48 ng/mL,W@V-NPs plus O@V-NPs inhibited the progression of brain metastases with prolonged survival of model *** combination did not induce brain edema,cognitive impairment,and systemic toxicity in healthy *** Wnt signaling could safely modulate the BTB to improve drug delivery and metabolic therapy against brain metastases.

关键词： Lipogenesis Brain metastases Blood-tumor barrier Wnt signaling Drug delivery Fatty acid synthase Nanoparticles Combination therapy

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